PMID

Data

Article Title

Organization

Discovery of isoquinolinone indole acetic acids as antagonists of chemoattractant receptor homologous molecule expressed on Th2 cells (CRTH2) for the treatment of allergic inflammatory diseases.

Pfizer

Discovery and characterization of NVP-QAV680, a potent and selective CRTh2 receptor antagonist suitable for clinical testing in allergic diseases.

Novartis Institutes For Biomedical Research

Diazine indole acetic acids as potent, selective, and orally bioavailable antagonists of chemoattractant receptor homologous molecule expressed on Th2 cells (CRTH2) for the treatment of allergic inflammatory diseases.

Pfizer

Discovery of potent, selective, and orally bioavailable alkynylphenoxyacetic acid CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseases.

Merck Serono

Switching between agonists and antagonists at CRTh2 in a series of highly potent and selective biaryl phenoxyacetic acids.

Astrazeneca R&D Charnwood

Exploration of SAR features by modifications of thiazoleacetic acids as CRTH2 antagonists.

7Tm Pharma

7-Azaindole-3-acetic acid derivatives: potent and selective CRTh2 receptor antagonists.

Novartis Institutes Of Biomedical Research

Novel selective orally active CRTH2 antagonists for allergic inflammation developed from in silico derived hits.

7Tm Pharma