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154 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review

Article Title
Design, synthesis and evaluation of novel indandione derivatives as multifunctional agents with cholinesterase inhibition, anti-▀-amyloid aggregation, antioxidant and neuroprotection properties against Alzheimer's disease.EBI
University of Delhi
Structure-Activity Relationship Studies of Isomeric 2,4-Diaminoquinazolines on▀-Amyloid Aggregation Kinetics.EBI
University of Waterloo
Design, synthesis and evaluation of novel tacrine-multialkoxybenzene hybrids as multi-targeted compounds against Alzheimer's disease.EBI
Guangzhou Medical University
Amyloid cascade in Alzheimer's disease: Recent advances in medicinal chemistry.EBI
University of Waterloo
Design and discovery of Novel Thiazole acetamide derivatives as anticholinesterase agent for possible role in the management of Alzheimer's.EBI
Linyi People's Hospital
Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography.EBI
China Pharmaceutical University
Structural insights into mechanisms for inhibiting amyloid▀42 aggregation by non-catechol-type flavonoids.EBI
Kyoto University
Diversification of edaravone via palladium-catalyzed hydrazine cross-coupling: Applications against protein misfolding and oligomerization of beta-amyloid.EBI
Dalhousie University
Highly Efficient Synthesis of 1,3-Dihydroxy-2-carboxycarbazole and Its Neuroprotective Effects.EBI
Virginia Commonwealth University
Design, Synthesis, and Characterization of 3-(Benzylidene)indolin-2-one Derivatives as Ligands fora-Synuclein Fibrils.EBI
Washington University
3,5-Diarylpyrazole Derivatives Obtained by Ammonolysis of the Total Flavonoids from Chrysanthemum indicum Extract Show Potential for the Treatment of Alzheimer's Disease.EBI
Sun Yat-sen University
NO-donor thiacarbocyanines as multifunctional agents for Alzheimer's disease.EBI
Universit£ degli Studi di Torino
Nodulisporiviridins A-H, Bioactive Viridins from Nodulisporium sp.EBI
Jinan University
Naturally occurring polyphenolic inhibitors of amyloid beta aggregation.EBI
CSIRO Manufacturing Flagship (Biomedical)
Imidazo[2,1]thiazol-3-one Derivatives Useful as Diagnostic Agents for Alzheimer's Disease.EBI
Temple University School of Pharmacy
Oxidative stress in Alzheimer's disease: are we connecting the dots?EBI
University of Bologna
Polyfluorinated bis-styrylbenzenes as amyloid-▀ plaque binding ligands.EBI
Leiden University
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 4. Further investigation on the inner spacer.EBI
University of Bologna
Aminostyrylbenzofuran derivatives as potent inhibitors for Abeta fibril formation.EBI
Institute of Science and Technology
Curcumin and dehydrozingerone derivatives: synthesis, radiolabeling, and evaluation for beta-amyloid plaque imaging.EBI
Sungkyunkwan University School of Medicine
F-18 stilbenes as PET imaging agents for detecting beta-amyloid plaques in the brain.EBI
University of Pennsylvania
Diphenylpropynone derivatives as probes for imagingß-amyloid plaques in Alzheimer's brains.EBI
Kyoto University
Novel pyrrolyl 2-aminopyridines as potent and selective human beta-secretase (BACE1) inhibitors.EBI
Discovery and initial optimization of 5,5'-disubstituted aminohydantoins as potent beta-secretase (BACE1) inhibitors.EBI
Wyeth Research
(3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone: a potent, selective, orally active dipeptidyl peptidase IV inhibitor.EBI
Pfizer Inc
Small conformationally restricted piperidine N-arylsulfonamides as orally active gamma-secretase inhibitors.EBI
Schering-Plough Research Institute
Design, synthesis, and evaluation of tetrahydroquinoline and pyrrolidine sulfonamide carbamates as gamma-secretase inhibitors.EBI
Pharmacopeia Drug Discovery Inc
Synthesis of biphenyltrienes as probes for beta-amyloid plaques.EBI
University of Pennsylvania
Novel benzofuran derivatives for PET imaging of beta-amyloid plaques in Alzheimer's disease brains.EBI
Nagasaki University
Synthesis and evaluation of two 18F-labeled imidazo[1,2-a]pyridine analogues as potential agents for imaging beta-amyloid in Alzheimer's disease.EBI
Emory University
Synthesis and evaluation of succinoyl-caprolactam gamma-secretase inhibitors.EBI
Bristol-Myers Squibb Pharmaceutical Research Institute
Design, synthesis, and structure-activity relationship of novel thiophene derivatives for beta-amyloid plaque imaging.EBI
University of Pennsylvania
Radioiodinated flavones for in vivo imaging of beta-amyloid plaques in the brain.EBI
Nagasaki University
Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion.EBI
Chiesi Farmaceutici S.p.A.
Molecular-modeling based design, synthesis, and activity of substituted piperidines as gamma-secretase inhibitors.EBI
Wyeth Research
Histamine HEBI
Heinrich Heine University D£sseldorf
Synthesis of the Potent, Selective, and Efficacious ?-Secretase (BACE1) Inhibitor NB-360.EBI
Discovery of Umibecestat (CNP520): A Potent, Selective, and Efficacious ?-Secretase (BACE1) Inhibitor for the Prevention of Alzheimer's Disease.EBI
Novartis Pharma AG
A Brain-Penetrant and Bioavailable Pyrazolopiperazine BACE1 Inhibitor Elicits Sustained Reduction of Amyloid ? In Vivo.EBI
Janssen Research & Development
Discovery of 1-(phenylsulfonyl)-1H-indole-based multifunctional ligands targeting cholinesterases and 5-HTEBI
Jagiellonian University Medical College
Inhibition of BACE1 and Amyloid-? Aggregation by Meroterpenoids from the Mushroom EBI
Meiji Pharmaceutical University
Novel hydroxybenzylamine-deoxyvasicinone hybrids as anticholinesterase therapeutics for Alzheimer's disease.EBI
University of Arkansas for Medical Sciences
Design, synthesis, and biological evaluation of furosemide analogs as therapeutics for the proteopathy and immunopathy of Alzheimer's disease.EBI
University Health Network
Design, synthesis and in-vitro evaluation of fluorinated triazoles as multi-target directed ligands for Alzheimer disease.EBI
National Institute of Pharmaceutical Education and Research (NIPER) Ahmedabad
Design, synthesis and evaluation of novel dimethylamino chalcone-O-alkylamines derivatives as potential multifunctional agents against Alzheimer's disease.EBI
Nanyang Normal University
Design, synthesis and biological evaluation of 2-styryl-5-hydroxy-4-pyrone derivatives and analogues as multiple functional agents with the potential for the treatment of Alzheimer's disease.EBI
Zhejiang University
Ferulic acid amide derivatives with varying inhibition of amyloid-? oligomerization and fibrillization.EBI
University of Toronto
Design, synthesis and biological evaluation of novel deoxyvasicinone-indole as multi-target agents for Alzheimer's disease.EBI
Kakatiya University
Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents.EBI
University of Pittsburgh
Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting beta-amyloid plaques in the brain.EBI
University of Pennsylvania
Hydroxypyridinone-Based Iron Chelators with Broad-Ranging Biological Activities.EBI
Zhejiang University
Novel deoxyvasicinone and tetrahydro-beta-carboline hybrids as inhibitors of acetylcholinesterase and amyloid beta aggregation.EBI
Xinyang Normal University
Toward the discovery and development of effective modulators of ?-synuclein amyloid aggregation.EBI
Universit£ degli Studi di Catania
Synthesis and biological evaluation of acridine-based histone deacetylase inhibitors as multitarget agents against Alzheimer's disease.EBI
Taipei Medical University
Inhibiting A? toxicity in Alzheimer's disease by a pyridine amine derivative.EBI
Nanjing University
Isomerization of (Z,Z) to (E,E)1-bromo-2,5-bis-(3-hydroxycarbonyl-4-hydroxy)styrylbenzene in strong base: probes for amyloid plaques in the brain.EBI
University of Pennsylvania
Radioiodinated styrylbenzenes and thioflavins as probes for amyloid aggregates.EBI
University of Pennsylvania
Isolation of three new meroterpenoids and seven known compounds from Albatrellus yasudae and their A?-aggregation inhibitory activity.EBI
Meiji Pharmaceutical University
Fenchylamine sulfonamide inhibitors of amyloid beta peptide production by the gamma-secretase proteolytic pathway: potential small-molecule therapeutic agents for the treatment of Alzheimer's disease.EBI
Amgen Inc
Discovery of novel series of 2-substituted benzo[d]oxazol-5-amine derivatives as multi-target directed ligands for the treatment of Alzheimer's disease.EBI
Indian Institute of Technology (Banaras Hindu University)
Ellagic acid a multi-target bioactive compound for drug discovery in CNS? A narrative review.EBI
University of Genoa
A multifunctional therapeutic approach: Synthesis, biological evaluation, crystal structure and molecular docking of diversified 1H-pyrazolo[3,4-b]pyridine derivatives against Alzheimer's disease.EBI
Jamia Millia Islamia (Central University)
Naphthalene-triazolopyrimidine hybrid compounds as potential multifunctional anti-Alzheimer's agents.EBI
Jamia Millia Islamia (Central University)
Naturally occurring biflavonoids with amyloid ? aggregation inhibitory activity for development of anti-Alzheimer agents.EBI
Meiji Pharmaceutical University
Advancement of multi-target drug discoveries and promising applications in the field of Alzheimer's disease.EBI
Jining Medical University
Discovery of novel 2,5-dihydroxyterephthalamide derivatives as multifunctional agents for the treatment of Alzheimer's disease.EBI
Sichuan University
Triazole derivatives as inhibitors of Alzheimer's disease: Current developments and structure-activity relationships.EBI
Wuhan Institute of Technology
Development of novel theranostic agents for inávivo amyloid imaging and protective effects on human neuroblastoma cells.EBI
Guangdong University of Technology
Synthetic approaches and pharmaceutical applications of chloro-containing molecules for drug discovery: A critical review.EBI
Wuhan University of Technology
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018).EBI
CSIR-Central Drug Research Institute
Rational Design of Multitarget-Directed Ligands: Strategies and Emerging Paradigms.EBI
China Pharmaceutical University
Discovery of TD-0212, an Orally Active Dual Pharmacology ATEBI
Theravance Biopharma US Inc.
Combined in Vitro Cell-Based/in Silico Screening of Naturally Occurring Flavonoids and Phenolic Compounds as Potential Anti-Alzheimer Drugs.EBI
University of Barcelona
Discovery and characterization of novel indole and 7-azaindole derivatives as inhibitors of ?-amyloid-42 aggregation for the treatment of Alzheimer's disease.EBI
AC Immune SA
Synthesis and biological evaluation of deferiprone-resveratrol hybrids as antioxidants, A?EBI
Zhejiang Chinese Medical University
Synthesis and structure-activity relationship of 2,6-disubstituted pyridine derivatives as inhibitors of ?-amyloid-42 aggregation.EBI
AC Immune SA
Preliminary evaluation of fluoro-pegylated benzyloxybenzenes for quantification of ?-amyloid plaques by positron emission tomography.EBI
Beijing Normal University
Spiroindole Alkaloids and Spiroditerpenoids from Aspergillus duricaulis and Their Potential Neuroprotective Effects.EBI
Korea University
?-sheet interfering molecules acting against ?-amyloid aggregation and fibrillogenesis.EBI
Sapienza University of Rome
Radioiodinated benzyloxybenzene derivatives: a class of flexible ligands target to ?-amyloid plaques in Alzheimer's brains.EBI
Beijing Normal University
Homoisoflavonoids as potential imaging agents for ?-amyloid plaques in Alzheimer's disease.EBI
Hefei University of Technology
Danshen diversity defeating dementia.EBI
RMIT University
Quinones bearing non-steroidal anti-inflammatory fragments as multitarget ligands for Alzheimer's disease.EBI
Alma Mater Studiorum University of Bologna
Syntheses and evaluation of novel isoliquiritigenin derivatives as potential dual inhibitors for amyloid-beta aggregation and 5-lipoxygenase.EBI
Sun Yat-sen University
Structure-Activity Relationships and in Vivo Evaluation of Quinoxaline Derivatives for PET Imaging of ?-Amyloid Plaques.EBI
Kyoto University
Synthesis and biological evaluation of 18F-labled 2-phenylindole derivatives as PET imaging probes for ?-amyloid plaques.EBI
Beijing Normal University
Therapeutic and pharmacokinetic characterizations of an anti-amyloidogenic bis-styrylbenzene derivative for Alzheimer's disease treatment.EBI
Korea Institute of Science and Technology
Design, synthesis and biological activity of multifunctional ?,?-unsaturated carbonyl scaffolds for Alzheimer's disease.EBI
University of Massachusetts Boston
Synthesis of tetrahydroxybiphenyls and tetrahydroxyterphenyls and their evaluation as amyloid-? aggregation inhibitors.EBI
Winthrop University
Synthesis and biological evaluation of radioiodinated quinacrine-based derivatives for SPECT imaging of A? plaques.EBI
Nagasaki University
Synthesis and Evaluation of 5-Fluoro-2-aryloxazolo[5,4-b]pyridines as ?-Amyloid PET Ligands and Identification of MK-3328.EBI
Merck Research Laboratories
Discovery of novel inhibitors of amyloid ?-peptide 1-42 aggregation.EBI
Universidad de Zaragoza
Synthesis and evaluation of ╣?F-labeled styryltriazole and resveratrol derivatives for ?-amyloid plaque imaging.EBI
Sungkyunkwan University School of Medicine
Protective effects of caffeoylquinic acids on the aggregation and neurotoxicity of the 42-residue amyloid ?-protein.EBI
University of Tsukuba
Design of ?-amyloid aggregation inhibitors from a predicted structural motif.EBI
Stanford University
The ?-Amyloid Hypothesis in Alzheimer's Disease: Seeing Is Believing.EBI
University of Pennsylvania
Small molecules that protect against ?-amyloid-induced cytotoxicity by inhibiting aggregation of ?-amyloid.EBI
Korea Institute of Science and Technology
Synthesis and evaluation of pyridylbenzofuran, pyridylbenzothiazole and pyridylbenzoxazole derivatives as ╣?F-PET imaging agents for ?-amyloid plaques.EBI
Multidentate (18)F-polypegylated styrylpyridines as imaging agents for A? plaques in cerebral amyloid angiopathy (CAA).EBI
University of Pennsylvania
A Novel (18)F-Labeled Imidazo[2,1-b]benzothiazole (IBT) for High-Contrast PET Imaging of ?-Amyloid Plaques.EBI
Technische Universit£t M£nchen
Synthesis and in vitro evaluation of fluorinated styryl benzazoles as amyloid-probes.EBI
Instituto Tecnol£gico e Nuclear
Aromatic radiofluorination and biological evaluation of 2-aryl-6-[18F]fluorobenzothiazoles as a potential positron emission tomography imaging probe for ?-amyloid plaques.EBI
Seoul National University Bundang Hospital
Synthesis and evaluation of 11C-labeled imidazo[2,1-b]benzothiazoles (IBTs) as PET tracers for imaging ?-amyloid plaques in Alzheimer's disease.EBI
Technische Universit£t M£nchen
Synthesis and evaluation of 2-pyridylbenzothiazole, 2-pyridylbenzoxazole and 2-pyridylbenzofuran derivatives as 11C-PET imaging agents for beta-amyloid plaques.EBI
Novel anilinophthalimide derivatives as potential probes for beta-amyloid plaque in the brain.EBI
Beijing Normal University
18F stilbenes and styrylpyridines for PET imaging of A beta plaques in Alzheimer's disease: a miniperspective.EBI
University of Pennsylvania
Synthesis and evaluation of three 18F-labeled aminophenylbenzothiazoles as amyloid imaging agents.EBI
Katholieke Universiteit Leuven
11C-labelled PIB analogues as potential tracer agents for in vivo imaging of amyloid beta in Alzheimer's disease.EBI
K.U. Leuven
Synthesis of 18F-labelled 2-(4'-fluorophenyl)-1,3-benzothiazole and evaluation as amyloid imaging agent in comparison with [11C]PIB.EBI
Synthesis and evaluation of 18F-labeled 2-phenylbenzothiazoles as positron emission tomography imaging agents for amyloid plaques in Alzheimer's disease.EBI
Katholieke Universiteit Leuven
Synthesis and evaluation of indolinyl- and indolylphenylacetylenes as PET imaging agents for beta-amyloid plaques.EBI
University of Pennsylvania
Synthesis and evaluation of N-methyl and S-methyl 11C-labeled 6-methylthio-2-(4'-N,N-dimethylamino)phenylimidazo[1,2-a]pyridines as radioligands for imaging beta-amyloid plaques in Alzheimer's disease.EBI
National Institute of Mental Health
Bis-styrylpyridine and bis-styrylbenzene derivatives as inhibitors for Abeta fibril formation.EBI
Korea Institute of Science and Technology
Radioiodinated aza-diphenylacetylenes as potential SPECT imaging agents for beta-amyloid plaque detection.EBI
University of Pennsylvania
Synthesis and structure-affinity relationships of new 4-(6-iodo-H-imidazo[1,2-a]pyridin-2-yl)-N-dimethylbenzeneamine derivatives as ligands for human beta-amyloid plaques.EBI
National Institute of Mental Health
Dibenzothiazoles as novel amyloid-imaging agents.EBI
Case Western Reserve University
New diphenylacetylenes as probes for positron emission tomographic imaging of amyloid plaques.EBI
University of Pennsylvania
Novel styrylpyridines as probes for SPECT imaging of amyloid plaques.EBI
University of Pennsylvania
Rationally designed divalent caffeic amides inhibit amyloid-? fibrillization, induce fibril dissociation, and ameliorate cytotoxicity.EBI
Academia Sinica
Resveratrol-maltol hybrids as multi-target-directed agents for Alzheimer's disease.EBI
Zhejiang University
Synthesis and evaluation of 1,2,3,4-tetrahydro-1-acridone analogues as potential dual inhibitors for amyloid-beta and tau aggregation.EBI
Sun Yat-sen University
Success stories of natural product-based hybrid molecules for multi-factorial diseases.EBI
Punjabi University
Novel 8-hydroxyquinoline derivatives targeting ?-amyloid aggregation, metal chelation and oxidative stress against Alzheimer's disease.EBI
Pharmaceutical University
New phenylaniline derivatives as modulators of amyloid protein precursor metabolism.EBI
University of Lille
Regioselective synthesis of 7-O-esters of the flavonolignan silibinin and SARs lead to compounds with overadditive neuroprotective effects.EBI
Julius-Maximilians-Universit£t W£rzburg
Novel sarsasapogenin-triazolyl hybrids as potential anti-Alzheimer's agents: Design, synthesis and biological evaluation.EBI
Shenyang Pharmaceutical University
Rational design, synthesis and biological screening of triazine-triazolopyrimidine hybrids as multitarget anti-Alzheimer agents.EBI
Jamia Millia Islamia (Central University)
Hydroxy-substituted trans-cinnamoyl derivatives as multifunctional tools in the context of Alzheimer's disease.EBI
Alma Mater Studiorum-University of Bologna
Structure-activity relations of rosmarinic acid derivatives for the amyloid ? aggregation inhibition and antioxidant properties.EBI
Muroran Institute of Technology
An overview of benzo[b]thiophene-based medicinal chemistry.EBI
Jain University
Isoxazole-tethered diarylheptanoid analogs: Discovery of a new drug-like PAR2 antagonist.EBI
Advinus Therapeutics Ltd
Structure-activity relationship of clovamide and its related compounds for the inhibition of amyloid? aggregation.EBI
University of Tsukuba
Fragment Profiling Approach to Inhibitors of the Orphan M. tuberculosis P450 CYP144A1.BDB
University of Cambridge
Substituted pyrazoles as hepatoselective HMG-CoA reductase inhibitors: discovery of (3R,5R)-7-[2-(4-fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H-pyrazol-3-yl]-3,5-dihydroxyheptanoic acid (PF-3052334) as a candidate for the treatment of hypercholesterolemia.BDB
Pfizer Inc