Target
Ubiquitin carboxyl-terminal hydrolase 30
Ligand
BDBM404471
Substrate
n/a
Meas. Tech.
Biochemical Fluorescence Intensity Kinetic Assay
IC50
<100±n/a nM
Citation
 Jones, AKemp, MStockley, MGibson, KWhitlock, G 1-cyano-pyrrolidine compounds as USP30 inhibitors US Patent  US11066365 Publication Date 7/20/2021 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase 30
Synonyms:
Deubiquitinating enzyme 30 | UBP30_HUMAN | USP30 | Ub-specific protease 30 | Ubiquitin carboxyl-terminal hydrolase 30 (USP30) | Ubiquitin thioesterase 30 | Ubiquitin-specific-processing protease 30
Type:
Protein
Mol. Mass.:
58522.90
Organism:
Homo sapiens (Human)
Description:
Q70CQ3
Residue:
517
Sequence:
MLSSRAEAAMTAADRAIQRFLRTGAAVRYKVMKNWGVIGGIAAALAAGIYVIWGPITERKKRRKGLVPGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTLLHLLKALSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQPRVTHLFDVHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQSPVRFDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESVRDVVCDNCTKIEAKGTLNGEKVEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEFLMMDIYKYHLLGHKPSQHNPKLNKNPGPTLELQDGPGAPTPVLNQPGAPKTQIFMNGACSPSLLPTLSAPMPFPLPVVPDYSSSTYLFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASLQEVLSSSAYLLFYERVLSRMQHQSQECKSEE
  
Inhibitor
Name:
BDBM404471
Synonyms:
(R)-3-chloro-N-(1- cyanopyrrolidin-3-yl)-5-(4- fluorophenyl)picolinamide | US10343992, Example 123 | US11066365, Example 123 | US11390584, Example 123
Type:
Small organic molecule
Emp. Form.:
C17H14ClFN4O
Mol. Mass.:
344.771
SMILES:
Fc1ccc(cc1)-c1cnc(C(=O)N[C@@H]2CCN(C2)C#N)c(Cl)c1
Structure:
Search PDB for entries with ligand similarity: