Target
Ubiquitin carboxyl-terminal hydrolase 30
Ligand
BDBM404561
Substrate
n/a
Meas. Tech.
Biochemical Fluorescence Intensity Kinetic Assay
IC50
<100±n/a nM
Citation
 Jones, AKemp, MStockley, MGibson, KWhitlock, G 1-cyano-pyrrolidine compounds as USP30 inhibitors US Patent  US11066365 Publication Date 7/20/2021 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase 30
Synonyms:
Deubiquitinating enzyme 30 | UBP30_HUMAN | USP30 | Ub-specific protease 30 | Ubiquitin carboxyl-terminal hydrolase 30 (USP30) | Ubiquitin thioesterase 30 | Ubiquitin-specific-processing protease 30
Type:
Protein
Mol. Mass.:
58522.90
Organism:
Homo sapiens (Human)
Description:
Q70CQ3
Residue:
517
Sequence:
MLSSRAEAAMTAADRAIQRFLRTGAAVRYKVMKNWGVIGGIAAALAAGIYVIWGPITERKKRRKGLVPGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTLLHLLKALSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQPRVTHLFDVHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQSPVRFDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESVRDVVCDNCTKIEAKGTLNGEKVEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEFLMMDIYKYHLLGHKPSQHNPKLNKNPGPTLELQDGPGAPTPVLNQPGAPKTQIFMNGACSPSLLPTLSAPMPFPLPVVPDYSSSTYLFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASLQEVLSSSAYLLFYERVLSRMQHQSQECKSEE
  
Inhibitor
Name:
BDBM404561
Synonyms:
(R)-N-(1-cyanopyrrolidin-3-yl)-4-((4-cyclopropylpyrimidin-2-yl)amino)-3-fluorobenzamide | US10343992, Example 213 | US10689345, Example 213 | US11053198, Example 213 | US11066365, Example 213 | US11390584, Example 213
Type:
Small organic molecule
Emp. Form.:
C19H19FN6O
Mol. Mass.:
366.3922
SMILES:
Fc1cc(ccc1Nc1nccc(n1)C1CC1)C(=O)N[C@@H]1CCN(C1)C#N |r|
Structure:
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