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437 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Probing the carboxyester side chain in controlled deactivation (-)-d(8)-tetrahydrocannabinols.EBI
Northeastern University
New pyridazinone-4-carboxamides as new cannabinoid receptor type-2 inverse agonists: Synthesis, pharmacological data and molecular docking.EBI
University of Sassari
Synthesis, binding assays, cytotoxic activity and docking studies of benzimidazole and benzothiophene derivatives with selective affinity for the CB2 cannabinoid receptor.EBI
Pontificia Universidad Cat£lica de Chile
Discovery of novel Tetrahydrobenzo[b]thiophene and pyrrole based scaffolds as potent and selective CB2 receptor ligands: The structural elements controlling binding affinity, selectivity and functionality.EBI
German University in Cairo
Tetrahydropyrazolo[4,3-c]pyridine derivatives as potent and peripherally selective cannabinoid-1 (CB1) receptor inverse agonists.EBI
Janssen Research and Development LLC
Tetrahydroindazole derivatives as potent and peripherally selective cannabinoid-1 (CB1) receptor inverse agonists.EBI
Janssen Research and Development LLC
A critical review of both the synthesis approach and the receptor profile of the 8-chloro-1-(2',4'-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide and analogue derivatives.EBI
Neuroscienze PharmaNess S.c.a r.l.
Synthesis and pharmacological evaluation of new biphenylic derivatives as CB2 receptor ligands.EBI
Universit£ di Pisa
Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain.EBI
University of Siena
Optimization of N'-(arylsulfonyl)pyrazoline-1-carboxamidines by exploiting a novel interaction site in the 5-HT6 antagonistic binding pocket.EBI
Abbott Healthcare Products BV
Identification of Novel GPR55 Modulators Using Cell-Impedance-Based Label-Free Technology.EBI
Instituto de Qu£mica M£dica
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 7. Synthesis and Pharmacological Evaluation of 4-Quinolone-3-carboxamides and 4-Hydroxy-2-quinolone-3-carboxamides as High Affinity Cannabinoid Receptor 2 (CB2R) Ligands with Improved Aqueous Solubility.EBI
Universit£ degli Studi di Siena
Tricyclic pyrazoles. Part 8. Synthesis, biological evaluation and modelling of tricyclic pyrazole carboxamides as potential CB2 receptor ligands with antagonist/inverse agonist properties.EBI
Universit£ degli Studi di Sassari
Synthesis and structure activity relationship investigation of triazolo[1,5-a]pyrimidines as CB2 cannabinoid receptor inverse agonists.EBI
Universit£ di Ferrara
Pyrazole antagonists of the CB1 receptor with reduced brain penetration.EBI
RTI International
Synthesis, pharmacological evaluation and docking studies of pyrrole structure-based CB2 receptor antagonists.EBI
Universit£ degli Studi di Sassari
Synthesis and biological evaluation of (3',5'-dichloro-2,6-dihydroxy-biphenyl-4-yl)-aryl/alkyl-methanone selective CB2 inverse agonist.EBI
University of Tennessee Health Science Center
Combining Mass Spectrometric Metabolic Profiling with Genomic Analysis: A Powerful Approach for Discovering Natural Products from Cyanobacteria.EBI
University of California Berkeley
Distinct Temporal Fingerprint for Cyclic Adenosine Monophosphate (cAMP) Signaling of Indole-2-carboxamides as Allosteric Modulators of the Cannabinoid Receptors.EBI
University of Auckland
Development of Quinoline-2,4(1H,3H)-diones as Potent and Selective Ligands of the Cannabinoid Type 2 Receptor.EBI
Zhejiang University
Isolation and Pharmacological Evaluation of Minor Cannabinoids from High-Potency Cannabis sativa.EBI
The University of Mississippi
Discovery of a high affinity and selective pyridine analog as a potential positron emission tomography imaging agent for cannabinoid type 2 receptor.EBI
Institute of Pharmaceutical Sciences
Novel azoles as potent and selective cannabinoid CB2 receptor agonists.EBI
Ipsen Innovation
New quinolone- and 1,8-naphthyridine-3-carboxamides as selective CB2 receptor agonists with anticancer and immuno-modulatory activity.EBI
University of Pisa
Conformational Restriction Leading to a Selective CB2 Cannabinoid Receptor Agonist Orally Active Against Colitis.EBI
University of Lille
3'-functionalized adamantyl cannabinoid receptor probes.EBI
University of Hawaii at Manoa
Selective, nontoxic CB(2) cannabinoid o-quinone with in vivo activity against triple-negative breast cancer.EBI
Instituto de Qu£mica M£dica
Design, syntheses, structure-activity relationships and docking studies of coumarin derivatives as novel selective ligands for the CB2 receptor.EBI
Zhejiang University
Synthesis, radiolabeling and evaluation of novel 4-oxo-quinoline derivatives as PET tracers for imaging cannabinoid type 2 receptor.EBI
Institute of Pharmaceutical Sciences
Cannabidiol (CBD) and its analogs: a review of their effects on inflammation.EBI
University of Massachusetts Medical School
Selective CB2 receptor agonists. Part 1: the identification of novel ligands through computer-aided drug design (CADD) approaches.EBI
Boehringer Ingelheim Pharmaceuticals Inc
Novel tail and head group prostamide probes.EBI
Northeastern University
Synthesis, biological activity and molecular modeling of new biphenylic carboxamides as potent and selective CB2 receptor ligands.EBI
Universit£ di Pisa
Design, synthesis and in vitro evaluation of novel uni- and bivalent ligands for the cannabinoid receptor type 1 with variation of spacer length and structure.EBI
Julius-Maximilians-Universit£t W£rzburg
One-pot heterogeneous synthesis of┐(3)-tetrahydrocannabinol analogues and xanthenes showing differential binding to CB(1) and CB(2) receptors.EBI
University of Perugia
Structure-affinity relationships and pharmacological characterization of new alkyl-resorcinol cannabinoid receptor ligands: Identification of a dual cannabinoid receptor/TRPA1 channel agonist.EBI
Universit£ degli Studi di Siena
Synthesis and biological evaluation of bivalent cannabinoid receptor ligands based on hCB2R selective benzimidazoles reveal unexpected intrinsic properties.EBI
Julius-Maximilians-Universit£t W£rzburg
Identification of endocannabinoid system-modulating N-alkylamides from Heliopsis helianthoides var. scabra and Lepidium meyenii.EBI
University of Szeged
DDD-028: a potent potential non-opioid, non-cannabinoid analgesic for neuropathic and inflammatory pain.EBI
University of Missouri
trans-Caryophyllene is a natural agonistic ligand for peroxisome proliferator-activated receptor-a.EBI
Korea University
Selective CB2 receptor agonists. Part 3: the optimization of a piperidine-based series that demonstrated efficacy in an in vivo neuropathic pain model.EBI
Boehringer Ingelheim Pharmaceuticals Inc
Selective CB2 receptor agonists. Part 2: Structure-activity relationship studies and optimization of proline-based compounds.EBI
Boehringer Ingelheim Pharma GmbH & Co. KG
Identification of a highly potent and selective CB2 agonist, RQ-00202730, for the treatment of irritable bowel syndrome.EBI
RaQualia Pharma Inc
Discovery of 1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalen-4-carboxamides as potent and selective CB2 receptor agonists.EBI
Arena Pharmaceuticals
Ligand-based virtual screening identifies a family of selective cannabinoid receptor 2 agonists.EBI
University of Oxford
The SAR development of substituted purine derivatives as selective CB2 agonists for the treatment of chronic pain.EBI
Eli Lilly and Company
CB2-selective cannabinoid receptor ligands: synthesis, pharmacological evaluation, and molecular modeling investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamides.EBI
Universit£ di Pisa
Diarylureas as allosteric modulators of the cannabinoid CB1 receptor: structure-activity relationship studies on 1-(4-chlorophenyl)-3-{3-[6-(pyrrolidin-1-yl)pyridin-2-yl]phenyl}urea (PSNCBAM-1).EBI
Research Triangle Institute
Tricyclic pyrazoles. Part 6. Benzofuro[3,2-c]pyrazole: a versatile architecture for CB2 selective ligands.EBI
Universit£ di Sassari
Ultrapure ajulemic acid has improved CB2 selectivity with reduced CB1 activity.EBI
Corbus Pharmaceuticals, Inc.
C-ring cannabinoid lactones: a novel cannabinergic chemotype.EBI
Northeastern University
Therapeutic utility of cannabinoid receptor type 2 (CB(2)) selective agonists.EBI
Arena Pharmaceuticals
Benzimidazole CB2 agonists: design, synthesis and SAR.EBI
Merck Research Laboratories
Novel adamantyl cannabinoids as CB1 receptor probes.EBI
Northeastern University
Evaluation of (Z)-2-((1-benzyl-1H-indol-3-yl)methylene)-quinuclidin-3-one analogues as novel, high affinity ligands for CB1 and CB2 cannabinoid receptors.EBI
University of Arkansas for Medical Sciences
Novel antiobesity agents: synthesis and pharmacological evaluation of analogues of Rimonabant and of LH21.EBI
Instituto de Qu£mica M£dica
Design, synthesis, and binding mode prediction of 2-pyridone-based selective CB2 receptor agonists.EBI
Shionogi Pharmaceutical Research Center
Highly potent and selective cannabinoid receptor 2 agonists: initial hit optimization of an adamantyl hit series identified from high-through-put screening.EBI
F. Hoffmann-La Roche Inc
Trisubstituted Sulfonamides: a New Chemotype for Development of Potent and Selective CBEBI
University of Pittsburgh
Magnolia Extract, Magnolol, and Metabolites: Activation of Cannabinoid CB2 Receptors and Blockade of the Related GPR55.EBI
University of Bonn
Novel triaryl sulfonamide derivatives as selective cannabinoid receptor 2 inverse agonists and osteoclast inhibitors: discovery, optimization, and biological evaluation.EBI
University of Pittsburgh
Design, synthesis, and pharmacological properties of new heteroarylpyridine/heteroarylpyrimidine derivatives as CB(2) cannabinoid receptor partial agonists.EBI
Universit£ di Ferrara
Discovery of agonists of cannabinoid receptor 1 with restricted central nervous system penetration aimed for treatment of gastroesophageal reflux disease.EBI
AstraZeneca
Synthesis and SAR studies of 2-oxoquinoline derivatives as CB2 receptor inverse agonists.EBI
University of Kuopio
Design, synthesis, and pharmacological characterization of indol-3-ylacetamides, indol-3-yloxoacetamides, and indol-3-ylcarboxamides: potent and selective CB2 cannabinoid receptor inverse agonists.EBI
Universit£ degli Studi di Siena
Discovery and optimization of 1-(4-(pyridin-2-yl)benzyl)imidazolidine-2,4-dione derivatives as a novel class of selective cannabinoid CB2 receptor agonists.EBI
Merck Research Laboratories
Pharmacokinetic optimisation of novel indole-2-carboxamide cannabinoid CB1 antagonists.EBI
MSD
Discovery of potent and orally bioavailable heterocycle-based cannabinoid CB1 receptor agonists.EBI
Merck Research Laboratories
Design, synthesis, and structure-activity relationship study of conformationally constrained analogs of indole-3-carboxamides as novel CB1 cannabinoid receptor agonists.EBI
Schering-Plough Research Institute
Synthesis and evaluation of 3-amino-6-aryl-pyridazines as selective CB(2) agonists for the treatment of inflammatory pain.EBI
GlaxoSmithKline
2-Amino-5-aryl-pyridines as selective CB2 agonists: synthesis and investigation of structure-activity relationships.EBI
GlaxoSmithKline
Synthesis of quinolinyl and isoquinolinyl phenyl ketones as novel agonists for the cannabinoid CB2 receptor.EBI
Helsinki University of Technology
Development of CoMFA and CoMSIA models of affinity and selectivity for indole ligands of cannabinoid CB1 and CB2 receptors.EBI
Universidade Federal do Rio de Janeiro
Structure-activity relationships of 2-arylamido-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide derivatives as cannabinoid receptor agonists and their analgesic action.EBI
Nycomed Pharma Pvt. Ltd
Synthesis and pharmacology of 1-alkyl-3-(1-naphthoyl)indoles: steric and electronic effects of 4- and 8-halogenated naphthoyl substituents.EBI
RTI International
Diphenyl purine derivatives as peripherally selective cannabinoid receptor 1 antagonists.EBI
Research Triangle Institute
Lead discovery, chemistry optimization, and biological evaluation studies of novel biamide derivatives as CB2 receptor inverse agonists and osteoclast inhibitors.EBI
University of Pittsburgh
7-Alkyl-3-benzylcoumarins: a versatile scaffold for the development of potent and selective cannabinoid receptor agonists and antagonists.EBI
University of Bonn
4-Oxo-1,4-dihydropyridines as selective CB2 cannabinoid receptor ligands. Part 2: discovery of new agonists endowed with protective effect against experimental colitis.EBI
University of Lille
Assay and inhibition of diacylglycerol lipase activity.EBI
Northeastern University
7-Oxo-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamides as selective CB(2) cannabinoid receptor ligands: structural investigations around a novel class of full agonists.EBI
Universit£ di Ferrara
2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents.EBI
University of Bologna
Scaffold hopping strategy toward original pyrazolines as selective CB2 receptor ligands.EBI
Avenue de l'Universit£
Investigations on the 4-quinolone-3-carboxylic acid motif. 6. Synthesis and pharmacological evaluation of 7-substituted quinolone-3-carboxamide derivatives as high affinity ligands for cannabinoid receptors.EBI
Universit£ degli Studi di Siena
JD-5006 and JD-5037: peripherally restricted (PR) cannabinoid-1 receptor blockers related to SLV-319 (Ibipinabant) as metabolic disorder therapeutics devoid of CNS liabilities.EBI
Jenrin Discovery
Indole-2-carboxamides as allosteric modulators of the cannabinoid CB1 receptor.EBI
Sapienza University of Rome
C3-heteroaroyl cannabinoids as photolabeling ligands for the CB2 cannabinoid receptor.EBI
University of Hawaii at Manoa
Design of a Potent CB1 Receptor Antagonist Series: Potential Scaffold for Peripherally-Targeted Agents.EBI
TBA
Discovery and optimization of novel purines as potent and selective CB2 agonists.EBI
Eli Lilly and Company
N-Methyl-3-(tetrahydro-2H-pyran-4-yl)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamides as a novel class of cannabinoid receptors agonists with low CNS penetration.EBI
AstraZeneca
Design and synthesis of cannabinoid receptor 1 antagonists for peripheral selectivity.EBI
Research Triangle Institute
Discovery of S-444823, a potent CB1/CB2 dual agonist as an antipruritic agent.EBI
Shionogi & Co., Ltd
Rational design, synthesis and anti-proliferative properties of new CB2 selective cannabinoid receptor ligands: an investigation of the 1,8-naphthyridin-2(1H)-one scaffold.EBI
Universit£ di Pisa
Discovery of S-777469: an orally available CB2 agonist as an antipruritic agent.EBI
Shionogi & Co., Ltd
CB 1/2 dual agonists with 3-carbamoyl 2-pyridone derivatives as antipruritics: reduction of CNS side effects by introducing polar functional groups.EBI
Shionogi & Co., Ltd
Low brain penetrant CB1 receptor agonists for the treatment of neuropathic pain.EBI
Merck Research Laboratories
Synthesis and evaluation of 2-amido-3-carboxamide thiophene CB2 receptor agonists for pain management.EBI
Abbott Laboratories
N-(4-cyanotetrahydro-2H-pyran-4-yl) and N-(1-cyanocyclohexyl) derivatives of 1,5-diarylpyrazole-3-carboxamides showing high affinity for 18 kDa translocator protein and/or cannabinoid receptors.EBI
National Institute of Mental Health
1-Bromo-3-(1',1'-dimethylalkyl)-1-deoxy-¿(8)-tetrahydrocannabinols: New selective ligands for the cannabinoid CB(2) receptor.EBI
Clemson University
Synthesis and biodistribution of [11C]A-836339, a new potential radioligand for PET imaging of cannabinoid type 2 receptors (CB2).EBI
Johns Hopkins Medical Institutions
Investigations on the 4-quinolone-3-carboxylic acid motif. 3. Synthesis, structure-affinity relationships, and pharmacological characterization of 6-substituted 4-quinolone-3-carboxamides as highly selective cannabinoid-2 receptor ligands.EBI
Universit£ degli Studi di Siena
Probing the cannabinoid CB1/CB2 receptor subtype selectivity limits of 1,2-diarylimidazole-4-carboxamides by fine-tuning their 5-substitution pattern.EBI
Solvay Pharma
Synthesis, SAR and intramolecular hydrogen bonding pattern of 1,3,5-trisubstituted 4,5-dihydropyrazoles as potent cannabinoid CB(1) receptor antagonists.EBI
Solvay Pharma
Synthesis and SAR of novel imidazoles as potent and selective cannabinoid CB2 receptor antagonists with high binding efficiencies.EBI
Solvay Pharma
Diaryl piperidines as CB1 receptor antagonists.EBI
Merck Research Laboratories
Synthesis, cannabinoid receptor affinity, molecular modeling studies and in vivo pharmacological evaluation of new substituted 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides. 2. Effect of the 3-carboxamide substituent on the affinity and selectivity profile.EBI
Sapienza University of Rome
Discovery and functional evaluation of diverse novel human CB(1) receptor ligands.EBI
Vernalis (R&D) Ltd
Rational design, synthesis, and pharmacological properties of new 1,8-naphthyridin-2(1H)-on-3-carboxamide derivatives as highly selective cannabinoid-2 receptor agonists.EBI
Universita di Pisa
Synthesis and pharmacological evaluation of coumarin derivatives as cannabinoid receptor antagonists and inverse agonists.EBI
University of Bonn
Discovery of novel CB2 receptor ligands by a pharmacophore-based virtual screening workflow.EBI
University of Innsbruck
6-Methoxy-N-alkyl isatin acylhydrazone derivatives as a novel series of potent selective cannabinoid receptor 2 inverse agonists: design, synthesis, and binding mode prediction.EBI
The University of Texas M.D. Anderson Cancer Center
Discovery and optimization of a novel series of N-arylamide oxadiazoles as potent, highly selective and orally bioavailable cannabinoid receptor 2 (CB2) agonists.EBI
Amgen Inc
Investigations on the 4-quinolone-3-carboxylic acid motif. 2. Synthesis and structure-activity relationship of potent and selective cannabinoid-2 receptor agonists endowed with analgesic activity in vivo.EBI
Universit£ degli Studi di Siena
Design and synthesis of a novel series of N-alkyl isatin acylhydrazone derivatives that act as selective cannabinoid receptor 2 agonists for the treatment of neuropathic pain.EBI
The University of Texas M.D. Anderson Cancer Center
Novel sterically hindered cannabinoid CB1 receptor ligands.EBI
University of Salerno
Aminopyrazine CB1 receptor inverse agonists.EBI
Neurogen Corporation
The SAR studies of novel CB2 selective agonists, benzimidazolone derivatives.EBI
Pfizer Inc
Sulfamoyl benzamides as novel CB2 cannabinoid receptor ligands.EBI
Adolor Corporation
New tetrazole-based selective anandamide uptake inhibitors.EBI
Sapienza University of Rome
5-Sulfonyl-benzimidazoles as selective CB2 agonists.EBI
Johnson & Johnson Pharmaceutical Research & Development
Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940.EBI
Clemson University
Imine derivatives as new potent and selective CB2 cannabinoid receptor agonists with an analgesic action.EBI
Taisho Pharmaceutical Co., Ltd
Tetrazole-biarylpyrazole derivatives as cannabinoid CB1 receptor antagonists.EBI
reen Cross Corporation
A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.EBI
Abbott Laboratories
New 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists.EBI
Universit£ di Pisa
N-Alkylidenearylcarboxamides as new potent and selective CB(2) cannabinoid receptor agonists with good oral bioavailability.EBI
Taisho Pharmaceutical Co., Ltd
Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration.EBI
Novartis Institutes for BioMedical Research
Design, synthesis, binding, and molecular modeling studies of new potent ligands of cannabinoid receptors.EBI
Universit£ degli Studi di Siena
Design, synthesis, and binding studies of new potent ligands of cannabinoid receptors.EBI
Universit£ degli Studi di Siena
Discovery of N-[(1S,2S)-3-(4-Chlorophenyl)-2- (3-cyanophenyl)-1-methylpropyl]-2-methyl-2- {[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), a novel, acyclic cannabinoid-1 receptor inverse agonist for the treatment of obesity.EBI
Merck Research Laboratories
Novel 4-oxo-1,4-dihydroquinoline-3-carboxamide derivatives as new CB2 cannabinoid receptors agonists: synthesis, pharmacological properties and molecular modeling.EBI
Universit£ de Lille 2
New metabolically stable fatty acid amide ligands of cannabinoid receptors: Synthesis and receptor affinity studies.EBI
Institute of Biomolecular Chemistry
Novel 3,4-diarylpyrazolines as potent cannabinoid CB1 receptor antagonists with lower lipophilicity.EBI
Solvay Pharma
Bioisosteric replacements of the pyrazole moiety of rimonabant: synthesis, biological properties, and molecular modeling investigations of thiazoles, triazoles, and imidazoles as potent and selective CB1 cannabinoid receptor antagonists.EBI
Solvay Pharma
The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications.EBI
Universit£ Catholique de Louvain
Design, synthesis, and biological evaluation of new inhibitors of the endocannabinoid uptake: comparison with effects on fatty acid amidohydrolase.EBI
Universidad Complutense
Rational design and synthesis of an orally active indolopyridone as a novel conformationally constrained cannabinoid ligand possessing antiinflammatory properties.EBI
Bristol-Myers Squibb Co.
Design, synthesis and biological evaluation of novel arachidonic acid derivatives as highly potent and selective endocannabinoid transporter inhibitors.EBI
Universidad Complutense
The bioactive conformation of aminoalkylindoles at the cannabinoid CB1 and CB2 receptors: insights gained from (E)- and (Z)-naphthylidene indenes.EBI
Kennesaw State University
¿-Carbolines: a novel class of cannabinoid agonists with high aqueous solubility and restricted CNS penetration.EBI
AstraZeneca R&D Montreal
Fatty acid amide hydrolase inhibitors. 3: tetra-substituted azetidine ureas with in vivo activity.EBI
Vernalis (R&D) Ltd
5-sulfonyl-benzimidazoles as selective CB2 agonists-part 2.EBI
Janssen Pharmaceutica NV
Novel bioactive metabolites of dipyrone (metamizol).EBI
Philipps-Universit£t
Cannabinomimetic lipid from a marine cyanobacterium.EBI
University of California
Resorcinol-sn-glycerol derivatives: novel 2-arachidonoylglycerol mimetics endowed with high affinity and selectivity for cannabinoid type 1 receptor.EBI
Universit£ degli Studi di Siena
1-Aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide: an effective scaffold for the design of either CB1 or CB2 receptor ligands.EBI
Sapienza University of Rome
Characterization of a novel and selective CB1 antagonist as a radioligand for receptor occupancy studies.EBI
Bristol-Myers Squibb Co.
Asymmetric synthesis and biological evaluation of N-cyclohexyl-4-[1-(2,4-dichlorophenyl)-1-(p-tolyl)methyl]piperazine-1-carboxamide as hCB1 receptor antagonists.EBI
Shanghai Institute of Materia Medica
Conformationally constrained analogs of BAY 59-3074 as novel cannabinoid receptor ligands.EBI
Northeastern University
Towards rational design of cannabinoid receptor 1 (CB1) antagonists for peripheral selectivity.EBI
RTI International
Design and evaluation of a novel fluorescent CB2 ligand as probe for receptor visualization in immune cells.EBI
University of Montana
Homology modeling in tandem with 3D-QSAR analyses: a computational approach to depict the agonist binding site of the human CB2 receptor.EBI
Universit£ di Genova
Bioactive prenylogous cannabinoid from fiber hemp (Cannabis sativa).EBI
Universita` del Piemonte Orientale
Fluorinated cannabinoid CB2 receptor ligands: synthesis and in vitro binding characteristics of 2-oxoquinoline derivatives.EBI
The University of Texas
Structure-activity relationship studies of novel pyrazole and imidazole carboxamides as cannabinoid-1 (CB1) antagonists.EBI
Dr. Reddy's Laboratories Ltd
Investigations on the 4-quinolone-3-carboxylic acid motif. 4. Identification of new potent and selective ligands for the cannabinoid type 2 receptor with diverse substitution patterns and antihyperalgesic effects in mice.EBI
Universita degli Studi di Siena
Benzyl derivatives with in vitro binding affinity for human opioid and cannabinoid receptors from the fungus Eurotium repens.EBI
The University of Mississippi
Synthesis, in vitro and in vivo evaluation of fluorine-18 labelled FE-GW405833 as a PET tracer for type 2 cannabinoid receptor imaging.EBI
IMIR K.U. Leuven
Aryl 1,4-diazepane compounds as potent and selective CB2 agonists: optimization of drug-like properties and target independent parameters.EBI
Boehringer Ingelheim Pharmaceuticals Inc
Development of endocannabinoid-based chemical probes for the study of cannabinoid receptors.EBI
Universidad Complutense de Madrid
Optimisation of a novel series of selective CNS penetrant CB(2) agonists.EBI
Pfizer Inc
Indazole derivatives as novel bradykinin B1 receptor antagonists.EBI
Merck Research Laboratories
Discovery of pyrimidine carboxamides as potent and selective CCK1 receptor agonists.EBI
Merck & Co. Inc
Decahydroquinoline amides as highly selective CB2 agonists: role of selectivity on in vivo efficacy in a rodent model of analgesia.EBI
Merck Research Laboratories
1,4-Diazepane compounds as potent and selective CB2 agonists: optimization of metabolic stability.EBI
Boehringer Ingelheim Pharmaceuticals Inc
Imidazopyridine CB2 agonists: optimization of CB2/CB1 selectivity and implications for in vivo analgesic efficacy.EBI
Merck Research Laboratories
Three-dimensional quantitative structure-selectivity relationships analysis guided rational design of a highly selective ligand for the cannabinoid receptor 2.EBI
Universit£ degli Studi di Siena
4-Oxo-1,4-dihydropyridines as selective CB2 cannabinoid receptor ligands: structural insights into the design of a novel inverse agonist series.EBI
Universite£? Lille-Nord de France
Structure-activity relationships of 2,4-diphenyl-1H-imidazole analogs as CB2 receptor agonists for the treatment of chronic pain.EBI
Merck Research Laboratory
Synthesis and biological evaluation of new N-alkyl 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides as cannabinoid receptor ligands.EBI
Sapienza University of Rome
Synthesis, binding studies and molecular modeling of novel cannabinoid receptor ligands.EBI
German University in Cairo
Expansion of SAR studies on triaryl bis sulfone cannabinoid CB2 receptor ligands.EBI
Merck Research Laboratories
Synthesis and biological evaluation of bivalent ligands for the cannabinoid 1 receptor.EBI
Research Triangle Institute
Novel 1',1'-chain substituted hexahydrocannabinols: 9ß-hydroxy-3-(1-hexyl-cyclobut-1-yl)-hexahydrocannabinol (AM2389) a highly potent cannabinoid receptor 1 (CB1) agonist.EBI
Northeastern University
Two distinct classes of novel pyrazolinecarboxamides as potent cannabinoid CB1 receptor agonists.EBI
Abbott Healthcare Products BV
Discovery of 2-(4-((1H-1,2,4-triazol-1-yl)methyl)-5-(4-bromophenyl)-1-(2-chlorophenyl)-1H-pyrazol-3-yl)-5-tert-butyl-1,3,4-thiadiazole (GCC2680) as a potent, selective and orally efficacious cannabinoid-1 receptor antagonist.EBI
Green Cross Corporation
Synthesis and pharmacology of 1-methoxy analogs of CP-47,497.EBI
Clemson University
Heteroadamantyl cannabinoids.EBI
University of Hawaii at Manoa
Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: synthesis, SAR and biological evaluation.EBI
Merck Research Laboratories
Emerging targets in osteoporosis disease modification.EBI
Amgen Inc
Discovery of N-[(4R)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-carboxamide (MK-5596) as a novel cannabinoid-1 receptor (CB1R) inverse agonist for the treatment of obesity.EBI
Merck Research Laboratories
Furo[2,3-b]pyridine-based cannabinoid-1 receptor inverse agonists: synthesis and biological evaluation. Part 1.EBI
Merck Research Laboratories
Radiosynthesis of novel carbon-11-labeled triaryl ligands for cannabinoid-type 2 receptor.EBI
National Institute of Radiological Sciences
Discovery of benzhydrylpiperazine derivatives as CB1 receptor inverse agonists via privileged structure-based approach.EBI
Chinese Academy of Sciences
Synthesis and in vitro autoradiographic evaluation of a novel high-affinity radioiodinated ligand for imaging brain cannabinoid subtype-1 receptors.EBI
National Institute of Mental Health
Synthesis and structure-activity relationship of 1,2,4-triazole-containing diarylpyrazolyl carboxamide as CB1 cannabinoid receptor-ligand.EBI
Green Cross Corporation
Synthesis and biological evaluation of new potential inhibitors of N-acylethanolamine hydrolyzing acid amidase.EBI
University of Salerno
Synthesis and in vitro biological evaluation of carbon-11-labeled quinoline derivatives as new candidate PET radioligands for cannabinoid CB2 receptor imaging.EBI
Indiana University School of Medicine
Synthesis and structure-activity relationship of substitutions at the C-1 position of Delta9-tetrahydrocannabinol.EBI
AMRI
Non-aromatic A-ring replacement in the triaryl bis-sulfone CB2 receptor inhibitors.EBI
Merck Research Laboratories
Novel sulfamoyl benzamides as selective CB(2) agonists with improved in vitro metabolic stability.EBI
Adolor Corporation
Design, synthesis, biological properties, and molecular modeling investigations of novel tacrine derivatives with a combination of acetylcholinesterase inhibition and cannabinoid CB1 receptor antagonism.EBI
Solvay Pharma
Indol-3-ylcycloalkyl ketones: effects of N1 substituted indole side chain variations on CB(2) cannabinoid receptor activity.EBI
Abbott Laboratories
Pentacycle derivatives as cannabinoid CB1 receptor ligands.EBI
Green Cross Corporation
Discovery of 1-[4-(3-chlorophenylamino)-1-methyl-1H-pyrrolo[3,2-c]pyridin-7-yl]-1-morpholin-4-ylmethanone (GSK554418A), a brain penetrant 5-azaindole CB2 agonist for the treatment of chronic pain.EBI
GlaxoSmithKline
Novel pyridine derivatives as potent and selective CB2 cannabinoid receptor agonists.EBI
Adolor Corporation
Discovery of N-(3-(morpholinomethyl)-phenyl)-amides as potent and selective CB2 agonists.EBI
Adolor Corporation
Synthesis and evaluation of N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-aminopropanamide as human cannabinoid-1 receptor (CB1R) inverse agonists.EBI
Merck Research Laboratories
Synthesis and SAR of 1,4,5,6-tetrahydropyridazines as potent cannabinoid CB1 receptor antagonists.EBI
Solvay Pharma
Substituted pyrimidines as cannabinoid CB1 receptor ligands.EBI
Green Cross Corporation
Rapid assessment of a novel series of selective CB(2) agonists using parallel synthesis protocols: A Lipophilic Efficiency (LipE) analysis.EBI
Pfizer Inc
Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas.EBI
Vernalis (R&D) Ltd
Total synthesis of photoactivatable or fluorescent anandamide probes: novel bioactive compounds with angiogenic activity.EBI
University of Montpellier
 
Structure activity relationships of tetrahydrocannabinol analogues on human cannabinoid receptorsEBI
TBA
 
New class of potent ligands for the human peripheral cannabinoid receptorEBI
TBA
Discovery of 2-[5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-1,5,5-trimethyl-1,5-dihydro-imidazol-4-thione (BPR-890) via an active metabolite. A novel, potent and selective cannabinoid-1 receptor inverse agonist with high antiobesity efficacy in DIO mice.EBI
National Health Research Institutes
New resorcinol-anandamide"hybrids" as potent cannabinoid receptor ligands endowed with antinociceptive activity in vivo.EBI
Universita degli Studi di Siena
Pyridopyrimidine based cannabinoid-1 receptor inverse agonists: Synthesis and biological evaluation.EBI
Merck Research Laboratories
Hair growth stimulator property of thienyl substituted pyrazole carboxamide derivatives as a CB1 receptor antagonist with in vivo antiobesity effect.EBI
Zydus Research Centre
1-Sulfonyl-4-acylpiperazines as selective cannabinoid-1 receptor (CB1R) inverse agonists for the treatment of obesity.EBI
Merck Research Laboratories
Oxadiazole-diarylpyrazole 4-carboxamides as cannabinoid CB1 receptor ligands.EBI
Green Cross Corporation
Quantitative structure-activity relationship (QSAR) for a series of novel cannabinoid derivatives using descriptors derived from semi-empirical quantum-chemical calculations.EBI
St. Jude Children's Research Hospital
Morpholine containing CB2 selective agonists.EBI
Boehringer Ingelheim Pharmaceuticals Inc
Design and synthesis of novel tri-aryl CB2 selective cannabinoid ligands.EBI
University of Tennessee-Memphis
Synthesis and characterization of a peripherally restricted CB1 cannabinoid antagonist, URB447, that reduces feeding and body-weight gain in mice.EBI
University of California
1,2,3-Triazole derivatives as new cannabinoid CB1 receptor antagonists.EBI
National Central University
CB2 selective sulfamoyl benzamides: optimization of the amide functionality.EBI
Adolor Corporation
Discovery of alpha-amidosulfones as potent and selective agonists of CB2: synthesis, SAR, and pharmacokinetic properties.EBI
Amgen Inc
New analgesics synthetically derived from the paracetamol metabolite N-(4-hydroxyphenyl)-(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-enamide.EBI
Martin-Luther-Universitaet
Diarylimidazolyl oxadiazole and thiadiazole derivatives as cannabinoid CB1 receptor antagonists.EBI
Green Cross Corporation
2-Arylimino-5,6-dihydro-4H-1,3-thiazines as a new class of cannabinoid receptor agonists. Part 3: Synthesis and activity of isosteric analogs.EBI
Shionogi & Co., Ltd
Biarylpyrazolyl oxadiazole as potent, selective, orally bioavailable cannabinoid-1 receptor antagonists for the treatment of obesity.EBI
Green Cross Corporation
Tetrahydrolipstatin analogues as modulators of endocannabinoid 2-arachidonoylglycerol metabolism.EBI
Sapienza University of Rome
Discovery and labeling of high-affinity 3,4-diarylpyrazolines as candidate radioligands for in vivo imaging of cannabinoid subtype-1 (CB1) receptors.EBI
National Institute of Mental Health
Bioisosteric replacement of the pyrazole 5-aryl moiety of N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A). A novel series of alkynylthiophenes as potent and selective cannabinoid-1 receptor antagonists.EBI
National Health Research Institutes
Structural modifications of N-arylamide oxadiazoles: Identification of N-arylpiperidine oxadiazoles as potent and selective agonists of CB2.EBI
Amgen Inc
Comparative molecular dynamics simulations of the potent synthetic classical cannabinoid ligand AMG3 in solution and at binding site of the CB1 and CB2 receptors.EBI
The National Hellenic Research Foundation
Exploring the substituent effects on a novel series of C1'-dimethyl-aryl Delta8-tetrahydrocannabinol analogs.EBI
University of Tennessee-Memphis
Novel benzimidazole derivatives as selective CB2 agonists.EBI
AstraZeneca R&D Montréal
Conformationally constrained analogues of N-(piperidinyl)-5-(4-chlorophenyl)-1-(2,4- dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716): design, synthesis, computational analysis, and biological evaluations.EBI
Research Triangle Institute
Rational design, synthesis and biological evaluation of new 1,5-diarylpyrazole derivatives as CB1 receptor antagonists, structurally related to rimonabant.EBI
Università di Genova
Design, synthesis and biological evaluation of piperazine analogues as CB1 cannabinoid receptor ligands.EBI
Central Research Institute
Synthesis and cannabinoid activity of 1-substituted-indole-3-oxadiazole derivatives: novel agonists for the CB1 receptor.EBI
Monash University (Parkville Campus)
Arylsulfonamide CB2 receptor agonists: SAR and optimization of CB2 selectivity.EBI
Evotec (UK) Ltd
Diaryl dihydropyrazole-3-carboxamides with significant in vivo antiobesity activity related to CB1 receptor antagonism: synthesis, biological evaluation, and molecular modeling in the homology model.EBI
Zydus Research Centre
Pharmacomodulations around the 4-oxo-1,4-dihydroquinoline-3-carboxamides, a class of potent CB2-selective cannabinoid receptor ligands: consequences in receptor affinity and functionality.EBI
Université de Lille 2
New 1,2,3,4-tetrahydropyrrolo[3,4-b]indole derivatives as selective CB2 receptor agonists.EBI
AstraZeneca R&D Montreal
Novel, potent THC/anandamide (hybrid) analogs.EBI
Organix Inc
Sulfonamide derivatives as new potent and selective CB2 cannabinoid receptor agonists.EBI
Taisho Pharmaceutical Co., Ltd
Discovery of N-{(1S,2S)-2-(3-cyanophenyl)- 3-[4-(2-[18F]fluoroethoxy)phenyl]-1-methylpropyl}- 2-methyl-2-[(5-methylpyridin-2-yl)oxy]propanamide, a cannabinoid-1 receptor positron emission tomography tracer suitable for clinical use.EBI
TBA
Metabolically labile cannabinoid esters: a 'soft drug' approach for the development of cannabinoid-based therapeutic drugs.EBI
Università di Pisa
Himbacine derived thrombin receptor (PAR-1) antagonists: SAR of the pyridine ring.EBI
Schering-Plough Research Institute
2-Arylimino-5,6-dihydro-4H-1,3-thiazines as a new class of cannabinoid receptor agonists. Part 2: orally bioavailable compounds.EBI
Shionogi & Co., Ltd
2-Arylimino-5,6-dihydro-4H-1,3-thiazines as a new class of cannabinoid receptor agonists. Part 1: discovery of CB2 receptor selective compounds.EBI
Shionogi & Co., Ltd
The application of 3D-QSAR studies for novel cannabinoid ligands substituted at the C1' position of the alkyl side chain on the structural requirements for binding to cannabinoid receptors CB1 and CB2.EBI
The National Hellenic Research Foundation
Biaryl cannabinoid mimetics--synthesis and structure-activity relationship.EBI
Adolor Corporation
Self-assembling cannabinomimetics: supramolecular structures of N-alkyl amides.EBI
Department of Chemistry and Applied Biosciences
Discovery of 2-[(2,4-dichlorophenyl)amino]-N-[(tetrahydro- 2H-pyran-4-yl)methyl]-4-(trifluoromethyl)- 5-pyrimidinecarboxamide, a selective CB2 receptor agonist for the treatment of inflammatory pain.EBI
GlaxoSmithKline
Optimization of imidazole amide derivatives as cannabinoid-1 receptor antagonists for the treatment of obesity.EBI
Bayer HealthCare
Substituted acyclic sulfonamides as human cannabinoid-1 receptor inverse agonists.EBI
Merck Research Laboratories
Lead optimization of 5,6-diarylpyridines as CB1 receptor inverse agonists.EBI
Merck Research Laboratories
Synthesis and biological evaluation of several structural analogs of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand.EBI
Teikyo University
Constrained analogs of CB-1 antagonists: 1,5,6,7-Tetrahydro-4H-pyrrolo[3,2-c]pyridine-4-one derivatives.EBI
Bayer HealthCare
1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors.EBI
Clemson University
Synthesis of a potential photoactivatable anandamide analog.EBI
University of Montpellier
Oxyhomologues of anandamide and related endolipids: chemoselective synthesis and biological activity.EBI
University of Piemonte Orientale
Synthesis and in vivo validation of [O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)piperazin- 1-yl]butyl}-4-methyl-2H-[1,2,4]triazine-3,5-dione: a novel 5-HT1A receptor agonist positron emission tomography ligand.EBI
Columbia University College of Physicians and Surgeons
Synthesis of functionalized 1,8-naphthyridinones and their evaluation as novel, orally active CB1 receptor inverse agonists.EBI
Merck Research Laboratories
New bicyclic cannabinoid receptor-1 (CB1-R) antagonists.EBI
Pfizer Inc
Triaryl bis-sulfones as cannabinoid-2 receptor ligands: SAR studies.EBI
Schering-Plough Research Institute
1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles.EBI
Clemson University
Chemical modification of the naphthoyl 3-position of JWH-015: in search of a fluorescent probe to the cannabinoid CB2 receptor.EBI
University of Nottingham
Triaryl bis-sulfones as a new class of cannabinoid CB2 receptor inhibitors: identification of a lead and initial SAR studies.EBI
Schering-Plough Research Institute
Synthesis and SAR of 5,6-diarylpyridines as human CB1 inverse agonists.EBI
Merck Research Laboratories
Rational Remodeling of Atypical Scaffolds for the Design of Photoswitchable Cannabinoid Receptor Tools.EBI
ShanghaiTech University
Synthesis, Biological Evaluation, and Molecular Modeling Studies of 3,4-Diarylpyrazoline Series of Compounds as Potent, Nonbrain Penetrant Antagonists of Cannabinoid-1 (CBEBI
National Institute on Alcohol Abuse and Alcoholism
Novel Functionalized Cannabinoid Receptor Probes: Development of Exceptionally Potent Agonists.EBI
The Scripps Research Institute
Synthesis and SAR evaluation of coumarin derivatives as potent cannabinoid receptor agonists.EBI
Karlsruhe Institute of Technology (KIT)
?EBI
ETH Z�rich
Rational design of cannabinoid type-1 receptor allosteric modulators: Org27569 and PSNCBAM-1 hybrids.EBI
Research Triangle Institute
Synthesis, biological properties, and molecular modeling investigations of novel 3,4-diarylpyrazolines as potent and selective CB(1) cannabinoid receptor antagonists.EBI
Solvay Pharma
Cannabinoid Receptor Agonists for the Potential Treatment of Pain, Neurological Disorders, Fibrotic Diseases, Obesity, and Many More.EBI
Therachem Research Medilab, LLC
Synthesis, Molecular Pharmacology, and Structure-Activity Relationships of 3-(Indanoyl)indoles as Selective Cannabinoid Type 2 Receptor Antagonists.EBI
West Virginia University
Variously substituted 2-oxopyridine derivatives: Extending the structure-activity relationships for allosteric modulation of the cannabinoid CB2 receptor.EBI
University of Pisa
Synthesis and testing of novel phenyl substituted side-chain analogues of classical cannabinoids.EBI
University of Tennessee-Memphis
From a Designer Drug to the Discovery of Selective Cannabinoid Type 2 Receptor Agonists with Favorable Pharmacokinetic Profiles for the Treatment of Systemic Sclerosis.EBI
East China Normal University
The discovery of a potent and selective pyrazolo-[2,3-e]-[1,2,4]-triazine cannabinoid type 2 receptor agonist.EBI
The University of Sydney
Design, synthesis and biological evaluation of second-generation benzoylpiperidine derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors.EBI
University of Pisa
Amide Bond Bioisosteres: Strategies, Synthesis, and Successes.EBI
University of Nebraska Medical Center
New cannabinoid receptor antagonists as pharmacological tool.EBI
Instituto de Qu£mica M£dica (CSIC)
Synthesis and biological evaluation of a ring analogs of the selective CB2 inverse agonist SMM-189.EBI
University of Tennessee Health Science Center
Treatment of Metabolic Disorders with CB-1 Receptor Inverse Agonists.EBI
Therachem Research Medilab (India) Pvt. Ltd.
Oxa-adamantyl cannabinoids.EBI
University of Hawaii at Manoa
The endocannabinoid system dual-target ligand N-cycloheptyl-1,2-dihydro-5-bromo-1-(4-fluorobenzyl)-6-methyl-2-oxo-pyridine-3-carboxamide improves disease severity in a mouse model of multiple sclerosis.EBI
University of Pisa
C-3 Amido-indole cannabinoid receptor modulators.EBI
Bristol-Myers Squibb Co.
Synthesis and structure-activity relationships of amide and hydrazide analogues of the cannabinoid CB(1) receptor antagonist N-(piperidinyl)- 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716).EBI
Research Triangle Institute
7-Azaindolequinuclidinones (7-AIQD): A novel class of cannabinoid 1 (CB1) and cannabinoid 2 (CB2) receptor ligands.EBI
University of Arkansas for Medical Sciences
The Essential Medicinal Chemistry of Cannabidiol (CBD).EBI
University of Minnesota
A perspective review on fatty acid amide hydrolase (FAAH) inhibitors as potential therapeutic agents.EBI
Assam University (A Central University)
Discovery of PEGylated 6-Benzhydryl-4-amino-quinazolines as Peripherally Restricted CBEBI
Janssen Research & Development
Synthesis of the Major Mammalian Metabolites of THCV.EBI
National Research Council of Italy
The discovery of azetidine-piperazine di-amides as potent, selective and reversible monoacylglycerol lipase (MAGL) inhibitors.EBI
Janssen Research & Development, L.L.C.
Synthetic bioactive olivetol-related amides: The influence of the phenolic group in cannabinoid receptor activity.EBI
Universit£ degli Studi di Siena
Exploration of Alternative Scaffolds for P2YEBI
National Institute of Diabetes and Digestive and Kidney Diseases
Design, Synthesis, and Physicochemical and Pharmacological Profiling of 7-Hydroxy-5-oxopyrazolo[4,3-EBI
University of Siena
Discovery of Aryl Formyl Piperidine Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase Inhibitors.EBI
China Pharmaceutical University
Novel cannabinol probes for CB1 and CB2 cannabinoid receptors.EBI
Organix Inc
Benzo[d]thiazol-2(3H)-ones as new potent selective CBEBI
Univ. Lille
Peripherally Selective Cannabinoid 1 Receptor (CB1R) Agonists for the Treatment of Neuropathic Pain.EBI
Research Triangle Institute
Synthesis, molecular modeling and SAR study of novel pyrazolo[5,1-f][1,6]naphthyridines as CBEBI
Universit£ degli Studi di Sassari
Novel C-Ring-Hydroxy-Substituted Controlled Deactivation Cannabinergic Analogues.EBI
Northeastern University
Chromenopyrazole, a Versatile Cannabinoid Scaffold with in Vivo Activity in a Model of Multiple Sclerosis.EBI
Instituto de Qu£mica M£dica
Plant-Based Modulators of Endocannabinoid Signaling.EBI
Concordia University Wisconsin
Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor.EBI
University of Pisa
Synthesis and Pharmacological Evaluation of 1-Phenyl-3-Thiophenylurea Derivatives as Cannabinoid Type-1 Receptor Allosteric Modulators.EBI
Research Triangle Institute
Medicinal properties of terpenes found in Cannabis sativa and Humulus lupulus.EBI
Univerisity of Eastern Finland (UEF)
Functionalized 6-(piperidin-1-yl)-8,9-diphenyl purines as inverse agonists of the CB1 receptor - SAR efforts towards selectivity and peripheralization.EBI
RTI International
Structure-activity relationships of thiazole and benzothiazole derivatives as selective cannabinoid CB2 agonists with inávivo anti-inflammatory properties.EBI
German University in Cairo
Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment.EBI
Alma Mater Studiorum-University of Bologna
Functionalized 6-(Piperidin-1-yl)-8,9-Diphenyl Purines as Peripherally Restricted Inverse Agonists of the CB1 Receptor.EBI
RTI International
Strategies to develop selective CBEBI
The University of Sydney
Dual-Acting Cholinesterase-Human Cannabinoid Receptor 2 Ligands Show Pronounced Neuroprotection in Vitro and Overadditive and Disease-Modifying Neuroprotective Effects in Vivo.EBI
Julius Maximilian University of W£rzburg
Preventing Morphine-Seeking Behavior through the Re-Engineering of Vincamine's Biological Activity.EBI
University of Florida
Isolation of a High-Affinity Cannabinoid for the Human CB1 Receptor from a Medicinal EBI
University of Modena and Reggio Emilia
Polycyclic Maleimide-based Scaffold as New Privileged Structure for Navigating the Cannabinoid System Opportunities.EBI
University of Bologna
Importance of the C-1 substituent in classical cannabinoids to CB2 receptor selectivity: synthesis and characterization of a series of O,2-propano-delta 8-tetrahydrocannabinol analogs.EBI
Kennesaw State University
Cannabinol derivatives: binding to cannabinoid receptors and inhibition of adenylylcyclase.EBI
Institute of Science
Synthesis of novel 2-(1-adamantanylcarboxamido)thiophene derivatives. Selective cannabinoid type 2 (CB2) receptor agonists as potential agents for the treatment of skin inflammatory disease.EBI
Universit£ degli Studi di Siena
Synthesis and pharmacology of a very potent cannabinoid lacking a phenolic hydroxyl with high affinity for the CB2 receptor.EBI
Clemson University
Benzimidazole: an emerging scaffold for analgesic and anti-inflammatory agents.EBI
ASBASJSM College of Pharmacy
Design, synthesis, biological evaluation, and comparative docking study of 1,2,4-triazolones as CB1 receptor selective antagonists.EBI
Zhejiang University
1,2-Dihydro-2-oxopyridine-3-carboxamides: the C-5 substituent is responsible for functionality switch at CB2 cannabinoid receptor.EBI
Universit£ di Pisa
Controlled-deactivation cannabinergic ligands.EBI
Northeastern University
Synthesis and preliminary evaluation of a new fluorine-18 labelled triazine derivative for PET imaging of cannabinoid CB2 receptor.EBI
Sanofi R&D
Development of fluorinated CB(2) receptor agonists for PET studies.EBI
Institut f£r Pharmazeutische und Medizinische Chemie der Universit£t M£nster
Selective cannabinoid receptor type 2 (CB2) agonists: optimization of a series of purines leading to the identification of a clinical candidate for the treatment of osteoarthritic pain.EBI
Lilly Research Laboratories
Identification of CB1/CB2 ligands from Zanthoxylum bungeanum.EBI
National Institute on Aging
Synthetic cannabinoid quinones: preparation, in vitro antiproliferative effects and in vivo prostate antitumor activity.EBI
Instituto de Qu£mica M£dica
Mastering tricyclic ring systems for desirable functional cannabinoid activity.EBI
The University of Montana
Peripherally selective diphenyl purine antagonist of the CB1 receptor.EBI
Research Triangle Institute
The importance of hydrogen bonding and aromatic stacking to the affinity and efficacy of cannabinoid receptor CB2 antagonist, 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]hept-2-yl]-1H-pyrazole-3-carboxamide (SR144528).EBI
University of Texas-Pan American
3-Carboxamido-5-aryl-isoxazoles as new CB2 agonists for the treatment of colitis.EBI
Universit£ Lille Nord de France
An effective prodrug strategy to selectively enhance ocular exposure of a cannabinoid receptor (CB1/2) agonist.EBI
Novartis Institutes for Biomedical Research
Selective CB2 agonists with anti-pruritic activity: discovery of potent and orally available bicyclic 2-pyridones.EBI
Shionogi Pharmaceutical Research Center
Discovery of 7-oxopyrazolo[1,5-a]pyrimidine-6-carboxamides as potent and selective CB(2) cannabinoid receptor inverse agonists.EBI
Universit£ di Ferrara
Design, synthesis, and biological evaluation of aminoalkylindole derivatives as cannabinoid receptor ligands with potential for treatment of alcohol abuse.EBI
The University of Kansas
Pharmaceutical and medicinal significance of sulfur (SEBI
Wuhan University of Technology
Microwave-assisted synthesis of quinoline, isoquinoline, quinoxaline and quinazoline derivatives as CB2 receptor agonists.EBI
University of Eastern Finland
Virtual screening of novel CB2 ligands using a comparative model of the human cannabinoid CB2 receptor.EBI
University of Kuopio
A 3D-QSAR study on the structural requirements for binding to CB(1) and CB(2) cannabinoid receptors.EBI
Universit£ di Catania
Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors.EBI
University of Pisa
6-Benzhydryl-4-amino-quinolin-2-ones as Potent Cannabinoid Type 1 (CBEBI
Janssen Research & Development
Alkyl indole-based cannabinoid type 2 receptor tools: Exploration of linker and fluorophore attachment.EBI
University of Otago
Bioactive products from singlet oxygen photooxygenation of cannabinoids.EBI
The University of Mississippi
Oximes short-acting CB1 receptor agonists.EBI
Northeastern University
Synthesis and pharmacological characterization of functionalized 6-piperazin-1-yl-purines as cannabinoid receptor 1 (CB1) inverse agonists.EBI
RTI International
Blocking Alcoholic Steatosis in Mice with a Peripherally Restricted Purine Antagonist of the Type 1 Cannabinoid Receptor.EBI
RTI International
( R)- N-(1-Methyl-2-hydroxyethyl)-13-( S)-methyl-arachidonamide (AMG315): A Novel Chiral Potent Endocannabinoid Ligand with Stability to Metabolizing Enzymes.EBI
Northeastern University
Novel sulfenamides and sulfonamides based on pyridazinone and pyridazine scaffolds as CBEBI
University of Sassari
Novel analogs of PSNCBAM-1 as allosteric modulators of cannabinoid CB1 receptor.EBI
University of Pisa
Synthesis of oxidative metabolites of CRA13 and their analogs: Identification of CRA13 active metabolites and analogs thereof with selective CBEBI
Kyung Hee University
Structure-activity relationships of imidazothiazinones and analogs as antagonists of the cannabinoid-activated orphan G protein-coupled receptor GPR18.EBI
University of Bonn
Polypharmacological profile of 1,2-dihydro-2-oxo-pyridine-3-carboxamides in the endocannabinoid system.EBI
University of Bern
Development of novel oxazolo[5,4-d]pyrimidines as competitive CBEBI
Univ. Lille
Antitumorigenic Properties of Omega-3 Endocannabinoid Epoxides.EBI
TBA
Discovery of APD371: Identification of a Highly Potent and Selective CBEBI
Arena Pharmaceuticals
Iodine-Promoted Aromatization of p-Menthane-Type Phytocannabinoids.EBI
University of Eastern Piedmont
Developing pyridazine-3-carboxamides to be CB2 agonists: The design, synthesis, structure-activity relationships and docking studies.EBI
Zhejiang University
Design, synthesis and biological evaluation of GPR55 agonists.EBI
University of North Carolina at Greensboro
Biological evaluation of pyridone alkaloids on the endocannabinoid system.EBI
University of Bern
Novel Diarylurea Based Allosteric Modulators of the Cannabinoid CB1 Receptor: Evaluation of Importance of 6-Pyrrolidinylpyridinyl Substitution.EBI
Research Triangle Institute
Amidoalkylindoles as Potent and Selective Cannabinoid Type 2 Receptor Agonists with in Vivo Efficacy in a Mouse Model of Multiple Sclerosis.EBI
East China Normal University
Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors.EBI
University of Ferrara
Development of Quinazoline/Pyrimidine-2,4(1EBI
Zhejiang University
Perspectives of Cannabinoid Type 2 Receptor (CB2R) Ligands in Neurodegenerative Disorders: Structure-Affinity Relationship (SAfiR) and Structure-Activity Relationship (SAR) Studies.EBI
Universit£ degli Studi di Bari Aldo Moro
Structure-Activity Relationships and Computational Investigations into the Development of Potent and Balanced Dual-Acting Butyrylcholinesterase Inhibitors and Human Cannabinoid Receptor 2 Ligands with Pro-Cognitive in Vivo Profiles.EBI
Julius Maximilian University of W£rzburg
 
Discovery of S-217622, a Non-Covalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19BDB
Shionogi Pharmaceutical Research Center
Carbonic anhydrase inhibitors. Phenols incorporating 2- or 3-pyridyl-ethenylcarbonyl and tertiary amine moieties strongly inhibit Saccharomyces cerevisiae ▀-carbonic anhydrase.BDB
Ataturk University
Inhibition of the Flavin-Dependent Monooxygenase Siderophore A (SidA) Blocks Siderophore Biosynthesis and Aspergillus fumigatus Growth.BDB
Virginia Tech
Capture-Tag-Release: A Strategy for Small Molecule Labeling of Native Enzymes.BDB
Fairfield University
2-Prenylated m-dimethoxybenzenes as potent inhibitors of 15-lipo-oxygenase: inhibitory mechanism and SAR studies.BDB
Ferdowsi University of Mashhad
Synthesis, anti-inflammatory, analgesic, 5-lipoxygenase (5-LOX) inhibition activities, and molecular docking study of 7-substituted coumarin derivatives.BDB
Nirma University
A Dual Non-ATP Analogue Inhibitor of Aurora Kinases A and B, Derived from Resorcinol with a Mixed Mode of Inhibition.BDB
Jawaharlal Nehru Centre for Advanced Scientific Research
Synthesis, Biological Evaluation, and Molecular Docking of 8-imino-2-oxo-2H,8H-pyrano[2,3-f]chromene Analogs: New Dual AChE Inhibitors as Potential Drugs for the Treatment of Alzheimer's Disease.BDB
Yogi Vemana University
Development of 2-(Substituted Benzylamino)-4-Methyl-1, 3-Thiazole-5-Carboxylic Acid Derivatives as Xanthine Oxidase Inhibitors and Free Radical Scavengers.BDB
Jamia Hamdard
Phosphorylation of Capsaicinoid Derivatives Provides Highly Potent and Selective Inhibitors of the Transcription Factor STAT5b.BDB
University of Leipzig
The natural product dihydrotanshinone I provides a prototype for uncharged inhibitors that bind specifically to the acetylcholinesterase peripheral site with nanomolar affinity.BDB
Mayo Clinic
Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1.BDB
Torrey Pines Institute for Molecular Studies
A novel competitive class of ╬▒-glucosidase inhibitors: (E)-1-phenyl-3-(4-styrylphenyl)urea derivatives.BDB
Gyeongsang National University
Effects of the 5-HT2B receptor agonist, BW 723C86, on three rat models of anxiety.BDB
SmithKline Beecham Pharmaceuticals Ltd
The C-terminal domain of the mGluR1 metabotropic glutamate receptor affects sensitivity to agonists.BDB
CNS Research
Properties of the VIP-PACAP type II receptor stably expressed in CHO cells.BDB
Université Libre de Bruxelles
Human glucagon receptor antagonists with thiazole cores. A novel series with superior pharmacokinetic properties.BDB
Novo Nordisk A/S
Novel glucocorticoids containing a 6,5-bicyclic core fused to a pyrazole ring: synthesis, in vitro profile, molecular modeling studies, and in vivo experiments.BDB
Merck Research Laboratories
A 2.13 A structure of E. coli dihydrofolate reductase bound to a novel competitive inhibitor reveals a new binding surface involving the M20 loop region.BDB
University of Prince Edward Island
Discovery and optimization of nonpeptide HIV-1 protease inhibitors.BDB
Parke-Davis Pharmaceutical Research
Identification of novel fragment compounds targeted against the pY pocket of v-Src SH2 by computational and NMR screening and thermodynamic evaluation.BDB
University College London
The development of cyclic sulfolanes as novel and high-affinity P2 ligands for HIV-1 protease inhibitors.BDB
Merck Research Laboratories
Design, activity, and 2.8 A crystal structure of a C2 symmetric inhibitor complexed to HIV-1 protease.BDB
Abbott Laboratories