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419 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
The 1,2,4-Triazolo[4,3-a]pyrazin-3-one as a Versatile Scaffold for the Design of Potent Adenosine Human Receptor Antagonists. Structural Investigations to Target the AEBI
Universit£
NEBI
Seoul National University
Design, Synthesis of Novel, Potent, Selective, Orally Bioavailable Adenosine AEBI
Advinus Therapeutics
AEBI
Advinus Therapeutics
Design and synthesis of novel, potent and selective hypoxanthine analogs as adenosine AEBI
Advinus Therapeutics
Design, Synthesis, and Pharmacological Characterization of 2-(2-Furanyl)thiazolo[5,4-d]pyrimidine-5,7-diamine Derivatives: New Highly Potent AEBI
Universit£
Synthesis and evaluation of N-substituted 2-amino-4,5-diarylpyrimidines as selective adenosine AEBI
Leiden University
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CHEBI
Jagiellonian University Medical College
Biphenyl Pyridazinone Derivatives as Inhaled PDE4 Inhibitors: Structural Biology and Structure-Activity Relationships.EBI
RhôNe-Poulenc Rorer
Structure-Based Scaffold Repurposing for G Protein-Coupled Receptors: Transformation of Adenosine Derivatives into 5HTEBI
National Institute Of Diabetes And Digestive And Kidney Diseases
Discovery of 7-(Prolinol-N-yl)-2-phenylamino-thiazolo[5,4-d]pyrimidines as Novel Non-Nucleoside Partial Agonists for the A2A Adenosine Receptor: Prediction from Molecular Modeling.EBI
Julius-Maximilians-Universit£T W£Rzburg
Similarities and differences in affinity and binding modes of tricyclic pyrimido- and pyrazinoxanthines at human and rat adenosine receptors.EBI
Jagiellonian University Medical College
Exploring the 2- and 5-positions of the pyrazolo[4,3-d]pyrimidin-7-amino scaffold to target human A1 and A2A adenosine receptors.EBI
Universit£
Purine (N)-Methanocarba Nucleoside Derivatives Lacking an Exocyclic Amine as Selective A3 Adenosine Receptor Agonists.EBI
National Institute Of Diabetes And Digestive And Kidney Diseases
Discovery of Potent and Highly Selective A2B Adenosine Receptor Antagonist Chemotypes.EBI
Uppsala University
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.EBI
Jagiellonian University Medical College
Tetrahydroisoquinoline Phenols: Selective Estrogen Receptor Downregulator Antagonists with Oral Bioavailability in Rat.EBI
Astrazeneca
Discovery of Novel Adenosine Receptor Agonists That Exhibit Subtype Selectivity.EBI
University Of Warwick
Discovery of Molecular Therapeutics for Glaucoma: Challenges, Successes, and Promising Directions.EBI
Georgia Institute Of Technology
Discovery of aminoquinazoline derivatives as human A(2A) adenosine receptor antagonists.EBI
Merck Research Laboratories
Structural refinement of pyrazolo[4,3-d]pyrimidine derivatives to obtain highly potent and selective antagonists for the human A3 adenosine receptor.EBI
Universit£
5,7-Disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazines as pharmacological tools to explore the antagonist selectivity profiles toward adenosine receptors.EBI
Universit£
Structure-kinetics relationships of Capadenoson derivatives as adenosine A1 receptor agonists.EBI
Leiden University
Rigidified A3 Adenosine Receptor Agonists: 1-Deazaadenine Modification Maintains High in Vivo Efficacy.EBI
National Institute Of Diabetes And Digestive And Kidney Diseases
Use of molecular modeling aided design to dial out hERG liability in adenosine A(2A) receptor antagonists.EBI
Merck Research Laboratories
One-pot reaction to obtain N,N'-disubstituted guanidines of pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine scaffold as human A3 adenosine receptor antagonists.EBI
Universit£
A solid-phase combinatorial approach for indoloquinolizidine-peptides with high affinity at D(1) and D(2) dopamine receptors.EBI
University Of Barcelona
Design, synthesis, and biological evaluation of novel 2-((2-(4-(substituted)phenylpiperazin-1-yl)ethyl)amino)-5'-N-ethylcarboxamidoadenosines as potent and selective agonists of the A2A adenosine receptor.EBI
Universit£
5'-C-Ethyl-tetrazolyl-N(6)-substituted adenosine and 2-chloro-adenosine derivatives as highly potent dual acting A1 adenosine receptor agonists and A3 adenosine receptor antagonists.EBI
University Of Camerino
A facile and novel synthesis of N(2)-, C(6)-substituted pyrazolo[3,4-d]pyrimidine-4 carboxylate derivatives as adenosine receptor antagonists.EBI
National University Of Singapore
Synthesis and SAR studies of analogues of 4-(3,3-dimethyl-butyrylamino)-3,5-difluoro-N-thiazol-2-yl-benzamide (Lu AA41063) as adenosine A2A receptor ligands with improved aqueous solubility.EBI
H. Lundbeck
Novel thiazole-thiophene conjugates as adenosine receptor antagonists: synthesis, biological evaluation and docking studies.EBI
B. V. Patel Pharmaceutical Education And Research Development (Perd) Centre
7-Amino-2-phenylpyrazolo[4,3-d]pyrimidine derivatives: structural investigations at the 5-position to target human A1 and A(2A) adenosine receptors. Molecular modeling and pharmacological studies.EBI
Universit£
Scaffold decoration at positions 5 and 8 of 1,2,4-triazolo[1,5-c]pyrimidines to explore the antagonist profiling on adenosine receptors: a preliminary structure-activity relationship study.EBI
Universit£
Extended N(6) substitution of rigid C2-arylethynyl nucleosides for exploring the role of extracellular loops in ligand recognition at the A3 adenosine receptor.EBI
National Institute Of Diabetes And Digestive And Kidney Diseases
DDD-028: a potent potential non-opioid, non-cannabinoid analgesic for neuropathic and inflammatory pain.EBI
University Of Missouri
1,2,4-triazolo[1,5-a]quinoxaline derivatives and their simplified analogues as adenosine A3 receptor antagonists. Synthesis, structure-affinity relationships and molecular modeling studies.EBI
Universit£
Further studies on pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as potent and selective human A1 adenosine receptor antagonists.EBI
Universit£
Structure-Based Design of Reactive Nucleosides for Site-Specific Modification of the A2A Adenosine Receptor.EBI
National Institute Of Diabetes And Digestive And Kidney Diseases
Synthesis and biological evaluation of novel allosteric enhancers of the A1 adenosine receptor based on 2-amino-3-(4'-chlorobenzoyl)-4-substituted-5-arylethynyl thiophene.EBI
Universit£
4-aminoquinolone piperidine amides: noncovalent inhibitors of DprE1 with long residence time and potent antimycobacterial activity.EBI
Astrazeneca
Adenosine A2A receptor as a drug discovery target.EBI
Merck Research Laboratories
Agonists for the adenosine A1 receptor with tunable residence time. A Case for nonribose 4-amino-6-aryl-5-cyano-2-thiopyrimidines.EBI
Leiden University
Structure-based approaches to ligands for G-protein-coupled adenosine and P2Y receptors, from small molecules to nanoconjugates.EBI
National Institute Of Diabetes And Digestive And Kidney Diseases
Substituted 7-amino-5-thio-thiazolo[4,5-d]pyrimidines as potent and selective antagonists of the fractalkine receptor (CX3CR1).EBI
Astrazeneca
2-Arylpyrazolo[4,3-d]pyrimidin-7-amino derivatives as new potent and selective human A3 adenosine receptor antagonists. Molecular modeling studies and pharmacological evaluation.EBI
Universit£
Synthesis and structure-activity relationships of 2-hydrazinyladenosine derivatives as A(2A) adenosine receptor ligands.EBI
University Of Bonn
Selective and potent adenosine A3 receptor antagonists by methoxyaryl substitution on the N-(2,6-diarylpyrimidin-4-yl)acetamide scaffold.EBI
University Of Santiago De Compostela
Pyrazolo[1,5-c]quinazoline derivatives and their simplified analogues as adenosine receptor antagonists: synthesis, structure-affinity relationships and molecular modeling studies.EBI
Universita' Di Firenze
Highly potent and selective fluorescent antagonists of the human adenosine A3 receptor based on the 1,2,4-triazolo[4,3-a]quinoxalin-1-one scaffold.EBI
University Of Nottingham
New fluorescent adenosine A1-receptor agonists that allow quantification of ligand-receptor interactions in microdomains of single living cells.EBI
University Of Nottingham
Truncated Nucleosides as A(3) Adenosine Receptor Ligands: Combined 2-Arylethynyl and Bicyclohexane Substitutions.EBI
TBA
Synthesis and pharmacological evaluation of novel substituted 9-deazaxanthines as A2B receptor antagonists.EBI
Universidade De A Coru£A
In silico directed chemical probing of the adenosine receptor family.EBI
Universidade Do Minho
Synthesis and pharmacological evaluation of novel 1,3,8- and 1,3,7,8-substituted xanthines as adenosine receptor antagonists.EBI
Universidade De Porto
Design, synthesis, and structure-activity relationships of 1-,3-,8-, and 9-substituted-9-deazaxanthines at the human A2B adenosine receptor.EBI
Universit£
Exploring the directionality of 5-substitutions in a new series of 5-alkylaminopyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine as a strategy to design novel human a(3) adenosine receptor antagonists.EBI
Universit£
Medicinal chemistry of A3 adenosine receptor modulators: pharmacological activities and therapeutic implications.EBI
Universit£
Structural sweet spot for A1 adenosine receptor activation by truncated (N)-methanocarba nucleosides: receptor docking and potent anticonvulsant activity.EBI
National Institute Of Diabetes And Digestive And Kidney Diseases
Synthesis and biological evaluation of 2-amino-3-(4-chlorobenzoyl)-4-[(4-arylpiperazin-1-yl)methyl]-5-substituted-thiophenes. effect of the 5-modification on allosteric enhancer activity at the A1 adenosine receptor.EBI
Universit£
Identifying novel adenosine receptor ligands by simultaneous proteochemometric modeling of rat and human bioactivity data.EBI
Leiden/Amsterdam Center For Drug Research
Orally active adenosine A(1) receptor agonists with antinociceptive effects in mice.EBI
University Of North Carolina At Chapel Hill
Design and characterization of optimized adenosine A2A/A1 receptor antagonists for the treatment of Parkinson's disease.EBI
Janssen Research And Development
Synthesis and biological activity of tricyclic cycloalkylimidazo-, pyrimido- and diazepinopurinediones.EBI
Jagiellonian University Medical College
Structure-activity relationships and molecular modeling of 1,2,4-triazoles as adenosine receptor antagonists.EBI
TBA
Water-soluble pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines as human A3 adenosine receptor antagonists.EBI
Universit£
Optimization of adenosine 5'-carboxamide derivatives as adenosine receptor agonists using structure-based ligand design and fragment screening.EBI
National Institute Of Diabetes And Digestive And Kidney Diseases
Structure-guided design of A(3) adenosine receptor-selective nucleosides: combination of 2-arylethynyl and bicyclo[3.1.0]hexane substitutions.EBI
National Institute Of Diabetes And Digestive And Kidney Diseases
New chromene scaffolds for adenosine A(2A) receptors: synthesis, pharmacology and structure-activity relationships.EBI
Universidade Do Minho
Synthesis and pharmacological evaluation of dual acting antioxidant A(2A) adenosine receptor agonists.EBI
Monash University
Development of Polar Adenosine A2A Receptor Agonists for Inflammatory Bowel Disease: Synergism with A2B Antagonists.EBI
TBA
Exploring activity cliffs in medicinal chemistry.EBI
Rheinische Friedrich-Wilhelms-Universit£T
3-aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one: a novel template for the design of highly selective A2B adenosine receptor antagonists.EBI
Universit£
Discovery of 1,2,4-triazine derivatives as adenosine A(2A) antagonists using structure based drug design.EBI
Heptares Therapeutics
Truncated (N)-Methanocarba Nucleosides as A(1) Adenosine Receptor Agonists and Partial Agonists: Overcoming Lack of a Recognition Element.EBI
TBA
Discovery of phosphoric acid mono-{2-[(E/Z)-4-(3,3-dimethyl-butyrylamino)-3,5-difluoro-benzoylimino]-thiazol-3-ylmethyl} ester (Lu AA47070): a phosphonooxymethylene prodrug of a potent and selective hA(2A) receptor antagonist.EBI
H. Lundbeck
Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity relaEBI
Pfizer
Discovery of a novel 5-HT(3) antagonist/5-HT(1A) agonist 3-amino-5,6,7,8-tetrahydro-2-{4-[4-(quinolin-2-yl)piperazin-1-yl]butyl}quinazolin-4(3H)-one (TZB-30878) as an orally bioavailable agent for irritable bowel syndrome.EBI
Aska Pharmaceutical
Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 receptor agonist with unprecedented selectivity and procognitive potential.EBI
H. Lundbeck
4-Substituted-7-N-alkyl-N-acetyl 2-aminobenzothiazole amides: drug-like and non-xanthine based A2B adenosine receptor antagonists.EBI
Roche Research Center
Novel N2-substituted pyrazolo[3,4-d]pyrimidine adenosine A3 receptor antagonists: inhibition of A3-mediated human glioblastoma cell proliferation.EBI
Universit£
Novel 8-(furan-2-yl)-3-substituted thiazolo [5,4-e][1,2,4] triazolo[1,5-c] pyrimidine-2(3H)-thione derivatives as potential adenosine A(2A) receptor antagonists.EBI
University Of Delhi
2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists.EBI
University Of Bonn
1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity.EBI
Institute
High-affinity, non-nucleotide-derived competitive antagonists of platelet P2Y12 receptors.EBI
University Of Bonn
8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands.EBI
University Of Camerino
2-Amino-6-furan-2-yl-4-substituted nicotinonitriles as A2A adenosine receptor antagonists.EBI
Leiden/Amsterdam Center For Drug Research
Luteolin, a compound with adenosine A(1) receptor-binding activity, and chromone and dihydronaphthalenone constituents from Senna siamea.EBI
Leiden University
Alkaloids from Eschscholzia californica and their capacity to inhibit binding of [3H]8-Hydroxy-2-(di-N-propylamino)tetralin to 5-HT1A receptors in Vitro.EBI
Tom'S Of Maine
Synthesis of eudistomin D analogues and its effects on adenosine receptors.EBI
Hokkaido University
Design of (N)-methanocarba adenosine 5'-uronamides as species-independent A3 receptor-selective agonists.EBI
National Institute Of Diabetes And Digestive And Kidney Diseases
Antagonists of the human adenosine A2A receptor. Part 3: Design and synthesis of pyrazolo[3,4-d]pyrimidines, pyrrolo[2,3-d]pyrimidines and 6-arylpurines.EBI
Vernalis (R&D)
Antagonists of the human adenosine A2A receptor. Part 2: Design and synthesis of 4-arylthieno[3,2-d]pyrimidine derivatives.EBI
Vernalis (R&D)
Antagonists of the human adenosine A2A receptor. Part 1: Discovery and synthesis of thieno[3,2-d]pyrimidine-4-methanone derivatives.EBI
Vernalis (R&D)
Discovery of a novel A2B adenosine receptor antagonist as a clinical candidate for chronic inflammatory airway diseases.EBI
Cv Therapeutics
Probing distal regions of the A2B adenosine receptor by quantitative structure-activity relationship modeling of known and novel agonists.EBI
National Institute Of Diabetes And Digestive And Kidney Diseases
1,3-Dipropyl-8-(1-phenylacetamide-1H-pyrazol-3-yl)-xanthine derivatives as highly potent and selective human A(2B) adenosine receptor antagonists.EBI
Universit£
N6-substituted C5'-modified adenosines as A1 adenosine receptor agonists.EBI
Monash University (Parkville Campus)
A new generation of adenosine receptor antagonists: from di- to trisubstituted aminopyrimidines.EBI
Leiden/Amsterdam Center For Drug Research
1-, 3- and 8-substituted-9-deazaxanthines as potent and selective antagonists at the human A2B adenosine receptor.EBI
Universit£
A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.EBI
Abbott Laboratories
Structure-activity relationships of 2-chloro-N6-substituted-4'-thioadenosine-5'-N,N-dialkyluronamides as human A3 adenosine receptor antagonists.EBI
Ewha Womans University
5'-Carbamoyl derivatives of 2'-C-methyl-purine nucleosides as selective A1 adenosine receptor agonists: affinity, efficacy, and selectivity for A1 receptor from different species.EBI
Universit£
Potent and selective xanthine-based inhibitors of phosphodiesterase 5.EBI
Novartis Institutes Of Biomedical Research
Structure-activity relationships of adenosines with heterocyclic N6-substituents.EBI
Monash University (Parkville Campus)
5-amino-2-phenyl[1,2,3]triazolo[1,2-a][1,2,4]benzotriazin-1-one: a versatile scaffold to obtain potent and selective A3 adenosine receptor antagonists.EBI
Universit£
N(6)-[(hetero)aryl/(cyclo)alkyl-carbamoyl-methoxy-phenyl]-(2-chloro)-5'-N-ethylcarboxamido-adenosines: the first example of adenosine-related structures with potent agonist activity at the human A(2B) adenosine receptor.EBI
Universit£
Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor.EBI
National Institute Of Diabetes And Digestive And Kidney Diseases
N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor.EBI
Universit£
Synthesis and biological evaluation of novel 1-deoxy-1-[6-[((hetero)arylcarbonyl)hydrazino]- 9H-purin-9-yl]-N-ethyl-beta-D-ribofuranuronamide derivatives as useful templates for the development of A2B adenosine receptor agonists.EBI
Universit£
SAR of a series of 5,6-dihydro-(9H)-pyrazolo[3,4-c]-1,2,4-triazolo[4,3-alpha]pyridines as potent inhibitors of human eosinophil phosphodiesterase.EBI
Pfizer
Structure-activity relationship study of prion inhibition by 2-aminopyridine-3,5-dicarbonitrile-based compounds: parallel synthesis, bioactivity, and in vitro pharmacokinetics.EBI
University Of California San Francisco
N6-ethyl-2-alkynyl NECAs, selective human A3 adenosine receptor agonists.EBI
University Of Virginia
Synthesis and biological studies of a new series of 5-heteroarylcarbamoylaminopyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidines as human A3 adenosine receptor antagonists. Influence of the heteroaryl substituent on binding affinity and molecular modeling investigations.EBI
Universit£
2-(Benzimidazol-2-yl)quinoxalines: a novel class of selective antagonists at human A(1) and A(3) adenosine receptors designed by 3D database searching.EBI
Universit£
2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization.EBI
Universit£
A series of ligands displaying a remarkable agonistic-antagonistic profile at the adenosine A1 receptor.EBI
Leiden/Amsterdam Center For Drug Research
Binding thermodynamics as a tool to investigate the mechanisms of drug-receptor interactions: thermodynamics of cytoplasmic steroid/nuclear receptors in comparison with membrane receptors.EBI
University Of Ferrara
Synthesis, biological evaluation, and molecular modeling of ribose-modified adenosine analogues as adenosine receptor agonists.EBI
Universit£
6-aryl-8H-indeno[1,2-d]thiazol-2-ylamines: A1 adenosine receptor agonist allosteric enhancers having improved potency.EBI
University Of Virginia
Synthesis and biological evaluation of novel N6-[4-(substituted)sulfonamidophenylcarbamoyl]adenosine-5'-uronamides as A3 adenosine receptor agonists.EBI
Universit£
2-Pyrazolyl-N(6)-substituted adenosine derivatives as high affinity and selective adenosine A(3) receptor agonists.EBI
Cv Therapeutics
Synthesis and biological activity of new potential agonists for the human adenosine A2A receptor.EBI
Iiqab (Csic)
A new orally bioavailable dual adenosine A2B/A3 receptor antagonist with therapeutic potential.EBI
Novartis Institutes For Biomedical Research
Design and synthesis of 3'-ureidoadenosine-5'-uronamides: effects of the 3'-ureido group on binding to the A3 adenosine receptor.EBI
Ewha Womans University
Design, synthesis, and biological evaluation of new 8-heterocyclic xanthine derivatives as highly potent and selective human A2B adenosine receptor antagonists.EBI
Universit£
New, non-adenosine, high-potency agonists for the human adenosine A2B receptor with an improved selectivity profile compared to the reference agonist N-ethylcarboxamidoadenosine.EBI
University Of Leiden
1,2,4-triazolo[4,3-a]quinoxalin-1-one moiety as an attractive scaffold to develop new potent and selective human A3 adenosine receptor antagonists: synthesis, pharmacological, and ligand-receptor modeling studies.EBI
Universit£
Incorporating molecular shape into the alignment-free Grid-Independent Descriptors.EBI
Universitat Pompeu Fabra
N6-cyclopentyl-2-(3-phenylaminocarbonyltriazene-1-yl)adenosine (TCPA), a very selective agonist with high affinity for the human adenosine A1 receptor.EBI
Leiden University
Design, synthesis, and biological evaluation of C9- and C2-substituted pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as new A2A and A3 adenosine receptors antagonists.EBI
Universit£
N(6)-alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A(3) receptor and a starting point for searching A(2B) ligands.EBI
Universit£
From hit to lead. Analyzing structure-profile relationships.EBI
Universities Of Lille
Methanocarba analogues of purine nucleosides as potent and selective adenosine receptor agonists.EBI
National Institute Of Diabetes
5'-N-substituted carboxamidoadenosines as agonists for adenosine receptors.EBI
Leiden University
9-Benzyladenines: potent and selective cAMP phosphodiesterase inhibitors.EBI
Upr 421 Du Cnrs
Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance.EBI
Kyowa Hakko Kogyo
(+/-)8-Amino-5,6,7,8-tetrahydroisoquinolines as novel antinociceptive agents.EBI
Virginia Commonwealth University
7-Nitrobenzofurazan (NBD) derivatives of 5'-N-ethylcarboxamidoadenosine (NECA) as new fluorescent probes for human A(3) adenosine receptors.EBI
Universit£
Introduction of alkynyl chains on C-8 of adenosine led to very selective antagonists of the A(3) adenosine receptor.EBI
Universit£
Ring-Constrained (N)-methanocarba nucleosides as adenosine receptor agonists: independent 5'-uronamide and 2'-deoxy modifications.EBI
Niddk
Adenosine receptor ligands with oxygenated N6-substituents.EBI
Deakin University
Diimidazo[1,2-c:4',5'-e]pyrimidines: adenosine agonist activity demonstrated by microphysiometry.EBI
Griffith University
 
New base-altered adenosine analogues: Synthesis and affinity at adenosine A1 and A2A receptorsEBI
TBA
 
The design and synthesis of novel adenosine agonistsEBI
TBA
Novel 1,3-dipropyl-8-(3-benzimidazol-2-yl-methoxy-1-methylpyrazol-5-yl)xanthines as potent and selective A2B adenosine receptor antagonists.EBI
University Of Ferrara
Evaluation of molecular modeling of agonist binding in light of the crystallographic structure of an agonist-bound A2A adenosine receptor.EBI
National Institute Of Diabetes And Digestive And Kidney Diseases
Structure-activity relationships of truncated C2- or C8-substituted adenosine derivatives as dual acting A2A and A3 adenosine receptor ligands.EBI
Ewha Womans University
Pyrrolo- and pyrazolo-[3,4-e][1,2,4]triazolo[1,5-c]pyrimidines as adenosine receptor antagonists.EBI
Universit£
Synthesis and Biological Evaluation of a New Series of 1,2,4-Triazolo[1,5-a]-1,3,5-triazines as Human A(2A) Adenosine Receptor Antagonists with Improved Water Solubility.EBI
Universita Di Trieste
Highly potent, selective, and orally active phosphodiesterase 10A inhibitors.EBI
Pfizer
Investigation of the pyrazinones as PDE5 inhibitors: evaluation of regioisomeric projections into the solvent region.EBI
Pfizer
Does the combination of optimal substitutions at the C²-, N¿?¿- and N¿?¿-positions of the pyrazolo-triazolo-pyrimidine scaffold guarantee selective modulation of the human A3 adenosine receptors?EBI
National University Of Singapore
New 2-heterocyclyl-imidazo[2,1-i]purin-5-one derivatives as potent and selective human A3 adenosine receptor antagonists.EBI
Universit£
Synthesis, structure-affinity relationships, and molecular modeling studies of novel pyrazolo[3,4-c]quinoline derivatives as adenosine receptor antagonists.EBI
Universita' Di Firenze
Molecular probes for the A2A adenosine receptor based on a pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine scaffold.EBI
National Institute Of Diabetes And Digestive And Kidney Diseases
Discovery of benzothiazole-based adenosine A2B receptor antagonists with improved A2A selectivity.EBI
Roche Research Center
Design and optimisation of orally active TLR7 agonists for the treatment of hepatitis C virus infection.EBI
Pfizer
Discovery of LAS101057: A Potent, Selective, and Orally Efficacious A2B Adenosine Receptor AntagonistEBI
TBA
Pyrimidine derivatives as potent and selective A3 adenosine receptor antagonists.EBI
University Of Santiago De Compostela
Discovery of novel quinolinone adenosine A2B antagonists.EBI
Ligand Pharmaceuticals
In vivo characterization of a dual adenosine A2A/A1 receptor antagonist in animal models of Parkinson's disease.EBI
Johnson & Johnson Pharmaceutical Research And Development
Molecular modeling study on potent and selective adenosine A(3) receptor agonists.EBI
University Of Camerino
Pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as selective human A(1) adenosine receptor ligands.EBI
Dipartimento Di Scienze Farmaceutiche
Identification and optimization of substituted 5-aminopyrazoles as potent and selective adenosine A1 receptor antagonists.EBI
Bayer Schering Pharma
Design, synthesis, and binding of homologated truncated 4'-thioadenosine derivatives at the human A3 adenosine receptors.EBI
Ewha Womans University
Hit-to-lead optimization of a series of carboxamides of ethyl 2-amino-4-phenylthiazole-5-carboxylates as novel adenosine A2A receptor antagonists.EBI
H. Lundbeck
A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase.EBI
Università
Insights into binding modes of adenosine A(2B) antagonists with ligand-based and receptor-based methods.EBI
East China University Of Science And Technology
Synthesis and evaluation of new N6-substituted adenosine-5'-N-methylcarboxamides as A3 adenosine receptor agonists.EBI
Monash University
Methylene amine substituted arylindenopyrimidines as potent adenosine A(2A)/A(1) antagonists.EBI
Johnson & Johnson Pharmaceutical Research And Development
Optimization of arylindenopyrimidines as potent adenosine A(2A)/A(1) antagonists.EBI
Johnson & Johnson Pharmaceutical Research And Development
Hybrid ortho/allosteric ligands for the adenosine A(1) receptor.EBI
Leiden University
The significance of 2-furyl ring substitution with a 2-(para-substituted) aryl group in a new series of pyrazolo-triazolo-pyrimidines as potent and highly selective hA(3) adenosine receptors antagonists: new insights into structure-affinity relationship and receptor-antagonist recognition.EBI
National University Of Singapore
Discovery of potent and selective bicyclic A(2B) adenosine receptor antagonists via bioisosteric amide replacement.EBI
RhôNe-Poulenc Rorer
Discovery of N-(5,6-diarylpyridin-2-yl)amide derivatives as potent and selective A(2B) adenosine receptor antagonists.EBI
RhôNe-Poulenc Rorer
Synthesis and evaluation of two series of 4'-aza-carbocyclic nucleosides as adenosine A2A receptor agonists.EBI
Novartis Institutes For Biomedical Research
Synthesis of theophylline derivatives and study of their activity as antagonists at adenosine receptors.EBI
Universidad De M£Laga
Design and synthesis of N(6)-substituted-4'-thioadenosine-5'-uronamides as potent and selective human A(3) adenosine receptor agonists.EBI
Ewha Womans University
3- and 6-Substituted 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridines as A1 adenosine receptor allosteric modulators and antagonists.EBI
Monash University (Parkville Campus)
2-Phenylpyrazolo[4,3-d]pyrimidin-7-one as a new scaffold to obtain potent and selective human A3 adenosine receptor antagonists: new insights into the receptor-antagonist recognition.EBI
Universit£
Functionalized congeners of A3 adenosine receptor-selective nucleosides containing a bicyclo[3.1.0]hexane ring system.EBI
National Institute Of Diabetes And Digestive And Kidney Diseases
Synthesis and biological evaluation of 2-alkynyl-N6-methyl-5'-N-methylcarboxamidoadenosine derivatives as potent and highly selective agonists for the human adenosine A3 receptor.EBI
University Of Camerino
Design, synthesis and biological evaluation of a bivalent micro opiate and adenosine A1 receptor antagonist.EBI
Aix-Marseille Universit£
Combining selectivity and affinity predictions using an integrated Support Vector Machine (SVM) approach: An alternative tool to discriminate between the human adenosine A(2A) and A(3) receptor pyrazolo-triazolo-pyrimidine antagonists binding sites.EBI
Universit£
Synthesis of hybrid analogues of caffeine and eudistomin D and its affinity for adenosine receptors.EBI
Hokkaido University
Structure-activity relationships of truncated adenosine derivatives as highly potent and selective human A3 adenosine receptor antagonists.EBI
Ewha Womans University
Antagonists of the human A(2A) receptor. Part 5: Highly bio-available pyrimidine-4-carboxamides.EBI
Vernalis (R+D)
The Role of Receptor Binding in Drug DiscoveryEBI
TBA
 
The discovery of CP-96,021 and CP-96,486, balanced, combined, potent and orally active leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonists.EBI
TBA
1,3-dialkyl-8-N-substituted benzyloxycarbonylamino-9-deazaxanthines as potent adenosine receptor ligands: Design, synthesis, structure-affinity and structure-selectivity relationships.EBI
Universidade De Santiago De Compostela
N6-Cycloalkyl- and N6-bicycloalkyl-C5'(C2')-modified adenosine derivatives as high-affinity and selective agonists at the human A1 adenosine receptor with antinociceptive effects in mice.EBI
University Of Camerino
Pyrido[2,3-e]-1,2,4-triazolo[4,3-a]pyrazin-1-one as a new scaffold to develop potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluation, and ligand-receptor modeling studies.EBI
Universita Di Firenze
Synthesis and SAR studies of trisubstituted purinones as potent and selective adenosine A2A receptor antagonists.EBI
Pharmacopeia
N-[6-amino-2-(heteroaryl)pyrimidin-4-yl]acetamides as A2A receptor antagonists with improved drug like properties and in vivo efficacy.EBI
Neurocrine Biosciences
Antagonists of the human A(2A) adenosine receptor. 4. Design, synthesis, and preclinical evaluation of 7-aryltriazolo[4,5-d]pyrimidines.EBI
Vernalis R&D
Synthesis of 2-amino-5-benzoyl-4-(2-furyl)thiazoles as adenosine A(2A) receptor antagonists.EBI
Pharmacopeia
Synthesis of a series of 8-(substituted-phenyl)xanthines and a study on the effects of substitution pattern of phenyl substituents on affinity for adenosine A(1) and A(2A) receptors.EBI
University Institute Of Pharmaceutical Sciences
Structure-activity relationship studies of a new series of imidazo[2,1-f]purinones as potent and selective A(3) adenosine receptor antagonists.EBI
Università
Novel potent and highly selective human A(3) adenosine receptor antagonists belonging to the 4-amido-2-arylpyrazolo[3,4-c]quinoline series: molecular docking analysis and pharmacological studies.EBI
Università
1,3-Dialkyl-8-(hetero)aryl-9-OH-9-deazaxanthines as potent A2B adenosine receptor antagonists: design, synthesis, structure-affinity and structure-selectivity relationships.EBI
Università
2,6-Diaryl-4-acylaminopyrimidines as potent and selective adenosine A(2A) antagonists with improved solubility and metabolic stability.EBI
Neurocrine Biosciences
Structure-activity relationships of truncated D- and l-4'-thioadenosine derivatives as species-independent A3 adenosine receptor antagonists.EBI
Ewha Womans University
2-aminothienopyridazines as novel adenosine A1 receptor allosteric modulators and antagonists.EBI
Monash University
Selective A(3) adenosine receptor antagonists derived from nucleosides containing a bicyclo[3.1.0]hexane ring system.EBI
National Institute Of Diabetes And Digestive And Kidney Diseases
Synthesis and biological evaluation of 2-amino-3-(4-chlorobenzoyl)-4-[N-(substituted) piperazin-1-yl]thiophenes as potent allosteric enhancers of the A1 adenosine receptor.EBI
Dipartimento Di Scienze Farmaceutiche
Synthesis, ligand-receptor modeling studies and pharmacological evaluation of novel 4-modified-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives as potent and selective human A3 adenosine receptor antagonists.EBI
Universita' Di Firenze
Lignans isolated from valerian: identification and characterization of a new olivil derivative with partial agonistic activity at A(1) adenosine receptors.EBI
University Of Bonn
Synthesis of N-pyrimidinyl-2-phenoxyacetamides as adenosine A2A receptor antagonists.EBI
Neurocrine Biosciences
Selective, high affinity A(2B) adenosine receptor antagonists: N-1 monosubstituted 8-(pyrazol-4-yl)xanthines.EBI
Cv Therapeutics
Identification of novel, water-soluble, 2-amino-N-pyrimidin-4-yl acetamides as A2A receptor antagonists with in vivo efficacy.EBI
Neurocrine Biosciences
Phenylethyl-substituted pyrimido[2,1-f]purinediones and related compounds: structure-activity relationships as adenosine A(1) and A(2A) receptor ligands.EBI
Jagiellonian University Medical College
Dual acting antioxidant A1 adenosine receptor agonists.EBI
Monash University (Parkville Campus)
New 2-arylpyrazolo[3,4-c]quinoline derivatives as potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluation, and ligand-receptor modeling studies.EBI
Università
Design, synthesis, and biological evaluation of LNA nucleosides as adenosine A3 receptor ligands.EBI
Santaris Pharma
Discovery of a new nucleoside template for human A3 adenosine receptor ligands: D-4'-thioadenosine derivatives without 4'-hydroxymethyl group as highly potent and selective antagonists.EBI
Ewha Womans University
Novel ergopeptides as dual ligands for adenosine and dopamine receptors.EBI
Institut D'Investigacions BiomèDiques August Pi I
N9-benzyl-substituted 1,3-dimethyl- and 1,3-dipropyl-pyrimido[2,1-f]purinediones: synthesis and structure-activity relationships at adenosine A1 and A2A receptors.EBI
Jagiellonian University
Discovery and characterization of 4'-(2-furyl)-N-pyridin-3-yl-4,5'-bipyrimidin-2'-amine (LAS38096), a potent, selective, and efficacious A2B adenosine receptor antagonist.EBI
Almirall
2,6,8-trisubstituted 1-deazapurines as adenosine receptor antagonists.EBI
Leiden/Amsterdam Center For Drug Research
Potent, selective, and orally active adenosine A2A receptor antagonists: arylpiperazine derivatives of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines.EBI
Schering-Plough Research Institute
2-triazole-substituted adenosines: a new class of selective A3 adenosine receptor agonists, partial agonists, and antagonists.EBI
Ghent University
Tricyclic imidazoline derivatives as potent and selective adenosine A1 receptor antagonists.EBI
Biogen Idec
Potent and orally bioavailable 8-bicyclo[2.2.2]octylxanthines as adenosine A1 receptor antagonists.EBI
Biogen Idec
N6-Cycloalkyl-2-substituted adenosine derivatives as selective, high affinity adenosine A1 receptor agonists.EBI
Cv Therapeutics
Identification of non-furan containing A2A antagonists using database mining and molecular similarity approaches.EBI
Vernalis (R&D)
A new synthesis of sulfonamides by aminolysis of p-nitrophenylsulfonates yielding potent and selective adenosine A2B receptor antagonists.EBI
University Of Bonn
Pharmacophore based receptor modeling: the case of adenosine A3 receptor antagonists. An approach to the optimization of protein models.EBI
Università
4-amido-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-ones as new potent and selective human A3 adenosine receptor antagonists. synthesis, pharmacological evaluation, and ligand-receptor modeling studies.EBI
Università
Novel 1,3-disubstituted 8-(1-benzyl-1H-pyrazol-4-yl) xanthines: high affinity and selective A2B adenosine receptor antagonists.EBI
Cv Therapeutics
Structure-activity relationships of new 1H-imidazo[4,5-c]quinolin-4-amine derivatives as allosteric enhancers of the A3 adenosine receptor.EBI
Leiden University
New pyrrolopyrimidin-6-yl benzenesulfonamides: potent A2B adenosine receptor antagonists.EBI
RhôNe-Poulenc Rorer
2,6-disubstituted and 2,6,8-trisubstituted purines as adenosine receptor antagonists.EBI
Leiden/Amsterdam Center For Drug Research
Synthesis, in vitro and in vivo evaluation of [O-methyl-11C] 2-{4-[4-(3-methoxyphenyl)piperazin-1-yl]-butyl}-4-methyl-2H-[1,2,4]-triazine-3,5-dione: a novel agonist 5-HT1A receptor PET ligand.EBI
Columbia University College Of Physicians And Surgeons
Structure-activity relationships of 2-chloro-N6-substituted-4'-thioadenosine-5'-uronamides as highly potent and selective agonists at the human A3 adenosine receptor.EBI
Ewha Womans University
Semi-rational design of (north)-methanocarba nucleosides as dual acting A(1) and A(3) adenosine receptor agonists: novel prototypes for cardioprotection.EBI
National Institute Of Diabetes And Digestive And Kidney Diseases
1,2,4-Triazolo[1,5-a]quinoxaline as a versatile tool for the design of selective human A3 adenosine receptor antagonists: synthesis, biological evaluation, and molecular modeling studies of 2-(hetero)aryl- and 2-carboxy-substituted derivatives.EBI
Università
Synthesis and biological characterization of [3H] (2-amino-4,5,6,7-tetrahydrobenzo[b]thiophen-3-yl)-(4-chlorophenyl)-methanone, the first radiolabelled adenosine A1 allosteric enhancer.EBI
Università
Conversion of A3 adenosine receptor agonists into selective antagonists by modification of the 5'-ribofuran-uronamide moiety.EBI
National Institute Of Diabetes And Digestive And Kidney Diseases
Synthesis and 3D QSAR of new pyrazolo[3,4-b]pyridines: potent and selective inhibitors of A1 adenosine receptors.EBI
Università
Novel 1,3-dipropyl-8-(1-heteroarylmethyl-1H-pyrazol-4-yl)-xanthine derivatives as high affinity and selective A2B adenosine receptor antagonists.EBI
Cv Therapeutics
1,8-Naphthyridin-4-one derivatives as new ligands of A2A adenosine receptors.EBI
Dipartimento Di Scienze Farmaceutiche
New 2-arylpyrazolo[4,3-c]quinoline derivatives as potent and selective human A3 adenosine receptor antagonists.EBI
Università
"Reversine" and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists.EBI
National Institute Of Diabetes And Digestive And Kidney Diseases
New pyrrolo[2,1-f]purine-2,4-dione and imidazo[2,1-f]purine-2,4-dione derivatives as potent and selective human A3 adenosine receptor antagonists.EBI
Università
(N)-methanocarba 2,N6-disubstituted adenine nucleosides as highly potent and selective A3 adenosine receptor agonists.EBI
National Institute Of Diabetes And Digestive And Kidney Diseases
The discovery of a selective, high affinity A(2B) adenosine receptor antagonist for the potential treatment of asthma.EBI
Cv Therapeutics
2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists.EBI
Leiden/Amsterdam Center For Drug Research
Discovery of Pyridone-Substituted Triazolopyrimidine Dual AEBI
Fudan University
Optimization of 2-Amino-4,6-diarylpyrimidine-5-carbonitriles as Potent and Selective AEBI
Universidade De Santiago De Compostela
Development and Application of Subtype-Selective Fluorescent Antagonists for the Study of the Human Adenosine AEBI
Monash University
Selective AEBI
National Institute Of Diabetes And Digestive And Kidney Diseases
Piperazine derivatives of [1,2,4]triazolo[1,5-a][1,3,5]triazine as potent and selective adenosine A2a receptor antagonists.EBI
Biogen Idec
Crystal Structure and Subsequent Ligand Design of a Nonriboside Partial Agonist Bound to the Adenosine AEBI
Leiden University
Development of Covalent, Clickable Probes for Adenosine AEBI
Monash University
Exploring Non-orthosteric Interactions with a Series of Potent and Selective AEBI
Universidade De Santiago De Compostela
Structure-activity relationships of adenosine A3 receptor ligands: new potential therapy for the treatment of glaucoma.EBI
Otsuka Pharmaceutical Factory
A mild, efficient and alpha-selective glycosidation by using potassium dodecatungstocobaltate trihydrate as catalyst.EBI
University Of Isfahan
Adenosine AEBI
Heinrich Heine University Duesseldorf
Structure-Based Design of Dual-Acting Compounds Targeting Adenosine AEBI
Shanghaitech University
Subtle Chemical Changes Cross the Boundary between Agonist and Antagonist: New AEBI
Ewha Womans University
Study on affinity profile toward native human and bovine adenosine receptors of a series of 1,8-naphthyridine derivatives.EBI
Università
Comparison of inhibitory activity of isomeric triazolopyridine derivatives towards adenosine receptor subtypes or do similar structures reveal similar bioactivities?EBI
F. Hoffmann-La Roche
JNJ-67569762, A 2-Aminotetrahydropyridine-Based Selective BACE1 Inhibitor Targeting the S3 Pocket: From Discovery to Clinical Candidate.EBI
Janssen Research & Development
2-(N-acyl) and 2-N-acyl-N(6)-substituted analogues of adenosine and their affinity at the human adenosine receptors.EBI
Inotek Pharmaceuticals
Synthesis and SAR evaluation of 1,2,4-triazoles as A(2A) receptor antagonists.EBI
F. Hoffmann-La Roche
Synthesis and evaluation of adenosine derivatives as AEBI
Institute Of Medical Biology Pas
Synthesis and biological evaluation of 2,3,5-substituted [1,2,4]thiadiazoles as allosteric modulators of adenosine receptors.EBI
Leiden University
Affinity and intrinsic efficacy (IE) of 5'-carbamoyl adenosine analogues for the A1 adenosine receptor--efforts towards the discovery of a chronic ventricular rate control agent for the treatment of atrial fibrillation (AF).EBI
Cv Therapeutics
Design, synthesis and biological evaluation of novel scaffold benzo[4,5]imidazo [1,2-a]pyrazin-1-amine: Towards adenosine AEBI
Sun Yat-Sen University
Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as adenosine receptor antagonists. Influence of the N5 substituent on the affinity at the human A 3 and A 2B adenosine receptor subtypes: a molecular modeling investigation.EBI
Università
3,4-Dihydropyrimidin-2(1EBI
Universidade De Santiago De Compostela
2-Amino-3-benzoylthiophene allosteric enhancers of A1 adenosine agonist binding: new 3, 4-, and 5-modifications.EBI
Deakin University
Design, synthesis and biological evaluation of Tozadenant analogues as adenosine AEBI
University Of Cologne
Direct Comparison of (N)-Methanocarba and Ribose-Containing 2-Arylalkynyladenosine Derivatives as AEBI
National Institute Of Diabetes And Digestive And Kidney Disease
3'-Aminoadenosine-5'-uronamides: discovery of the first highly selective agonist at the human adenosine A3 receptor.EBI
Pfizer
Conjugable AEBI
Universit£
Novel Irreversible Agonists Acting at the AEBI
Monash University
New irreversible adenosine A(1) antagonists based on FSCPX.EBI
Monash University (Parkville Campus)
Structure-affinity relationships of the affinity of 2-pyrazolyl adenosine analogues for the adenosine A2A receptor.EBI
Cv Therapeutics
1,2,4-Triazolo[5,1-i]purine derivatives as highly potent and selective human adenosine A(3) receptor ligands.EBI
Nutrition Research Institute
Synthesis, biological properties, and molecular modeling investigation of the first potent, selective, and water-soluble human A(3) adenosine receptor antagonist.EBI
TBA
Discovery of first-in-class multi-target adenosine AEBI
Universit£
Pyrido[2,1-f]purine-2,4-dione derivatives as a novel class of highly potent human A(3) adenosine receptor antagonists.EBI
Instituto De QuíMica MéDica (Csic)
2-Aminothiazoles: a new class of agonist allosteric enhancers of A(1) adenosine receptors.EBI
University Of Virginia
Adenosine AEBI
Fudan University
Biological Evaluation of 5'-(EBI
National Institute Of Diabetes And Digestive And Kidney Diseases
5'-Deoxy congeners of 9-(3-amido-3-deoxy-beta-D-xylofuranosyl)-N(6)-cyclopentyladenine: new adenosine A(1) receptor antagonists and inverse agonists.EBI
Ghent University
1,8-disubstituted xanthine derivatives: synthesis of potent A2B-selective adenosine receptor antagonists.EBI
University Of Bonn
Substituted 4-phenylthiazoles: Development of potent and selective AEBI
University Of Bonn
Synthesis, biological activity, and molecular modeling investigation of new pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as human A(3) adenosine receptor antagonists.EBI
Università
7-Substituted 5-amino-2-(2-furyl)pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as A2A adenosine receptor antagonists: a study on the importance of modifications at the side chain on the activity and solubility.EBI
Università
Potent and selective AEBI
Universit�
Ocular Disease Therapeutics: Design and Delivery of Drugs for Diseases of the Eye.EBI
Taipei Medical University
New 8-amino-1,2,4-triazolo[4,3-a]pyrazin-3-one derivatives. Evaluation of different moieties on the 6-aryl ring to obtain potent and selective human AEBI
Universit£
Structural investigation on thiazolo[5,4-d]pyrimidines to obtain dual-acting blockers of CD73 and adenosine AEBI
Universit£
Fluorosulfonyl- and bis-(beta-chloroethyl)amino-phenylamino functionalized pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives: irreversible antagonists at the human A3 adenosine receptor and molecular modeling studies.EBI
Università
C2-substituted quinazolinone derivatives exhibit AEBI
North-West University
Nitrogen-Walk Approach to Explore Bioisosteric Replacements in a Series of Potent AEBI
Uppsala University
2-Alkynyl-8-aryl-9-methyladenines as novel adenosine receptor antagonists: their synthesis and structure-activity relationships toward hepatic glucose production induced via agonism of the A(2B) receptor.EBI
Eisai
Fluorosulfonyl-substituted xanthines as selective irreversible antagonists for the A(1)-adenosine receptor.EBI
Deakin University
Pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists: influence of the chain at the N(8) pyrazole nitrogen.EBI
Università
Design, radiosynthesis, and biodistribution of a new potent and selective ligand for in vivo imaging of the adenosine A(2A) receptor system using positron emission tomography.EBI
University Of Milano-Bicocca
Novel multi-target directed ligands based on annelated xanthine scaffold with aromatic substituents acting on adenosine receptor and monoamine oxidase B. Synthesis, in vitro and in silico studies.EBI
Jagiellonian University Medical College
8-Substituted 1,3-dimethyltetrahydropyrazino[2,1-f]purinediones: Water-soluble adenosine receptor antagonists and monoamine oxidase B inhibitors.EBI
University Of Bonn
Novel non-xanthine antagonist of the AEBI
Bayer Pharmaceuticals
Identification of new potent AEBI
Nankai University
Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A(2B) adenosine receptors.EBI
National Institute Of Diabetes
Trifluorinated Pyrimidine-Based AEBI
Uppsala University
Imidazopyridine-based selective and multifunctional ligands of biological targets associated with psychiatric and neurodegenerative diseases.EBI
Palack£
Synthesis and preliminary biological evaluation of [3H]-MRE 3008-F20: the first high affinity radioligand antagonist for the human A3 adenosine receptors.EBI
Università
Water-soluble phosphate prodrugs of 1-propargyl-8-styrylxanthine derivatives, A(2A)-selective adenosine receptor antagonists.EBI
University Of WüRzburg
Modifications on the Amino-3,5-dicyanopyridine Core To Obtain Multifaceted Adenosine Receptor Ligands with Antineuropathic Activity.EBI
Universit£
Truncated (N)-Methanocarba Nucleosides as Partial Agonists at Mouse and Human AEBI
Medical College Of Wisconsin
Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists.EBI
Università
Selective A1-adenosine receptor antagonists identified using yeast Saccharomyces cerevisiae functional assays.EBI
Cadus Pharmaceutical
The chemical biology of apoptosis: Revisited after 17 years.EBI
Tsinghua University
Development of Covalent Ligands for G Protein-Coupled Receptors: A Case for the Human Adenosine AEBI
Leiden University
2-Aryladenine derivatives as a potent scaffold for AEBI
Universidade Do Minho
Docking Finds GPCR Ligands in Dark Chemical Matter.EBI
Uppsala University
Structure-Based Optimization of Coumarin hAEBI
University Of Porto
Design and in Vivo Characterization of AEBI
Medical College Of Wisconsin
Design, synthesis and biological evaluation of 2-hydrazinyladenosine derivatives as AEBI
National Engineering Research Center For The Emergency Drug
AEBI
Rheinische Friedrich-Wilhelms-Universitat Bonn
Thieno[2,3-d]pyrimidine as a promising scaffold in medicinal chemistry: Recent advances.EBI
University Of Science & Technology (Ust)
Design, synthesis, and biological evaluation of a second generation of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as potent and selective A2A adenosine receptor antagonists.EBI
Università
Novel human adenosine receptor antagonists based on the 7-amino-thiazolo[5,4-d]pyrimidine scaffold. Structural investigations at the 2-, 5- and 7-positions to enhance affinity and tune selectivity.EBI
Universit£
Synthesis and biological evaluation of the enantiomers of the potent and selective A1-adenosine antagonist 1,3-dipropyl-8-[2-(5,6-epoxynorbonyl)]-xanthine.EBI
Cv Therapeutics
Antioxidant-Conjugated 1,2,4-Triazolo[4,3-EBI
Universit£
Derivatives of the triazoloquinazoline adenosine antagonist (CGS15943) are selective for the human A3 receptor subtype.EBI
National Institute Of Diabetes
Fragment-Based Discovery of Subtype-Selective Adenosine Receptor Ligands from Homology Models.EBI
Stockholm University
Structure-Based Design, Synthesis by Click Chemistry and EBI
National Institute Of Diabetes And Digestive And Kidney Diseases
Synthesis and anti-renal fibrosis activity of conformationally locked truncated 2-hexynyl-N(6)-substituted-(N)-methanocarba-nucleosides as A3 adenosine receptor antagonists and partial agonists.EBI
Seoul National University
Novel 8-(p-substituted-phenyl/benzyl)xanthines with selectivity for the A2A adenosine receptor possess bronchospasmolytic activity.EBI
Panjab University
Discovery of simplified Nē-substituted pyrazolo[3,4-d]pyrimidine derivatives as novel adenosine receptor antagonists: efficient synthetic approaches, biological evaluations and molecular docking studies.EBI
National University Of Singapore
1,3-Dialkyl-substituted tetrahydropyrimido[1,2-f]purine-2,4-diones as multiple target drugs for the potential treatment of neurodegenerative diseases.EBI
University Of Bonn
Discovery of 3,4-Dihydropyrimidin-2(1H)-ones As a Novel Class of Potent and Selective A2B Adenosine Receptor Antagonists.EBI
University Of Santiago De Compostela
8-(2-Furyl)adenine derivatives as A?A adenosine receptor ligands.EBI
University Of Camerino
Modulation of A2B adenosine receptor by 1-Benzyl-3-ketoindole derivatives.EBI
Universit£
Substituted 1,3-dipropylxanthines as irreversible antagonists of A1 adenosine receptors.EBI
University Of South Florida
Design and synthesis of (4E)-4-(4-substitutedbenzylideneamino)-3-substituted-2,3-dihydro-2-thioxothiazole-5-carbonitrile as novel A2A receptor antagonists.EBI
University Of Delhi
Synthesis and biological evaluation of metabolites of 2-n-butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine (ST1535), a potent antagonist of the A2A adenosine receptor for the treatment of Parkinson's disease.EBI
Universit£
New insight into adenosine receptors selectivity derived from a novel series of [5-substituted-4-phenyl-1,3-thiazol-2-yl] benzamides and furamides.EBI
B.V. Patel Pharmaceutical Education And Research Development
Dual targeting of adenosine A(2A) receptors and monoamine oxidase B by 4H-3,1-benzothiazin-4-ones.EBI
University Of Bonn
Novel adenosine A(2A) receptor ligands: a synthetic, functional and computational investigation of selected literature adenosine A(2A) receptor antagonists for extending into extracellular space.EBI
Monash University (Parkville Campus)
Substituted thieno[2,3-d]pyrimidines as adenosine A2A receptor antagonists.EBI
Janssen Research & Development
Synthesis, adenosine receptor binding and 3D-QSAR of 4-substituted 2-(2'-furyl)-1,2,4-triazolo[1,5-a]quinoxalines.EBI
University Of Santiago De Compostela
Synthesis and biological evaluation of a new series of 2,3,5-substituted [1,2,4]-thiadiazoles as modulators of adenosine A1 receptors and their molecular mechanism of action.EBI
Leiden/Amsterdam Center For Drug Research
Discovery of 6-oxo-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1(6H)- pyridazinebutanoic acid (FK 838): a novel non-xanthine adenosine A1 receptor antagonist with potent diuretic activity.EBI
Fujisawa Pharmaceutical
[1,2,4]Triazolo[1,5-c]pyrimidines as adenosine receptor antagonists: Modifications at the 8 position to reach selectivity towards AEBI
Universit£
Antagonists of the adenosine AEBI
Umr-S1172 - Jparc - Centre De Recherche Jean-Pierre Aubert Neurosciences Et Cancer
The aminopyridine-3,5-dicarbonitrile core for the design of new non-nucleoside-like agonists of the human adenosine AEBI
Universit£
Discovery of Potent and Selective AEBI
Advinus Therapeutics
Fluorescent-Labeled Selective Adenosine AEBI
University Of Bonn
Highly potent and selective NaEBI
Pfizer
Structure-activity relationship studies and pharmacological characterization of NEBI
Universit£
New potent and selective AEBI
University Of Camerino
Nanomolar anti-sickling compounds identified by ligand-based pharmacophore approach.EBI
Universidade Estadual De Feira De Santana
2,4-Diaminoquinazolines as Dual Toll-like Receptor (TLR) 7/8 Modulators for the Treatment of Hepatitis B Virus.EBI
Janssen Infectious Diseases-Diagnostics
Identification of novel thiazolo[5,4-d]pyrimidine derivatives as human AEBI
Universit£
Docking Screens for Dual Inhibitors of Disparate Drug Targets for Parkinson's Disease.EBI
Uppsala University
Identification and biological evaluation of thiazole-based inverse agonists of ROR?t.EBI
Phenex Pharmaceuticals
Development of novel pyridazinone-based adenosine receptor ligands.EBI
Universit£
Exploring the Role of NEBI
University Of Camerino
Enantiospecific Recognition at the AEBI
Uppsala University
A Structure-Activity Relationship Study of Bitopic NEBI
Monash University
Imidazo[1,2-a]pyrazin-8-amine core for the design of new adenosine receptor antagonists: Structural exploration to target the AEBI
Universita Degli Studi Di Firenze
Effect of Nitrogen Atom Substitution in AEBI
Uppsala University
Structure-activity relationships of 8-cycloalkyl-1,3-dipropylxanthines as antagonists of adenosine receptors.EBI
Vanderbilt University
Synthesis and biological evaluation of 4-purinylpyrrolidine nucleosides.EBI
University Of Minnesota
Structure-Based Design, Synthesis, and In Vivo Antinociceptive Effects of Selective AEBI
University Of Camerino
Polypharmacology of NEBI
Sahmyook University
Laccaic acid A is a direct, DNA-competitive inhibitor of DNA methyltransferase 1.BDB
University Of Iowa
Synthesis, Biological Evaluation, and Molecular Docking of 8-imino-2-oxo-2H,8H-pyrano[2,3-f]chromene Analogs: New Dual AChE Inhibitors as Potential Drugs for the Treatment of Alzheimer's Disease.BDB
Yogi Vemana University
Synthesis, cholinesterase inhibition and molecular modelling studies of coumarin linked thiourea derivatives.BDB
Quaid-I-Azam University
Synthesis, in vitro evaluation and molecular docking studies of biscoumarin thiourea as a new inhibitor of a-glucosidases.BDB
Universiti Teknologi Mara
Phosphorylation of Capsaicinoid Derivatives Provides Highly Potent and Selective Inhibitors of the Transcription Factor STAT5b.BDB
University Of Leipzig
In vitro receptor screening of pure constituents of St. John's wort reveals novel interactions with a number of GPCRs.BDB
WestfÄLische Wilhelms-UniversitÄ
Psychotomimetic opiate receptors labeled and visualized with (+)-[3H]3-(3-hydroxyphenyl)-N-(1-propyl)piperidine.BDB
TBA
Cloning, molecular characterization, and chromosomal assignment of a gene encoding a second D1 dopamine receptor subtype: differential expression pattern in rat brain compared with the D1A receptor.BDB
Duke University
N-acylpolyamine inhibitors of HDM2 and HDMX binding to p53.BDB
Nih