Reaction Details Report a problem with these data
Target
Diacylglycerol O-acyltransferase 2
Ligand
BDBM504495
Substrate
n/a
Meas. Tech.
In Vitro Assay
IC50
19.0±n/a nM
Citation
 Edmonds, DJ; Filipski, KJ; Futatsugi, K; Garnsey, MR; Lee, JC; Smaltz, DJ Diacylglycerol acyl transferase 2 inhibitor US Patent  US11065249 Publication Date 7/20/2021 
Target
Name:
Diacylglycerol O-acyltransferase 2
Synonyms:
ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase
Type:
Multi-pass membrane protein
Mol. Mass.:
43848.90
Organism:
Homo sapiens (Human)
Description:
Q96PD7
Residue:
388
Sequence:
MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN
  
Inhibitor
Name:
BDBM504495
Synonyms:
First-eluting isomer (see footnote 4 in Table 1); rac-2-{5-[(3-ethoxypyridin-2- yl)oxy]pyridin-3-yl}-N-[(3R,6S)-6- (trifluoromethyl)piperidin-3- yl]pyrimidine-5-carboxamide or rac-2-{5-[(3-ethoxypyridin-2- yl)oxy]pyridin-3-yl}-N-[(3R,6R)-6- (trifluoromethyl)piperidin-3- yl]pyrimidine-5-carboxamide | US11065249, Example 8 | US11065249, Example 9 | US11471458, Example 9 | US20230405002, Example 11
Type:
Small organic molecule
Emp. Form.:
C23H23F3N6O3
Mol. Mass.:
488.4623
SMILES:
CCOc1cccnc1Oc1cncc(c1)-c1ncc(cn1)C(=O)N[C@H]1CC[C@@H](NC1)C(F)(F)F |r|
Structure:
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