| Assay Method Information | |
| | In vitro MKP-3 Phosphatase Dose Response Hit/Probe Assessment Assay |
| Description: | The in vitro MKP-3 Phosphatase dose response hit/probe assessment assay has been developed and run at the University of Pittsburgh Molecular Screening Center (PMLSC) part of the Molecular Library Screening Center Network (MLSCN)to follow up on actives identified in the MKP-3 HTS run at (Burham Institute) SDCCG center AID # 425 and the MKP-1 HTS run at the PMLSC AID # 374. XO1 submission MH-76390 In vitro HTS assay for MKP-3, Assay Provider Dr. John S. Lazo, Department of Pharmacology at the University of Pittsburgh. The 107 protein tyrosine phosphatases (PTPs) found in the human genome are defined by the active site sequence C(X)5R(S/T), with X being any amino acid, and they are critical regulators of mammalian cell proliferation, differentiation, and apoptosis. PTPs can be divided into at least four subfamilies based on their tertiary structure: Classical phosphotyrosine specific PTPs, dual specificity phosphatases (DSPase), Cdc25 phosphatases and low molecular weight PTPs. One |
| Affinity data for this assay | |
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