| Assay Method Information | |
| | TACE Inhibition Assay |
| Description: | The compounds were tested for TACE inhibition using fluorescence resonance energy transfer (FRET) assay. TACE catalyzed cleavage of the substrate peptide liberates the fluoropore from the proximity of the adjacent quenching moiety, and an increase in fluorescence signal results. |
| Affinity data for this assay | |
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