Target
Tyrosine-protein kinase JAK3 [512-1124]
Ligand
BDBM505113
Substrate
n/a
Meas. Tech.
Enzymatic Inhibition Assay
IC50
98.4±n/a nM
Citation
 Fernandes, PKrawczuk, PJTichenor, MS Small molecule inhibitors of the JAK family of kinases US Patent  US11066406 Publication Date 7/20/2021 
Target
Name:
Tyrosine-protein kinase JAK3 [512-1124]
Synonyms:
JAK3 | JAK3 (aa 512-1124) | JAK3_HUMAN
Type:
Protein
Mol. Mass.:
68951.94
Organism:
Homo sapiens (Human)
Description:
P52333[512-1124]
Residue:
613
Sequence:
TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS
  
Inhibitor
Name:
BDBM505113
Synonyms:
US11066406, Ex. 7
Type:
Small organic molecule
Emp. Form.:
C23H27N7O
Mol. Mass.:
417.5068
SMILES:
CC(C)(CNC(=O)Cc1nc2cnc3[nH]ccc3c2n1C1CCC(CC#N)CC1)C#N |(12.86,2.75,;12.09,1.42,;11.32,.08,;10.75,2.19,;9.42,1.42,;8.08,2.19,;8.08,3.73,;6.75,1.42,;5.42,2.19,;5.26,3.72,;3.75,4.04,;2.98,5.37,;1.44,5.37,;.67,4.04,;-.84,3.72,;-1,2.19,;.41,1.56,;1.44,2.71,;2.98,2.71,;4.01,1.56,;3.69,.06,;4.83,-.98,;4.51,-2.48,;3.05,-2.96,;2.73,-4.46,;1.26,-4.94,;-.2,-5.42,;1.91,-1.93,;2.23,-.42,;13.42,.65,;14.75,-.12,)|
Structure:
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