Assay Method Information

Assay Name:  Dose Response of Developing T Cell Immune Modulators with powder sourced compounds
Description:  University of New Mexico Assay Overview: Assay Support: 1 X01 MH085707-01 Project Title: HTS for developing T Cell Immune Modulators Assay Provider: Inkyu Hwang, PhD The Scripps Research Institute (La Jolla) Lead Biologist: Mark K Haynes, PhD Chemistry Center/ PI: Craig Lindsley Specialized Chemistry Center: The Vanderbilt Specialized Chemistry Center Accelerated Probe Development Assay Implementation: Mark K. Haynes PhD, Chelin Hu MS, Anna Waller PhD, Mark Carter MS Assay Background and Significance: When naive T cells encounter antigen presenting cells (APC) displaying cognate MHC-peptide complexes (pMHCs), the T cell and the APC form a highly organized structure at the contact site termed the 'immunological synapse', which is critical not only for prolonged and stable T/APC contact but also for the efficient and organized T cell signaling required for cell cycle progression and development of effector functions. Several membrane proteins and their ligand partners
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