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79 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Bivalent SIRT1 inhibitors.EBI
Jiangsu University
Cyclic peptide-based potent and selective SIRT1/2 dual inhibitors harboring NEBI
Jiangsu University
Guttiferone A Aggregates Modulate Silent Information Regulator 1 (SIRT1) Activity.EBI
University Of Paris
How much successful are the medicinal chemists in modulation of SIRT1: A critical review.EBI
Guru Jambheshwar University Of Science And Technology
5-((3-Amidobenzyl)oxy)nicotinamides as Sirtuin 2 Inhibitors.EBI
University Of Minnesota
Simple N(e)-thioacetyl-lysine-containing cyclic peptides exhibiting highly potent sirtuin inhibition.EBI
Jiangsu University
Aminothiazoles as Potent and Selective Sirt2 Inhibitors: A Structure-Activity Relationship Study.EBI
Albert-Ludwigs-University Of Freiburg
Synthesis and Characterization of 4,11-Diaminoanthra[2,3-b]furan-5,10-diones: Tumor Cell Apoptosis through tNOX-Modulated NAD(+)/NADH Ratio and SIRT1.EBI
Gause Institute Of New Antibiotics
Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics.EBI
University Of Genoa
Novel thiourea-based sirtuin inhibitory warheads.EBI
Jiangsu University
New indole-isoxazolone derivatives: Synthesis, characterisation and in vitro SIRT1 inhibition studies.EBI
National Institute Of Technology Karnataka
Discovery of bicyclic pyrazoles as class III histone deacetylase SIRT1 and SIRT2 inhibitors.EBI
Methylgene
Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells.EBI
Istituto Ortopedico Rizzoli (Ior)
Functionalized tetrahydro-1H-pyrido[4,3-b]indoles: a novel chemotype with Sirtuin 2 inhibitory activity.EBI
National University Of Singapore
Structure-activity relationship and interaction studies of new SIRT1 inhibitors with the scaffold of 3-(furan-2-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole.EBI
Chinese Academy Of Sciences
Design, synthesis and structure-activity relationship studies of novel sirtuin 2 (SIRT2) inhibitors with a benzamide skeleton.EBI
The University Of Tokyo
Discovery of potent and selective sirtuin 2 (SIRT2) inhibitors using a fragment-based approach.EBI
University Of Minnesota
Benzimidazoles as new scaffold of sirtuin inhibitors: green synthesis, in vitro studies, molecular docking analysis and evaluation of their anti-cancer properties.EBI
Universiti Sains Malaysia
Discovery of novel and selective SIRT6 inhibitors.EBI
University Of Bologna
Development of pyrazolone and isoxazol-5-one cambinol analogues as sirtuin inhibitors.EBI
Fred Hutchinson Cancer Research Center
Identification of novel SIRT2-selective inhibitors using a click chemistry approach.EBI
Nagoya City University
Synthesis and evaluation of novel benzimidazole derivatives as sirtuin inhibitors with antitumor activities.EBI
Universiti Sains Malaysia
Evaluation of benzoic acid derivatives as sirtuin inhibitors.EBI
San Francisco State University
Screen of pseudopeptidic inhibitors of human sirtuins 1-3: two lead compounds with antiproliferative effects in cancer cells.EBI
University Of Eastern Finland
Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3.EBI
Sirtris A Gsk
Discovery and mechanism study of SIRT1 activators that promote the deacetylation of fluorophore-labeled substrate.EBI
Chinese Academy Of Sciences
Identification of benzofuran-3-yl(phenyl)methanones as novel SIRT1 inhibitors: binding mode, inhibitory mechanism and biological action.EBI
Chinese Academy Of Sciences
The 2.5Å crystal structure of the SIRT1 catalytic domain bound to nicotinamide adenine dinucleotide (NAD+) and an indole (EX527 analogue) reveals a novel mechanism of histone deacetylase inhibition.EBI
Eli Lilly
Creation of an HDAC-based yeast screening method for evaluation of marine-derived actinomycetes: discovery of streptosetin A.EBI
San Francisco State University
Inhibitors of the NAD(+)-Dependent Protein Desuccinylase and Demalonylase Sirt5.EBI
TBA
Discovery of salermide-related sirtuin inhibitors: binding mode studies and antiproliferative effects in cancer cells including cancer stem cells.EBI
Sapienza University Of Rome
Ethylenediamine diacetate (EDDA) mediated synthesis of aurones under ultrasound: their evaluation as inhibitors of SIRT1.EBI
University Of Hyderabad Campus
Benzodeazaoxaflavins as sirtuin inhibitors with antiproliferative properties in cancer stem cells.EBI
Sapienza University Of Rome
SIRT1 modulation as a novel approach to the treatment of diseases of aging.EBI
Sirtris A Gsk
Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors.EBI
Kyoto Prefectural University Of Medicine
Appraisal of GABA and PABA as linker: design and synthesis of novel benzamide based histone deacetylase inhibitors.EBI
Guru Ghasidas University
Novel acridinedione derivatives: design, synthesis, SIRT1 enzyme and tumor cell growth inhibition studies.EBI
Birla Institute Of Technology
Identification and characterization of novel sirtuin inhibitor scaffolds.EBI
Institute
Novel 3-arylideneindolin-2-ones as inhibitors of NAD+ -dependent histone deacetylases (sirtuins).EBI
Ludwig-Maximilians-Universit£T M£Nchen
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.EBI
Sirtris Pharmaceuticals
N-(3-(4-Hydroxyphenyl)-propenoyl)-amino acid tryptamides as SIRT2 inhibitors.EBI
University Of Kuopio
Synthesis and biological characterisation of sirtuin inhibitors based on the tenovins.EBI
University Of St. Andrews
Structure-based design of pseudopeptidic inhibitors for SIRT1 and SIRT2.EBI
University Of Eastern Finland
A mechanism-based potent sirtuin inhibitor containing Ne-thiocarbamoyl-lysine (TuAcK).EBI
University Of Akron
Synthesis and biological activity of splitomicin analogs targeted at human NAD(+)-dependent histone deacetylases (sirtuins).EBI
Ernst-Moritz-Arndt University Greifswald
After the grape rush: sirtuins as epigenetic drug targets in neurodegenerative disorders.EBI
Cemm-Research Center For Molecular Medicine Of The Austrian Academy Of Sciences
Simplification of the tetracyclic SIRT1-selective inhibitor MC2141: coumarin- and pyrimidine-based SIRT1/2 inhibitors with different selectivity profile.EBI
Sapienza University Of Rome
Two-step synthesis of novel, bioactive derivatives of the ubiquitous cofactor nicotinamide adenine dinucleotide (NAD).EBI
University Of East Anglia
N(epsilon)-Modified lysine containing inhibitors for SIRT1 and SIRT2.EBI
University Of Eastern Finland
Characterization of sirtuin inhibitors in nematodes expressing a muscular dystrophy protein reveals muscle cell and behavioral protection by specific sirtinol analogues.EBI
Institute Of Psychiatry And Neuroscience Of Paris
Identification of a cell-active non-peptide sirtuin inhibitor containing N-thioacetyl lysine.EBI
Nagoya City University
Design, synthesis, enzyme inhibition, and tumor cell growth inhibition of 2-anilinobenzamide derivatives as SIRT1 inhibitors.EBI
Nagoya City University
Discovery of imidazo[1,2-b]thiazole derivatives as novel SIRT1 activators.EBI
Sirtris Pharmaceuticals
N(epsilon)-thioacetyl-lysine-containing tri-, tetra-, and pentapeptides as SIRT1 and SIRT2 inhibitors.EBI
University Of Kuopio
Oxadiazole-carbonylaminothioureas as SIRT1 and SIRT2 inhibitors.EBI
University Of Kuopio
Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease.EBI
Harvard Medical School
Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition.EBI
Albert-Ludwigs-University Of Freiburg
Nepsilon-thioacetyl-lysine: a multi-facet functional probe for enzymatic protein lysine Nepsilon-deacetylation.EBI
University Of Akron
Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1.EBI
Elixir Pharmaceuticals
Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors.EBI
Sapienza University Of Rome
Thienopyrimidinone Based Sirtuin-2 (SIRT2)-Selective Inhibitors Bind in the Ligand Induced Selectivity Pocket.EBI
Imperial College
Human SIRT3 tripeptidic inhibitors containing N(?)-thioacetyl-lysine.EBI
Jiangsu University
The Discovery of Novel 10,11-Dihydro-5H-dibenz[b,f]azepine SIRT2 Inhibitors.EBI
Imperial College London
Structural Basis of Sirtuin 6 Inhibition by the Hydroxamate Trichostatin A: Implications for Protein Deacylase Drug Development.EBI
University Of Bayreuth
Squaramides as novel class I and IIB histone deacetylase inhibitors for topical treatment of cutaneous t-cell lymphoma.EBI
Nestle Skin Health R&D
Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals).EBI
University Of Freiburg
Lysine Deacetylase Inhibitors in Parasites: Past, Present, and Future Perspectives.EBI
Dipartimento Di Chimica E Tecnologie Del Farmaco "Sapienza" Universit£
SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects.EBI
University Of Genoa
X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells.EBI
West China School Of Pharmacy
The mimics of NEBI
School Of Pharmacy
Discovery and Characterization of R/S-N-3-Cyanophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea, a New Histone Deacetylase Class III Inhibitor Exerting Antiproliferative Activity against Cancer Cell Lines.EBI
H�Pital Kirchberg
(N-Hydroxycarbonylbenylamino)quinolines as Selective Histone Deacetylase 6 Inhibitors Suppress Growth of Multiple Myeloma in Vitro and in Vivo.EBI
Taipei Medical University
Discovery of 2-((4,6-dimethylpyrimidin-2-yl)thio)-N-phenylacetamide derivatives as new potent and selective human sirtuin 2 inhibitors.EBI
Xihua University
Tyrosinase inhibitory activities of the compounds isolated from Neolitsea aciculata (Blume) Koidz.BDB
Jeju National University
The antiparasitic clioquinol induces apoptosis in leukemia and myeloma cells by inhibiting histone deacetylase activity.BDB
Soochow University
Cloning and expression of a novel neuropeptide Y receptor.BDB
Merck Research Laboratories