Assay Method Information

Assay Name:  In vitro MKP-1 Phosphatase Dose Response Active/Probe Assessment Assay - Reproducibility testing
Description:  The MKP-1 dose response assay Active/Probe Assessment Assay - Reproducibility testing has been developed to test the reproducibility of MKP-1 inhibitors identified in the MH-76391 In vitro HTS assay for MKP-1 inhibitors AID #374 and subsequently confirmed in the MKP-1 HTS dose response confirmation assay AID # 551.The MKP-1 Phosphatase dose response assay Active/Probe Assessment Assay - Reproducibility testing has been Developed and Run at the University of Pittsburgh Molecular Screening Center (PMLSC) part of the Molecular Library Screening Center Network (MLSCN). XO1 submission MH-76391 In vitro HTS assay for MKP-1, Assay Provider Dr. John S. Lazo, Department of Pharmacology at the University of Pittsburgh. The 107 protein tyrosine phosphatases (PTPs) found in the human genome are defined by the active site sequence C(X)5R(S/T), with X being any amino acid, and they are critical regulators of mammalian cell proliferation, differentiation, and apoptosis. PTPs can be divided into at
Affinity data for this assay
 

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