Assay Method Information

Assay Name:  TR-FRET counterscreen for FAK inhibitors: dose-response biochemical high throughput screening assay to identify inhibitors of Proline-rich tyrosine kinase 2 (Pyk2)
Description:  Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assay Provider: Peter Hodder, TSRI Network: Molecular Library Probe Production Centers Network (MLPCN) Grant Proposal Number: Not Applicable Grant Proposal PI: Peter Hodder, TSRI External Assay ID: PYK2_INH_HTRF_1536_3XIC50 Name: TR-FRET counterscreen for FAK inhibitors: dose-response biochemical high throughput screening assay to identify inhibitors of Proline-rich tyrosine kinase 2 (Pyk2) Description: The focal adhesion kinase (FAK) is a tyrosine kinase involved in growth factor and integrin-mediated signal transduction pathways (1). It controls cell motility and migration by regulating the turnover of focal adhesions (2). The expression of FAK is elevated in malignant breast cancer and its activity is required in vitro for the invasion of breast carcinoma cells and in vivo for lethal metastasis formation in mice (3). Moreover, FAK mRNA
Affinity data for this assay
 

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