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Assay Method Information

Assay Name:  SAR analysis of antagonists of the Cannabinoid Receptor 1 using an Image-Based Assay - Set 3
Description:  Data Source: Sanford-Burnham Center for Chemical Genomics Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, CA) Network: NIH Molecular Libraries Production Centers Network (MLPCN) Grant Number: 1X01 DA026205-01 Assay Provider: Dr. Mary Abood, Temple University, formerly at California Pacific Medical Center Research Institute Drug addiction is a disease that involves the G-protein coupled receptors in the central nervous system resulting in compulsive or abnormal behavior. Recent studies have shown that opioid receptors play a role in regulating other receptors that interact with drug and other substance abuse. The cannabinoid receptors (type 1 and 2) are members of the G-protein coupled receptor family and have been found to be involved in alterations in mood and cognition, as experienced by marijuana users. The specific aim of this assay is to identify small molecule antagonists of the human cannabinoid receptor type 1 (CB1). This dose response a
Affinity data for this assay
 

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Last update November 1, 2007
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