| Assay Method Information | |
| | TRFRET-based biochemical high throughput dose response assay for inhibitors of the interaction of the Ras and Rab interactor 1 protein (Rin1) and the c-abl oncogene 1 |
| Description: | Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assay Provider: John Colicelli, UCLA Network: Molecular Library Probe Production Centers Network (MLPCN) Grant Proposal Number: 1 R01 CA136699-01A1 Grant Proposal PI: John Colicelli, UCLA External Assay ID: RIN1-ABL_INH_TRFRET_1536_3XIC50 DRUN Name: TRFRET-based biochemical high throughput dose response assay for inhibitors of the interaction of the Ras and Rab interactor 1 protein (Rin1) and the c-abl oncogene 1, non-receptor tyrosine kinase (Abl). Description: Chromosome translocations that join the BCR and ABL1 (a.k.a. c-Abl) genes give rise to BCR-ABL1 fusion proteins causative in chronic myeloid leukemia (CML), some cases of acute lymphocytic leukemia (ALL) and occasionally other myeloproliferative disorders (1). In addition, ETV6 forms fusion oncogenes with ABL1 (2) and the closely related ABL2 (a.k.a. Arg) (3) in some leukemias. ABL |
| Affinity data for this assay | |
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