PMID

Data

Article Title

Organization

2-Indolylmethylenebenzofuranones as first effective inhibitors of ABCC2.

Bmssi Umr 5086 Cnrs/Universit£

Mechanistic studies on the absorption and disposition of scutellarin in humans: selective OATP2B1-mediated hepatic uptake is a likely key determinant for its unique pharmacokinetic characteristics.

Chinese Academy Of Sciences

In vitro investigations into the roles of drug transporters and metabolizing enzymes in the disposition and drug interactions of dolutegravir, a HIV integrase inhibitor.

Glaxosmithkline

Optimization of pyrrolamide topoisomerase II inhibitors toward identification of an antibacterial clinical candidate (AZD5099).

Astrazeneca

Potent nonimmunosuppressive cyclophilin inhibitors with improved pharmaceutical properties and decreased transporter inhibition.

Novartis Institutes For Biomedical Research

ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2.

Deutsches Krebsforschungszentrum

Are MDCK cells transfected with the human MRP2 gene a good model of the human intestinal mucosa?

The University Of Kansas

Differential interaction of 3-hydroxy-3-methylglutaryl-coa reductase inhibitors with ABCB1, ABCC2, and OATP1B1.

Pfizer

Interaction of ivermectin with multidrug resistance proteins (MRP1, 2 and 3).

Laboratoire De Pharmacologie-Toxicologie Inra

Effect of multidrug resistance-reversing agents on transporting activity of human canalicular multispecific organic anion transporter.

Kagoshima University

Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.

Uppsala University

Discovery of GS-9451: an acid inhibitor of the hepatitis C virus NS3/4A protease.

Gilead Sciences

Potent and selective inhibitors of breast cancer resistance protein (ABCG2) derived from the p-glycoprotein (ABCB1) modulator tariquidar.

University Of Regensburg

A 4-aminobenzoic acid derivative as novel lead for selective inhibitors of multidrug resistance-associated proteins.

University Of Bonn

Interaction potential of etravirine with drug transporters assessed in vitro.

University Hospital Heidelberg

Modulation of multidrug resistance protein 1 (MRP1/ABCC1)-mediated multidrug resistance by bivalent apigenin homodimers and their derivatives.

The Hong Kong Polytechnic University

Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).

Uppsala University

Discovery of (

Bristol-Myers Squibb

Discovery of Encequidar, First-in-Class Intestine Specific P-glycoprotein Inhibitor.

Athenex

Pyxinol bearing amino acid residues: Easily achievable and promising modulators of P-glycoprotein-mediated multidrug resistance.

Universities Of Shandong

ATP-dependent para-aminohippurate transport by apical multidrug resistance protein MRP2.

Deutsches Krebsforschungszentrum

The potential for an interaction between MRP2 (ABCC2) and various therapeutic agents: probenecid as a candidate inhibitor of the biliary excretion of irinotecan metabolites.

University Of Tokyo

Transport of monoglucuronosyl and bisglucuronosyl bilirubin by recombinant human and rat multidrug resistance protein 2.

Deutsches Krebsforschungszentrum

Design and optimization of 2,3-dihydrobenzo[b][1,4]dioxine propanoic acids as novel GPR40 agonists with improved pharmacokinetic and safety profiles.

Chinese Academy Of Sciences

A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.

Amgen