PMID

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Article Title

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Structural Basis of Small-Molecule Aggregate Induced Inhibition of a Protein-Protein Interaction.

Janssen Research And Development

Discovery of highly potent TNFa inhibitors using virtual screen.

Peking University

Prediction of anti-tumor chemical probes of a traditional Chinese medicine formula by HPLC fingerprinting combined with molecular docking.

The Second People'S Hospital Of Fujian Provinc

Solvent Selection for Insoluble Ligands, a Challenge for Biological Assay Development: A TNF-?/SPD304 Study.

The Centre For Research And Technology Of Thessaly (Ce.Re.Te.Th.)

Reaching for high-hanging fruit in drug discovery at protein-protein interfaces.

University Of California San Francisco

Substituted isoquinolines and quinazolines as potential antiinflammatory agents. Synthesis and biological evaluation of inhibitors of tumor necrosis factor alpha.

University Of California

Discovery of 3-OH-3-methylpipecolic hydroxamates: potent orally active inhibitors of aggrecanase and MMP-13.

Pfizer

Discovery of an Orally Active Small-Molecule Tumor Necrosis Factor-? Inhibitor.

Huazhong University Of Science And Technology

Development of Small-Molecules Targeting Receptor Activator of Nuclear Factor-?B Ligand (RANKL)-Receptor Activator of Nuclear Factor-?B (RANK) Protein-Protein Interaction by Structure-Based Virtual Screening and Hit Optimization.

Shanghai Jiaotong University School Of Medicine

Structural modifications of thalidomide produce analogs with enhanced tumor necrosis factor inhibitory activity.

Celgene

Potent inhibition of tumor necrosis factor-alpha production by tetrafluorothalidomide and tetrafluorophthalimides.

Institute Of Technology

Substituted xanthines, pteridinediones, and related compounds as potential antiinflammatory agents. Synthesis and biological evaluation of inhibitors of tumor necrosis factor alpha.

University Of California

Beta-aryl-succinic acid hydroxamates as dual inhibitors of matrix metalloproteinases and tumor necrosis factor alpha converting enzyme.

Preclinical Research Novartis Pharma

Synthesis and in vitro evaluations of 6-(hetero)-aryl-imidazo[1,2-b]pyridazine-3-sulfonamide's as an inhibitor of TNF-? production.

Padmashri Vikhe Patil College Of Arts

Synthesis and biological evaluation of pyridine-linked indanone derivatives: Potential agents for inflammatory bowel disease.

Yeungnam University

Synthesis, pH dependent, plasma and enzymatic stability of bergenin prodrugs for potential use against rheumatoid arthritis.

Csir-Indian Institute Of Integrative Medicine

Structure-based design of new KSP-Eg5 inhibitors assisted by a targeted multicomponent reaction.

University Of Santiago De Compostela

A Selective Phenelzine Analogue Inhibitor of Histone Demethylase LSD1.

Johns Hopkins University

Reversal of enzyme regiospecificity with alternative substrates for aspartokinase I from Escherichia coli.

University Of Akron

The pharmacological characterization of a novel selective 5-hydroxytryptamine1A receptor antagonist, NAD-299.

Preclinical R & D, Astra Arcus

Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes.

Novartis

Optimization of benzimidazole series as opioid receptor-like 1 (ORL1) antagonists: SAR study directed toward improvement of selectivity over hERG activity.

Banyu Pharmaceutical

Synthesis and biological evaluation of 3-aryl-3-(4-phenoxy)-propionic acid as a novel series of G protein-coupled receptor 40 agonists.

Johnson & Johnson Pharmaceutical

Synthesis of indoleamine 2,3-dioxygenase inhibitory analogues of the sponge alkaloid exiguamine a.

University Of British Columbia

Glutamylsulfamoyladenosine and pyroglutamylsulfamoyladenosine are competitive inhibitors of E. coli glutamyl-tRNA synthetase.

Crefsip

2-[3-[2-[(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethylamino]-3-methyl-1-oxobutyl]-1,2,3,4-tetrahydroisoquinoline: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV.

National Health Research Institutes

 

INFLUENCE OF STEREOCHEMISTRY ON ACTIVITY AND BINDING MODES FOR C(2) SYMMETRY-BASED DIOL INHIBITORS OF HIV-1 PROTEASE.

Nci-Fcrdc