Assay Method Information

Assay Name:  Allosteric Modulators of D1 Receptors: Dose-dependent Counterscreen
Description:  Assay Provider: Val Watts Assay Provider Affiliation: Purdue University Grant Title: Allosteric Modulators of D1 Receptors Grant Number: 1 X01 MH077619-01 Dopamine receptors have been classified into two large families, the D1-like and the D2-like (Neve et al., 2004). Members of the D1-like receptor family include D1 and D5 dopamine receptors. Activation of D1-like receptors stimulate Gs which in turn activates adenylate cyclase resulting in enhanced cyclic AMP accumulation (Neve et al., 2004). Members of the D2-like receptor family include D2, D3, and D4 dopamine receptors. Activation of D2-like dopamine receptors is often linked to inhibition of drug-stimulated cyclic AMP accumulation (Watts et al., 1999, Watts et al., 1998). The field of dopamine research greatly benefited in the latter part of the last century by the availability of dopamine D2 agonists and antagonists. Indeed, the 'dopamine hypothesis' of schizophrenia resulted directly from the availability of D2 dopami
Affinity data for this assay
 

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