PMID

Data

Article Title

Organization

Synthesis and evaluation of the structural elements in alkylated tetrahydroisoquinolines for binding to CNS receptors.

Florida A&M University

Design and synthesis of dual 5-HT1A and 5-HT7 receptor ligands.

Florida A&M University

Further evaluation of the tropane analogs of haloperidol.

Florida A&M University

Identification of a new selective dopamine D4 receptor ligand.

Florida A&M University

Discovery and SAR of org 24598-a selective glycine uptake inhibitor.

Organon Research And Development Group

Benzothiazoles as probes for the 5HT1A receptor and the serotonin transporter (SERT): a search for new dual-acting agents as potential antidepressants.

Florida A&M University

Dibenzazecine scaffold rebuilding--is the flexibility always essential for high dopamine receptor affinities?

Friedrich-Schiller-Universit£T Jena

Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a dopaminergic agent with a novel mode of action for the potential treatment of erectile dysfunction.

Abbott Laboratories

Structure-activity relationship studies of SYA 013, a homopiperazine analog of haloperidol.

Florida A&M University

Multi-receptor drug design: Haloperidol as a scaffold for the design and synthesis of atypical antipsychotic agents.

Florida A&M University

Evaluation of 18F-labeled benzodioxine piperazine-based dopamine D4 receptor ligands: lipophilicity as a determinate of nonspecific binding.

Forschungszentrum J£Lich

Design, synthesis, radiolabeling, and in vivo evaluation of carbon-11 labeled N-[2-[4-(3-cyanopyridin-2-yl)piperazin-1-yl]ethyl]-3-methoxybenzamide, a potential positron emission tomography tracer for the dopamine D(4) receptors.

Universita` Degli Studi Di Bari A Moro

Synthesis, structure-affinity relationships, and radiolabeling of selective high-affinity 5-HT4 receptor ligands as prospective imaging probes for positron emission tomography.

National Institute Of Mental Health

Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction.

Abbott Laboratories

11C-labeling of n-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]arylcarboxamide derivatives and evaluation as potential radioligands for PET imaging of dopamine D3 receptors.

University Of Milano/Bicocca

Enantiomerically pure hexahydropyrazinoquinolines as potent and selective dopamine 3 subtype receptor ligands.

University Of Michigan

Synthesis and structure--activity relationship in a class of indolebutylpiperazines as dual 5-HT(1A) receptor agonists and serotonin reuptake inhibitors.

Merck

Synthesis of potent and selective dopamine D(4) antagonists as candidate radioligands.

Columbia University College Of Physicians And Surgeons

(S)-(-)-4-[4-[2-(isochroman-1-yl)ethyl]-piperazin-1-yl] benzenesulfonamide, a selective dopamine D4 antagonist.

Pharmacia & Upjohn

Evaluation of Natural and Synthetic 1,4-naphthoquinones as Inhibitors of Monoamine Oxidase.

North-West University