Reaction Details Report a problem with these data
Target
Diacylglycerol O-acyltransferase 2
Ligand
BDBM504502
Substrate
n/a
Meas. Tech.
In Vitro Assay
IC50
3300±n/a nM
Citation
Edmonds, DJ; Filipski, KJ; Futatsugi, K; Garnsey, MR; Lee, JC; Smaltz, DJ Diacylglycerol acyl transferase 2 inhibitor US Patent US11065249 Publication Date 7/20/2021
More Info.:
Target
Name:
Diacylglycerol O-acyltransferase 2
Synonyms:
ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase
Type:
Multi-pass membrane protein
Mol. Mass.:
43848.90
Organism:
Homo sapiens (Human)
Description:
Q96PD7
Residue:
388
Sequence:
MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN
Inhibitor
Name:
BDBM504502
Synonyms:
From first-eluting enantiomer of intermediate (see footnote 7, Table 1); N-[(3S)-4,4-difluoropiperidin-3-yl]-2- {5-[(3-ethoxypyridin-2-yl)oxy]pyridin-3- yl}pyrimidine-5-carboxamide, trifluoroacetate salt or N-[(3R)-4,4-difluoropiperidin-3-yl]-2- {5-[(3-ethoxypyridin-2-yl)oxy]pyridin-3- yl}pyrimidine-5-carboxamide, trifluoroacetate salt | US11065249, Example 15 | US11065249, Example 16 | US11471458, Example 15 | US20230405002, Example 15
Type:
Small organic molecule
Emp. Form.:
C22H22F2N6O3
Mol. Mass.:
456.4453
SMILES:
CCOc1cccnc1Oc1cncc(c1)-c1ncc(cn1)C(=O)N[C@H]1CNCCC1(F)F |r|