| Assay Method Information | |
| | Absorbance-based biochemical high throughput dose response assay for activators of Methionine sulfoxide reductase A (MsrA) |
| Description: | Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assay Provider: Herbert Weissbach, Florida Atlantic University Network: Molecular Library Probe Production Centers Network (MLPCN) Grant Proposal Number: 1R03DA032473-01 Grant Proposal PI: Herbert Weissbach, Florida Atlantic University External Assay ID: MSRA_ACT_ABS_1536_3XEC50 DRUN Name: Absorbance-based biochemical high throughput dose response assay for activators of Methionine sulfoxide reductase A (MsrA). Description: Oxidative damage, resulting from the production of reactive oxygen species (ROS) within cells, is believed to be a major factor in age-related diseases and the aging process. One of the mechanisms by which this damage occurs is via oxidation of methionine residues to methionine sulfoxide (Met(O)) derivatives in cellular proteins, which can lead to protein inactivation (1). These Met(O) species can be repaired/reduced by |
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