79 articles for thisTarget
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Cyclic peptide-based potent and selective SIRT1/2 dual inhibitors harboring N
Jiangsu University
Guttiferone A Aggregates Modulate Silent Information Regulator 1 (SIRT1) Activity.
University Of Paris
How much successful are the medicinal chemists in modulation of SIRT1: A critical review.
Guru Jambheshwar University Of Science And Technology
Simple N(e)-thioacetyl-lysine-containing cyclic peptides exhibiting highly potent sirtuin inhibition.
Jiangsu University
Aminothiazoles as Potent and Selective Sirt2 Inhibitors: A Structure-Activity Relationship Study.
Albert-Ludwigs-University Of Freiburg
Synthesis and Characterization of 4,11-Diaminoanthra[2,3-b]furan-5,10-diones: Tumor Cell Apoptosis through tNOX-Modulated NAD(+)/NADH Ratio and SIRT1.
Gause Institute Of New Antibiotics
Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics.
University Of Genoa
New indole-isoxazolone derivatives: Synthesis, characterisation and in vitro SIRT1 inhibition studies.
National Institute Of Technology Karnataka
Discovery of bicyclic pyrazoles as class III histone deacetylase SIRT1 and SIRT2 inhibitors.
Methylgene
Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells.
Istituto Ortopedico Rizzoli (Ior)
Functionalized tetrahydro-1H-pyrido[4,3-b]indoles: a novel chemotype with Sirtuin 2 inhibitory activity.
National University Of Singapore
Structure-activity relationship and interaction studies of new SIRT1 inhibitors with the scaffold of 3-(furan-2-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole.
Chinese Academy Of Sciences
Design, synthesis and structure-activity relationship studies of novel sirtuin 2 (SIRT2) inhibitors with a benzamide skeleton.
The University Of Tokyo
Discovery of potent and selective sirtuin 2 (SIRT2) inhibitors using a fragment-based approach.
University Of Minnesota
Benzimidazoles as new scaffold of sirtuin inhibitors: green synthesis, in vitro studies, molecular docking analysis and evaluation of their anti-cancer properties.
Universiti Sains Malaysia
Development of pyrazolone and isoxazol-5-one cambinol analogues as sirtuin inhibitors.
Fred Hutchinson Cancer Research Center
Identification of novel SIRT2-selective inhibitors using a click chemistry approach.
Nagoya City University
Synthesis and evaluation of novel benzimidazole derivatives as sirtuin inhibitors with antitumor activities.
Universiti Sains Malaysia
Evaluation of benzoic acid derivatives as sirtuin inhibitors.
San Francisco State University
Screen of pseudopeptidic inhibitors of human sirtuins 1-3: two lead compounds with antiproliferative effects in cancer cells.
University Of Eastern Finland
Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3.
Sirtris A Gsk
Discovery and mechanism study of SIRT1 activators that promote the deacetylation of fluorophore-labeled substrate.
Chinese Academy Of Sciences
Identification of benzofuran-3-yl(phenyl)methanones as novel SIRT1 inhibitors: binding mode, inhibitory mechanism and biological action.
Chinese Academy Of Sciences
The 2.5Å crystal structure of the SIRT1 catalytic domain bound to nicotinamide adenine dinucleotide (NAD+) and an indole (EX527 analogue) reveals a novel mechanism of histone deacetylase inhibition.
Eli Lilly
Creation of an HDAC-based yeast screening method for evaluation of marine-derived actinomycetes: discovery of streptosetin A.
San Francisco State University
Discovery of salermide-related sirtuin inhibitors: binding mode studies and antiproliferative effects in cancer cells including cancer stem cells.
Sapienza University Of Rome
Ethylenediamine diacetate (EDDA) mediated synthesis of aurones under ultrasound: their evaluation as inhibitors of SIRT1.
University Of Hyderabad Campus
Benzodeazaoxaflavins as sirtuin inhibitors with antiproliferative properties in cancer stem cells.
Sapienza University Of Rome
SIRT1 modulation as a novel approach to the treatment of diseases of aging.
Sirtris A Gsk
Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors.
Kyoto Prefectural University Of Medicine
Appraisal of GABA and PABA as linker: design and synthesis of novel benzamide based histone deacetylase inhibitors.
Guru Ghasidas University
Novel acridinedione derivatives: design, synthesis, SIRT1 enzyme and tumor cell growth inhibition studies.
Birla Institute Of Technology
Novel 3-arylideneindolin-2-ones as inhibitors of NAD+ -dependent histone deacetylases (sirtuins).
Ludwig-Maximilians-Universit£T M£Nchen
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.
Sirtris Pharmaceuticals
N-(3-(4-Hydroxyphenyl)-propenoyl)-amino acid tryptamides as SIRT2 inhibitors.
University Of Kuopio
Synthesis and biological characterisation of sirtuin inhibitors based on the tenovins.
University Of St. Andrews
Structure-based design of pseudopeptidic inhibitors for SIRT1 and SIRT2.
University Of Eastern Finland
A mechanism-based potent sirtuin inhibitor containing Ne-thiocarbamoyl-lysine (TuAcK).
University Of Akron
Synthesis and biological activity of splitomicin analogs targeted at human NAD(+)-dependent histone deacetylases (sirtuins).
Ernst-Moritz-Arndt University Greifswald
After the grape rush: sirtuins as epigenetic drug targets in neurodegenerative disorders.
Cemm-Research Center For Molecular Medicine Of The Austrian Academy Of Sciences
Simplification of the tetracyclic SIRT1-selective inhibitor MC2141: coumarin- and pyrimidine-based SIRT1/2 inhibitors with different selectivity profile.
Sapienza University Of Rome
Two-step synthesis of novel, bioactive derivatives of the ubiquitous cofactor nicotinamide adenine dinucleotide (NAD).
University Of East Anglia
N(epsilon)-Modified lysine containing inhibitors for SIRT1 and SIRT2.
University Of Eastern Finland
Characterization of sirtuin inhibitors in nematodes expressing a muscular dystrophy protein reveals muscle cell and behavioral protection by specific sirtinol analogues.
Institute Of Psychiatry And Neuroscience Of Paris
Identification of a cell-active non-peptide sirtuin inhibitor containing N-thioacetyl lysine.
Nagoya City University
Design, synthesis, enzyme inhibition, and tumor cell growth inhibition of 2-anilinobenzamide derivatives as SIRT1 inhibitors.
Nagoya City University
Discovery of imidazo[1,2-b]thiazole derivatives as novel SIRT1 activators.
Sirtris Pharmaceuticals
N(epsilon)-thioacetyl-lysine-containing tri-, tetra-, and pentapeptides as SIRT1 and SIRT2 inhibitors.
University Of Kuopio
Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease.
Harvard Medical School
Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition.
Albert-Ludwigs-University Of Freiburg
Nepsilon-thioacetyl-lysine: a multi-facet functional probe for enzymatic protein lysine Nepsilon-deacetylation.
University Of Akron
Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1.
Elixir Pharmaceuticals
Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors.
Sapienza University Of Rome
Thienopyrimidinone Based Sirtuin-2 (SIRT2)-Selective Inhibitors Bind in the Ligand Induced Selectivity Pocket.
Imperial College
Human SIRT3 tripeptidic inhibitors containing N(?)-thioacetyl-lysine.
Jiangsu University
The Discovery of Novel 10,11-Dihydro-5H-dibenz[b,f]azepine SIRT2 Inhibitors.
Imperial College London
Structural Basis of Sirtuin 6 Inhibition by the Hydroxamate Trichostatin A: Implications for Protein Deacylase Drug Development.
University Of Bayreuth
Squaramides as novel class I and IIB histone deacetylase inhibitors for topical treatment of cutaneous t-cell lymphoma.
Nestle Skin Health R&D
Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals).
University Of Freiburg
Lysine Deacetylase Inhibitors in Parasites: Past, Present, and Future Perspectives.
Dipartimento Di Chimica E Tecnologie Del Farmaco "Sapienza" Universit£
SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects.
University Of Genoa
X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells.
West China School Of Pharmacy
Discovery and Characterization of R/S-N-3-Cyanophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea, a New Histone Deacetylase Class III Inhibitor Exerting Antiproliferative Activity against Cancer Cell Lines.
H�Pital Kirchberg
(N-Hydroxycarbonylbenylamino)quinolines as Selective Histone Deacetylase 6 Inhibitors Suppress Growth of Multiple Myeloma in Vitro and in Vivo.
Taipei Medical University
Discovery of 2-((4,6-dimethylpyrimidin-2-yl)thio)-N-phenylacetamide derivatives as new potent and selective human sirtuin 2 inhibitors.
Xihua University
Tyrosinase inhibitory activities of the compounds isolated from Neolitsea aciculata (Blume) Koidz.
Jeju National University
The antiparasitic clioquinol induces apoptosis in leukemia and myeloma cells by inhibiting histone deacetylase activity.
Soochow University