Reaction Details Report a problem with these data
Target
Diacylglycerol O-acyltransferase 2
Ligand
BDBM504497
Substrate
n/a
Meas. Tech.
In Vitro Assay
IC50
4.40±n/a nM
Citation
 Edmonds, DJ; Filipski, KJ; Futatsugi, K; Garnsey, MR; Lee, JC; Smaltz, DJ Diacylglycerol acyl transferase 2 inhibitor US Patent  US11065249 Publication Date 7/20/2021 
Target
Name:
Diacylglycerol O-acyltransferase 2
Synonyms:
ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase
Type:
Multi-pass membrane protein
Mol. Mass.:
43848.90
Organism:
Homo sapiens (Human)
Description:
Q96PD7
Residue:
388
Sequence:
MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN
  
Inhibitor
Name:
BDBM504497
Synonyms:
First-eluting enantiomer from separation of Example 9 (see footnote 5 in Table 1); 2-{5-[(3-ethoxypyridin-2-yl)oxy]pyridin- 3-yl}-N-[6-(trifluoromethyl)piperidin-3- yl]pyrimidine-5-carboxamide, trifluoroacetate salt, ENT-1 | US11065249, Example 10 | US11065249, Example 11 | US11471458, Example 11
Type:
Small organic molecule
Emp. Form.:
C23H23F3N6O3
Mol. Mass.:
488.4623
SMILES:
CCOc1cccnc1Oc1cncc(c1)-c1ncc(cn1)C(=O)NC1CCC(NC1)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: