74 articles for thisTarget
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Xanthine oxidase inhibitory activity of nicotino/isonicotinohydrazides: A systematic approach from in vitro, in silico to in vivo studies.
University of Karachi
Synthesis and evaluation of xanthine oxidase inhibitory and antioxidant activities of 2-arylbenzo[b]furan derivatives based on salvianolic acid C.
China Pharmaceutical University
Discovery of novel curcumin derivatives targeting xanthine oxidase and urate transporter 1 as anti-hyperuricemic agents.
Soochow University
On the vasoprotective mechanisms underlying novelß-phosphorylated nitrones: Focus on free radical characterization, scavenging and NO-donation in a biological model of oxidative stress.
Aix-Marseille Universit£
Hydroxylated chalcones with dual properties: Xanthine oxidase inhibitors and radical scavengers.
Northern Kentucky University
9-Benzoyl 9-deazaguanines as potent xanthine oxidase inhibitors.
Universidade Estadual De Campinas
An oxidative coupling product of luteolin with cysteine ester and its enhanced inhibitory activity for xanthine oxidase.
Osaka City University
Discovery of xanthine oxidase inhibitors and/ora-glucosidase inhibitors by carboxyalkyl derivatization based on the flavonoid of apigenin.
Beijing Institute of Pharmacology & Toxicology
HTS followed by NMR based counterscreening. Discovery and optimization of pyrimidones as reversible and competitive inhibitors of xanthine oxidase.
Astrazeneca
Isocytosine-based inhibitors of xanthine oxidase: design, synthesis, SAR, PK and in vivo efficacy in rat model of hyperuricemia.
Piramal Healthcare
Radical scavenging and antioxidant activities of isocoumarins and a phthalide from the endophytic fungus Colletotrichum sp.
Chulabhorn Institute
Structure-activity relationship and classification of flavonoids as inhibitors of xanthine oxidase and superoxide scavengers.
University of Antwerp
Makaluvamine P, a new cytotoxic pyrroloiminoquinone from Zyzzya cf. fuliginosa.
University of Salerno
Quercinol, an anti-inflammatory chromene from the wood-rotting fungus Daedalea quercina (Oak Mazegill).
Institute For Natural Product Research and Infection Biology
Novel 3-O-acyl mesquitol analogues as free-radical scavengers and enzyme inhibitors: synthesis, biological evaluation and structure-activity relationship.
Institute of Chemical Technology
Design, synthesis and biological activity of original pyrazolo-pyrido-diazepine, -pyrazine and -oxazine dione derivatives as novel dual Nox4/Nox1 inhibitors.
Genkyotex
Antioxidant xanthone derivatives induce cell cycle arrest and apoptosis and enhance cell death induced by cisplatin in NTUB1 cells associated with ROS.
Kaohsiung Medical University
First in class, potent, and orally bioavailable NADPH oxidase isoform 4 (Nox4) inhibitors for the treatment of idiopathic pulmonary fibrosis.
Genkyotex
Glutarimide alkaloids and a terpenoid benzoquinone from Cordia globifera.
Chulabhorn Research Institute
Chemical constituents from the aerial parts of Artemisia minor.
Chinese Academy of Sciences
Insights into the inhibition of xanthine oxidase by curcumin.
Shandong University of Technology
Preparation of two sets of 5,6,7-trioxygenated dihydroflavonol derivatives as free radical scavengers and neuronal cell protectors to oxidative damage.
Pharmacy School of Wenzhou Medical College
ortho-dihydroxyisoflavone derivatives from aged Doenjang (Korean fermented soypaste) and its radical scavenging activity.
Amorepacific
Synthesis and cytotoxic, anti-inflammatory, and anti-oxidant activities of 2',5'-dialkoxylchalcones as cancer chemopreventive agents.
Kaohsiung Medical University
Phloroglucinols with antioxidant activity and xanthonolignoids from the heartwood of Hypericum geminiflorum.
Kaohsiung Medical University
Schiff base transition metal complexes as novel inhibitors of xanthine oxidase.
Nanjing University
Synthesis of N-aryl-5-amino-4-cyanopyrazole derivatives as potent xanthine oxidase inhibitors.
Universidade Do Minho
An apigenin-derived xanthine oxidase inhibitor from Palhinhaea cernua.
Nanjing University
Free-radical-scavenging and xanthine oxidase inhibitory constituents from Stereospermum personatum.
Institute of Chemical Technology
Structural revision of aspernigrin A, reisolated from Cladosporium herbarum IFB-E002.
Nanjing University
Antioxidant and free-radical scavenging activity of constituents of the leaves of Tachigalia paniculata.
Università
New guaianolides and xanthine oxidase inhibitory flavonols from ajania fruticulosa
Nanjing University
Agents for the Treatment of Gout: Current Advances and Future Perspectives.
Shenyang Pharmaceutical University
Discovery and Characterization of Moracin C as an Anti-Gouty Arthritis/Hyperuricemia Candidate by Docking-Based Virtual Screening and Pharmacological Evaluation.
Southern Medical University
Past, present and future of xanthine oxidase inhibitors: design strategies, structural and pharmacological insights, patents and clinical trials.
Guru Nanak Dev University
Design, synthesis, and evaluation of tricyclic compounds containing phenyl-tetrazole as XOR inhibitors.
South China University of Technology
The screening and characterization of 6-aminopurine-based xanthine oxidase inhibitors.
Institute of Biological Chemistry and The Genomics Research Center
Relationship between quantum-chemical descriptors of proton dissociation and experimental acidity constants of various hydroxylated coumarins. Identification of the biologically active species for xanthine oxidase inhibition.
Università
Intramolecular hydrogen bond interruption and scaffold hopping of TMC-5 led to 2-(4-alkoxy-3-cyanophenyl)pyrimidine-4/5-carboxylic acids and 6-(4-alkoxy-3-cyanophenyl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-ones as potent pyrimidine-based xanthine oxidase inhibitors.
Shenyang Pharmaceutical University
Identification of novel xanthine oxidase inhibitors via virtual screening with enhanced characterization of molybdopterin binding groups.
Peking Union Medical College
Design, synthesis, and biological evaluation of N-(3-cyano-1H-indol-5/6-yl)-6-oxo-1,6-dihydropyrimidine-4-carboxamides and 5-(6-oxo-1,6-dihydropyrimidin-2-yl)-1H-indole-3-carbonitriles as novel xanthine oxidase inhibitors.
Shenyang Pharmaceutical University
Isolation and biological activity of azocine and azocane alkaloids.
University of Auckland
Development of novel NLRP3-XOD dual inhibitors for the treatment of gout.
Soochow University
Pharmacological urate-lowering approaches in chronic kidney disease.
West China Hospital of Sichuan University
Discovery of 2-phenylthiazole-4-carboxylic acid, a novel and potent scaffold as xanthine oxidase inhibitors.
Guangzhou General Pharmaceutical Research Institute
Synthesis and biological evaluation of new imidazole, pyrimidine, and purine derivatives and analogs as inhibitors of xanthine oxidase.
Università
Thioxo-dihydroquinazolin-one Compounds as Novel Inhibitors of Myeloperoxidase.
Emory University
X-ray crystal structure of a xanthine oxidase complex with the flavonoid inhibitor quercetin.
University of California
Synthesis and biological evaluation of pyrazolo[4,3-d]pyrimidine analogues.
Sichuan University
Xanthine oxidase inhibitory activity of constituents of Cinnamomum cassia twigs.
National Institute of Medicinal Materials
Development of benzoxazole deoxybenzoin oxime and acyloxylamine derivatives targeting innate immune sensors and xanthine oxidase for treatment of gout.
Soochow University
Design, synthesis and bioevaluation of 2-mercapto-6-phenylpyrimidine-4-carboxylic acid derivatives as potent xanthine oxidase inhibitors.
Shenyang Pharmaceutical University
Trisubstituted barbiturates and thiobarbiturates: Synthesis and biological evaluation as xanthine oxidase inhibitors, antioxidants, antibacterial and anti-proliferative agents.
University of Beira Interior
Berchemiosides A-C, 2-Acetoxy-ω-phenylpentaene Fatty Acid Triglycosides from the Unripe Fruits of Berchemia berchemiifolia.
Seoul National University
Xanthine oxidase inhibitors beyond allopurinol and febuxostat; an overview and selection of potential leads based on in silico calculated physico-chemical properties, predicted pharmacokinetics and toxicity.
University of Nis
Potential anti-gout constituents as xanthine oxidase inhibitor from the fruits of Stauntonia brachyanthera.
Shenyang Pharmaceutical University
Type of aryl benzofuran amidated derivative and medical use thereof
China Pharmaceutical University
Carboxy substituted (hetero) aromatic ring derivatives and preparation method and uses thereof
Sunshine Lake Pharma
2-aryl selenazole compound and pharmaceutical composition thereof
Jiangsu Atom Bioscience and Pharmaceutical
6-(N-benzoylamino)purine as a novel and potent inhibitor of xanthine oxidase: inhibition mechanism and molecular modeling studies.
National Institute of Pharmaceutical Education and Research