365 articles for thisTarget
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Phloroglucinol Derivatives with Protein Tyrosine Phosphatase 1B Inhibitory Activities from Eugenia jambolana Seeds.
Northeastern University
A tetramic acid derivative with protein tyrosine phosphatase 1B inhibitory activity and a new nortriterpene glycoside from the Indonesian marine sponge Petrosia sp.
Tohoku Medical And Pharmaceutical University
Discovery of core-structurally novel PTP1B inhibitors with specific selectivity containing oxindole-fused spirotetrahydrofurochroman by one-pot reaction.
East China Normal University
Furanoterpenes, new types of protein tyrosine phosphatase 1B inhibitors, from two Indonesian marine sponges, Ircinia and Spongia spp.
Tohoku Medical And Pharmaceutical University
Discovery of 4-[(5-arylidene-4-oxothiazolidin-3-yl)methyl]benzoic acid derivatives active as novel potent allosteric inhibitors of protein tyrosine phosphatase 1B: In silico studies and in vitro evaluation as insulinomimetic and anti-inflammatory agents.
University Of Messina
An epigenetic modifier induces production of (10'S)-verruculide B, an inhibitor of protein tyrosine phosphatases by Phoma sp. nov. LG0217, a fungal endophyte of Parkinsonia microphylla.
University Of Arizona
Rational design, synthesis, and structure-activity relationships of 5-amino-1H-pyrazole-4-carboxylic acid derivatives as protein tyrosine phosphatase 1B inhibitors.
Advinus Therapeutics
Design and synthesis of new potent PTP1B inhibitors with the skeleton of 2-substituted imino-3-substituted-5-heteroarylidene-1,3-thiazolidine-4-one: Part I.
Xi'An Jiaotong University
Sesquiterpene Hydroquinones with Protein Tyrosine Phosphatase 1B Inhibitory Activities from a Dysidea sp. Marine Sponge Collected in Okinawa.
Tohoku Medical And Pharmaceutical University
Eucarobustols A-I, Conjugates of Sesquiterpenoids and Acylphloroglucinols from Eucalyptus robusta.
Chinese Academy Of Sciences
Discovery of novel, high potent, ABC type PTP1B inhibitors with TCPTP selectivity and cellular activity.
Qilu University Of Technology
The design strategy of selective PTP1B inhibitors over TCPTP.
Chinese Academy Of Sciences
Bioactive Constituents of Glycyrrhiza uralensis (Licorice): Discovery of the Effective Components of a Traditional Herbal Medicine.
Peking University
In vitro and in silico PTP-1B inhibition and in vivo antidiabetic activity of semisynthetic moronic acid derivatives.
Universidad Aut£Noma Del Estado De Morelos
Novel Imbricatolic acid derivatives as protein tyrosine phosphatase-1B inhibitors: Design, synthesis, biological evaluation and molecular docking.
University Of Lucknow
Design, synthesis and in vitro activity of phidianidine B derivatives as novel PTP1B inhibitors with specific selectivity.
Shanghai Institute Of Materia Medica
Novel chromenedione derivatives displaying inhibition of protein tyrosine phosphatase 1B (PTP1B) from Flemingia philippinensis.
Qiqihar University
A dimeric urea of the bisabolene sesquiterpene from the Okinawan marine sponge Axinyssa sp. inhibits protein tyrosine phosphatase 1B activity in Huh-7 human hepatoma cells.
Tohoku Pharmaceutical University
Novel, potent, selective and cellular active ABC type PTP1B inhibitors containing (methanesulfonyl-phenyl-amino)-acetic acid methyl ester phosphotyrosine mimetic.
Qilu University Of Technology
Identification of Bidentate Salicylic Acid Inhibitors of PTP1B.
University Of Toronto Mississauga
Identification of Substituted Naphthotriazolediones as Novel Tryptophan 2,3-Dioxygenase (TDO) Inhibitors through Structure-Based Virtual Screening.
National Health Research Institutes
Synthesis, biological evaluation and 3D-QSAR studies of imidazolidine-2,4-dione derivatives as novel protein tyrosine phosphatase 1B inhibitors.
Tianjin Medical University
Strongylophorines, new protein tyrosine phosphatase 1B inhibitors, from the marine sponge Strongylophora strongilata collected at Iriomote Island.
Tohoku Pharmaceutical University
Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors.
Indiana University School Of Medicine
Verruculides A and B, two new protein tyrosine phosphatase 1B inhibitors from an Indonesian ascidian-derived Penicillium verruculosum.
Tohoku Pharmaceutical University
Synthesis of oleanolic acid derivatives: In vitro, in vivo and in silico studies for PTP-1B inhibition.
Universidad Aut£Noma Del Estado De Morelos
Structure-based optimization of a peptidyl inhibitor against calcineurin-nuclear factor of activated T cell (NFAT) interaction.
The Ohio State University
Crystal structures of the apo form and a complex of human LMW-PTP with a phosphonic acid provide new evidence of a secondary site potentially related to the anchorage of natural substrates.
University Of Campinas
Discovery of novel, potent, selective and cellular active ADC type PTP1B inhibitors via fragment-docking-oriented de novel design.
Qilu University Of Technology
Selaginellin and biflavonoids as protein tyrosine phosphatase 1B inhibitors from Selaginella tamariscina and their glucose uptake stimulatory effects.
Catholic University Of Daegu
Thiazolidine-2,4-dione derivatives: programmed chemical weapons for key protein targets of various pathological conditions.
Punjabi University
Structures and Biological Evaluations of Agelasines Isolated from the Okinawan Marine Sponge Agelas nakamurai.
Tohoku Pharmaceutical University
Steroidal Alkaloids from Veratrum nigrum Enhance Glucose Uptake in Skeletal Muscle Cells.
Chungnam National University
Is RK-682 a promiscuous enzyme inhibitor? Synthesis and in vitro evaluation of protein tyrosine phosphatase inhibition of racemic RK-682 and analogues.
University Of Campinas
Perspective: Tyrosine phosphatases as novel targets for antiplatelet therapy.
Sanford-Burnham Medical Research Institute
Light-switched inhibitors of protein tyrosine phosphatase PTP1B based on phosphonocarbonyl phenylalanine as photoactive phosphotyrosine mimetic.
Freie Universit£T Berlin
A potent and selective inhibitor for the UBLCP1 proteasome phosphatase.
Indiana University
Synthesis and biological evaluation of 3-aminoisoquinolin-1(2H)-one based inhibitors of the dual-specificity phosphatase Cdc25B.
University Of Pittsburgh
Chalcones and their therapeutic targets for the management of diabetes: structural and pharmacological perspectives.
Guru Ghasidas Vishwavidyalaya (A Central University)
Design and synthesis of novel 1,2-dithiolan-4-yl benzoate derivatives as PTP1B inhibitors.
Chinese Academy Of Sciences
Canthinone alkaloids are novel protein tyrosine phosphatase 1B inhibitors.
Toho University
Absolute structures and bioactivities of euryspongins and eurydiene obtained from the marine sponge Euryspongia sp. collected at Iriomote Island.
Tohoku Pharmaceutical University
Two new protein tyrosine phosphatase 1B inhibitors, hyattellactones A and B, from the Indonesian marine sponge Hyattella sp.
Tohoku Pharmaceutical University
Insulin-mimetic selaginellins from Selaginella tamariscina with protein tyrosine phosphatase 1B (PTP1B) inhibitory activity.
Catholic University Of Daegu
Synthesis and biological evaluation of novel thiadiazole amides as potent Cdc25B and PTP1B inhibitors.
Liaoning Normal University
Discovery of diethyl 2,5-diaminothiophene-3,4-dicarboxylate derivatives as potent anticancer and antimicrobial agents and screening of anti-diabetic activity: synthesis and in vitro biological evaluation. Part 1.
Chinese Academy Of Sciences
Therapeutic potential of targeting the oncogenic SHP2 phosphatase.
Indiana University School Of Medicine
Design, synthesis and docking study of 5-(substituted benzylidene)thiazolidine-2,4-dione derivatives as inhibitors of protein tyrosine phosphatase 1B.
Chonnam National University
4-Quinolone-3-carboxylic acids as cell-permeable inhibitors of protein tyrosine phosphatase 1B.
Chinese Academy Of Sciences
Tanzawaic acid derivatives from a marine isolate of Penicillium sp. (SF-6013) with anti-inflammatory and PTP1B inhibitory activities.
Wonkwang University
Fast identification of novel lymphoid tyrosine phosphatase inhibitors using target-ligand interaction-based virtual screening.
Shandong University
Ingol-type diterpenes from Euphorbia antiquorum with mouse 11ß-hydroxysteroid dehydrogenase type 1 inhibition activity.
Lanzhou University
Highly conjugated norditerpenoid and pyrroloquinoline alkaloids with potent PTP1B inhibitory activity from Nigella glandulifera.
Chinese Academy Of Sciences
Synthesis and evaluation of several oleanolic acid glycoconjugates as protein tyrosine phosphatase 1B inhibitors.
North-West University
Synthesis, biological activity and structure-activity relationships of new benzoic acid-based protein tyrosine phosphatase inhibitors endowed with insulinomimetic effects in mouse C2C12 skeletal muscle cells.
University Of Messina
Protein tyrosine phosphatase 1B (PTP1B) inhibitors from Morinda citrifolia (Noni) and their insulin mimetic activity.
Chosun University
Design, synthesis and molecular modelling studies of novel 3-acetamido-4-methyl benzoic acid derivatives as inhibitors of protein tyrosine phosphatase 1B.
School Of Pharmaceutical Sciences
Discovery of novel PTP1B inhibitors via pharmacophore-oriented scaffold hopping from Ertiprotafib.
Chinese Academy Of Medical Sciences And Peking Union Medical College
Design, synthesis, and biological evaluation of novel 2-ethyl-5-phenylthiazole-4-carboxamide derivatives as protein tyrosine phosphatase 1B inhibitors with improved cellular efficacy.
Chinese Academy Of Sciences
Evaluation of licorice flavonoids as protein tyrosine phosphatase 1B inhibitors.
Toho University
Calix[4]arene methylenebisphosphonic acids as inhibitors of protein tyrosine phosphatase 1B.
National Academy Of Sciences Of Ukraine
Identification of cryptotanshinone as an inhibitor of oncogenic protein tyrosine phosphatase SHP2 (PTPN11).
Case Western Reserve University
The first synthesis of natural disulfide bruguiesulfurol and biological evaluation of its derivatives as a novel scaffold for PTP1B inhibitors.
Chinese Academy Of Sciences
Cembrane diterpenoids from the soft coral Sarcophyton trocheliophorum Marenzeller as a new class of PTP1B inhibitors.
Chinese Academy Of Sciences
A potent and selective small-molecule inhibitor for the lymphoid-specific tyrosine phosphatase (LYP), a target associated with autoimmune diseases.
Indiana University School Of Medicine
Discovery of novel bromophenol 3,4-dibromo-5-(2-bromo-3,4-dihydroxy-6-(isobutoxymethyl)benzyl)benzene-1,2-diol as protein tyrosine phosphatase 1B inhibitor and its anti-diabetic properties in C57BL/KsJ-db/db mice.
Chinese Academy Of Sciences
Synthesis and biological evaluation of oleanolic acid derivatives as PTP1B inhibitors.
North-West University
Design and synthesis of 2-substituted benzoxazoles as novel PTP1B inhibitors.
Aurigene Discovery Technologies
Design, synthesis and insulin-sensitising effects of novel PTP1B inhibitors.
Chinese Academy Of Medical Sciences And Peking Union Medical College
Euryspongins A-C, three new unique sesquiterpenes from a marine sponge Euryspongia sp.
Tohoku Pharmaceutical University
Bioactive polyhydroxylated steroids from the Hainan soft coral Sinularia depressa Tixier-Durivault.
Chinese Academy Of Sciences
Discovery and evaluation of novel inhibitors of mycobacterium protein tyrosine phosphatase B from the 6-Hydroxy-benzofuran-5-carboxylic acid scaffold.
Indiana University School Of Medicine
Protein tyrosine phosphatase 1B inhibitory effect by dammarane-type triterpenes from hydrolyzate of total Gynostemma pentaphyllum saponins.
Shenyang Pharmaceutical University
Studies on two types of PTP1B inhibitors for the treatment of type 2 diabetes: Hologram QSAR for OBA and BBB analogues.
Tsinghua University
Large-scale application of high-throughput molecular mechanics with Poisson-Boltzmann surface area for routine physics-based scoring of protein-ligand complexes.
Abbott Laboratories
Building predictive models for protein tyrosine phosphatase 1B inhibitors based on discriminating structural features by reassembling medicinal chemistry building blocks.
Leadscope
Finding discriminating structural features by reassembling common building blocks.
Leadscope
Recent developments and biological activities of thiazolidinone derivatives: a review.
Dr. Hari Singh Gour University
Design and synthesis of novel bis-thiazolone derivatives as micromolar CDC25 phosphatase inhibitors: effect of dimerisation on phosphatase inhibition.
University Of Paris
7-Phenyl-pyrido[2,3-d]pyrimidine-2,4-diamines: novel and highly selective protein tyrosine phosphatase 1B inhibitors.
Roche Research Center
Discovery of di-indolinone as a novel scaffold for protein tyrosine phosphatase 1B inhibitors.
East China University Of Science And Technology
Synthesis and biological evaluation of 4,4-dimethyl lithocholic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B.
East China Normal University
Synthesis of propiophenone derivatives as new class of antidiabetic agents reducing body weight in db/db mice.
Central Drug Research Institute
New prenylated isoflavonoids as protein tyrosine phosphatase 1B (PTP1B) inhibitors from Erythrina addisoniae.
Chosun University
Low molecular weight phosphotyrosine protein phosphatases as emerging targets for the design of novel therapeutic agents.
University Of Messina
Antidiabetic activity of some pentacyclic acid triterpenoids, role of PTP-1B: in vitro, in silico, and in vivo approaches.
Universidad Aut£Noma Del Estado De Morelos
Design, synthesis, and evaluation of 2-substituted ethenesulfonic acid ester derivatives as protein tyrosine phosphatase 1B inhibitors.
Shanghai Jiao Tong University
Rhododendric acid A, a new ursane-type PTP1B inhibitor from the endangered plant Rhododendron brachycarpum G. Don.
Yeungnam University
Structure and bioassay of triterpenoids and steroids isolated from Sinocalamus affinis.
Chinese Academy Of Medical Sciences And Peking Union Medical College
Dual-Specificity Phosphatase CDC25A/B Inhibitor Identified from a Focused Library with Nonelectrophilic Core Structure.
TBA
Arylstibonic acids are potent and isoform-selective inhibitors of Cdc25a and Cdc25b phosphatases.
Imperial College
Synthesis, in vitro and in silico screening of ethyl 2-(6-substituted benzo[d]thiazol-2-ylamino)-2-oxoacetates as protein-tyrosine phosphatase 1B inhibitors.
Universidad Aut£Noma Del Estado De Morelos
Bromophenols as inhibitors of protein tyrosine phosphatase 1B with antidiabetic properties.
Chinese Academy Of Sciences
Discovery of novel and potent heterocyclic carboxylic acid derivatives as protein tyrosine phosphatase 1B inhibitors.
Advinus Therapeutics
New 4-[(5-arylidene-2-arylimino-4-oxo-3-thiazolidinyl)methyl]benzoic acids active as protein tyrosine phosphatase inhibitors endowed with insulinomimetic effect on mouse C2C12 skeletal muscle cells.
University Of Messina
Bicyclic benzofuran and indole-based salicylic acids as protein tyrosine phosphatase inhibitors.
Indiana University
Prenylflavonoids from Glycyrrhiza uralensis and their protein tyrosine phosphatase-1B inhibitory activities.
Toho University
Inhibition of Mycobacterium tuberculosis tyrosine phosphatase PtpA by synthetic chalcones: kinetics, molecular modeling, toxicity and effect on growth.
Universidade Federal De Santa Catarina
Novel thiophene derivatives as PTP1B inhibitors with selectivity and cellular activity.
Chinese Academy Of Sciences
Protein tyrosine phosphatase 1B inhibitors isolated from Morus bombycis.
Korea Research Institute Of Bioscience And Biotechnology
Inhibitory effect of chalcones and their derivatives from Glycyrrhiza inflata on protein tyrosine phosphatase 1B.
Institute
Structure-based virtual screening approach to identify novel classes of PTP1B inhibitors.
Sejong University
Protein tyrosine phosphatase 1B inhibitory effects of depsidone and pseudodepsidone metabolites from the Antarctic lichen Stereocaulon alpinum.
Silla University
Flavanones from the stem bark of Erythrina abyssinica.
Korea Research Institute Of Bioscience And Biotechnology (Kribb)
Triterpenoids from the leaves of Diospyros kaki (persimmon) and their inhibitory effects on protein tyrosine phosphatase 1B.
Chosun University
A re-examination of the difluoromethylenesulfonic acid group as a phosphotyrosine mimic for PTP1B inhibition.
University Of Waterloo
Protein tyrosine phosphatase-1B inhibitory activity of isoprenylated flavonoids isolated from Erythrina mildbraedii.
Korea Research Institute Of Bioscience And Biotechnology
Usimines A-C, bioactive usnic acid derivatives from the Antarctic lichen Stereocaulon alpinum.
Silla University
Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases.
Indiana University School Of Medicine
PTP1B inhibitors: synthesis and evaluation of difluoro-methylenephosphonate bioisosteres on a sulfonamide scaffold.
Affymax
Ohioensins F and G: protein tyrosine phosphatase 1B inhibitory benzonaphthoxanthenones from the Antarctic moss Polytrichastrum alpinum.
Silla University
Discovery of [(3-bromo-7-cyano-2-naphthyl)(difluoro)methyl]phosphonic acid, a potent and orally active small molecule PTP1B inhibitor.
Merck Frosst Centre For Therapeutic Research
2-O-carboxymethylpyrogallol derivatives as PTP1B inhibitors with antihyperglycemic activity.
Inha University
5-Arylidene-2,4-thiazolidinediones as inhibitors of protein tyrosine phosphatases.
Universit£
Design, synthesis, and discovery of stilbene derivatives based on lithospermic acid B as potent protein tyrosine phosphatase 1B inhibitors.
Yonsei University
Methylenedisalicylic acid derivatives: new PTP1B inhibitors that confer resistance to diet-induced obesity.
Inha University
Isoprenylated flavonoids from the stem bark of Erythrina abyssinica.
Korea Research Institute Of Bioscience And Biotechnology
Inhibition of protein tyrosine phosphatase 1B by diterpenoids isolated from Acanthopanax koreanum.
Korea Research Institute Of Bioscience And Biotechnology
Protein tyrosine phosphatase 1B inhibitory activity of triterpenes isolated from Astilbe koreana.
Korea Research Institute Of Bioscience And Biotechnology
Molecular docking and high-throughput screening for novel inhibitors of protein tyrosine phosphatase-1B.
Pfizer
Structure of protein tyrosine phosphatase 1B in complex with inhibitors bearing two phosphotyrosine mimetics.
University Of Waterloo
A model for binding of structurally diverse natural product inhibitors of protein phosphatases PP1 and PP2A.
University Of California
The first two cantharidin analogues displaying PP1 selectivity.
The University Of Newcastle
Synthesis of [difluoro-(3-alkenylphenyl)-methyl]-phosphonic acids on non-crosslinked polystyrene and their evaluation as inhibitors of PTP1B.
University Of Waterloo
Cantharimides: a new class of modified cantharidin analogues inhibiting protein phosphatases 1 and 2A.
The University Of Newcastle
Synthesis and characterization of a novel class of protein tyrosine phosphatase inhibitors.
New York University
Naphthalenebis[alpha,alpha-difluoromethylenephosphonates] as potent inhibitors of protein tyrosine phosphatases.
University Of Toronto
The conserved acid binding domain model of inhibitors of protein phosphatases 1 and 2A: Molecular modelling aspects.
TBA
Exploration ofa-aminophosphonate N-derivatives as novel, potent and selective inhibitors of protein tyrosine phosphatases.
Shanxi University
Synthesis, biological evaluation, and molecular modeling of chalcone derivatives as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatases (PtpA and PtpB).
Universidade Federal De Santa Catarina
Discovery of potent, selective and orally bioavailable triaryl-sulfonamide based PTP1B inhibitors.
M.S. University Of Baroda
Novel (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids: peroxisome proliferator-activated receptor¿ selective agonists with protein-tyrosine phosphatase 1B inhibition.
Kyoto Pharmaceutical Industries
Cucurbitane glucosides from the root of Machilus yaoshansis.
State Key Laboratory Of Bioactive Substance And Function Of Natural Medicines, And Key Laboratory Of Bioactive Substances And Resources Utilization Of Chinese Herbal Medicine
Small molecule receptor protein tyrosine phosphatase¿ (RPTP¿) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop.
Bristol-Myers Squibb Research And Development
Click to a focused library of benzyl 6-triazolo(hydroxy)benzoic glucosides: novel construction of PTP1B inhibitors on a sugar scaffold.
East China University Of Science And Technology
Synthesis and biological evaluation of (±)-3-(2-(2-fluorobenzyloxy) naphthalen-6-yl)-2-aminopropanoic acid derivatives as novel PTP1B inhibitors.
Yanbian University
New 5-deoxyflavonoids and their inhibitory effects on protein tyrosine phosphatase 1B (PTP1B) activity.
Chosun University
Novel thiazolidinedione derivatives with anti-obesity effects: dual action as PTP1B inhibitors and PPAR-¿ activators.
Inha University
Small molecule inhibitors of SHP2 tyrosine phosphatase discovered by virtual screening.
Indiana University
Pyrrolo[2,3-c]azepine derivatives: a new class of potent protein tyrosine phosphatase 1B inhibitors.
Sun Yat-Sen University
Facile fabrication of promising protein tyrosine phosphatase (PTP) inhibitor entities based on 'clicked' serine/threonine-monosaccharide hybrids.
East China University Of Science And Technology
Design and synthesis of 3,5-diarylisoxazole derivatives as novel class of anti-hyperglycemic and lipid lowering agents.
Central Drug Research Institute
Hippolides A-H, acyclic manoalide derivatives from the marine sponge Hippospongia lachne.
Second Military Medical University
Design, synthesis, and evaluation of bromo-retrochalcone derivatives as protein tyrosine phosphatase 1B inhibitors.
Chonnam National University
Utilization of nitrophenylphosphates and oxime-based ligation for the development of nanomolar affinity inhibitors of the Yersinia pestis outer protein H (YopH) phosphatase.
National Cancer Institute-Frederick
Using small molecules to target protein phosphatases.
Max Planck Institute Of Molecular Physiology
A unique and rapid approach toward the efficient development of novel protein tyrosine phosphatase (PTP) inhibitors based on 'clicked' pseudo-glycopeptides.
East China University Of Science And Technology
Inhibition of lymphoid tyrosine phosphatase by benzofuran salicylic acids.
Sanford-Burnham Medical Research Institute
Shp2 protein tyrosine phosphatase inhibitor activity of estramustine phosphate and its triterpenoid analogs.
H. Lee Moffitt Cancer Center And Research Institute
Synthesis and biological evaluation of oleanolic acid derivatives as inhibitors of protein tyrosine phosphatase 1B.
Xihua University
Synthesis and evaluation of some novel dibenzo[b,d]furan carboxylic acids as potential anti-diabetic agents.
Glenmark Research Center
Bioactivity-guided isolation of 1,2,3,4,6-Penta-O-galloyl-D-glucopyranose from Paeonia lactiflora roots as a PTP1B inhibitor.
University Of Vienna
Dammaranes from Gynostemma pentaphyllum and synthesis of their derivatives as inhibitors of protein tyrosine phosphatase 1B.
Chinese Academy Of Sciences
Design and synthesis of 2,4-disubstituted polyhydroquinolines as prospective antihyperglycemic and lipid modulating agents.
Central Drug Research Institute
Discovery and structural optimization of pyrazole derivatives as novel inhibitors of Cdc25B.
Chinese Academy Of Sciences
Fragment-based discovery of selective inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase PtpA.
University Of California
Pyranocoumarins: a new class of anti-hyperglycemic and anti-dyslipidemic agents.
Central Drug Research Institute
Isolation of the protein tyrosine phosphatase 1B inhibitory metabolite from the marine-derived fungus Cosmospora sp. SF-5060.
Silla University
Chemical Constituents of the Roots of Euphorbia micractina.
Chinese Academy Of Medical Sciences And Peking Union Medical College
Chemical constituents from the aerial parts of Artemisia minor.
Chinese Academy Of Sciences
Recent advances in the discovery of competitive protein tyrosine phosphatase 1B inhibitors for the treatment of diabetes, obesity, and cancer.
Incyte
Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2).
Indiana University School Of Medicine
Multidentate small-molecule inhibitors of vaccinia H1-related (VHR) phosphatase decrease proliferation of cervix cancer cells.
Institute For Medical Research
Synthesis and biological evaluation of heterocyclic ring-substituted maslinic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B.
East China Normal University
Knowledge-based characterization of similarity relationships in the human protein-tyrosine phosphatase family for rational inhibitor design.
University Of Miami
Thiazolidinedione derivatives as PTP1B inhibitors with antihyperglycemic and antiobesity effects.
Inha University
Structure-based virtual screening approach to identify novel classes of Cdc25B phosphatase inhibitors.
Sejong University
Synthesis and evaluation of some novel isochroman carboxylic acid derivatives as potential anti-diabetic agents.
Glenmark Research Center
Synthesis, in vitro and computational studies of protein tyrosine phosphatase 1B inhibition of a small library of 2-arylsulfonylaminobenzothiazoles with antihyperglycemic activity.
Universidad AutóNoma Del Estado De Morelos
5,6-Diarylanthranilo-1,3-dinitriles as a new class of antihyperglycemic agents.
Central Drug Research Institute
Synthesis, activity and molecular modeling of a new series of chromones as low molecular weight protein tyrosine phosphatase inhibitors.
University Of Modena And R.E.
Synthesis of protein tyrosine phosphatase 1B inhibitors: model validation and docking studies.
Central Drug Research Institute
5-Arylidene-2-phenylimino-4-thiazolidinones as PTP1B and LMW-PTP inhibitors.
University Of Messina
A novel sesquiterpene quinone from Hainan sponge Dysidea villosa.
Chinese Academy Of Sciences
Derivatives of 1,4-bis(3-hydroxycarbonyl-4-hydroxyl)styrylbenzene as PTP1B inhibitors with hypoglycemic activity.
Inha University
Oleanolic acid and its derivatives: new inhibitor of protein tyrosine phosphatase 1B with cellular activities.
Chinese Academy Of Sciences
Oxidative inactivation of protein tyrosine phosphatase 1B by organic hydroperoxides.
University Of Missouri-Columbia
Illudalic acid as a potential LAR inhibitor: synthesis, SAR, and preliminary studies on the mechanism of action.
Chinese Academy Of Sciences
Novel 2-aryl-naphtho[1,2-d]oxazole derivatives as potential PTP-1B inhibitors showing antihyperglycemic activities.
Central Drug Research Institute
Lateral compartmentalization of T cell receptor versus CD45 by galectin-N-glycan binding and microfilaments coordinate basal and activation signaling.
University Of California
Vanillic acid derivatives from the green algae Cladophora socialis as potent protein tyrosine phosphatase 1B inhibitors.
Griffith University
2-Aryl-3,3,3-trifluoro-2-hydroxypropionic acids: a new class of protein tyrosine phosphatase 1B inhibitors.
Heriot-Watt University
Structure-based optimization of protein tyrosine phosphatase 1B inhibitors: from the active site to the second phosphotyrosine binding site.
Wyeth Research
Mono- and disalicylic acid derivatives: PTP1B inhibitors as potential anti-obesity drugs.
Inha University
Inhibitory effect of 2-arylbenzofurans from Erythrina addisoniae on protein tyrosine phosphatase-1B.
Korea Research Institute Of Bioscience And Biotechnology
PTP1B inhibitor Ertiprotafib is also a potent inhibitor of IkappaB kinase beta (IKK-beta).
Inha University
Development of molecular probes for second-site screening and design of protein tyrosine phosphatase inhibitors.
Institute For Medical Research
Structures, biogenesis, and biological activities of pyrano[4,3-c]isochromen-4-one derivatives from the Fungus Phellinus igniarius.
Chinese Academy Of Medical Sciences And Peking Union Medical College
Synthesis and cell-based activity of a potent and selective protein tyrosine phosphatase 1B inhibitor prodrug.
Purdue University
Synthesis of benzofuran scaffold-based potential PTP-1B inhibitors.
Central Drug Research Institute
Brunsvicamides A-C: sponge-related cyanobacterial peptides with Mycobacterium tuberculosis protein tyrosine phosphatase inhibitory activity.
University Of Bonn
Potent benzimidazole sulfonamide protein tyrosine phosphatase 1B inhibitors containing the heterocyclic (S)-isothiazolidinone phosphotyrosine mimetic.
Incyte
Design and synthesis of potent, non-peptidic inhibitors of HPTPbeta.
Procter & Gamble Pharmaceuticals
A gatekeeper residue for inhibitor sensitization of protein tyrosine phosphatases.
Amherst College
Two novel aromatic valerenane-type sesquiterpenes from the Chinese green alga Caulerpa taxifolia.
Chinese Academy Of Sciences
Synthesis of novel benzofuran isoxazolines as protein tyrosine phosphatase 1B inhibitors.
Central Drug Research Institute
Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases.
Graduate School Of Chinese Academy Of Sciences
Protein tyrosine phosphatase 1B inhibitors from Morus root bark.
Korea Research Institute Of Bioscience And Biotechnology (Kribb)
PTP-1B inhibitors: cyclopenta[d][1,2]-oxazine derivatives.
Korea Research Institute Of Chemical Technology
3-Substituted indolizine-1-carbonitrile derivatives as phosphatase inhibitors.
Technische UniversitäT MüNchen
Structure-based design and discovery of protein tyrosine phosphatase inhibitors incorporating novel isothiazolidinone heterocyclic phosphotyrosine mimetics.
Incyte
Discovery and structure-activity relationships of novel sulfonamides as potent PTP1B inhibitors.
Affymax
Synthesis of tripeptides as potent Yersinia protein tyrosine phosphatase inhibitors.
Nih
Germacrane sesquiterpenes from leaves of Eupatorium chinense inhibit protein tyrosine phosphatase.
Tohoku Medical And Pharmaceutical University
Prospects for inhibitors of protein tyrosine phosphatase 1B as antidiabetic drugs.
Serono Pharmaceutical Research Institute
Discovery of Anti-TNBC Agents Targeting PTP1B: Total Synthesis, Structure-Activity Relationship,
Northeastern University
The Inhibitors of Protein Tyrosine Phosphatase Nonreceptor Type 2 (PTPN2) as Potential Enhancers of Cancer Immunotherapy and Type 1 (PTPN1) as Treatment of Metabolic Diseases.
Therachem Research Medilab
Design, synthesis, kinetic, molecular dynamics, and hypoglycemic effect characterization of new and potential selective benzimidazole derivatives as Protein Tyrosine Phosphatase 1B inhibitors.
Universidad Ju£Rez Del Estado De Durango
Structure based design of a series of potent and selective non peptidic PTP-1B inhibitors.
Merck Frosst Centre For Therapeutic Research
The development of potent non-peptidic PTP-1B inhibitors.
Merck Frosst Centre For Therapeutic Research
Dual High-Resolution ?-Glucosidase and PTP1B Inhibition Profiling Combined with HPLC-PDA-HRMS-SPE-NMR Analysis for the Identification of Potentially Antidiabetic Chromene Meroterpenoids from
University Of Copenhagen
Rearranged Diels-Alder Adducts and Prenylated Flavonoids as Potential PTP1B Inhibitors from
Nanchang University
Identification of a novel class of orally active pyrimido[5,4-3][1,2,4]triazine-5,7-diamine-based hypoglycemic agents with protein tyrosine phosphatase inhibitory activity.
Roche Research Center
Fragment screening and assembly: a highly efficient approach to a selective and cell active protein tyrosine phosphatase 1B inhibitor.
Abbott Laboratories
Pyrrolo[1,2-a]quinoxal-5-inium salts and 4,5-dihydropyrrolo[1,2-a]quinoxalines: Synthesis, activity and computational docking for protein tyrosine phosphatase 1B.
Universidad De Alcal£
Discovery and SAR of novel, potent and selective protein tyrosine phosphatase 1B inhibitors.
Abbott Laboratories
Acylsulfonamide-containing PTP1B inhibitors designed to mimic an enzyme-bound water of hydration.
Nih
Selective protein tyrosine phosphatase 1B inhibitors: targeting the second phosphotyrosine binding site with non-carboxylic acid-containing ligands.
Abbott Laboratories
Tripeptide inhibitors of Yersinia protein-tyrosine phosphatase.
National Cancer Institute-Frederick
Formylchromone derivatives as a novel class of protein tyrosine phosphatase 1B inhibitors.
Inha University
Synthesis and biological evaluation of geniposide derivatives as potent and selective PTPlB inhibitors.
Shanghai Jiao Tong University
Inhibition of striatal-enriched protein tyrosine phosphatase by targeting computationally revealed cryptic pockets.
Shandong University
Modification of the N-terminus of peptidomimetic protein tyrosine phosphatase 1B (PTP1B) inhibitors: identification of analogues with cellular activity.
Pharmacia
Inhibition of Low Molecular Weight Protein Tyrosine Phosphatase by an Induced-Fit Mechanism.
Purdue University
alpha-bromoacetophenone derivatives as neutral protein tyrosine phosphatase inhibitors: structure-Activity relationship.
The Ohio State University
Novel PTP1B inhibitors identified by DNA display of fragment pairs.
University Of Geneva
Discovery of Novel PTP1B Inhibitors Derived from the BH3 Domain of Proapoptotic Bcl-2 Proteins with Antidiabetic Potency.
Qingdao University Of Science And Technology
Discovery and SAR of a novel selective and orally bioavailable nonpeptide classical competitive inhibitor class of protein-tyrosine phosphatase 1B.
Novo Nordisk
Divalent and trivalent alpha-ketocarboxylic acids as inhibitors of protein tyrosine phosphatases.
Brown University
From Pyrazolones to Azaindoles: Evolution of Active-Site SHP2 Inhibitors Based on Scaffold Hopping and Bioisosteric Replacement.
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Synthesis and PTP1B inhibition of 1,2-naphthoquinone derivatives as potent anti-diabetic agents.
Korea Research Institute Of Chemical Technology
Investigation of potential bioisosteric replacements for the carboxyl groups of peptidomimetic inhibitors of protein tyrosine phosphatase 1B: identification of a tetrazole-containing inhibitor with cellular activity.
Biovitrum
Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25.
University Of Pittsburgh
Recent Advances of SHP2 Inhibitors in Cancer Therapy: Current Development and Clinical Application.
China Pharmaceutical University
Utilization of a peptide lead for the discovery of a novel PTP1B-binding motif.
National Cancer Institute-Frederick
alpha-Ketocarboxylic acid-based inhibitors of protein tyrosine phosphatases.
Brown University
A chalcone derivative binds a putative allosteric site of YopH: Inhibition of a virulence factor of Yersinia.
Universidade Federal De Santa Catarina
Potent reversible inhibitors of the protein tyrosine phosphatase CD45.
Astrazeneca Pharmaceuticals
Synthesis and biological evaluation of heterocyclic bis-aryl amides as novel Src homology 2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors.
Jiangnan University
Sulfonylated aminothiazoles as new small molecule inhibitors of protein phosphatases.
University Of Pittsburgh
?-Glucosidase and Protein Tyrosine Phosphatase 1B Inhibitors from
University Of North Carolina Greensboro
Spirobiflavonoid stereoisomers from the endangered conifer Glyptostrobus pensilis and their protein tyrosine phosphatase 1B inhibitory activity.
Fudan University
Synthesis and characterization of a potent and selective protein tyrosine phosphatase inhibitor, 2.
Taisho Pharmaceutical
Stilbenes with Potent Protein Tyrosine Phosphatase-1B Inhibitory Activity from the Roots of
Kyungpook National University
Identification of PTP1B and ?-Glucosidase Inhibitory Serrulatanes from Eremophila spp. by Combined use of Dual High-Resolution PTP1B and ?-Glucosidase Inhibition Profiling and HPLC-HRMS-SPE-NMR.
University Of Copenhagen
Tapping the therapeutic potential of protein tyrosine phosphatase 4A with small molecule inhibitors.
University Of Pittsburgh
Identification and characterization of potent and selective inhibitors targeting protein tyrosine phosphatase 1B (PTP1B).
Zhejiang Sci-Tech University
Synthesis and PTP1B inhibition of novel 4-aryl-1-oxa-9-thiacyclopenta[b]fluorenes.
Wyeth-Ayerst Research
Structure and Configuration of Phosphoeleganin, a Protein Tyrosine Phosphatase 1B Inhibitor from the Mediterranean Ascidian Sidnyum elegans.
University Of Naples Federico Ii
Examination of novel non-phosphorus-containing phosphotyrosyl mimetics against protein-tyrosine phosphatase-1B and demonstration of differential affinities toward Grb2 SH2 domains.
National Cancer Institute-Bethesda
Synthesis, biological evaluation, and molecular docking study of novel allyl-retrochalcones as a new class of protein tyrosine phosphatase 1B inhibitors.
Wenzhou Medical University
Calixarene-based phosphinic acids as inhibitors of protein tyrosine phosphatases.
V.P. Kukhar Institute Of Bioorganic Chemistry And Petrochemistry Of The National Academy Of Sciences Of Ukraine
Investigation of stereoisomeric bisarylethenesulfonic acid esters for discovering potent and selective PTP1B inhibitors.
Shanghai Jiao Tong University (Sjtu)
Novel benzofuran and benzothiophene biphenyls as inhibitors of protein tyrosine phosphatase 1B with antihyperglycemic properties.
Wyeth-Ayerst Research
Psiguadiols A-J, Rearranged Meroterpenoids as Potent PTP1B Inhibitors from
China Pharmaceutical University
Protein Tyrosine Phosphatase 1B Inhibitory Iridoids from
University Of Illinois At Chicago
New azolidinediones as inhibitors of protein tyrosine phosphatase 1B with antihyperglycemic properties.
Wyeth-Ayerst Research
Cinerols, Nitrogenous Meroterpenoids from the Marine Sponge
Shanghai Jiao Tong University
Indole-Diterpenoids with Protein Tyrosine Phosphatase Inhibitory Activities from the Marine-Derived Fungus
Hebei University
Toward a treatment of diabesity: In vitro and in vivo evaluation of uncharged bromophenol derivatives as a new series of PTP1B inhibitors.
Chinese Academy Of Sciences
PTP1B inhibition and antihyperglycemic activity in the ob/ob mouse model of novel 11-arylbenzo[b]naphtho[2,3-d]furans and 11-arylbenzo[b]naphtho[2,3-d]thiophenes.
Wyeth-Ayerst Research
Diketopiperazine-Type Alkaloids from a Deep-Sea-Derived Aspergillus puniceus Fungus and Their Effects on Liver X Receptor ?.
Chinese Academy Of Sciences
Dual-targeting GroEL/ES chaperonin and protein tyrosine phosphatase B (PtpB) inhibitors: A polypharmacology strategy for treating Mycobacterium tuberculosis infections.
Indiana University School Of Medicine
Benzofuran derivatives and their anti-tubercular, anti-bacterial activities.
Huanghuai University
Synthesis and biological evaluation of alpha,alpha-difluorobenzylphosphonic acid derivatives as small molecular inhibitors of protein-tyrosine phosphatase 1B.
Tokyo University Of Pharmacy & Life Science
Celastrol Promotes Weight Loss in Diet-Induced Obesity by Inhibiting the Protein Tyrosine Phosphatases PTP1B and TCPTP in the Hypothalamus.
Helmholtz Zentrum M�Nchen
Novel phosphate mimetics for the design of non-peptidyl inhibitors of protein tyrosine phosphatases.
University Of Toronto
BH3 mimetics derived from Bim-BH3 domain core region show PTP1B inhibitory activity.
Ocean University Of China
Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design.
Bristol-Myers Squibb
Potent inhibition of protein-tyrosine phosphatase-1B using the phosphotyrosyl mimetic fluoro-O-malonyl tyrosine (FOMT).
National Cancer Institute-Bethesda
Potential Anticancer Agents Characterized from Selected Tropical Plants.
The Ohio State University
Synthesis and biological evaluation of tryptophan-derived rhodanine derivatives as PTP1B inhibitors and anti-bacterial agents.
Yanbian University College Of Pharmacy
An investigation on 4-thiazolidinone derivatives as dual inhibitors of aldose reductase and protein tyrosine phosphatase 1B, in the search for potential agents for the treatment of type 2 diabetes mellitus and its complications.
University Of Messina
Discovery of 1,3-diphenyl-1H-pyrazole derivatives containing rhodanine-3-alkanoic acid groups as potential PTP1B inhibitors.
Yanbian University
An overview of grayanane diterpenoids and their biological activities from the Ericaceae family in the last seven years.
Northwest A & F University
4'-O-[2-(2-fluoromalonyl)]-L-tyrosine: a phosphotyrosyl mimic for the preparation of signal transduction inhibitory peptides.
National Cancer Institute-Bethesda
Diversity-Oriented Synthesis for Novel, Selective and Drug-like Inhibitors for a Phosphatase from Mycobacterium Tuberculosis.
Indiana University School Of Medicine
Highly brominated metabolites from marine red alga Laurencia similis inhibit protein tyrosine phosphatase 1B.
Jilin University
Lipidyl pseudopteranes A-F: isolation, biomimetic synthesis, and PTP1B inhibitory activity of a new class of pseudopteranoids from the Gorgonian Pseudopterogorgia acerosa.
University Of Prince Edward Island
Oculatol, oculatolide, and A-nor sterols from the sponge Haliclona oculata.
Peking University
Molecular docking and 3D-QSAR on 2-(oxalylamino) benzoic acid and its analogues as protein tyrosine phosphatase 1B inhibitors.
Graduate University Of Chinese Academy Of Sciences
Synthetic thiosemicarbazones as a new class of Mycobacterium tuberculosis protein tyrosine phosphatase A inhibitors.
Universidade Federal De Santa Catarina
Development of inhibitors of receptor protein tyrosine phosphatase ?/? (PTPRZ1) as candidates for CNS disorders.
Universidad San Pablo-Ceu
Naturally occurring Diels-Alder-type adducts from Morus nigra as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B.
Universidade Federal De Santa Catarina
Structurally Diverse Sesquiterpenoids from the Endangered Ornamental Plant Michelia shiluensis.
Chinese Academy Of Sciences
Dihydrochalcone Glucosides from the Subaerial Parts of Thonningia sanguinea and Their in Vitro PTP1B Inhibitory Activities.
University Of Innsbruck
Structure-Based Design of MptpB Inhibitors That Reduce Multidrug-Resistant Mycobacterium tuberculosis Survival and Infection Burden in Vivo.
University Of Manchester
Enantiomeric Pairs of Meroterpenoids with Diverse Heterocyclic Systems from Rhododendron nyingchiense.
Fudan University
Identification of caffeoylquinic acid derivatives as natural protein tyrosine phosphatase 1B inhibitors from Artemisia princeps.
China Pharmaceutical University
Inhibition of protein tyrosine phosphatase 1B (PTP1B) and ?-glucosidase by xanthones from Cratoxylum cochinchinense, and their kinetic characterization.
Gyeongsang National University
Benzo[c][1,2,5]thiadiazole derivatives: A new class of potent Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors.
Jiangnan University
Total Syntheses of Lobaric Acid and Its Derivatives from the Antarctic Lichen Stereocaulon alpinum.
Korea Polar Research Institute
Discovery of novel high potent and cellular active ADC type PTP1B inhibitors with selectivity over TC-PTP via modification interacting with C site.
Qilu University Of Technology
Design, synthesis and biological evaluation of uncharged catechol derivatives as selective inhibitors of PTP1B.
Chinese Academy Of Sciences
Camellianols A-G, Barrigenol-like Triterpenoids with PTP1B Inhibitory Effects from the Endangered Ornamental Plant Camellia crapnelliana.
Fudan University
Meroterpenoids with Protein Tyrosine Phosphatase 1B Inhibitory Activity from a Hyrtios sp. Marine Sponge.
Shenyang Pharmaceutical University
Optimized allosteric inhibition of engineered protein tyrosine phosphatases with an expanded palette of biarsenical small molecules.
Amherst College
Varic acid analogues from fungus as PTP1B inhibitors: Biological evaluation and structure-activity relationships.
Dalian University Of Technology
Anti-diabetic xanthones from the bark of Garcinia xanthochymus.
Vnuhcm-University Of Science
Glycybridins A-K, Bioactive Phenolic Compounds from Glycyrrhiza glabra.
Peking University
PTP1B inhibitors from the seeds of Iris sanguinea and their insulin mimetic activities via AMPK and ACC phosphorylation.
Seoul National University
A bromopyrrole-containing diterpene alkaloid from the Okinawan marine sponge Agelas nakamurai activates the insulin pathway in Huh-7 human hepatoma cells by inhibiting protein tyrosine phosphatase 1B.
Tohoku Medical And Pharmaceutical University
Y-shaped bis-arylethenesulfonic acid esters: Potential potent and membrane permeable protein tyrosine phosphatase 1B inhibitors.
Shanghai Jiao Tong University
Competitive protein tyrosine phosphatase 1B (PTP1B) inhibitors, prenylated caged xanthones from Garcinia hanburyi and their inhibitory mechanism.
Gyeongsang National University
Design, synthesis, in silico and in vitro evaluation of thiophene derivatives: A potent tyrosine phosphatase 1B inhibitor and anticancer activity.
K L University
Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata.
Peking University
Allosteric Inhibitors of SHP2 with Therapeutic Potential for Cancer Treatment.
Chinese Academy Of Sciences
X-ray Characterization and Structure-Based Optimization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors.
Yale University
Structure-related protein tyrosine phosphatase 1B inhibition by naringenin derivatives.
Chonbuk National University
Discovery and evaluation of the hybrid of bromophenol and saccharide as potent and selective protein tyrosine phosphatase 1B inhibitors.
Chinese Academy Of Sciences
Secondary/tertiary benzenesulfonamides with inhibitory action against the cytosolic human carbonic anhydrase isoforms I and II.
Ataturk University
A Molecular Dynamics Investigation of Mycobacterium tuberculosis Prenyl Synthases: Conformational Flexibility and Implications for Computer-aided Drug Discovery.
University Of California San Diego
Structural investigation of the binding of 5-substituted swainsonine analogues to Golgi alpha-mannosidase II.
University Of Toronto
Application of fragment-based drug discovery to membrane proteins: identification of ligands of the integral membrane enzyme DsbB.
Leiden University