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59 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Fluorinated Chaperone-ß-Cyclodextrin Formulations forß-Glucocerebrosidase Activity Enhancement in Neuronopathic Gaucher Disease.EBI
University Of Sevilla
Inhibitor versus chaperone behaviour of d-fagomine, DAB and LAB sp(2)-iminosugar conjugates against glycosidases: A structure-activity relationship study in Gaucher fibroblasts.EBI
University Of Seville
Design and Synthesis of Potent Quinazolines as Selectiveß-Glucocerebrosidase Modulators.EBI
Northwestern University Feinberg School Of Medicine
Conformationally-locked N-glycosides: exploiting long-range non-glycone interactions in the design of pharmacological chaperones for Gaucher disease.EBI
Universitat Rovira I Virgili
Identification and development of biphenyl substituted iminosugars as improved dual glucosylceramide synthase/neutral glucosylceramidase inhibitors.EBI
Leiden University
Concise synthesis of C-1-cyano-iminosugars via a new Staudinger/aza Wittig/Strecker multicomponent reaction strategy.EBI
Technical University Graz
Docking and SAR studies of calystegines: binding orientation and influence on pharmacological chaperone effects for Gaucher's disease.EBI
University Of Toyama
Rapid modifications of N-substitution in iminosugars: development of newß-glucocerebrosidase inhibitors and pharmacological chaperones for Gaucher disease.EBI
Genomics Research Center
Rational design and synthesis of highly potent pharmacological chaperones for treatment of N370S mutant Gaucher disease.EBI
Peking University
a-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based orala-glucosidase inhibitor for improving postprandial hyperglycemia.EBI
University Of Toyama
Discovery, structure-activity relationship, and biological evaluation of noninhibitory small molecule chaperones of glucocerebrosidase.EBI
National Center For Advancing Translation Sciences
Conformationally-locked N-glycosides with selectiveß-glucosidase inhibitory activity: identification of a new non-iminosugar-type pharmacological chaperone for Gaucher disease.EBI
Universitat Rovira I Virgili
Potent aminocyclitol glucocerebrosidase inhibitors are subnanomolar pharmacological chaperones for treating gaucher disease.EBI
Institut De Qu£Mica Avan£Ada De Catalunya (Iqac-Csic)
Rapid assembly of a library of lipophilic iminosugars via the thiol-ene reaction yields promising pharmacological chaperones for the treatment of Gaucher disease.EBI
University Of British Columbia
The myo-1,2-Diaminocyclitol Scaffold Defines Potent Glucocerebrosidase Activators and Promising Pharmacological Chaperones for Gaucher Disease.EBI
TBA
Click chemistry approach to new N-substituted aminocyclitols as potential pharmacological chaperones for Gaucher disease.EBI
Universitat De Barcelona
In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures.EBI
Hokuriku University
Novel alpha-glucosidase inhibitors with a tetrachlorophthalimide skeleton.EBI
University Of Tokyo
Homoisofagomines: chemical-enzymatic synthesis and evaluation as alpha- and beta-glucosidase inhibitors.EBI
Technische Universit£T Berlin
A new strong inhibitor of beta-mannosidase.EBI
S.E.S.N.A.B., Pole Sciences Et Technologie, Universit�
 
Potent glycosidase inhibitors, N-phenyl cyclic isourea derivatives of 5-amino- and 5-amino-1-C-(hydroxymethyl)-cyclopentane-1,2,3,4-tetraolsEBI
TBA
 
The Interaction of Anhydroalditols with Sweet-Almond -glucosidase and Escherichia coli -galactosidase: implications for the design of potent glycosidase inhibitorsEBI
TBA
Synthesis and glycosidase inhibitory profiles of functionalised morpholines and oxazepanes.EBI
University Of Reading
Docking and SAR studies of D- and L-isofagomine isomers as humanß-glucocerebrosidase inhibitors.EBI
University Of Toyama
New glucocerebrosidase inhibitors by exploration of chemical diversity of N-substituted aminocyclitols using click chemistry and in situ screening.EBI
Spanish National Research Council (Consejo Superior De Investigaciones Cienti£?Ficas)
Synthesis of N-alkylated noeurostegines and evaluation of their potential as treatment for Gaucher's disease.EBI
Aarhus University
Identification of Potent and Selective Glucosylceramide Synthase Inhibitors from a Library of N-Alkylated IminosugarsEBI
TBA
Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease.EBI
Harvard Medical School
Synthesis of new beta-1-C-alkylated imino-L-iditols: A comparative study of their activity as beta-glucocerebrosidase inhibitors.EBI
Universit£
Nanomolar affinity, iminosugar-based chemical probes for specific labeling of lysosomal glucocerebrosidase.EBI
Utrecht University
 
Synthesis of a new inhibitor of α-fucosidaseEBI
TBA
 
Synthesis of C2-symmetrical polyhydroxyazepanes as inhibitors of glycosidasesEBI
TBA
 
β-Glucosidase inhibitors incorporating pyridinium as a glucosyl mimicEBI
TBA
 
Synthesis and biological activity of C-6 modified derivatives of the glucosidase inhibitor 1-deoxynojirimycin.EBI
TBA
Glycosidase-inhibiting pyrrolidines and pyrrolizidines with a long side chain in Scilla peruviana.EBI
Hokuriku University
Powerful probes for glycosidases: novel, fluorescently tagged glycosidase inhibitors.EBI
Institut FüR Biochemie Der Technischen UniversitäT Graz
Novel, lipophilic derivatives of 2,5-dideoxy-2,5-imino-D-mannitol (DMDP) are powerful beta-glucosidase inhibitors.EBI
Technische UniversitäT Graz
Novel compounds that reverse the disease phenotype in Type 2 Gaucher disease patient-derived cells.EBI
Temple University School Of Pharmacy
Conversion of Quinazoline Modulators from Inhibitors to Activators of ?-Glucocerebrosidase.EBI
Northwestern University
Exploring the effect of chirality on the therapeutic potential of N-alkyl-deoxyiminosugars: anti-inflammatory response to Pseudomonas aeruginosa infections for application in CF lung disease.EBI
University Of Napoli Federico Ii
Tuning of ?-glucosidase and ?-galactosidase inhibition by generation and in situ screening of a library of pyrrolidine-triazole hybrid molecules.EBI
University Of Seville
A new type of pharmacological chaperone for GEBI
Graz University Of Technology
N-Butyl-l-deoxynojirimycin (l-NBDNJ): Synthesis of an Allosteric Enhancer of?-Glucosidase Activity for the Treatment of Pompe Disease.EBI
Universit£
Enzymatic Studies of Isoflavonoids as Selective and Potent Inhibitors of Human Leukocyte 5-Lipo-Oxygenase.BDB
Universidad De Santiago
Comparison of [Dmt1]DALDA and DAMGO in binding and G protein activation at mu, delta, and kappa opioid receptors.BDB
Cornell University
Discovery of novel nitrobenzothiazole inhibitors for Mycobacterium tuberculosis ATP phosphoribosyl transferase (HisG) through virtual screening.BDB
Yale University
Analysis of HIV-1 CRF_01 A/E protease inhibitor resistance: structural determinants for maintaining sensitivity and developing resistance to atazanavir.BDB
Johnson & Johnson Pharmaceutical