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33 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Structure-activity studies on benzhydrol-containing nipecotic acid and guvacine derivatives as potent, orally-active inhibitors of GABA uptake.EBI
Warner-Lambert
Sodium channel binding and anticonvulsant activities for the enantiomers of a bicyclic 2,4-oxazolidinedione and monocyclic models.EBI
University Of Alabama
Anticonvulsant activities of phenyl-substituted bicyclic 2,4-oxazolidinediones and monocyclic models. Comparison with binding to the neuronal voltage-dependent sodium channel.EBI
University Of Alabama
2-Alkyl-4-arylimidazoles: structurally novel sodium channel modulators.EBI
Institut Henri Beaufour
Synthesis and preliminary biological evaluation of new alpha-amino amide anticonvulsants incorporating a dextromethorphan moiety.EBI
Pharmacia & Upjohn
Voltage-Gated Sodium Channels: Structure, Function, Pharmacology, and Clinical Indications.EBI
Merck Research Laboratories
Studies examining the relationship between the chemical structure of protoxin II and its activity on voltage gated sodium channels.EBI
Purdue Pharma
Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies.EBI
Johnson & Johnson Pharmaceutical Research & Development
Synthesis and pharmacological evaluation of N,N'-diarylguanidines as potent sodium channel blockers and anticonvulsant agents.EBI
Cambridge Neuroscience
Design, synthesis, and pharmacological evaluation of conformationally constrained analogues of N,N'-diaryl- and N-aryl-N-aralkylguanidines as potent inhibitors of neuronal Na+ channels.EBI
Cambridge Neuroscience
Synthesis and pharmacological evaluation of phenylacetamides as sodium-channel blockers.EBI
Warner-Lambert
A novel class of Na+ and Ca2+ channel dual blockers with highly potent anti-ischemic effects.EBI
Institute For Bio-Medical Research
Sodium channel activity and sigma binding of 2-aminopropanamide anticonvulsants.EBI
Pharmacia & Upjohn
 
Batrachotoxin binding site antagonistsEBI
TBA
Lactam-stabilized helical analogues of the analgesicµ-conotoxin KIIIA.EBI
Monash University
Discovery and stereoselective synthesis of the novel isochroman neurokinin-1 receptor antagonist 'CJ-17,493'.EBI
Pfizer
Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.EBI
University Of Utah
The design, preparation and SAR of novel small molecule sodium (Na(+)) channel blockers.EBI
Arqule
Isolation and Biological Activity of 8- Epitetrodotoxin and the Structure of a Possible Biosynthetic Shunt Product of Tetrodotoxin, Cep-226A, from the Newt Cynops ensicauda popei.EBI
Tohoku University
A structure-activity relationship study of novel phenylacetamides which are sodium channel blockers.EBI
Warner-Lambert
Synthesis and evaluation of a 125I-labeled iminodihydroquinoline-derived tracer for imaging of voltage-gated sodium channels.EBI
Institute Of Nuclear Medicine
Expanding chemical diversity of conotoxins: peptoid-peptide chimeras of the sodium channel blocker ?-KIIIA and its selenopeptide analogues.EBI
University Of Gdansk
Synthesis and structure-activity relationships of 6,7-benzomorphan derivatives as use-dependent sodium channel blockers for the treatment of stroke.EBI
Boehringer Ingelheim Pharma
Comparative molecular field analysis of hydantoin binding to the neuronal voltage-dependent sodium channel.EBI
University Of Alabama At Birmingham
Anticonvulsant and sodium channel-blocking properties of novel 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives.EBI
Bial
Effects of log P and phenyl ring conformation on the binding of 5-phenylhydantoins to the voltage-dependent sodium channel.EBI
University Of Alabama At Birmingham
Synthesis and anticonvulsant activity of enaminones. 3. Investigations on 4'-, 3'-, and 2'-substituted and polysubstituted anilino compounds, sodium channel binding studies, and toxicity evaluations.EBI
Howard University
Bicyclic hydantoins with a bridgehead nitrogen. Comparison of anticonvulsant activities with binding to the neuronal voltage-dependent sodium channel.EBI
University Of Alabama At Birmingham
Discovery of a Potent, Selective T-type Calcium Channel Blocker as a Drug Candidate for the Treatment of Generalized Epilepsies.EBI
Idorsia Pharmaceuticals