PMID

Data

Article Title

Organization

Identification, synthesis and evaluation of SARS-CoV and MERS-CoV 3C-like protease inhibitors.

Academia Sinica

Virtual screening identification of novel severe acute respiratory syndrome 3C-like protease inhibitors and in vitro confirmation.

Chonnam National University

Investigation of the pharmacophore space of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) NTPase/helicase by dihydroxychromone derivatives.

Konkuk University

Aryl diketoacids (ADK) selectively inhibit duplex DNA-unwinding activity of SARS coronavirus NTPase/helicase.

Konkuk University

Identification of novel drug scaffolds for inhibition of SARS-CoV 3-Chymotrypsin-like protease using virtual and high-throughput screenings.

University Of Illinois At Chicago

Synthesis, modification and docking studies of 5-sulfonyl isatin derivatives as SARS-CoV 3C-like protease inhibitors.

Tianjin University Of Science And Technology

Design, synthesis, and bioevaluation of viral 3C and 3C-like protease inhibitors.

Kansas State University

Dieckol, a SARS-CoV 3CL(pro) inhibitor, isolated from the edible brown algae Ecklonia cava.

Korea Research Institute Of Bioscience And Biotechnology

Design, synthesis and crystallographic analysis of nitrile-based broad-spectrum peptidomimetic inhibitors for coronavirus 3C-like proteases.

The Chinese University Of Hong Kong

Synthesis and evaluation of pyrazolone compounds as SARS-coronavirus 3C-like protease inhibitors.

Academia Sinica

Biflavonoids from Torreya nucifera displaying SARS-CoV 3CL(pro) inhibition.

Korea Research Institute Of Bioscience And Biotechnology

SARS-CoV 3CLpro inhibitory effects of quinone-methide triterpenes from Tripterygium regelii.

Korea Research Institute Of Bioscience And Biotechnology

Quantitative high-throughput screening identifies inhibitors of anthrax-induced cell death.

National Human Genome Research Institute

New developments for the design, synthesis and biological evaluation of potent SARS-CoV 3CL(pro) inhibitors.

Kyoto Pharmaceutical University

Novel small-molecule inhibitors of transmissible gastroenteritis virus.

National Health Research Institute

Structure-based design, synthesis, and biological evaluation of peptidomimetic SARS-CoV 3CLpro inhibitors.

Purdue University

Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element.

Wichita State University

A selective matrix metalloprotease 12 inhibitor for potential treatment of chronic obstructive pulmonary disease (COPD): discovery of (S)-2-(8-(methoxycarbonylamino)dibenzo[b,d]furan-3-sulfonamido)-3-methylbutanoic acid (MMP408).

Wyeth Research

Hit to lead account of the discovery of a new class of inhibitors of Pim kinases and crystallographic studies revealing an unusual kinase binding mode.

Boehringer Ingelheim Pharmaceuticals

Exploiting the pyrazolo[3,4-d]pyrimidin-4-one ring system as a useful template to obtain potent adenosine deaminase inhibitors.

Universita Di Pisa

Discovery and optimization of piperidyl benzamide derivatives as a novel class of 11beta-HSD1 inhibitors.

Amgen

Development of a novel virtual screening cascade protocol to identify potential trypanothione reductase inhibitors.

University Of Alberta