PMID

Data

Article Title

Organization

Probing the carboxyester side chain in controlled deactivation (-)-d(8)-tetrahydrocannabinols.

Northeastern University

Design, Synthesis, and Biological Evaluation of Novel, Non-Brain-Penetrant, Hybrid Cannabinoid CB

National Institute On Alcohol Abuse And Alcoholism

Two new unsaturated fatty acid ethanolamides in brain that bind to the cannabinoid receptor.

Hebrew University

A critical review of both the synthesis approach and the receptor profile of the 8-chloro-1-(2',4'-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide and analogue derivatives.

Neuroscienze Pharmaness S.C.A R.L.

Synthesis and biological evaluation of (3',5'-dichloro-2,6-dihydroxy-biphenyl-4-yl)-aryl/alkyl-methanone selective CB2 inverse agonist.

University Of Tennessee Health Science Center

Discovery of a high affinity and selective pyridine analog as a potential positron emission tomography imaging agent for cannabinoid type 2 receptor.

Institute Of Pharmaceutical Sciences

3'-functionalized adamantyl cannabinoid receptor probes.

University Of Hawaii At Manoa

Novel tail and head group prostamide probes.

Northeastern University

Tricyclic pyrazoles part 7. Discovery of potent and selective dihydrothienocyclopentapyrazole derived CB2 ligands.

Universit£

Discovery of 1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalen-4-carboxamides as potent and selective CB2 receptor agonists.

Arena Pharmaceuticals

Tricyclic pyrazoles. Part 6. Benzofuro[3,2-c]pyrazole: a versatile architecture for CB2 selective ligands.

Universit£

C-ring cannabinoid lactones: a novel cannabinergic chemotype.

Northeastern University

Therapeutic utility of cannabinoid receptor type 2 (CB(2)) selective agonists.

Arena Pharmaceuticals

Novel adamantyl cannabinoids as CB1 receptor probes.

Northeastern University

Highly potent and selective cannabinoid receptor 2 agonists: initial hit optimization of an adamantyl hit series identified from high-through-put screening.

F. Hoffmann-La Roche

Novel pyrazole derivatives as neutral CB1 antagonists with significant activity towards food intake.

Neuroscienze Pharmaness S.C.A R.L.

Structure-activity relationships of 2-arylamido-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide derivatives as cannabinoid receptor agonists and their analgesic action.

Nycomed Pharma

Sulfonyl fluoride inhibitors of fatty acid amide hydrolase.

Northeastern University

Assay and inhibition of diacylglycerol lipase activity.

Northeastern University

C3-heteroaroyl cannabinoids as photolabeling ligands for the CB2 cannabinoid receptor.

University Of Hawaii At Manoa

Tricyclic pyrazoles. 4. Synthesis and biological evaluation of analogues of the robust and selective CB2 cannabinoid ligand 1-(2',4'-dichlorophenyl)-6-methyl-N-piperidin-1-yl-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamide.

Universit£

Design, synthesis, and biological evaluation of new 1,8-naphthyridin-4(1H)-on-3-carboxamide and quinolin-4(1H)-on-3-carboxamide derivatives as CB2 selective agonists.

Universit£

Potent cannabinergic indole analogues as radioiodinatable brain imaging agents for the CB1 cannabinoid receptor.

Northeastern University

Unsaturated side chain beta-11-hydroxyhexahydrocannabinol analogs.

University Of Hawaii

Conformationally constrained analogs of BAY 59-3074 as novel cannabinoid receptor ligands.

Northeastern University

Novel 1',1'-chain substituted hexahydrocannabinols: 9ß-hydroxy-3-(1-hexyl-cyclobut-1-yl)-hexahydrocannabinol (AM2389) a highly potent cannabinoid receptor 1 (CB1) agonist.

Northeastern University

Heteroadamantyl cannabinoids.

University Of Hawaii At Manoa

A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase.

Università

Bornyl- and isobornyl-Delta8-tetrahydrocannabinols: a novel class of cannabinergic ligands.

Northeastern University

Development of novel tail-modified anandamide analogs.

Northeastern University

Cannabilactones: a novel class of CB2 selective agonists with peripheral analgesic activity.

Northeastern University

Conformationally constrained analogues of 2-arachidonoylglycerol.

Northeastern University

C1'-cycloalkyl side chain pharmacophore in tetrahydrocannabinols.

National Hellenic Research Foundation

2-Arylimino-5,6-dihydro-4H-1,3-thiazines as a new class of cannabinoid receptor agonists. Part 2: orally bioavailable compounds.

Shionogi

2-Arylimino-5,6-dihydro-4H-1,3-thiazines as a new class of cannabinoid receptor agonists. Part 1: discovery of CB2 receptor selective compounds.

Shionogi

Structural modifications of the cannabinoid side chain towards C3-aryl and 1',1'-cycloalkyl-1'-cyano cannabinoids.

National Hellenic Research Foundation

Tricyclic pyrazoles. 3. Synthesis, biological evaluation, and molecular modeling of analogues of the cannabinoid antagonist 8-chloro-1-(2',4'-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide.

Università

Adamantyl cannabinoids: a novel class of cannabinergic ligands.

Northeastern University

Novel Functionalized Cannabinoid Receptor Probes: Development of Exceptionally Potent Agonists.

The Scripps Research Institute

Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1'.

National Hellenic Research Foundation

Novel 1',1'-chain substituted Delta(8)-tetrahydrocannabinols.

National Hellenic Research Foundation

Oxa-adamantyl cannabinoids.

University Of Hawaii At Manoa

Synthesis, molecular modeling and SAR study of novel pyrazolo[5,1-f][1,6]naphthyridines as CB

Universit£

Novel C-Ring-Hydroxy-Substituted Controlled Deactivation Cannabinergic Analogues.

Northeastern University

Plant-Based Modulators of Endocannabinoid Signaling.

Concordia University Wisconsin

Novel conformationally restricted tetracyclic analogs of delta8-tetrahydrocannabinol.

University Of Connecticut

Structure-activity relationships of pyrazole derivatives as cannabinoid receptor antagonists.

University Of Connecticut

Novel analogues of arachidonylethanolamide (anandamide): affinities for the CB1 and CB2 cannabinoid receptors and metabolic stability.

University Of Connecticut

Biased Ligands of G Protein-Coupled Receptors (GPCRs): Structure-Functional Selectivity Relationships (SFSRs) and Therapeutic Potential.

Shanghaitech University

Classical/nonclassical hybrid cannabinoids: southern aliphatic chain-functionalized C-6beta methyl, ethyl, and propyl analogues.

University Of Hawaii

Pharmacophoric requirements for cannabinoid side chains: multiple bond and C1'-substituted delta 8-tetrahydrocannabinols.

National Hellenic Research Foundation

Head group analogs of arachidonylethanolamide, the endogenous cannabinoid ligand.

University Of Connecticut

Controlled-deactivation cannabinergic ligands.

Northeastern University

N-Alkyl dien- and trienamides from the roots of Otanthus maritimus with binding affinity for opioid and cannabinoid receptors.

Uos Of Cagliari

High affinity electrophilic and photoactivatable covalent endocannabinoid probes for the CB1 receptor.

Northeastern University

Oximes short-acting CB1 receptor agonists.

Northeastern University

( R)- N-(1-Methyl-2-hydroxyethyl)-13-( S)-methyl-arachidonamide (AMG315): A Novel Chiral Potent Endocannabinoid Ligand with Stability to Metabolizing Enzymes.

Northeastern University

Novel Diarylurea Based Allosteric Modulators of the Cannabinoid CB1 Receptor: Evaluation of Importance of 6-Pyrrolidinylpyridinyl Substitution.

Research Triangle Institute

Development of 2-(Substituted Benzylamino)-4-Methyl-1, 3-Thiazole-5-Carboxylic Acid Derivatives as Xanthine Oxidase Inhibitors and Free Radical Scavengers.

Jamia Hamdard