PMID

Data

Article Title

Organization

High-Potency Phenylquinoxalinone Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activators.

University Of California

Nanomolar-Potency Aminophenyl-1,3,5-triazine Activators of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Chloride Channel for Prosecretory Therapy of Dry Eye Diseases.

University Of California

Synthesis and structure-activity relationship of aminoarylthiazole derivatives as correctors of the chloride transport defect in cystic fibrosis.

Istituto Giannina Gaslini

Flavones: an important scaffold for medicinal chemistry.

Punjabi University

¿F508-CFTR correctors: synthesis and evaluation of thiazole-tethered imidazolones, oxazoles, oxadiazoles, and thiadiazoles.

Wuhan University Of Science And Technology

Discovery of N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (VX-770, ivacaftor), a potent and orally bioavailable CFTR potentiator.

Vertex Pharmaceuticals

Discovery heralds new approach to the treatment of cystic fibrosis.

Jl3Pharma

A new 9-alkyladenine-cyclic methylglyoxal diadduct activates wt- and F508del-cystic fibrosis transmembrane conductance regulator (CFTR) in vitro and in vivo.

Universit£

ABSOLUTE CONFIGURATION AND BIOLOGICAL PROPERTIES OF ENANTIOMERS OF CFTR INHIBITOR BPO-27.

University Of California

A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

University Of Oxford

Potent, metabolically stable benzopyrimido-pyrrolo-oxazine-dione (BPO) CFTR inhibitors for polycystic kidney disease.

University Of California

An expeditious access to 5-pyrimidinol derivatives from cyclic methylglyoxal diadducts, formation of argpyrimidines under physiological conditions and discovery of new CFTR inhibitors.

University Joseph Fourier-Grenoble 1/Cnrs

Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease model.

University Of California

Thiazolidinone CFTR inhibitors with improved water solubility identified by structure-activity analysis.

University Of California

Rational design of the first small-molecule antagonists of NHERF1/EBP50 PDZ domains.

St. Jude Children'S Research Hospital

Discovery of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid diamides that increase CFTR mediated chloride transport.

Genzyme

Synthesis, SAR, crystal structure, and biological evaluation of benzoquinoliziniums as activators of wild-type and mutant cystic fibrosis transmembrane conductance regulator channels.

Université

Novel Hits in the Correction of ?F508-Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Protein: Synthesis, Pharmacological, and ADME Evaluation of Tetrahydropyrido[4,3-d]pyrimidines for the Potential Treatment of Cystic Fibrosis.

Siena Biotech

Constrained bithiazoles: small molecule correctors of defective ?F508-CFTR protein trafficking.

University Of California

Click-based synthesis of triazolobithiazole ?F508-CFTR correctors for cystic fibrosis.

University Of California Davis

Structure-activity relationships of cyanoquinolines with corrector-potentiator activity in ?F508 cystic fibrosis transmembrane conductance regulator protein.

University Of California Davis

Fluorinated ?F508-CFTR correctors and potentiators for PET imaging.

University Of California Davis

Pyrazolylthiazole as DeltaF508-cystic fibrosis transmembrane conductance regulator correctors with improved hydrophilicity compared to bithiazoles.

University Of California Davis

4'-Methyl-4,5'-bithiazole-based correctors of defective delta F508-CFTR cellular processing.

University Of California

Asperidines A-C, pyrrolidine and piperidine derivatives from the soil-derived fungus Aspergillus sclerotiorum PSU-RSPG178.

Prince Of Songkla University

Modulators of the Cystic Fibrosis Transmembrane Conductance Regulator Protein.

Usona Institute

Synthesis and biological evaluation of novel thiazole- VX-809 hybrid derivatives as F508del correctors by QSAR-based filtering tools.

University Of Genoa

N-[3H]methylscopolamine labeling of non-M1, non-M2 muscarinic receptor binding sites in rat brain.

University Of California

Acyclic, orally bioavailable ketone-based cathepsin K inhibitors.

Gsk

Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity.

Methylgene

Design and Synthesis of Classical and Nonclassical 6-Arylthio-2,4-diamino-5-ethylpyrrolo[2,3-d]pyrimidines as Antifolates.

Duquesne University

Discovery of potent, efficacious, and orally bioavailable inhibitors of blood coagulation factor Xa with neutral P1 moieties.

Bristol-Myers Squibb Pharmaceutical Research Institute