Reaction Details Report a problem with these data
Target
Diacylglycerol O-acyltransferase 2
Ligand
BDBM504510
Substrate
n/a
Meas. Tech.
In Vitro Assay
IC50
14000±n/a nM
Citation
 Edmonds, DJ; Filipski, KJ; Futatsugi, K; Garnsey, MR; Lee, JC; Smaltz, DJ Diacylglycerol acyl transferase 2 inhibitor US Patent  US11065249 Publication Date 7/20/2021 
Target
Name:
Diacylglycerol O-acyltransferase 2
Synonyms:
ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase
Type:
Multi-pass membrane protein
Mol. Mass.:
43848.90
Organism:
Homo sapiens (Human)
Description:
Q96PD7
Residue:
388
Sequence:
MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN
  
Inhibitor
Name:
BDBM504510
Synonyms:
2-{5-[(3-ethoxypyridin-2-yl)oxy]pyridin- 3-yl}-N-(2-methylpiperidin-3- yl)pyrimidine-5-carboxamide, trifluoroacetate salt, mixture of stereoisomers | US11065249, Example 23 | US11471458, Example 23 | US20230405002, Example 23
Type:
Small organic molecule
Emp. Form.:
C23H26N6O3
Mol. Mass.:
434.4909
SMILES:
CCOc1cccnc1Oc1cncc(c1)-c1ncc(cn1)C(=O)NC1CCCNC1C
Structure:
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