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386 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Adamantyl Antiestrogens with Novel Side Chains Reveal a Spectrum of Activities in Suppressing Estrogen Receptor Mediated Activities in Breast Cancer Cells.EBI
The Scripps Research Institute
Discovery of an Acrylic Acid Based Tetrahydroisoquinoline as an Orally Bioavailable Selective Estrogen Receptor Degrader for ERa+ Breast Cancer.EBI
Novartis Institutes for BioMedical Research
Novel Selective Estrogen Receptor Downregulators (SERDs) Developed against Treatment-Resistant Breast Cancer.EBI
University of Illinois College of Pharmacy
An in-tether sulfoxide chiral center influences the biophysical properties of the N-capped peptides.EBI
Peking University Shenzhen Graduate School
Antiestrogens. 3. Estrogen receptor affinities and antiproliferative effects in MCF-7 cells of phenolic analogues of trioxifene, [3,4-dihydro-2-(4- methoxyphenyl)-1-naphthalenyl][4-[2-(1-pyrrolidinyl)ethoxy]- phenyl]methanone.EBI
Eli Lilly and Company
17-Desoxy estrogen analogues.EBI
SRI International
Synthesis and biological evaluation of novel thio-substituted chromanes as high-affinity partial agonists for the estrogen receptor.EBI
Novo Nordisk A/S
Synthesis and pharmacology of a novel pyrrolo[2,1,5-cd] indolizine (NNC 45-0095), a high affinity non-steroidal agonist for the estrogen receptor.EBI
Novo Nordisk A/S
Synthesis and estrogen receptor binding affinities of novel pyrrolo[2,1,5-cd]indolizine derivatives.EBI
Novo Nordisk A/S
Synthesis and biological activity of trans-2,3-dihydroraloxifene.EBI
Eli Lilly and Company
Novel nonsteroidal selective estrogen receptor modulators. Carbon and heteroatom replacement of oxygen in the ethoxypiperidine region of raloxifene.EBI
Eli Lilly and Company
Synthesis and estrogen receptor binding affinity of a porphyrin-estradiol conjugate for targeted photodynamic therapy of cancer.EBI
Boston University School of Medicine
Rational Design of a Boron-Modified Triphenylethylene (GLL398) as an Oral Selective Estrogen Receptor Downregulator.EBI
Xavier University of Louisiana
Discovery of indazole ethers as novel, potent, non-steroidal glucocorticoid receptor modulators.EBI
AstraZeneca
Development ofEBI
Tokyo Medical and Dental University
Design and synthesis of triarylacrylonitrile analogues of tamoxifen with improved binding selectivity to protein kinase C.EBI
University of Michigan
A new Suzuki synthesis of triphenylethylenes that inhibit aromatase and bind to estrogen receptorsa and▀.EBI
Purdue University
Synthesis and biological evaluation of novel 4-hydroxytamoxifen analogs as estrogen-related receptor gamma inverse agonists.EBI
Daegu-Gyeongbuk Medical Innovation Foundation
Design, synthesis and evaluation of 6-aryl-indenoisoquinolone derivatives dual targeting ERa and VEGFR-2 as anti-breast cancer agents.EBI
China Pharmaceutical University
Synthesis, antiproliferative and pro-apoptotic activity of 2-phenylindoles.EBI
Trinity College
De Novo Design at the Edge of Chaos.EBI
Swiss Federal Institute of Technology (ETH)
Synthesis and evaluation of raloxifene derivatives as a selective estrogen receptor down-regulator.EBI
National Institute of Health Sciences
Identification of novel estrogen receptor (ER) agonists that have additional and complementary anti-cancer activities via ER-independent mechanism.EBI
Kyung Hee University
Identification of spirooxindole and dibenzoxazepine motifs as potent mineralocorticoid receptor antagonists.EBI
Vitae Pharmaceuticals
Design and synthesis of novel tamoxifen analogues that avoid CYP2D6 metabolism.EBI
German University in Cairo
Tetrahydroisoquinoline Phenols: Selective Estrogen Receptor Downregulator Antagonists with Oral Bioavailability in Rat.EBI
AstraZeneca
Selective Human Estrogen Receptor Partial Agonists (ShERPAs) for Tamoxifen-Resistant Breast Cancer.EBI
University of Illinois at Chicago
Peptide-based inhibitors of protein-protein interactions.EBI
Wroclaw University of Technology
Optimization of a Novel Binding Motif to (E)-3-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic Acid (AZD9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist.EBI
AstraZeneca
Discovery and Development of the Aryl O-Sulfamate Pharmacophore for Oncology and Women's Health.EBI
University of Bath
Structural development of stabilized helical peptides as inhibitors of estrogen receptor (ER)-mediated transcription.EBI
National Institute of Health Sciences
Novel Bioactive Hybrid Compound Dual Targeting Estrogen Receptor and Histone Deacetylase for the Treatment of Breast Cancer.EBI
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University)
Synthesis and evaluation of tamoxifen derivatives with a long alkyl side chain as selective estrogen receptor down-regulators.EBI
National Institute of Health Sciences
Identification of GDC-0810 (ARN-810), an Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) that Demonstrates Robust Activity in Tamoxifen-Resistant Breast Cancer Xenografts.EBI
Seragon Pharmaceuticals
Discovery of benzimidazole oxazolidinediones as novel and selective nonsteroidal mineralocorticoid receptor antagonists.EBI
Merck Research Laboratories
Investigation of (E)-3-[4-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators.EBI
AstraZeneca
Design and synthesis of norendoxifen analogues with dual aromatase inhibitory and estrogen receptor modulatory activities.EBI
Purdue University
2-Aryl-3-methyloctahydrophenanthrene-2,3,7-triols as potent dissociated glucocorticoid receptor agonists.EBI
TBA
Highly selective salicylketoxime-based estrogen receptor▀ agonists display antiproliferative activities in a glioma model.EBI
Universit£ di Pisa
3-alkoxy-pyrrolo[1,2-b]pyrazolines as selective androgen receptor modulators with ideal physicochemical properties for transdermal administration.EBI
Novartis Institutes for BioMedical Research
Discovery of acylurea isosteres of 2-acylaminothiadiazole in the azaxanthene series of glucocorticoid receptor agonists.EBI
Bristol-Myers Squibb Co.
▀-Lactam estrogen receptor antagonists and a dual-targeting estrogen receptor/tubulin ligand.EBI
Trinity College
Identification of the first inverse agonist of retinoid-related orphan receptor (ROR) with dual selectivity for ROR▀ and ROR┐t.EBI
Phenex Pharmaceuticals AG
Novel estrogen receptor (ER) modulators containing various hydrophobic bent-core structures.EBI
Tohoku Pharmaceutical University
Influence of the length and positioning of the antiestrogenic side chain of endoxifen and 4-hydroxytamoxifen on gene activation and growth of estrogen receptor positive cancer cells.EBI
Georgetown University
The discovery of potent and selective non-steroidal glucocorticoid receptor modulators, suitable for inhalation.EBI
AstraZeneca
Identification of (R)-6-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxynicotinic acid, a highly potent and selective nonsteroidal mineralocorticoid receptor antagonist.EBI
Pfizer Inc
Mineralocorticoid receptor antagonists: identification of heterocyclic amide replacements in the oxazolidinedione series.EBI
Merck Research Laboratories
Triaryl-substituted Schiff bases are high-affinity subtype-selective ligands for the estrogen receptor.EBI
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University)
Design and synthesis of silicon-containing steroid sulfatase inhibitors possessing pro-estrogen antagonistic character.EBI
The University of Tokyo
Thiophene-core estrogen receptor ligands having superagonist activity.EBI
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University)
"True" antiandrogens-selective non-ligand-binding pocket disruptors of androgen receptor-coactivator interactions: novel tools for prostate cancer.EBI
Trinity College
Synthesis and biochemical characterization of a series of 17a-perfluoroalkylated estradiols as selective ligands for estrogen receptora.EBI
Charles University in Prague
QSAR of estrogen receptor modulators: exploring selectivity requirements for ER(alpha) versus ER(beta) binding of tetrahydroisoquinoline derivatives using E-state and physicochemical parameters.EBI
University of Calcutta
Effects of C2-alkylation, N-alkylation, and N,N'-dialkylation on the stability and estrogen receptor interaction of (4R,5S)/(4S,5R)-4,5-bis(4-hydroxyphenyl)-2-imidazolines.EBI
Free University of Berlin
(4R,5S)/(4S,5R)-4,5-Bis(4-hydroxyphenyl)-2-imidazolines: ligands for the estrogen receptor with a novel binding mode.EBI
Free University of Berlin
Novel progesterone receptor modulators: 4-aryl-phenylsulfonamides.EBI
Pfizer Inc
Influence of chlorine or fluorine substitution on the estrogenic properties of 1-alkyl-2,3,5-tris(4-hydroxyphenyl)-1H-pyrroles.EBI
Freie Universit£t Berlin
Syntheses and biological activities of sulfoximine-based acyclic triaryl olefins.EBI
RWTH Aachen University
Discovery and structure-activity analysis of selective estrogen receptor modulators via similarity-based virtual screening.EBI
East China University of Science and Technology
Hydrophobic Interactions Improve Selectivity to ERa for Ben-zothiophene SERMs.EBI
TBA
Synthesis and evaluation of 11ß-(4-substituted phenyl) estradiol analogs: transition from estrogen receptor agonists to antagonists.EBI
Northeastern University
Identification and structure-activity relationships of a novel series of estrogen receptor ligands based on 7-thiabicyclo[2.2.1]hept-2-ene-7-oxide.EBI
Wuhan University
Recent advances in the synthesis of raloxifene: a selective estrogen receptor modulator.EBI
Torrey Pines Institute for Molecular Studies
Dimethyl-diphenyl-propanamide Derivatives As Nonsteroidal Dissociated Glucocorticoid Receptor Agonists.EBI
Bristol-Myers Squibb Co.
Identification of diaryl ether-based ligands for estrogen-related receptora as potential antidiabetic agents.EBI
Johnson & Johnson Pharmaceutical Research and Development LLC
Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity relaEBI
Pfizer Inc
2-phenyl-1-[4-(2-piperidine-1-yl-ethoxy)benzyl]-1H-benzimidazoles as ligands for the estrogen receptor: synthesis and pharmacological evaluation.EBI
Freie Universit£t Berlin
Discovery of (3S,3aR)-2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic acid (PF-3882845), an orally efficacious mineralocorticoid receptor (MR) antagonist for hypertension and nephropathy.EBI
Pfizer Inc
Aromatic beta-amino-ketone derivatives as novel selective non-steroidal progesterone receptor antagonists.EBI
Chinese Academy of Sciences
Discovery of potent ligands for estrogen receptor beta by structure-based virtual screening.EBI
East China University of Science and Technology
The lecanindoles, nonsteroidal progestins from the terrestrial fungus Verticillium lecanii 6144.EBI
Wyeth Research
Structure-based design, synthesis and in vitro characterization of potent 17beta-hydroxysteroid dehydrogenase type 1 inhibitors based on 2-substitutions of estrone and D-homo-estrone.EBI
Institute of Experimental Genetics
Synthesis and biological evaluation of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) inhibitors based on a thieno[2,3-d]pyrimidin-4(3H)-one core.EBI
FIN-00014 University of Helsinki
Discovery of novel dihydro-9,10-ethano-anthracene carboxamides as glucocorticoid receptor modulators.EBI
Bristol-Myers Squibb Co.
1,5-Dihydro-benzo[e][1,4]oxazepin-2(1H)-ones containing a 7-(5'-cyanopyrrol-2-yl) group as nonsteroidal progesterone receptor modulators.EBI
Wyeth Research
Estrogenic and anticarcinogenic properties of kurarinone, a lavandulyl flavanone from the roots of Sophora flavescens.EBI
Ghent University
Design, synthesis, and SAR of new pyrrole-oxindole progesterone receptor modulators leading to 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile (WAY-255348).EBI
Wyeth Research
Monoaryl-substituted salicylaldoximes as ligands for estrogen receptor beta.EBI
Universita di Pisa
Androstene-3,5-dienes as ER-beta selective SERMs.EBI
Merck Research Laboratories
Bridged androstenediol analogs as ER-beta selective SERMs.EBI
Merck Research Laboratories
Design, synthesis, and estrogenic activity of a novel estrogen receptor modulator--a hybrid structure of 17beta-estradiol and vitamin E in hippocampal neurons.EBI
University of Southern California
Androstenediol analogs as ER-beta-selective SERMs.EBI
Merck Research Laboratories
A selective estrogen receptor modulator for the treatment of hot flushes.EBI
Eli Lilly and Company
Structure-based virtual screening for plant-based ERbeta-selective ligands as potential preventative therapy against age-related neurodegenerative diseases.EBI
University of Southern California
Liver-selective glucocorticoid antagonists: a novel treatment for type 2 diabetes.EBI
Abbott Laboratories
De novo design, synthesis, and evaluation of novel nonsteroidal phenanthrene ligands for the estrogen receptor.EBI
SignalGene Inc.
Discovery of potent, nonsteroidal, and highly selective glucocorticoid receptor antagonists.EBI
Pfizer Inc
Synthesis and structure-activity relationship of 3-arylbenzoxazines as selective estrogen receptor beta agonists.EBI
Bristol-Myers Squibb Pharmaceutical Research Institute
Synthesis and biological evaluation of novel, selective, nonsteroidal glucocorticoid receptor antagonists.EBI
Abbott Laboratories
6-(2-adamantan-2-ylidene-hydroxybenzoxazole)-O-sulfamate: a potent non-steroidal irreversible inhibitor of human steroid sulfatase.EBI
Novartis Forschungsinstitut
Development of progesterone receptor antagonists from 1,2-dihydrochromeno[3,4-f]quinoline agonist pharmacophore.EBI
Ligand Pharmaceuticals
Synthesis and biological activity of 5-methylidene 1,2-dihydrochromeno[3,4-f]quinoline derivatives as progesterone receptor modulators.EBI
Ligand Pharmaceuticals
Phytoestrogens from the roots of Polygonum cuspidatum (Polygonaceae): structure-requirement of hydroxyanthraquinones for estrogenic activity.EBI
Kyoto Pharmaceutical University
Nonsteroidal progesterone receptor antagonists based on 6-thiophenehydroquinolines.EBI
Ligand Pharmaceuticals
Synthesis and estrogenic activities of novel 7-thiosubstituted estratriene derivatives.EBI
Wyeth-Ayerst Research
Diarylpropionitrile (DPN) enantiomers: synthesis and evaluation of estrogen receptorß-selective ligands.EBI
University of Illinois
Investigation of the diastereomerism of dihydrobenzoxathiin SERMs for ER alpha by molecular modeling.EBI
Zhejiang University
Recent progress in synthesis and bioactivity studies of indolizines.EBI
University of Botswana
Azaxanthene based selective glucocorticoid receptor modulators: design, synthesis, and pharmacological evaluation of (S)-4-(5-(1-((1,3,4-thiadiazol-2-yl)amino)-2-methyl-1-oxopropan-2-yl)-5H-chromeno[2,3-b]pyridin-2-yl)-2-fluoro-N,N-dimethylbenzamide (BMS-776532) and its methylene homologue (BMS-791EBI
Bristol-Myers Squibb Co.
Sulfonamides as selective oestrogen receptorß agonists.EBI
Pfizer Inc
DNA site-specific N3-adenine methylation targeted to estrogen receptor-positive cells.EBI
University of North Carolina at Wilmington
Selective and potent agonists for estrogen receptor beta derived from molecular refinements of salicylaldoximes.EBI
Universit£ di Pisa
Estrogenic activity of chemical constituents from Tephrosia candida.EBI
National Research Centre
Design and evaluation of fragment-like estrogen receptor tetrahydroisoquinoline ligands from a scaffold-detection approach.EBI
Technische Universiteit Eindhoven
Synthesis, modification, and evaluation of (R)-de-O-methyllasiodiplodin and analogs as nonsteroidal antagonists of mineralocorticoid receptor.EBI
Chinese Academy of Sciences
Novel approaches for targeting thymidylate synthase to overcome the resistance and toxicity of anticancer drugs.EBI
Institute of Theoretical Studies gGmbH
Spiroindolones, a potent compound class for the treatment of malaria.EBI
Swiss Tropical and Public Health Institute
A mutant selective anti-estrogen is a pure antagonist on EREs and AP-1 response elements.EBI
University of Delaware
Virtual and biomolecular screening converge on a selective agonist for GPR30.EBI
University of New Mexico Health Sciences Center
Effects of 7-O substitutions on estrogenic and anti-estrogenic activities of daidzein analogues in MCF-7 breast cancer cells.EBI
Xavier University of Louisiana
Genomic action of permanently charged tamoxifen derivatives via estrogen receptor-alpha.EBI
Instituto Politécnico Nacional 2508
Bioactivity-guided mapping and navigation of chemical space.EBI
Institut für Molekulare Physiologie
Synthesis and pharmacological validation of a novel series of non-steroidal FXR agonists.EBI
Phenex Pharmaceuticals AG
New estrogenic compounds isolated from Broussonetia kazinoki.EBI
Sookmyung Women's University
Rational design of a topical androgen receptor antagonist for the suppression of sebum production with properties suitable for follicular delivery.EBI
Pfizer Inc
Optimisation of a pyrazole series of progesterone antagonists; Part 1.EBI
Pfizer Inc
Stereochemical requirements for the mineralocorticoid receptor antagonist activity of dihydropyridines.EBI
Pfizer Inc
Synthesis and evaluation of 17alpha-arylestradiols as ligands for estrogen receptor alpha and beta.EBI
Academy of Sciences of the Czech Republic
LXXLL peptide mimetics as inhibitors of the interaction of vitamin D receptor with coactivators.EBI
The University of Tokyo
Isoflavonoids from Erythrina poeppigiana: evaluation of their binding affinity for the estrogen receptor.EBI
University of Athens
Identification and structure-activity relationships of chromene-derived selective estrogen receptor modulators for treatment of postmenopausal symptoms.EBI
Johnson & Johnson Pharmaceutical Research & Development LLC
Click synthesis of estradiol-cyclodextrin conjugates as cell compartment selective estrogens.EBI
University of Illinois at Chicago
Coumarins as novel 17beta-hydroxysteroid dehydrogenase type 3 inhibitors for potential treatment of prostate cancer.EBI
Sumitomo Chemical Co., Ltd
Bibenzyl- and stilbene-core compounds with non-polar linker atom substituents as selective ligands for estrogen receptor beta.EBI
University of Illinois
Phenethyl pyridines with non-polar internal substituents as selective ligands for estrogen receptor beta.EBI
University of Illinois
Design, synthesis, and biological evaluation of 16-substituted 4-azasteroids as tissue-selective androgen receptor modulators (SARMs).EBI
Merck Research Laboratories
Steroidal bivalent ligands for the estrogen receptor: design, synthesis, characterization and binding affinities.EBI
University of Illinois at Urbana-Champaign
Synthesis and evaluation of aryl-substituted diarylpropionitriles, selective ligands for estrogen receptor beta, as positron-emission tomographic imaging agents.EBI
Institute of Radiological and Medical Sciences
Biphenyl C-cyclopropylalkylamides: New scaffolds for targeting estrogen receptor beta.EBI
University of Pittsburgh
Octahydrophenanthrene-2,7-diol analogues as dissociated glucocorticoid receptor agonists: discovery and lead exploration.EBI
Pfizer Inc
Structural evolutions of salicylaldoximes as selective agonists for estrogen receptor beta.EBI
Universita di Pisa
Analogs of methyl-piperidinopyrazole (MPP): antiestrogens with estrogen receptor alpha selective activity.EBI
University of Illinois
Synthesis and biological evaluation of guanylhydrazone coactivator binding inhibitors for the estrogen receptor.EBI
University of Illinois at Urbana-Champaign
Cobalt-alkyne complexes with imidazoline ligands as estrogenic carriers: synthesis and pharmacological investigations.EBI
Freie Universitat Berlin
Synthesis, biological evaluation, structural-activity relationship, and docking study for a series of benzoxepin-derived estrogen receptor modulators.EBI
Trinity College
Blocking estrogen signaling after the hormone: pyrimidine-core inhibitors of estrogen receptor-coactivator binding.EBI
University of Illinois at Urbana-Champaign
Promising core structure for nuclear receptor ligands: design and synthesis of novel estrogen receptor ligands based on diphenylamine skeleton.EBI
Tohoku Pharmaceutical University
Synthesis of 3-alkyl naphthalenes as novel estrogen receptor ligands.EBI
GlaxoSmithKline
Recent developments in fragment-based drug discovery.EBI
Astex Therapeutics Ltd
Bioactive compounds from Peperomia pellucida.EBI
Chinese Academy of Sciences
Isoflavonoids with antiestrogenic activity from Millettia pachycarpa.EBI
Meijo University
Isolation and structure elucidation of an isoflavone and a sesterterpenoic acid from Henriettella fascicularis.EBI
Université de Lausanne
Three new arylobenzofurans from Onobrychis ebenoides and evaluation of their binding affinity for the estrogen receptor.EBI
University of Athens
(S)-N-{3-[1-cyclopropyl-1-(2,4-difluoro-phenyl)-ethyl]-1H-indol-7-yl}-methanesulfonamide: a potent, nonsteroidal, functional antagonist of the mineralocorticoid receptor.EBI
Eli Lilly and Company
Target specific virtual screening: optimization of an estrogen receptor screening platform.EBI
Trinity College
Estrogen receptor dependent inhibitors of NF-kappaB transcriptional activation-1 synthesis and biological evaluation of substituted 2-cyanopropanoic acid derivatives: pathway selective inhibitors of NF-kappaB, a potential treatment for rheumatoid arthritis.EBI
Wyeth Research
Aza analogues of equol: novel ligands for estrogen receptor beta.EBI
Chinese Academy of Sciences
Bicyclo[2.2.2]octanes: close structural mimics of the nuclear receptor-binding motif of steroid receptor coactivators.EBI
University of Illinois
Structure-activity relationships of SERMs optimized for uterine antagonism and ovarian safety.EBI
Eli Lilly and Company
Synthesis, characterization, and estrogen receptor binding affinity of flavone-, indole-, and furan-estradiol conjugates.EBI
Université de Sherbrooke
Estrogen receptor ligands. Part 16: 2-Aryl indoles as highly subtype selective ligands for ERalpha.EBI
Merck Research Laboratories
Synthesis, structure, and estrogenic activity of 4-amino-3-(2-methylbenzyl)coumarins on human breast carcinoma cells.EBI
Equipe de Chimie Thérapeutique
ERbeta ligands. Part 5: synthesis and structure-activity relationships of a series of 4'-hydroxyphenyl-aryl-carbaldehyde oxime derivatives.EBI
Wyeth Research
Estrogen receptor beta ligands: design and synthesis of new 2-phenyl-isoindole-1,3-diones.EBI
Wyeth Research
A structure-guided approach to an orthogonal estrogen-receptor-based gene switch activated by ligands suitable for in vivo studies.EBI
IRBM (Merck Research Laboratories Rome)
Synthesis of anthranylaldoxime derivatives as estrogen receptor ligands and computational prediction of binding modes.EBI
Università di Pisa
Tetrahydrofluorenones with conformationally restricted side chains as selective estrogen receptor beta ligands.EBI
Merck Research Laboratories
Triazolo-tetrahydrofluorenones as selective estrogen receptor beta agonists.EBI
Merck Research Laboratories
Estrogen receptor beta-subtype selective tetrahydrofluorenones: use of a fused pyrazole as a phenol bioisostere.EBI
Merck Research Laboratories
Novel chromene-derived selective estrogen receptor modulators useful for alleviating hot flushes and vaginal dryness.EBI
Johnson & Johnson Pharmaceutical Research & Development LLC
The discovery of tetrahydrofluorenones as a new class of estrogen receptor beta-subtype selective ligands.EBI
Merck Research Laboratories
6H-Benzo[c]chromen-6-one derivatives as selective ERbeta agonists.EBI
Merck Research Laboratories
Substituted 4-hydroxyphenyl sulfonamides as pathway-selective estrogen receptor ligands.EBI
Wyeth Research
Estrogen receptor beta selective ligands: discovery and SAR of novel heterocyclic ligands.EBI
Pfizer Inc
Estrogen receptor ligands. Part 14: application of novel antagonist side chains to existing platforms.EBI
Merck Research Laboratories
Differential response of estrogen receptor subtypes to 1,3-diarylindene and 2,3-diarylindene ligands.EBI
University of California
ERbeta ligands. Part 4: Synthesis and structure-activity relationships of a series of 2-phenylquinoline derivatives.EBI
Wyeth Research
ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity.EBI
Wyeth Research
Novel ketal ligands for the glucocorticoid receptor: in vitro and in vivo activity.EBI
Merck Research Laboratories
Benzothieno[3,2-b]indole derivatives as potent selective estrogen receptor modulators.EBI
Chinese Academy of Sciences
Estrogen receptor ligands: design and synthesis of new 2-arylindene-1-ones.EBI
Wyeth Research
Estrogen receptor ligands. Part 10: Chromanes: old scaffolds for new SERAMs.EBI
Merck Research Laboratories
Benzothiophenes containing a piperazine side chain as selective ligands for the estrogen receptor alpha and their bioactivities in vivo.EBI
Chinese Academy of Sciences
Structure-activity relationships and sub-type selectivity in an oxabicyclic estrogen receptor alpha/beta agonist scaffold.EBI
Ligand Pharmaceuticals
Estrogen receptor ligands. Part 11: Synthesis and activity of isochromans and isothiochromans.EBI
Merck Research Laboratories
Investigations on the effects of basic side chains on the hormonal profile of (4R,5S)/(4S,5R)-4,5-bis(4-hydroxyphenyl)-2-imidazolines.EBI
Free University of Berlin
Synthesis and activity of substituted 4-(indazol-3-yl)phenols as pathway-selective estrogen receptor ligands useful in the treatment of rheumatoid arthritis.EBI
Wyeth Research
Estrogen receptor ligands. Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrrolidine side chains and linkers.EBI
Merck Research Laboratories
Searching for an ideal SERM: Mining tamoxifen structure-activity relationships.EBI
University of Texas at Austin
Heterodimeric GW7604 Derivatives: Modification of the Pharmacological Profile by Additional Interactions at the Coactivator Binding Site.EBI
University of Innsbruck
Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands.EBI
Wyeth Research
Activable Targeted Protein Degradation Platform Based on Light-triggered Singlet Oxygen.EBI
Wuhan University of Science and Technology
7-Substituted 2-phenyl-benzofurans as ER beta selective ligands.EBI
Wyeth Research
Balanced dual acting compounds targeting aromatase and estrogen receptor ? as an emerging therapeutic opportunity to counteract estrogen responsive breast cancer.EBI
Alma Mater Studiorum-University of Bologna
Estrogen receptor ligands. Part 8: Dihydrobenzoxathiin SERAMs with heteroatom-substituted side chains.EBI
Merck Research Laboratories
Estrogen receptor ligands. Part 7: Dihydrobenzoxathiin SERAMs with bicyclic amine side chains.EBI
Merck Research Laboratories
Estrogen receptor ligands. Part 6: Synthesis and binding affinity of dihydrobenzodithiins.EBI
Merck Research Laboratories
Estrogen receptor ligands. Part 5: The SAR of dihydrobenzoxathiins containing modified basic side chains.EBI
Merck Research Laboratories
Development of novel tetrahydroisoquinoline-hydroxamate conjugates as potent dual SERDs/HDAC inhibitors for the treatment of breast cancer.EBI
China Pharmaceutical University
Dynamics-Based Discovery of Novel, Potent Benzoic Acid Derivatives as Orally Bioavailable Selective Estrogen Receptor Degraders for ER?+ Breast Cancer.EBI
Nanjing University of Chinese Medicine
Mechanistic Investigation of Site-specific DNA Methylating Agents Targeting Breast Cancer Cells.EBI
University of North Carolina Wilmington
Estrogen receptor ligands. Part 4: The SAR of the syn-dihydrobenzoxathiin SERAMs.EBI
Merck Research Laboratories
Tetrahydroisoquinolines as subtype selective estrogen agonists/antagonists.EBI
Pfizer Inc
Estrogen receptor ligands. Part 3: The SAR of dihydrobenzoxathiin SERMs.EBI
Merck Research Laboratories
Estrogen receptor ligands. II. Discovery of benzoxathiins as potent, selective estrogen receptor alpha modulators.EBI
Merck Research Laboratories
Estrogen receptor ligands. Part 1: The discovery of flavanoids with subtype selectivity.EBI
Merck Research Laboratories
Comparison of 2-phenylspiroindenes and 2-phenylspiroindenediones as estrogen receptor ligands--modeling and binding data don't agree!EBI
Merck Research Laboratories
Bispecific Estrogen Receptor ? Degraders Incorporating Novel Binders Identified Using DNA-Encoded Chemical Library Screening.EBI
X-Chem Inc.
GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer.EBI
Genentech
Discovery of BMS-986318, a Potent Nonbile Acid FXR Agonist for the Treatment of Nonalcoholic Steatohepatitis.EBI
Bristol-Myers Squibb
Discovery of chiral N-2'-aryletheryl-1'-alkoxy-ethyl substituted arylisoquinolones with anti-inflammatory activity from the nucleophilic addition reactions of the thiophenols and oxazolinium.EBI
Chinese Academy of Sciences
Novel hybrid conjugates with dual estrogen receptor ? degradation and histone deacetylase inhibitory activities for breast cancer therapy.EBI
Wuhan University
B-ring unsaturated estrogens: biological evaluation of 17alpha-Dihydroequilein and novel B-Nor-6-thiaequilenins as tissue selective estrogens.EBI
Eli Lilly and Company
Utility of boron clusters for drug design. Relation between estrogen receptor binding affinity and hydrophobicity of phenols bearing various types of carboranyl groups.EBI
Tohoku Pharmaceutical University
Novel estrogen receptor ligands based on an anthranylaldoxime structure: role of the phenol-type pseudocycle in the binding process.EBI
Università di Pisa
Discovery of GNE-502 as an orally bioavailable and potent degrader for estrogen receptor positive breast cancer.EBI
Genentech
Identification of"latent hits" in compound screening collections.EBI
Organon Laboratories Ltd
Constrained phytoestrogens and analogues as ERbeta selective ligands.EBI
Wyeth Research
A novel estrogen receptor ligand template.EBI
Bayer Corporation
Tetrahydroquinoline-based selective estrogen receptor modulators (SERMs).EBI
Eli Lilly and Company
Synthesis and estrogen receptor binding affinities of 7-hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-ones containing a basic side chain.EBI
The Ohio State University
Antiestrogens and selective estrogen receptor modulators as multifunctional medicines. 2. Clinical considerations and new agents.EBI
The Feinberg School of Medicine of Northwestern University
Addition of Fluorine and a Late-Stage Functionalization (LSF) of the Oral SERD AZD9833.EBI
AstraZeneca
Synthesis and evaluation of 17?-triazolyl and 9?-cyano derivatives of estradiol.EBI
Marquette University
2-Phenylspiroindenes: a novel class of selective estrogen receptor modulators (SERMs).EBI
Merck Research Laboratories
Machine Learning on DNA-Encoded Libraries: A New Paradigm for Hit Finding.EBI
Google Research Applied Science, Mountain View, California 94043, United States.
A new series of estrogen receptor modulators that display selectivity for estrogen receptor beta.EBI
GlaxoSmithKline
Investigations on estrogen receptor binding. The estrogenic, antiestrogenic, and cytotoxic properties of C2-alkyl-substituted 1,1-bis(4-hydroxyphenyl)-2-phenylethenes.EBI
Free University of Berlin
Synthesis and structure-activity relationships of 1-benzylindane derivatives as selective agonists for estrogen receptor beta.EBI
Kissei Pharmaceutical Co., Ltd.
Synthesis of Triphenylethylene Bisphenols as Aromatase Inhibitors That Also Modulate Estrogen Receptors.EBI
Purdue University
Sulfoximines as Rising Stars in Modern Drug Discovery? Current Status and Perspective on an Emerging Functional Group in Medicinal Chemistry.EBI
Endotherm GmbH
An orally available inverse agonist of estrogen-related receptor gamma showed expanded efficacy for the radioiodine therapy of poorly differentiated thyroid cancer.EBI
Daegu-Gyeongbuk Medical Innovation Foundation
Design, syntheses and evaluations of novel indole derivatives as orally selective estrogen receptor degraders (SERD).EBI
Luoxin Pharmaceutical (Shanghai) Co., Ltd.
Synthesis of a novel fluorescent probe for estrogen receptor.EBI
Abbott Laboratories
Discovery of bazedoxifene analogues targeting glycoprotein 130.EBI
China Pharmaceutical University
Development of bivalent triarylalkene- and cyclofenil-derived dual estrogen receptor antagonists and downregulators.EBI
University of Innsbruck
Insights of a Lead Optimization Study and Biological Evaluation of Novel 4-Hydroxytamoxifen Analogs as Estrogen-Related Receptor ? (ERR?) Inverse Agonists.EBI
Daegu-Gyeongbuk Medical Innovation Foundation
Discovery of 3?,7?,11?-Trihydroxy-6?-ethyl-5?-cholan-24-oic Acid (TC-100), a Novel Bile Acid as Potent and Highly Selective FXR Agonist for Enterohepatic Disorders.EBI
TES Pharma S.r.l.
Discovery of AZD9833, a Potent and Orally Bioavailable Selective Estrogen Receptor Degrader and Antagonist.EBI
AstraZeneca
Estrogen Receptor Degrading PROTACS for the Treatment of Breast Cancer.EBI
Usona Institute
Estrogen receptor-beta potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues.EBI
University of Illinois
Screening and Reverse-Engineering of Estrogen Receptor Ligands as Potent Pan-Filovirus Inhibitors.EBI
University of Illinois at Chicago
Furans with basic side chains: synthesis and biological evaluation of a novel series of antagonists with selectivity for the estrogen receptor alpha.EBI
University of Illinois
2-Amino-4,6-diarylpyridines as novel ligands for the estrogen receptor.EBI
Glaxo Wellcome Research and Development
Optimisation of estrogen receptor subtype-selectivity of a 4-Aryl-4H-chromene scaffold previously identified by virtual screening.EBI
Trinity College
Bisphenol AF: Halogen bonding effect is a major driving force for the dual ER?-agonist and ER?-antagonist activities.EBI
Kyushu University
Design, synthesis, and preclinical characterization of novel, highly selective indole estrogens.EBI
Wyeth-Ayerst Research
Discovery of GNE-149 as a Full Antagonist and Efficient Degrader of Estrogen Receptor alpha for ER+ Breast Cancer.EBI
Genentech
Phosphine boranes as less hydrophobic building blocks than alkanes and silanes: Structure-property relationship and estrogen-receptor-modulating potency of 4-phosphinophenol derivatives.EBI
the University of Tokyo
HOPPI-NMR: Hot-Peptide-Based Screening Assay for Inhibitors of Protein-Protein Interactions by NMR.EBI
University of Naples "Federico II"
Antiausterity Activity of Secondary Metabolites from the Roots of EBI
University of Innsbruck
Non-canonical modulators of nuclear receptors.EBI
Vitae Pharmaceuticals, Inc.
Fulvestrant-3 Boronic Acid (ZB716): An Orally Bioavailable Selective Estrogen Receptor Downregulator (SERD).EBI
Xavier University of Louisiana
Unexpected equivalent potency of a constrained chromene enantiomeric pair rationalized by co-crystal structures in complex with estrogen receptor alpha.EBI
Genentech Inc.
Discovery of Potent, Selective, and Orally Bioavailable Estrogen-Related Receptor-? Inverse Agonists To Restore the Sodium Iodide Symporter Function in Anaplastic Thyroid Cancer.EBI
Daegu-Gyeongbuk Medical Innovation Foundation
Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis.EBI
Genomics Institute of the Novartis Research Foundation (GNF)
Structure-based drug design, synthesis, Inávitro, and Inávivo biological evaluation of indole-based biomimetic analogs targeting estrogen receptor-? inhibition.EBI
The British University in Egypt
Estrogen signaling: An emanating therapeutic target for breast cancer treatment.EBI
Indian Institute of Technology (BHU)
Carboxylic acid analogues of tamoxifen: (Z)-2-[p-(1, 2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine. Estrogen receptor affinity and estrogen antagonist effects in MCF-7 cells.EBI
University of Georgia
Structure-activity relationship study of estrogen receptor down-regulators with a diphenylmethane skeleton.EBI
the University of Tokyo
Discovery of a C-8 hydroxychromene as a potent degrader of estrogen receptor alpha with improved rat oral exposure over GDC-0927.EBI
Genentech Inc.
Nonsteroidal androgen receptor agonists based on 4-(trifluoromethyl)-2H-pyrano[3,2-g]quinolin-2-one.EBI
Ligand Pharmaceuticals
Potent estrogenic agonists bearing dicarba-closo-dodecaborane as a hydrophobic pharmacophore.EBI
University of Tokyo
Selective Estrogen Receptor Degraders for the Potential Treatment of Cancer.EBI
Usona Institute
Cereblon Based Immunomodulatory Therapeutics.EBI
Usona Institute
A-C Estrogens as Potent and Selective Estrogen Receptor-Beta Agonists (SERBAs) to Enhance Memory Consolidation under Low-Estrogen Conditions.EBI
Concordia University Wisconsin
Tricyclic Indazoles-A Novel Class of Selective Estrogen Receptor Degrader Antagonists.EBI
AstraZeneca
Boron in drug design: Recent advances in the development of new therapeutic agents.EBI
S£o Paulo State University
Nitric Oxide-Releasing Selective Estrogen Receptor Modulators: A Bifunctional Approach to Improve the Therapeutic Index.EBI
Helmholtz-Zentrum Dresden-Rossendorf
Design and Synthesis of Basic Selective Estrogen Receptor Degraders for Endocrine Therapy Resistant Breast Cancer.EBI
University of Illinois at Chicago
Validation of Phosphodiesterase-10 as a Novel Target for Pulmonary Arterial Hypertension via Highly Selective and Subnanomolar Inhibitors.EBI
Sun Yat-sen University
New nonsteroidal androgen receptor modulators based on 4-(trifluoromethyl)-2(1H)-pyrrolidino[3,2-g] quinolinone.EBI
Ligand Pharmaceuticals
Exploring the PROTAC degron candidates: OBHSA with different side chains as novel selective estrogen receptor degraders (SERDs).EBI
Wuhan University
Maximizing ER-? Degradation Maximizes Activity in a Tamoxifen-Resistant Breast Cancer Model: Identification of GDC-0927.EBI
Seragon Pharmaceuticals
Selective estrogen receptor degraders with novel structural motifs induce regression in a tamoxifen-resistant breast cancer xenograft.EBI
Seragon Pharmaceuticals, Inc.
Synthesis and biological evaluation of 3-aryl-quinolin derivatives as anti-breast cancer agents targeting ER? and VEGFR-2.EBI
China Pharmaceutical University
Structure-Based and Property-Driven Optimization of EBI
Global Discovery Chemistry
Discovery of 6-(2,4-Dichlorophenyl)-5-[4-[(3EBI
Sanofi
Myrmenaphthol A, Isolated from a Hawaiian Sponge of the Genus EBI
University of Hawaii at Manoa
Building Bridges in a Series of Estrogen Receptor Degraders: An Application of Metathesis in Medicinal Chemistry.EBI
AstraZeneca
PROTAC-Mediated Degradation of Estrogen Receptor in the Treatment of Cancer.EBI
Usona Institute
Symmetric 4,4'-(piperidin-4-ylidenemethylene)bisphenol derivatives as novel tunable estrogen receptor (ER) modulators.EBI
Tohoku Pharmaceutical University
Structural features underlying raloxifene's biophysical interaction with bone matrix.EBI
Lilly Research Laboratories
Design, synthesis and evaluation of antiestrogen and histone deacetylase inhibitor molecular hybrids.EBI
McGill University
4,4'-Unsymmetrically substituted 3,3'-biphenyl alpha helical proteomimetics as potential coactivator binding inhibitors.EBI
Northeastern University
Probing the human estrogen receptor-? binding requirements for phenolic mono- and di-hydroxyl compounds: a combined synthesis, binding and docking study.EBI
Marquette University
3D-QSAR using pharmacophore-based alignment and virtual screening for discovery of novel MCF-7 cell line inhibitors.EBI
University of Siena
Histone deacetylase inhibitors equipped with estrogen receptor modulation activity.EBI
Georgia Institute of Technology
Discovery of natural estrogen receptor modulators with structure-based virtual screening.EBI
East China University of Science and Technology
Discovery of novel quinoline-based estrogen receptor ligands using peptide interaction profiling.EBI
GlaxoSmithKline Research & Development
Benzoxepin-derived estrogen receptor modulators: a novel molecular scaffold for the estrogen receptor.EBI
Trinity College Dublin
Benzothiophene and naphthalene derived constrained SERMs.EBI
Eli Lilly and Company
Synthesis and biological evaluation of stilbene-based pure estrogen antagonists.EBI
Universit£t Regensburg
Design, synthesis, and biological evaluation of doxorubicin-formaldehyde conjugates targeted to breast cancer cells.EBI
University of Colorado
Design, synthesis, and in vitro biological evaluation of small molecule inhibitors of estrogen receptor alpha coactivator binding.EBI
University of Illinois
Antiestrogenically active 1,1,2-tris(4-hydroxyphenyl)alkenes without basic side chain: synthesis and biological activity.EBI
Free University of Berlin
Discovery and preclinical characterization of (+)-3-[4-(1- piperidinoethoxy)phenyl]spiro[indene- 1,1'-indane]-5,5'-diol hydrochloride: a promising nonsteroidal estrogen receptor agonist for hot flush.EBI
Dainippon Pharmaceutical Co., Ltd.
Flexible estrogen receptor modulators: design, synthesis, and antagonistic effects in human MCF-7 breast cancer cells.EBI
Trinity College
Photochemical synthesis of N-arylbenzophenanthridine selective estrogen receptor modulators (serms).EBI
Eli Lilly and Company
Cytotoxicity and antiestrogenicity of a novel series of basic diphenylethylenes.EBI
Universit£ de Versailles/St. Quentin-en-Yvelines
Synthesis and biological evaluation of 4-(hydroxyalkyl)estradiols and related compounds.EBI
Ohio State University
Structure-activity relationships of selective estrogen receptor modulators: modifications to the 2-arylbenzothiophene core of raloxifene.EBI
Eli Lilly and Company
Steroidal affinity labels of the estrogen receptor. 3. Estradiol 11 beta-n-alkyl derivatives bearing a terminal electrophilic group: antiestrogenic and cytotoxic properties.EBI
INSERM Unit� 439
(S)-(+)-4-[7-(2,2-dimethyl-1-oxopropoxy)-4-methyl-2-[4-[2-(1-piperidinyl)-ethoxy]phenyl]-2H-1-benzopyran-3-yl]-phenyl 2,2-dimethylpropanoate (EM-800): a highly potent, specific, and orally active nonsteroidal antiestrogen.EBI
Le Centre Hospitalier Universitaire de Qu£bec
2-(Hydroxyalkyl)estradiols: synthesis and biological evaluation.EBI
Ohio State University
Novel 5-aminoflavone derivatives as specific antitumor agents in breast cancer.EBI
Kyowa Hakko Kogyo Co., Ltd
Synthesis and evaluation of 4-cycloheptylphenols as selective Estrogen receptor-? agonists (SERBAs).EBI
Marquette University
Estrogen Receptor (ER) Subtype Selectivity Identifies 8-Prenylapigenin as an ER? Agonist from Glycyrrhiza inflata and Highlights the Importance of Chemical and Biological Authentication.EBI
TBA
Tamoxifen a pioneering drug: An update on the therapeutic potential of tamoxifen derivatives.EBI
American University of Ras Al Khaimah
Incorporation of histone deacetylase inhibitory activity into the core of tamoxifen - A new hybrid design paradigm.EBI
McGill University
Recent advances in peptidomimetics antagonists targeting estrogen receptor ?-coactivator interaction in cancer therapy.EBI
Peking University Shenzhen Graduate School
Success stories of natural product-based hybrid molecules for multi-factorial diseases.EBI
Punjabi University
Structure-activity relationships of 2, 4-disubstituted pyrimidines as dual ER?/VEGFR-2 ligands with anti-breast cancer activity.EBI
China Pharmaceutical University
Design and synthesis of estrogen receptor ligands with a 4-heterocycle-4-phenylheptane skeleton.EBI
Nagasaki University
Lead Optimization of Benzoxepin-Type Selective Estrogen Receptor (ER) Modulators and Downregulators with Subtype-Specific ER? and ER? Activity.EBI
Trinity College
Novel Hybrid Conjugates with Dual Suppression of Estrogenic and Inflammatory Activities Display Significantly Improved Potency against Breast Cancer.EBI
Wuhan University
Discovery of a Novel Oral Glucocorticoid Receptor Modulator (AZD9567) with Improved Side Effect Profile.EBI
AstraZeneca
DESIGNER Extracts as Tools to Balance Estrogenic and Chemopreventive Activities of Botanicals for Women's Health.EBI
Hallertauer Hopfenveredelung GmbH
Design, synthesis and biological evaluation of novel indole-xanthendione hybrids as selective estrogen receptor modulators.EBI
Central University of Punjab
Phenolic metabolites of clomiphene: [(E,Z)-2-[4-(1,2-diphenyl-2-chlorovinyl)phenoxy]ethyl]diethylamine. Preparation, electrophilicity, and effects in MCF 7 breast cancer cells.EBI
University of Georgia
Potential Antiosteoporotic Natural Product Lead Compounds That Inhibit 17?-Hydroxysteroid Dehydrogenase Type 2.EBI
University of Basel
Identification of an Orally Bioavailable Chromene-Based Selective Estrogen Receptor Degrader (SERD) That Demonstrates Robust Activity in a Model of Tamoxifen-Resistant Breast Cancer.EBI
TBA
Dehydrodiconiferyl Alcohol Inhibits Osteoclast Differentiation and Ovariectomy-Induced Bone Loss through Acting as an Estrogen Receptor Agonist.EBI
Seoul National University
Design, synthesis and biological evaluation of novel indole-benzimidazole hybrids targeting estrogen receptor alpha (ER-?).EBI
Central University of Punjab
Disconnecting the Estrogen Receptor Binding Properties and Antimicrobial Properties of Parabens through 3,5-Substitution.EBI
Longwood University
Selective Estrogen Receptor Degraders (SERDs): A Promising Treatment to Overcome Resistance to Endocrine Therapy in ER?-Positive Breast Cancer.EBI
Therachem Research Medilab (India) Pvt. Ltd.
Novel SERMs based on 3-aryl-4-aryloxy-2H-chromen-2-one skeleton - A possible way to dual ER?/VEGFR-2 ligands for treatment of breast cancer.EBI
China Pharmaceutical University
An overview of benzo[b]thiophene-based medicinal chemistry.EBI
Jain University
Indazole-based ligands for estrogen-related receptor ? as potential anti-diabetic agents.EBI
Janssen Research and Development LLC
A prodrug design for improved oral absorption and reduced hepatic interaction.EBI
Evestra, Inc.
Design and synthesis of benzoacridines as estrogenic and anti-estrogenic agents.EBI
Kyushu University
Dual functional small molecule fluorescent probes for image-guided estrogen receptor-specific targeting coupled potent antiproliferative potency for breast cancer therapy.EBI
Wuhan University School of Pharmaceutical Sciences
Selective Nonsteroidal Glucocorticoid Receptor Modulators for the Inhaled Treatment of Pulmonary Diseases.EBI
AstraZeneca
Identification of Morpholino-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-ones as Nonsteroidal Mineralocorticoid Antagonists.EBI
Pfizer Inc
Discovery of LSZ102, a Potent, Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen Receptor Positive Breast Cancer.EBI
Novartis Institutes for BioMedical Research
Structural Basis of Inhibition of ER?-Coactivator Interaction by High-Affinity N-Terminus Isoaspartic Acid Tethered Helical Peptides.EBI
Shenzhen Graduate School of Peking University
Efficient synthesis of a multi-substituted diphenylmethane skeleton as a steroid mimetic.EBI
National Institute of Health Sciences
Design, synthesis, molecular docking, anti-Proteus mirabilis and urease inhibition of new fluoroquinolone carboxylic acid derivatives.BDB
Minia University
Perfluoro-tert-butyl Homoserine Is a Helix-Promoting, Highly Fluorinated, NMR-Sensitive Aliphatic Amino Acid: Detection of the Estrogen ReceptorĚCoactivator Protein-Protein Interaction by (19)F NMR.BDB
University of Delaware
Electrostatic Control of Isoform Selective Inhibitor Binding in Nitric Oxide Synthase.BDB
University of California Irvine
Systems-based design of bi-ligand inhibitors of oxidoreductases: filling the chemical proteomic toolbox.BDB
Triad Therapeutics, Inc
Structural determinants of CDK4 inhibition and design of selective ATP competitive inhibitors.BDB
Cyclacel Limited
Inhibitor specificity via protein dynamics: insights from the design of antibacterial agents targeted against thymidylate synthase.BDB
Università di Modena e Reggio Emilia
Synthesis and structure-activity relationships of N-substituted spiropiperidines as nociceptin receptor ligands: part 2.BDB
Schering-Plough Research Institute
Design and synthesis of novel and potent inhibitors of the type II transmembrane serine protease, matriptase, based upon the sunflower trypsin inhibitor-1.BDB
Georgetown University Medical Center
Arylaminoethyl carbamates as a novel series of potent and selective cathepsin S inhibitors.BDB
GNF
Arylisothiocyanato selective androgen receptor modulators (SARMs) for prostate cancer.BDB
University of Tennessee Health Science Center
Thyroid receptor ligands. 3. Design and synthesis of 3,5-dihalo-4-alkoxyphenylalkanoic acids as indirect antagonists of the thyroid hormone receptor.BDB
Karo Bio AB
Lead optimization of 7-benzyloxy 2-(4'-pyridylmethyl)thio isoflavone aromatase inhibitors.BDB
Ohio State University
First non-ATP competitive glycogen synthase kinase 3 beta (GSK-3beta) inhibitors: thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's disease.BDB
Instituto de Quimica Medica (CSIC)
Discovery of a new class of anilinoquinazoline inhibitors with high affinity and specificity for the tyrosine kinase domain of c-Src.BDB
AstraZeneca
Tyrosine kinase inhibitors. 1. Structure-activity relationships for inhibition of epidermal growth factor receptor tyrosine kinase activity by 2,3-dihydro-2-thioxo-1H-indole-3-alkanoic acids and 2,2'-dithiobis(1H-indole-3-alkanoic acids).BDB
University of Auckland
Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. 1. Tricyclic pyridobenzo- and dipyridodiazepinones.BDB
Boehringer Ingelheim Pharmaceuticals Inc