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191 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Design, synthesis, biological evaluation, molecular docking and QSAR studies of 2,4-dimethylacridones as anticancer agents.EBI
Svkm'S Dr. Bhanuben Nanavati College Of Pharmacy
Dregamine and tabernaemontanine derivatives as ABCB1 modulators on resistant cancer cells.EBI
Universidade De Lisboa
Phenyltetrazolyl-phenylamides: Substituent impact on modulation capability and selectivity toward the efflux protein ABCG2 and investigation of interaction with the transporter.EBI
Rheinische Friedrich-Wilhelms-Universit£T Bonn
Hernandezine, a Bisbenzylisoquinoline Alkaloid with Selective Inhibitory Activity against Multidrug-Resistance-Linked ATP-Binding Cassette Drug Transporter ABCB1.EBI
Chang Gung Memorial Hospital
Halogenated naphthochalcones and structurally related naphthopyrazolines with antitumor activity.EBI
University Bayreuth
Synthesis and bioevaluation of novel benzodipyranone derivatives as P-glycoprotein inhibitors for multidrug resistance reversal agents.EBI
China Medical University
Structure-activity relationships of dibenzoylhydrazines for the inhibition of P-glycoprotein-mediated quinidine transport.EBI
Kyoto University
The combination of quinazoline and chalcone moieties leads to novel potent heterodimeric modulators of breast cancer resistance protein (BCRP/ABCG2).EBI
University Of Bonn
Optimization by Molecular Fine Tuning of Dihydro-ß-agarofuran Sesquiterpenoids as Reversers of P-Glycoprotein-Mediated Multidrug Resistance.EBI
Instituto Universitario De Bio-Org£Nica&Quot;Antonio Gonz£Lez&Quot
Flavonoid derivatives as selective ABCC1 modulators: Synthesis and functional characterization.EBI
University Of Regensburg
The interaction of 4-thiazolidinone derivatives containing indolin-2-one moiety with P-glycoprotein studied using K562 cell lines.EBI
The First Affiliated Hospital Of Dalian Medical University
Optimization of permethyl ningalin B analogs as P-glycoprotein inhibitors.EBI
Ocean University Of China
Discovery of substituted 1,4-dihydroquinolines as novel promising class of P-glycoprotein inhibitors: First structure-activity relationships and bioanalytical studies.EBI
Martin-Luther-University Halle-Wittenberg
Potent and Nontoxic Chemosensitizer of P-Glycoprotein-Mediated Multidrug Resistance in Cancer: Synthesis and Evaluation of Methylated Epigallocatechin, Gallocatechin, and Dihydromyricetin Derivatives.EBI
The Hong Kong Polytechnic University
Restoration of Chemosensitivity in P-Glycoprotein-Dependent Multidrug-Resistant Cells by Dihydro-ß-agarofuran Sesquiterpenes from Celastrus vulcanicola.EBI
Instituto Universitario De Bio-Org£Nica Antonio Gonz£Lez (Iubo-Ag)
In vitro investigations into the roles of drug transporters and metabolizing enzymes in the disposition and drug interactions of dolutegravir, a HIV integrase inhibitor.EBI
Glaxosmithkline
HM30181 Derivatives as Novel Potent and Selective Inhibitors of the Breast Cancer Resistance Protein (BCRP/ABCG2).EBI
University Of Bonn
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding.EBI
Universit£
Investigating the binding interactions of the anti-Alzheimer's drug donepezil with CYP3A4 and P-glycoprotein.EBI
University Of Waterloo
Deconstruction of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety to separate P-glycoprotein (P-gp) activity froms2 receptor affinity in mixed P-gp/s2 receptor agents.EBI
Universit£
SAR studies on tetrahydroisoquinoline derivatives: the role of flexibility and bioisosterism to raise potency and selectivity toward P-glycoprotein.EBI
Universit£
Potent nonimmunosuppressive cyclophilin inhibitors with improved pharmaceutical properties and decreased transporter inhibition.EBI
Novartis Institutes For Biomedical Research
4,5-Di-substituted benzyl-imidazol-2-substituted amines as the structure template for the design and synthesis of reversal agents against P-gp-mediated multidrug resistance breast cancer cells.EBI
Ocean University Of China
Design and synthesis of human ABCB1 (P-glycoprotein) inhibitors by peptide coupling of diverse chemical scaffolds on carboxyl and amino termini of (S)-valine-derived thiazole amino acid.EBI
St. John'S University
Synthesis, biological evaluation and 3D-QSAR studies of new chalcone derivatives as inhibitors of human P-glycoprotein.EBI
Medical University Vienna
SAR study on arylmethyloxyphenyl scaffold: looking for a P-gp nanomolar affinity.EBI
Universit£
Investigation of quinazolines as inhibitors of breast cancer resistance protein (ABCG2).EBI
University Of Bonn
Development of 3,4-dihydroisoquinolin-1(2H)-one derivatives for the Positron Emission Tomography (PET) imaging ofs2 receptors.EBI
Universit£
Synthesis of N(4)-(substituted phenyl)-N(4)-alkyl/desalkyl-9H-pyrimido[4,5-b]indole-2,4-diamines and identification of new microtubule disrupting compounds that are effective against multidrug resistant cells.EBI
Duquesne University
Potent and selective tariquidar bioisosters as potential PET radiotracers for imaging P-gp.EBI
Universit£
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters.EBI
Universit£
Benzanilide-Biphenyl Replacement: A Bioisosteric Approach to Quinoline Carboxamide-Type ABCG2 Modulators.EBI
University Of Regensburg
Docking and 3D-QSAR (quantitative structure activity relationship) studies of flavones, the potent inhibitors of p-glycoprotein targeting the nucleotide binding domain.EBI
Chosun University
Intrinsic and acquired forms of resistance against the anticancer ruthenium compound KP1019 [indazolium trans-[tetrachlorobis(1H-indazole)ruthenate (III)] (FFC14A).EBI
Institute Of Cancer Research
Transport characteristics of fexofenadine in the Caco-2 cell model.EBI
Uppsala University
Inhibitory effects of a cyclosporin derivative, SDZ PSC 833, on transport of doxorubicin and vinblastine via human P-glycoprotein.EBI
Kobe University
Inhibitory potencies of 1,4-dihydropyridine calcium antagonists to P-glycoprotein-mediated transport: comparison with the effects on CYP3A4.EBI
Kanazawa University
Inhibitory effects of CYP3A4 substrates and their metabolites on P-glycoprotein-mediated transport.EBI
Kanazawa University
Cepharanthin, a multidrug resistant modifier, is a substrate for P-glycoprotein.EBI
Kyoto University Hospital
Ranking of P-glycoprotein substrates and inhibitors by a calcein-AM fluorometry screening assay.EBI
Strasbourg 1 University
Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa?EBI
The University Of Kansas
HMG-CoA reductase inhibitors (statins) characterized as direct inhibitors of P-glycoprotein.EBI
Schering-Plough Research Institute
Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4.EBI
Schering-Plough Research Institute
The farnesyl protein transferase inhibitor SCH66336 is a potent inhibitor of MDR1 product P-glycoprotein.EBI
Schering-Plough Research Institute
Cholesterol interaction with the daunorubicin binding site of P-glycoprotein.EBI
Schering-Plough Research Institute
P-glycoprotein interactions of nefazodone and trazodone in cell culture.EBI
Tufts University School Of Medicine
Methadone inhibits rhodamine123 transport in Caco-2 cells.EBI
Tufts University School Of Medicine
Evaluation of the interaction of loratadine and desloratadine with P-glycoprotein.EBI
Schering-Plough Research Institute
Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors.EBI
Schering-Plough Research Institute
Interaction of common azole antifungals with P glycoprotein.EBI
Schering-Plough Research Institute
Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testes.EBI
Vanderbilt University School Of Medicine
Lopinavir: acute exposure inhibits P-glycoprotein; extended exposure induces P-glycoprotein.EBI
Tufts University School Of Medicine
Mibefradil is a P-glycoprotein substrate and a potent inhibitor of both P-glycoprotein and CYP3A in vitro.EBI
Vanderbilt University School Of Medicine
Interaction of morphine, fentanyl, sufentanil, alfentanil, and loperamide with the efflux drug transporter P-glycoprotein.EBI
Vanderbilt University
Interaction of omeprazole, lansoprazole and pantoprazole with P-glycoprotein.EBI
Institute Of Clinical Pharmacology
Characterization of the major metabolites of verapamil as substrates and inhibitors of P-glycoprotein.EBI
Dr. Margarete Fischer-Bosch-Institute Of Clinical Pharmacology
Inhibition of the P-glycoprotein- and multidrug resistance protein-mediated efflux of anthracyclines and calceinacetoxymethyl ester by PAK-104P.EBI
Universit£
Reversal of P-glycoprotein-mediated MDR by 5,7,3',4',5'-pentamethoxyflavone and SAR.EBI
Chosun University
Differential interaction of 3-hydroxy-3-methylglutaryl-coa reductase inhibitors with ABCB1, ABCC2, and OATP1B1.EBI
Pfizer
Differential effects of the optical isomers of KR30031 on cardiotoxicity and on multidrug resistance reversal activity.EBI
Korea Research Institute Of Chemical Technology
Imaging reversal of multidrug resistance in living mice with bioluminescence: MDR1 P-glycoprotein transports coelenterazine.EBI
Washington University
Selectivity of the multidrug resistance modulator, LY335979, for P-glycoprotein and effect on cytochrome P-450 activities.EBI
Eli Lilly
New functional assay of P-glycoprotein activity using Hoechst 33342.EBI
University Of Bonn
New potent P-glycoprotein inhibitors carrying a polycyclic scaffold.EBI
University Of Bologna
Increased anti-P-glycoprotein activity of baicalein by alkylation on the A ring.EBI
Yale University
C-7 analogues of progesterone as potent inhibitors of the P-glycoprotein efflux pump.EBI
Georgetown University School Of Medicine
Synthesis and evaluation of hapalosin and analogs as MDR-reversing agents.EBI
Eisai Research Institute
Thiorhodamines containing amide and thioamide functionality as inhibitors of the ATP-binding cassette drug transporter P-glycoprotein (ABCB1).EBI
The State University Of New York
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.EBI
Uppsala University
Pharmacokinetics and interactions of a novel antagonist of chemokine receptor 5 (CCR5) with ritonavir in rats and monkeys: role of CYP3A and P-glycoprotein.EBI
Merck Research Laboratories
Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein.EBI
Eli Lilly
Effect of modulators on the ATPase activity and vanadate nucleotide trapping of human P-glycoprotein.EBI
Eli Lilly
Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4.EBI
Dr. Margarete Fischer-Bosch-Institute Of Clinical Pharmacology
PSC833, cyclosporin A, and dexniguldipine effects on cellular calcein retention and inhibition of the multidrug resistance pump in human leukemic lymphoblasts.EBI
University Of Tennessee Medical Center
Nonclinical pharmacokinetics of oseltamivir and oseltamivir carboxylate in the central nervous system.EBI
F. Hoffmann-La Roche
From taxuspine x to structurally simplified taxanes with remarkable p-glycoprotein inhibitory activity.EBI
TBA
Effects of human immunodeficiency virus protease inhibitors on the intestinal absorption of tenofovir disoproxil fumarate in vitro.EBI
Gilead Sciences
Potent and selective inhibitors of breast cancer resistance protein (ABCG2) derived from the p-glycoprotein (ABCB1) modulator tariquidar.EBI
University Of Regensburg
Functional assay and structure-activity relationships of new third-generation P-glycoprotein inhibitors.EBI
University Of Bonn
Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives.EBI
Universit£
Synthesis and biological evaluation of (hetero)arylmethyloxy- and arylmethylamine-phenyl derivatives as potent P-glycoprotein modulating agents.EBI
Universita Degli Studi Di Bari
Self-organizing maps for identification of new inhibitors of P-glycoprotein.EBI
University Of Vienna
Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells.EBI
Universit£
Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery.EBI
F. Hoffmann-La Roche
Pharmacophore model of drugs involved in P-glycoprotein multidrug resistance: explanation of structural variety (hypothesis).EBI
Bulgarian Academy Of Sciences
Cyclosporins: structure-activity relationships for the inhibition of the human MDR1 P-glycoprotein ABC transporter.EBI
Strasbourg 1 University
Aureobasidins: structure-activity relationships for the inhibition of the human MDR1 P-glycoprotein ABC-transporter.EBI
Strasbourg 1 University
Substituted 4-acylpyrazoles and 4-acylpyrazolones: synthesis and multidrug resistance-modulating activity.EBI
University Of Vienna
Potent galloyl-based selective modulators targeting multidrug resistance associated protein 1 and P-glycoprotein.EBI
Universit£
Overcoming human P-glycoprotein-dependent multidrug resistance with novel dihydro-ß-agarofuran sesquiterpenes.EBI
Instituto Universitario De Bio-Org£Nica Antonio Gonz£Lez (Iubo-Ag)
Solid phase synthesis of tariquidar-related modulators of ABC transporters preferring breast cancer resistance protein (ABCG2).EBI
Universidad Nacional De Colombia
A novel approach for predicting P-glycoprotein (ABCB1) inhibition using molecular interaction fields.EBI
University Of Perugia
Interaction potential of etravirine with drug transporters assessed in vitro.EBI
University Hospital Heidelberg
Structure-activity relationships of flavonoids as inhibitors of breast cancer resistance protein (BCRP).EBI
University Of Bonn
Potent and fully noncompetitive peptidomimetic inhibitor of multidrug resistance P-glycoprotein.EBI
Umr 5086 Cnrs
Phenylsulfonylfuroxans as modulators of multidrug-resistance-associated protein-1 and P-glycoprotein.EBI
Universita Degli Studi Di Torino
Antimalarial and antitrypanosomal activity of a series of amide and sulfonamide derivatives of a 2,5-diaminobenzophenone.EBI
Philipps-Universit£T Marburg
Rhodamine inhibitors of P-glycoprotein: an amide/thioamide"switch" for ATPase activity.EBI
The State University Of New York
2-[(3-Methoxyphenylethyl)phenoxy]-based ABCB1 inhibitors: effect of different basic side-chains on their biological properties.EBI
Universita Degli Studi Di Bari
Bis-pyranobenzoquinones as a new family of reversal agents of the multidrug resistance phenotype mediated by P-glycoprotein in mammalian cells and the protozoan parasite Leishmania.EBI
Instituto Universitario De Bio-OrgáNica Antonio GonzáLez
Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum.EBI
Università
Biological evaluation, structure-activity relationships, and three-dimensional quantitative structure-activity relationship studies of dihydro-beta-agarofuran sesquiterpenes as modulators of P-glycoprotein-dependent multidrug resistance.EBI
Instituto Universitario De Bio-Organica Antonio Gonzalez
In vitro activity of novel dual action MDR anthranilamide modulators with inhibitory activity on CYP-450 (Part 2).EBI
Université
Arylmethyloxyphenyl derivatives: small molecules displaying P-glycoprotein inhibition.EBI
Università
Biological evaluation of bishydroxymethyl-substituted cage dimeric 1,4-dihydropyridines as a novel class of p-glycoprotein modulating agents in cancer cells.EBI
Martin-Luther-University Halle-Wittenberg
Synthesis, in vitro and in vivo evaluation of [O-methyl-11C] 2-{4-[4-(3-methoxyphenyl)piperazin-1-yl]-butyl}-4-methyl-2H-[1,2,4]-triazine-3,5-dione: a novel agonist 5-HT1A receptor PET ligand.EBI
Columbia University College Of Physicians And Surgeons
Synthesis and in vivo validation of [O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)piperazin- 1-yl]butyl}-4-methyl-2H-[1,2,4]triazine-3,5-dione: a novel 5-HT1A receptor agonist positron emission tomography ligand.EBI
Columbia University College Of Physicians And Surgeons
Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3-(3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-isopropoxybenzamido)-1EBI
Bristol Myers Squibb
Neochrysosporazines: Precursor-Directed Biosynthesis Defines a Marine-Derived Fungal Natural Product P-Glycoprotein Inhibitory Pharmacophore.EBI
The University Of Queensland
Discovery and Characterization of Potent Dual P-Glycoprotein and CYP3A4 Inhibitors: Design, Synthesis, Cryo-EM Analysis, and Biological Evaluations.EBI
Athenex
Synthesis and evaluation of stereoisomers of methylated catechin and epigallocatechin derivatives on modulating P-glycoprotein-mediated multidrug resistance in cancers.EBI
Hong Kong Polytechnic University
Discovery of New 4-Indolyl Quinazoline Derivatives as Highly Potent and Orally Bioavailable P-Glycoprotein Inhibitors.EBI
Zhengzhou University
Flavonoid Monomers as Potent, Nontoxic, and Selective Modulators of the Breast Cancer Resistance Protein (ABCG2).EBI
Hong Kong Polytechnic University
Discovery of Encequidar, First-in-Class Intestine Specific P-glycoprotein Inhibitor.EBI
Athenex
C@PA: Computer-Aided Pattern Analysis to Predict Multitarget ABC Transporter Inhibitors.EBI
University Of Bonn
Design, synthesis, and biological evaluation of hederagenin derivatives with improved aqueous solubility and tumor resistance reversal activity.EBI
Yantai University
Design, synthesis and bioactivity study on 5-phenylfuran derivatives as potent reversal agents against P-glycoprotein-mediated multidrug resistance in MCF-7/ADR cell.EBI
Zhejiang University
Dihydro-?-agarofuran-Type Sesquiterpenoids from the Seeds of EBI
Chinese Academy Of Sciences
Structure-Based Discovery of Pyrimidine Aminobenzene Derivatives as Potent Oral Reversal Agents against P-gp- and BCRP-Mediated Multidrug Resistance.EBI
China Pharmaceutical University
Synthesis and biological evaluation of thiophenylbenzofuran derivatives as potential P-glycoprotein inhibitors.EBI
China Medical University
Water-soluble inhibitors of ABCG2 (BCRP) - A fragment-based and computational approach.EBI
University Of Regensburg
Superior Pyrimidine Derivatives as Selective ABCG2 Inhibitors and Broad-Spectrum ABCB1, ABCC1, and ABCG2 Antagonists.EBI
Rheinische Friedrich-Wilhelms-University Bonn
Rational drug design of 6-substituted 4-anilino-2-phenylpyrimidines for exploration of novel ABCG2 binding site.EBI
Rheinische Friedrich-Wilhelms-University Of Bonn
Tricyclic isoxazoles are novel inhibitors of the multidrug resistance protein (MRP1).EBI
Eli Lilly
Tariquidar-related triazoles as potent, selective and stable inhibitors of ABCG2 (BCRP).EBI
University Of Regensburg
Structure-Based Design, Synthesis, and Biological Evaluation of New Triazolo[1,5-EBI
Zhengzhou University
Licochalcone A Selectively Resensitizes ABCG2-Overexpressing Multidrug-Resistant Cancer Cells to Chemotherapeutic Drugs.EBI
Taipei Chang Gung Memorial Hospital
Discovery of Potent Inhibitors against P-Glycoprotein-Mediated Multidrug Resistance Aided by Late-Stage Functionalization of a 2-(4-(Pyridin-2-yl)phenoxy)pyridine Analogue.EBI
Chinese Academy Of Medical Sciences & Peking Union Medical College
Chrysosporazines F-M: P-Glycoprotein Inhibitory Phenylpropanoid Piperazines from an Australian Marine Fish Derived Fungus, EBI
The University Of Queensland
Synthesis and Investigation of Tetrahydro-?-carboline Derivatives as Inhibitors of the Breast Cancer Resistance Protein (ABCG2).EBI
University Of Bonn
Structure-Activity Relationship Studies on Tetrahydroisoquinoline Derivatives: [4'-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl)biphenyl-4-ol] (MC70) Conjugated through Flexible Alkyl Chains with Furazan Moieties Gives Rise to Potent and Selective Ligands of P-glycoprotein.EBI
Universit£
Synthesis and Biological Evaluation of 4-Anilino-quinazolines and -quinolines as Inhibitors of Breast Cancer Resistance Protein (ABCG2).EBI
University Of Bonn
Jatrophane Diterpenoids from Euphorbia glomerulans.EBI
Chinese Academy Of Sciences
Novel chalcone and flavone derivatives as selective and dual inhibitors of the transport proteins ABCB1 and ABCG2.EBI
Rheinische Friedrich-Wilhelms-University Of Bonn
Design, Biological Evaluation, and Molecular Modeling of Tetrahydroisoquinoline Derivatives: Discovery of A Potent P-Glycoprotein Ligand Overcoming Multidrug Resistance in Cancer Stem Cells.EBI
Universit£
Potential Tools for Eradicating HIV Reservoirs in the Brain: Development of Trojan Horse Prodrugs for the Inhibition of P-Glycoprotein with Anti-HIV-1 Activity.EBI
Purdue University
Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug resistance (MDR) modulators.EBI
University Of Florence
Tetrazole hybrids with potential anticancer activity.EBI
Henan University Of Chinese Medicine
Discovery and synthesis of 3- and 21-substituted fusidic acid derivatives as reversal agents of P-glycoprotein-mediated multidrug resistance.EBI
Yantai University
Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers.EBI
University Of Florence
Design, synthesis and biological evaluation of chalcones as reversers of P-glycoprotein-mediated multidrug resistance.EBI
East China University Of Science And Technology
Optimizing Targeted Inhibitors of P-Glycoprotein Using Computational and Structure-Guided Approaches.EBI
TBA
Natural products as multidrug resistance modulators in cancer.EBI
Central University Of Punjab
Identification of Thienopyrimidine Scaffold as an Inhibitor of the ABC Transport Protein ABCC1 (MRP1) and Related Transporters Using a Combined Virtual Screening Approach.EBI
Rheinische Friedrich-Wilhelms-University Of Bonn
Synthesis and biological evaluation of quinazoline derivatives - A SAR study of novel inhibitors of ABCG2.EBI
University Of Bonn
1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1.EBI
Universit£
Synthesis and biological evaluation of novel H6 analogues as drug resistance reversal agents.EBI
Key Laboratory Of Molecular Pharmacology And Drug Evaluation (Yantai University)
Design, synthesis, and discovery of ocotillol-type amide derivatives as orally available modulators of P-glycoprotein-mediated multidrug resistance.EBI
Universities Of Shandong
Triazole Bridged Flavonoid Dimers as Potent, Nontoxic, and Highly Selective Breast Cancer Resistance Protein (BCRP/ABCG2) Inhibitors.EBI
Hong Kong Polytechnic University
Novel virosecurinine bivalent mimetics as potent reversal agents against P-glycoprotein-mediated multidrug resistance.EBI
Jinan University
Multidrug resistance (MDR) reversers: High activity and efficacy in a series of asymmetrical N,N-bis(alkanol)amine aryl esters.EBI
Universit£
Selenorhodamine photosensitizers for photodynamic therapy of P-glycoprotein-expressing cancer cells.EBI
The State University Of New York
Homodimers of the Antiviral Abacavir as Modulators of P-glycoprotein Transport in Cell Culture: Probing Tether Length.EBI
Purdue University
Structure-activity relationship study of permethyl ningalin B analogues as P-glycoprotein chemosensitizers.EBI
Ocean University Of China
Structure-activity relationship and in vitro and in vivo evaluation of the potent cytotoxic anti-microtubule agent N-(4-methoxyphenyl)-N,2,6-trimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium chloride and its analogues as antitumor agents.EBI
Duquesne University
20(S)-Protopanaxadiol (PPD) analogues chemosensitize multidrug-resistant cancer cells to clinical anticancer drugs.EBI
Chinese Academy Of Sciences
New structure-activity relationship studies in a series of N,N-bis(cyclohexanol)amine aryl esters as potent reversers of P-glycoprotein-mediated multidrug resistance (MDR).EBI
Universit£
Amine linked flavonoid dimers as modulators for P-glycoprotein-based multidrug resistance: structure-activity relationship and mechanism of modulation.EBI
The Hong Kong Polytechnic University
Chalcogenopyrylium compounds as modulators of the ATP-binding cassette transporters P-glycoprotein (P-gp/ABCB1) and multidrug resistance protein 1 (MRP1/ABCC1).EBI
The State University Of New York
Interaction of cytochrome P450 3A inhibitors with P-glycoprotein.EBI
St. Jude Children'S Research Hospital
Effects of 12 Ca2+ antagonists on multidrug resistance, MDR1-mediated transport and MDR1 mRNA expression.EBI
Kyoto Pharmaceutical University
Isolation and characterization of Caco-2 subclones expressing high levels of multidrug resistance protein efflux transporter.EBI
The University Of Kansas
Inhibition of P-glycoprotein by newer antidepressants.EBI
University Of Heidelberg
A functional assay for quantitation of the apparent affinities of ligands of P-glycoprotein in Caco-2 cells.EBI
The University Of Kansas
Reversal of P-glycoprotein-associated multidrug resistance by ivermectin.EBI
Institute Of Parasitology Of Mcgill University
Selective inhibition of human cytochrome P450 3A4 by N-[2(R)-hydroxy-1(S)-indanyl]-5-[2(S)-(1, 1-dimethylethylaminocarbonyl)-4-[(furo[2, 3-b]pyridin-5-yl)methyl]piperazin-1-yl]-4(S)-hydroxy-2(R)-phenylmethy lpentanamide and P-glycoprotein by valspodar in gene transfectant systems.EBI
University Of Tokyo
P-glycoprotein inhibition by the multidrug resistance-reversing agent MS-209 enhances bioavailability and antitumor efficacy of orally administered paclitaxel.EBI
Nihon Schering K.K.
Sirolimus oral absorption in rats is increased by ketoconazole but is not affected by D-alpha-tocopheryl poly(ethylene glycol 1000) succinate.EBI
Avmax
Direct demonstration of high affinity interactions of immunosuppressant drugs with the drug binding site of the human P-glycoprotein.EBI
University Of North Carolina
Interaction of cyclosporin derivatives with the ATPase activity of human P-glycoprotein.EBI
Novartis Takarazuka Research Institute
Interactions of tamoxifen, N-desmethyltamoxifen and 4-hydroxytamoxifen with P-glycoprotein and CYP3A.EBI
Tufts University School Of Medicine
Structure-activity relationships, ligand efficiency, and lipophilic efficiency profiles of benzophenone-type inhibitors of the multidrug transporter P-glycoprotein.EBI
University Of Vienna
Click chemistry-derived bivalent quinine inhibitors of P-glycoprotein-mediated cellular efflux.EBI
Purdue University
Analogs of a 4-aminothieno[2,3-d]pyrimidine lead (QB13) as modulators of P-glycoprotein substrate specificity.EBI
University Of Bonn
Synthesis and biological evaluation of a small molecule library of 3rd generation multidrug resistance modulators.EBI
University Of Bonn
Discovery of traditional Chinese medicine monomers and their synthetic intermediates, analogs or derivatives for battling P-gp-mediated multi-drug resistance.EBI
Anhui University Of Chinese Medicine
Multifunctional thiosemicarbazones and deconstructed analogues as a strategy to study the involvement of metal chelation, Sigma-2 (?EBI
Universit£
Structure activity relationships, multidrug resistance reversal and selectivity of heteroarylphenyl ABCG2 inhibitors.EBI
Rheinische Friedrich-Wilhelms-Universit£T Bonn
Natural alkaloids as P-gp inhibitors for multidrug resistance reversal in cancer.EBI
Csir - Indian Institute Of Integrative Medicine
Discovery of a non-toxic [1,2,4]triazolo[1,5-a]pyrimidin-7-one (WS-10) that modulates ABCB1-mediated multidrug resistance (MDR).EBI
Zhengzhou University
Synthesis and biological investigation of 2,4-substituted quinazolines as highly potent inhibitors of breast cancer resistance protein (ABCG2).EBI
University Of Bonn
Synthesis and biological evaluation of JL-A7 derivatives as potent ABCB1 inhibitors.EBI
China Pharmaceutical University
Exploration of 2-((Pyridin-4-ylmethyl)amino)nicotinamide Derivatives as Potent Reversal Agents against P-Glycoprotein-Mediated Multidrug Resistance.EBI
China Pharmaceutical University
Dual inhibitors of the human blood-brain barrier drug efflux transporters P-glycoprotein and ABCG2 based on the antiviral azidothymidine.EBI
Purdue University
Comprehensive Synthesis of Amino Acid-Derived Thiazole Peptidomimetic Analogues to Understand the Enigmatic Drug/Substrate-Binding Site of P-Glycoprotein.EBI
St. John'S University
Dimeric isoxazolyl-1,4-dihydropyridines have enhanced binding at the multi-drug resistance transporter.EBI
University Of Montana
4-Anilino-2-pyridylquinazolines and -pyrimidines as Highly Potent and Nontoxic Inhibitors of Breast Cancer Resistance Protein (ABCG2).EBI
University Of Bonn
 
Cycloalkylpiperazines as HIV-1 Protease Inhibitors: Enhanced Oral AbsorptionBDB
Merck Research Laboratories