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312 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Pyrimidine-Based Inhibitors of Dynamin I GTPase Activity: Competitive Inhibition at the Pleckstrin Homology Domain.EBI
The University of Newcastle
Pyrano[2,3,4-EBI
Polish Academy of Sciences
Synthesis and alpha 2-adrenoceptor effects of substituted catecholimidazoline and catecholimidazole analogues in human platelets.EBI
Ohio State University
Structure-activity relationships in potentially hallucinogenic N,N-dialkyltryptamines substituted in the benzene moiety.EBI
TBA
New tetrahydrobenzindoles as potent and selective 5-HT(7) antagonists with increased In vitro metabolic stability.EBI
Meiji Seika Kaisha, Ltd
SB-656104-A: a novel 5-HT(7) receptor antagonist with improved in vivo properties.EBI
GlaxoSmithKline
Bicyclic piperazinylbenzenesulphonamides are potent and selective 5-HT6 receptor antagonists.EBI
GlaxoSmithKline
Design and synthesis of novel 2,3-dihydro-1H-isoindoles with high affinity and selectivity for the dopamine D3 receptor.EBI
SmithKline Beecham Pharmaceuticals Ltd
Novel (4-piperazin-1-ylquinolin-6-yl) arylsulfonamides with high affinity and selectivity for the 5-HT(6) receptor.EBI
GlaxoSmithKline
New N- and O-arylpiperazinylalkyl pyrimidines and 2-methylquinazolines derivatives as 5-HTEBI
Universit£ di Catania
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CHEBI
Jagiellonian University Medical College
Discovery of dual positive allosteric modulators (PAMs) of the metabotropic glutamate 2 receptor and CysLT1 antagonists for treating migraine headache.EBI
Eli Lilly and Company
5-HT7 receptor modulators: Amino groups attached to biphenyl scaffold determine functional activity.EBI
Yonsei University
Decahydrobenzoquinolin-5-one sigma receptor ligands: Divergent development of both sigma 1 and sigma 2 receptor selective examples.EBI
University of Kansas
Synthesis and evaluation of the structural elements in alkylated tetrahydroisoquinolines for binding to CNS receptors.EBI
Florida A&M University
Structural modifications of the serotonin 5-HT7 receptor agonist N-(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve invitro microsomal stability: A case study.EBI
Universit£ degli Studi di Bari"A. Moro"
Development of CNS multi-receptor ligands: Modification of known D2 pharmacophores.EBI
Florida A&M University
Design and synthesis of dual 5-HT1A and 5-HT7 receptor ligands.EBI
Florida A&M University
Optimization of N'-(arylsulfonyl)pyrazoline-1-carboxamidines by exploiting a novel interaction site in the 5-HT6 antagonistic binding pocket.EBI
Abbott Healthcare Products BV
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.EBI
Jagiellonian University Medical College
Rational design in search for 5-phenylhydantoin selective 5-HT7R antagonists. Molecular modeling, synthesis and biological evaluation.EBI
Jagiellonian University Medical College
Further Advances in Optimizing (2-Phenylcyclopropyl)methylamines as Novel Serotonin 2C Agonists: Effects on Hyperlocomotion, Prepulse Inhibition, and Cognition Models.EBI
University of Illinois at Chicago
Structure-Based Discovery of Novel and Selective 5-Hydroxytryptamine 2B Receptor Antagonists for the Treatment of Irritable Bowel Syndrome.EBI
National Institute of Biological Sciences, Beijing
Novel N-acyl-carbazole derivatives as 5-HT7R antagonists.EBI
Yonsei University
Towards new 5-HT7 antagonists among arylsulfonamide derivatives of (aryloxy)ethyl-alkyl amines: Multiobjective based design, synthesis, and antidepressant and anxiolytic properties.EBI
Jagiellonian University Medical College
Receptor binding profiles and quantitative structure-affinity relationships of some 5-substituted-N,N-diallyltryptamines.EBI
The Alexander Shulgin Research Institute
N-Alkylated arylsulfonamides of (aryloxy)ethyl piperidines: 5-HT(7) receptor selectivity versus multireceptor profile.EBI
Jagiellonian University Medical College
Synthesis and evaluation of aporphine analogs containing C1 allyl isosteres at the h5-HT(2A) receptor.EBI
City University of New York
Therapeutic Potential of 5-HT6 Receptor Agonists.EBI
Universit£ de Caen Basse-Normandie
Semisynthetic Studies on and Biological Evaluation of N-Methyllaurotetanine Analogues as Ligands for 5-HT Receptors.EBI
City University of New York
Structure-activity relationships and molecular studies of novel arylpiperazinylalkyl purine-2,4-diones and purine-2,4,8-triones with antidepressant and anxiolytic-like activity.EBI
Jagiellonian University Medical College
Optimization of 2-phenylcyclopropylmethylamines as selective serotonin 2C receptor agonists and their evaluation as potential antipsychotic agents.EBI
University of Illinois at Chicago
Novel 5-HT6 receptor antagonists/D2 receptor partial agonists targeting behavioral and psychological symptoms of dementia.EBI
Jagiellonian University Collegium Medicum
Towards novel 5-HT7versus 5-HT1A receptor ligands among LCAPs with cyclic amino acid amide fragments: design, synthesis, and antidepressant properties. Part II.EBI
Jagiellonian University Medical College
Fingerprint-based consensus virtual screening towards structurally new 5-HT(6)R ligands.EBI
Jagiellonian University
Synthesis and binding properties of new long-chain 4-substituted piperazine derivatives as 5-HT1A and 5-HT7 receptor ligands.EBI
Universit£ di Catania
Structure-activity relationships and molecular modeling studies of novel arylpiperazinylalkyl 2-benzoxazolones and 2-benzothiazolones as 5-HT(7) and 5-HT(1A) receptor ligands.EBI
Universit£ di Catania
Novel N-biphenyl-2-ylmethyl 2-methoxyphenylpiperazinylalkanamides as 5-HT7R antagonists for the treatment of depression.EBI
Yonsei University
The extracellular entrance provides selectivity to serotonin 5-HT7 receptor antagonists with antidepressant-like behavior in vivo.EBI
Universidad Complutense de Madrid
Further evaluation of the tropane analogs of haloperidol.EBI
Florida A&M University
Synthesis and structure-activity relationships of new carbonyl guanidine derivatives as novel dual 5-HT2B and 5-HT7 receptor antagonists. Part 2.EBI
Astellas Pharma Inc
DDD-028: a potent potential non-opioid, non-cannabinoid analgesic for neuropathic and inflammatory pain.EBI
University of Missouri
Antidepressant- and anxiolytic-like activity of 7-phenylpiperazinylalkyl-1,3-dimethyl-purine-2,6-dione derivatives with diversified 5-HT1A receptor functional profile.EBI
Jagiellonian University Medical College
Novel arylsulfonamide derivatives with 5-HT6/5-HT7 receptor antagonism targeting behavioral and psychological symptoms of dementia.EBI
Adamed Ltd.
Identification of a new selective dopamine D4 receptor ligand.EBI
Florida A&M University
Towards the development of 5-HT7 ligands combining serotonin-like and arylpiperazine moieties.EBI
Universit£ degli Studi di Urbino
SAR-studies on the importance of aromatic ring topologies in search for selective 5-HT(7) receptor ligands among phenylpiperazine hydantoin derivatives.EBI
Jagiellonian University Medical College
Solid-supported synthesis, molecular modeling, and biological activity of long-chain arylpiperazine derivatives with cyclic amino acid amide fragments as 5-HT(7) and 5-HT(1A) receptor ligands.EBI
Jagiellonian University Medical College
Discovery of aryl-biphenyl-2-ylmethylpiperazines as novel scaffolds for 5-HT(7) ligands and role of the aromatic substituents in binding to the target receptor.EBI
Institute of Science and Technology
Diaryl substituted pyrrolidinones and pyrrolones as 5-HT2C inhibitors: synthesis and biological evaluation.EBI
GlaxoSmithKline
Antidepressant and antipsychotic activity of new quinoline- and isoquinoline-sulfonamide analogs of aripiprazole targeting serotonin 5-HT1A/5-HT2A/5-HT7 and dopamine D2/D3 receptors.EBI
Jagiellonian University Medical College
Quantitative structure-activity relationship study of serotonin (5-HT7) receptor inhibitors using modified ant colony algorithm and adaptive neuro-fuzzy interference system (ANFIS).EBI
Sharif University of Technology
Discovery of potent, orally bioavailable, selective 5-HT1A/B/D receptor antagonists.EBI
GlaxoSmithKline
Influence of the 5-HT6 receptor on acetylcholine release in the cortex: pharmacological characterization of 4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine, a potent and selective 5-HT6 receptor antagonist.EBI
F. Hoffmann-La Roche Inc
Synthesis and structure-activity relationship of 2-(aminoalkyl)-2,3,3a,8-tetrahydrodibenzo[c,f]isoxazolo[2,3-a]azepine derivatives: a novel series of 5-HT(2A/2C) receptor antagonists. Part 1.EBI
Janssen-Cilag S.A.
Phenyl benzenesulfonamides are novel and selective 5-HT6 antagonists: identification of N-(2,5-dibromo-3-fluorophenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide (SB-357134).EBI
SmithKline Beecham Pharmaceuticals Ltd
First pharmacophoric hypothesis for 5-HT7 antagonism.EBI
Universidad Complutense
As(1) receptor pharmacophore derived from a series of N-substituted 4-azahexacyclo[5.4.1.0(2,6).0(3,10).0(5,9).0(8,11)]dodecan-3-ols (AHDs).EBI
The University of Sydney
Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder.EBI
H. Lundbeck A/S
Synthesis and structure-affinity relationships of selective high-affinity 5-HT(4) receptor antagonists: application to the design of new potential single photon emission computed tomography tracers.EBI
Universit£ de Caen Basse-Normandie
Design, synthesis, and pharmacological evaluation of piperidin-4-yl amino aryl sulfonamides: novel, potent, selective, orally active, and brain penetrant 5-HT6 receptor antagonists.EBI
Suven Life Sciences Ltd
Moderate chemical modifications of WAY-100635 improve the selectivity for 5-HT1A versus D4 receptors.EBI
University of Li£ge
Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin(7) (5-HT(7)) receptor with agonist or antagonist action in vitro or ex vivo.EBI
Universit£ degli Studi di Bari A. Moro
Life beyond kinases: structure-based discovery of sorafenib as nanomolar antagonist of 5-HT receptors.EBI
National Institute of Biological Sciences
The multiobjective based design, synthesis and evaluation of the arylsulfonamide/amide derivatives of aryloxyethyl- and arylthioethyl- piperidines and pyrrolidines as a novel class of potent 5-HT7 receptor antagonists.EBI
TBA
Microwave assisted synthesis of spirocyclic pyrrolidines -s1 receptor ligands with modified benzene-N-distance.EBI
Institut f£r Pharmazeutische und Medizinische Chemie
Benzothiazoles as probes for the 5HT1A receptor and the serotonin transporter (SERT): a search for new dual-acting agents as potential antidepressants.EBI
Florida A&M University
Radiosynthesis and evaluation of an (18)F-labeled positron emission tomography (PET) radioligand for brain histamine subtype-3 receptors based on a nonimidazole 2-aminoethylbenzofuran chemotype.EBI
National Institute of Mental Health
Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators.EBI
University of Namur
Syntheses of 2-amino and 2-halothiazole derivatives as high-affinity metabotropic glutamate receptor subtype 5 ligands and potential radioligands for in vivo imaging.EBI
National Institute of Mental Health
Discovery of a novel 5-HT(3) antagonist/5-HT(1A) agonist 3-amino-5,6,7,8-tetrahydro-2-{4-[4-(quinolin-2-yl)piperazin-1-yl]butyl}quinazolin-4(3H)-one (TZB-30878) as an orally bioavailable agent for irritable bowel syndrome.EBI
ASKA Pharmaceutical Co., Ltd
Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 receptor agonist with unprecedented selectivity and procognitive potential.EBI
H. Lundbeck A/S
Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: improving metabolic stability and reducing ion channel activity.EBI
Pfizer Inc
Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine.EBI
Hunter College and the Graduate Center of the City University of New York
Benzimidazole derivatives as new serotonin 5-HT6 receptor antagonists. Molecular mechanisms of receptor inactivation.EBI
Universidad Complutense de Madrid
Sulfonamides with the N-alkyl-N'-dialkylguanidine moiety as 5-HT7 receptor ligands.EBI
Jagiellonian University Medical College
Alkaloids from Eschscholzia californica and their capacity to inhibit binding of [3H]8-Hydroxy-2-(di-N-propylamino)tetralin to 5-HT1A receptors in Vitro.EBI
Tom's of Maine
High specific activity tritium-labeled N-(2-methoxybenzyl)-2,5-dimethoxy-4-iodophenethylamine (INBMeO): a high-affinity 5-HT2A receptor-selective agonist radioligand.EBI
Purdue University
(Phenylpiperazinyl-butyl)oxindoles as selective 5-HT7 receptor antagonists.EBI
EGIS Pharmaceuticals Plc
Novel quinazolinone derivatives as 5-HT7 receptor ligands.EBI
Institute of Science and Technology
A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.EBI
Abbott Laboratories
Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: optimising brain penetration.EBI
F. Hoffmann-La Roche Inc
Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation.EBI
F. Hoffmann-La Roche Inc
Advances in development of dopaminergic aporphinoids.EBI
Chinese Academy of Sciences
Novel CCR1 antagonists with oral activity in the mouse collagen induced arthritis.EBI
Novartis Institutes for BioMedical Research
Discovery of 5-arylsulfonamido-3-(pyrrolidin-2-ylmethyl)-1H-indole derivatives as potent, selective 5-HT6 receptor agonists and antagonists.EBI
Wyeth Research
A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole.EBI
Alcon Research Ltd
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).EBI
Virginia Commonwealth University
Lysergamides of isomeric 2,4-dimethylazetidines map the binding orientation of the diethylamide moiety in the potent hallucinogenic agent N,N-diethyllysergamide (LSD).EBI
Purdue University
N-[3-(2-Dimethylaminoethyl)-2-methyl-1H- indol-5-yl]-4-fluorobenzamide: a potent, selective, and orally active 5-HT(1F) receptor agonist potentially useful for migraine therapy.EBI
Eli Lilly and Company
From hit to lead. Analyzing structure-profile relationships.EBI
Universities of Lille
(+/-)8-Amino-5,6,7,8-tetrahydroisoquinolines as novel antinociceptive agents.EBI
Virginia Commonwealth University
Quinoline- and isoquinoline-sulfonamide derivatives of LCAP as potent CNS multi-receptor-5-HT1A/5-HT2A/5-HT7 and D2/D3/D4-agents: the synthesis and pharmacological evaluation.EBI
Jagiellonian University Medical College
Multi-receptor drug design: Haloperidol as a scaffold for the design and synthesis of atypical antipsychotic agents.EBI
Florida A&M University
Arene- and quinoline-sulfonamides as novel 5-HT7 receptor ligands.EBI
Jagiellonian University Medical College
Design, synthesis and in vitro evaluation of bridgehead fluoromethyl analogs of N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexanecarboxamide (WAY-100635) for the 5-HT(1A) receptor.EBI
VU University Medical Center
N'-(arylsulfonyl)pyrazoline-1-carboxamidines as novel, neutral 5-hydroxytryptamine 6 receptor (5-HT6R) antagonists with unique structural features.EBI
Abbott Healthcare Products BV
Optimization of (arylpiperazinylbutyl)oxindoles exhibiting selective 5-HT7 receptor antagonist activity.EBI
EGIS Pharmaceuticals Plc
CNS and antimalarial activity of synthetic meridianin and psammopemmin analogs.EBI
University of South Florida
Design and synthesis of novel arylpiperazine derivatives containing the imidazole core targeting 5-HT(2A) receptor and 5-HT transporter.EBI
Green Cross Corporation
Synthesis and structural investigation of some pyrimido[5,4-c]quinolin-4(3H)-one derivatives with a long-chain arylpiperazine moiety as potent 5-HT(1A/2A) and 5-HT(7) receptor ligands.EBI
Medical University of Lodz
Synthesis and biological evaluation of potential 5-HT(7) receptor PET radiotracers.EBI
Universit£ de Lyon
Novel and Potent 5-Piperazinyl Methyl-N 1-aryl Sulfonyl Indole Derivatives as 5-HT6 Receptor Ligands.EBI
TBA
Design, synthesis, radiolabeling, and in vitro and in vivo evaluation of bridgehead iodinated analogues of N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexanecarboxamide (WAY-100635) as potential SPECT ligands for the 5-HT1A receptor.EBI
VU University Medical Center
Identification of 3-sulfonylindazole derivatives as potent and selective 5-HT(6) antagonists.EBI
Wyeth Research
Novel tetrahydropyrido[3,2-c]pyrroles as 5-HT(7) antagonists.EBI
Johnson & Johnson Pharmaceutical Research and Development LLC
1-(Arylsulfonyl)-2,3-dihydro-1H-quinolin-4-one derivatives as 5-HT(6) serotonin receptor ligands.EBI
Korea Research Institute of Chemical Technology
Conformationally restricted homotryptamines. Part 7: 3-cis-(3-aminocyclopentyl)indoles as potent selective serotonin reuptake inhibitors.EBI
Bristol-Myers Squibb Co.
5-Piperazinyl-3-sulfonylindazoles as potent and selective 5-hydroxytryptamine-6 antagonists.EBI
Wyeth Research
Synthesis, structure-affinity relationships, and radiolabeling of selective high-affinity 5-HT4 receptor ligands as prospective imaging probes for positron emission tomography.EBI
National Institute of Mental Health
Facile synthesis of octahydrobenzo[h]isoquinolines: novel and highly potent D1 dopamine agonists.EBI
Purdue University
Synthesis and SAR of (piperazin-1-yl-phenyl)-arylsulfonamides: a novel series of atypical antipsychotic agents.EBI
Korea Research Institute of Chemical Technology
Smoothened antagonists for hair inhibition.EBI
Pfizer Inc
A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase.EBI
Università degli Studi di Milano
8-Sulfonyl-substituted tetrahydro-1H-pyrido[4,3-b]indoles as 5-HT6 receptor antagonists.EBI
Chemical Diversity Research Institute
The development and validation of a novel virtual screening cascade protocol to identify potential serotonin 5-HT(7)R antagonists.EBI
Polish Academy of Sciences
Synthesis and biological evaluation of 3-aminopyrrolidine derivatives as CC chemokine receptor 2 antagonists.EBI
Yangji Chemicals
Arylpiperazine-containing pyrrole 3-carboxamide derivatives targeting serotonin 5-HT(2A), 5-HT(2C), and the serotonin transporter as a potential antidepressant.EBI
Green Cross Corporation
Molecular modeling study of 4-phenylpiperazine and 4-phenyl-1,2,3,6-tetrahydropyridine derivatives: a new step towards the design of high-affinity 5-HT1A ligands.EBI
University of Li£ge
SAR studies on new bis-aryls 5-HT7 ligands: Synthesis and molecular modeling.EBI
Universit£ d'Orl£ans
Synthesis and biological evaluation of (phenylpiperazinyl-propyl)arylsulfonamides as selective 5-HT(2A) receptor antagonists.EBI
Ewha Womans University
Novel delta opioid receptor agonists exhibit differential stimulation of signaling pathways.EBI
University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School and the Informatics Institute of UMDNJ
Novel 1-aminoethyl-3-arylsulfonyl-1H-pyrrolo[2,3-b]pyridines are potent 5-HT(6) agonists.EBI
Wyeth Research
Special ergolines are highly selective, potent antagonists of the chemokine receptor CXCR3: discovery, characterization and preliminary SAR of a promising lead.EBI
Novartis Institutes for BioMedical Research
Synthesis and in vitro affinities of various MDL 100907 derivatives as potential 18F-radioligands for 5-HT2A receptor imaging with PET.EBI
Institute of Nuclear Chemistry Johannes Gutenberg-University Mainz
Synthesis of new serotonin 5-HT7 receptor ligands. Determinants of 5-HT7/5-HT1A receptor selectivity.EBI
Universidad Complutense de Madrid
Synthesis and structure-activity relationship of 1H-indole-3-carboxylic acid pyridine-3-ylamides: a novel series of 5-HT2C receptor antagonists.EBI
Korea Research Institute of Chemical Technology
Structure-activity relationships of the cycloalkanol ethylamine scaffold: discovery of selective norepinephrine reuptake inhibitors.EBI
Wyeth Research
Preparation of piperazine derivatives as 5-HT7 receptor antagonists.EBI
Ewha Womans University
Brominated cyclodipeptides from the marine sponge Geodia barretti as selective 5-HT ligands.EBI
Uppsala University
Serotonergic activity-guided phytochemical investigation of the roots of Angelica sinensis.EBI
University of Illinois at Chicago
Inhibition of [3H]-LSD binding to 5-HT7 receptors by flavonoids from Scutellaria lateriflora.EBI
Tom's of Maine
Discovery of 3-aryl-3-methyl-1H-quinoline-2,4-diones as a new class of selective 5-HT6 receptor antagonists.EBI
Korea Research Institute of Chemical Technology
Synthesis and simple 18F-labeling of 3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethynyl)benzonitrile as a high affinity radioligand for imaging monkey brain metabotropic glutamate subtype-5 receptors with positron emission tomography.EBI
National Institute of Mental Health
3-Arylamino-2H-1,2,4-benzothiadiazin-5-ol 1,1-dioxides as novel and selective CXCR2 antagonists.EBI
GlaxoSmithKline
Novel aminoethylbiphenyls as 5-HT7 receptor ligands.EBI
Université de Caen
M4 agonists/5HT7 antagonists with potential as antischizophrenic drugs: serominic compounds.EBI
University of Strathclyde
Discovery of a novel, orally active, small molecule gonadotropin-releasing hormone (GnRH) receptor antagonist.EBI
Pfizer Inc
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.EBI
Predix Pharmaceuticals Ltd.
Synthesis, in vitro and in vivo evaluation of [O-methyl-11C] 2-{4-[4-(3-methoxyphenyl)piperazin-1-yl]-butyl}-4-methyl-2H-[1,2,4]-triazine-3,5-dione: a novel agonist 5-HT1A receptor PET ligand.EBI
Columbia University College of Physicians and Surgeons
1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity.EBI
Alcon Research Ltd
Synthesis and in vivo validation of [O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)piperazin- 1-yl]butyl}-4-methyl-2H-[1,2,4]triazine-3,5-dione: a novel 5-HT1A receptor agonist positron emission tomography ligand.EBI
Columbia University College of Physicians and Surgeons
Synthesis and biological evaluation of novel hexahydro-pyrido[3',2':4,5]pyrrolo[1,2-a]pyrazines as potent and selective 5-HT(2C) receptor agonists.EBI
F. Hoffmann-La Roche Inc
Synthesis and SAR of highly potent dual 5-HT1A and 5-HT1B antagonists as potential antidepressant drugs.EBI
Abbott GmbH & Co. KG
Synthesis of potent and selective serotonin 5-HT1B receptor ligands.EBI
Columbia University College of Physicians and Surgeons
2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT6 receptor agonists.EBI
Carlsson Research AB
Phenylpyrroles, a new chemolibrary virtual screening class of 5-HT7 receptor ligands.EBI
Université de Caen
Discovery of a new series of centrally active tricyclic isoxazoles combining serotonin (5-HT) reuptake inhibition with alpha2-adrenoceptor blocking activity.EBI
Janssen-Cilag S.A.
Discovery of new tetracyclic tetrahydrofuran derivatives as potential broad-spectrum psychotropic agents.EBI
Johnson & Johnson Pharmaceutical Research & Development
N1-arylsulfonyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives are potent and selective 5-HT6 receptor antagonists.EBI
Wyeth Research
Structure-affinity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides, a new class of 5-hydroxytryptamine7 receptor agents.EBI
Università degli Studi di Bari
Diaminopyrimidine and diaminopyridine 5-HT7 ligands.EBI
Bristol-Myers Squibb Pharmaceutical Research Institute
Aminotriazine 5-HT7 antagonists.EBI
Bristol-Myers Squibb Pharmaceutical Research Institute
Structure-Based Design and Optimization of FPPQ, a Dual-Acting 5-HTEBI
Jagiellonian University Medical College
Thiazoles and thiopyridines: novel series of high affinity h5HT(7) ligands.EBI
Merck Sharp & Dohme Research Laboratories
Discovery of G Protein-Biased Antagonists against 5-HTEBI
Korea Institute of Science and Technology
Binding of beta-carbolines at 5-HT(2) serotonin receptors.EBI
Virginia Commonwealth University
Radioligand and computational insight in structure - Activity relationship of saccharin derivatives being ipsapirone and revospirone analogues.EBI
Cracow University of Technology
Chlorine substituents and linker topology as factors of 5-HTEBI
Jagiellonian University
New dual 5-HT1A and 5-HT7 receptor ligands derived from SYA16263.EBI
Florida A&M University
Novel potent 5-HT(1F) receptor agonists: structure-activity studies of a series of substituted N-[3-(1-methyl-4-piperidinyl)-1H-pyrrolo[3,2-b]pyridin-5-yl]amides.EBI
Eli Lilly and Company
Novel anilide and benzylamide derivatives of arylpiperazinylalkanoic acids as 5-HTEBI
Jagiellonian University Medical College
Antitubercular polyhalogenated phenothiazines and phenoselenazine with reduced binding to CNS receptors.EBI
University of Perugia
Privileged scaffold-based design to identify a novel drug-like 5-HTEBI
Universit£ degli Studi di Bari Aldo Moro
Imidazopyridine-Based 5-HTEBI
Palack£ University
Pleiotropic prodrugs: Design of a dual butyrylcholinesterase inhibitor and 5-HTEBI
Normandie Univ
Identification of a novel series of selective 5-HT7 receptor antagonists.EBI
GlaxoSmithKline
Homoazanicotine: a structure-affinity study for nicotinic acetylcholine (nACh) receptor binding.EBI
Universita di Camerino
Ifenprodil Stereoisomers: Synthesis, Absolute Configuration, and Correlation with Biological Activity.EBI
Westf£lische Wilhelms-Universit£t M£nster
A dual-acting 5-HTEBI
Jagiellonian University Medical College
1-(Bicyclopiperazinyl)ethylindoles and 1-(homopiperazinyl)ethyl-indoles as highly selective and potent 5-HT(7) receptor ligands.EBI
NPS Pharmaceuticals Inc
Isoquinolinone derivatives as potent CNS multi-receptor DEBI
Jiangsu Ocean University
Synthesis, receptor potency, and selectivity of halogenated diphenylpiperidines as serotonin 5-HT2A ligands for PET or SPECT brain imaging.EBI
Yale University
A study of the structure-affinity relationship in SYA16263; is a DEBI
Florida A&M University
Multifunctional 6-fluoro-3-[3-(pyrrolidin-1-yl)propyl]-1,2-benzoxazoles targeting behavioral and psychological symptoms of dementia (BPSD).EBI
Jagiellonian University Medical College
Discovery and SAR studies of 2-alkyl-3-phenyl-2,4,5,6,7,8-hexahydropyrazolo[3,4-d]azepines as 5-HTEBI
Janssen Research & Development, LLC
N-Arylsulfonylindole derivatives as serotonin 5-HT(6) receptor ligands.EBI
Merck Sharp & Dohme Research Laboratories
Chemical puzzles in the search for new, flexible derivatives of lurasidone as antipsychotic drugs.EBI
Cracow University of Technology
Conformationally restricted indolopiperidine derivatives as potent CCR2B receptor antagonists.EBI
GlaxoSmithKline
Structural manipulation of aporphines via C10 nitrogenation leads to the identification of new 5-HTEBI
City University of New York
Synthesis of potent and selective dopamine D(4) antagonists as candidate radioligands.EBI
Columbia University College of Physicians and Surgeons
Synthesis of novel 5-substituted-2-aminotetralin analogs: 5-HTEBI
Northeastern University
Isolation and Synthesis of Veranamine, an Antidepressant Lead from the Marine Sponge EBI
University of Mississippi
N1-(Benzenesulfonyl)tryptamines as novel 5-HT6 antagonists.EBI
Virginia Commonwealth University
South (S)- and North (N)-Methanocarba-7-Deazaadenosine Analogues as Inhibitors of Human Adenosine Kinase.EBI
National Institute of Diabetes and Digestive and Kidney Diseases
Design and synthesis of new homo and hetero bis-piperazinyl-1-propanone derivatives as 5-HT7R selective ligands over 5-HT1AR.EBI
Universit£ di Catania
N1-Azinylsulfonyl-1H-indoles: 5-HT6 Receptor Antagonists with Procognitive and Antidepressant-Like Properties.EBI
Jagiellonian University Medical College
Design, synthesis, and structure-activity relationships of phthalimide-phenylpiperazines: a novel series of potent and selective alpha(1)(a)-adrenergic receptor antagonists.EBI
The R. W. Johnson Pharmaceutical Research Institute
Synthesis of spiro-2,6-dioxopiperazine and spiro-2,6-dioxopyrazine scaffolds using amino acids in a three-component reaction to generate potential Sigma-1 (?EBI
Memorial Sloan Kettering Cancer Center
2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors.EBI
Virginia Commonwealth University
Synthesis and antidepressant-like activity of novel alkoxy-piperidine derivatives targeting SSRI/5-HTEBI
China Pharmaceutical University
Synthesis and antidepressant effect of novel aralkyl piperazine and piperidine derivatives targeting SSRI/5-HTEBI
China State Institute of Pharmaceutical Industry
Discovery, Optimization, and Characterization of ML417: A Novel and Highly Selective DEBI
National Institute of Neurological Disorders and Stroke
Synthesis of novel pyrido[1,2-c]pyrimidine derivatives with rigidized tryptamine moiety as potential SSRI and 5-HTEBI
Medical University of Warsaw
Leveraging a Low-Affinity Diazaspiro Orthosteric Fragment to Reduce Dopamine DEBI
University of Pennsylvania
Fluorinated indole-imidazole conjugates: Selective orally bioavailable 5-HTEBI
Polish Academy of Sciences
Defining Structure-Functional Selectivity Relationships (SFSR) for a Class of Non-Catechol Dopamine DEBI
University of North Carolina at Chapel Hill
Design, synthesis and molecular modelling of new bulky Fananserin derivatives with altered pharmacological profile as potential antidepressants.EBI
Cracow University of Technology
New dual ligands for the DEBI
Cracow University of Technology
Synthesis and biological activity of oxo-7H-benzo[e]perimidine-4-carboxylic acid derivatives as potent, nonpeptide corticotropin releasing factor (CRF) receptor antagonists.EBI
Agouron Pharmaceuticals Inc
Design and in Vivo Characterization of AEBI
Medical College of Wisconsin
Synthesis of new 5,6,7,8-tetrahydropyrido[1,2-c]pyrimidine derivatives with rigidized tryptamine moiety as potential SSRI and 5-HTEBI
Medical University of Warsaw
Synthesis and computer-aided SAR studies for derivatives of phenoxyalkyl-1,3,5-triazine as the new potent ligands for serotonin receptors 5-HTEBI
Jagiellonian University
2-Aminoimidazole-based antagonists of the 5-HTEBI
Polish Academy of Sciences
Research progress in the biological activities of 3,4,5-trimethoxycinnamic acid (TMCA) derivatives.EBI
Northwest University
Structure-activity relationships of serotonin 5-HTEBI
Normandie Univ
Novel multitarget 5-arylidenehydantoins with arylpiperazinealkyl fragment: Pharmacological evaluation and investigation of cytotoxicity and metabolic stability.EBI
Jagiellonian University Medical College
Virtual screening-driven discovery of dual 5-HTEBI
Polish Academy of Sciences
Synthesis and biological evaluation of new multi-target 3-(1H-indol-3-yl)pyrrolidine-2,5-dione derivatives with potential antidepressant effect.EBI
Medical University of Warsaw
[1]Benzothieno[3,2-d]pyrimidine derivatives as ligands for the serotonergic 5-HTEBI
Universit£ di Catania
3-Amino-chromanes and Tetrahydroquinolines as Selective 5-HTEBI
University of Minnesota Twin Cities
Design, synthesis and biological evaluation of novel serotonin and dopamine receptor ligands being 6-bromohexyl saccharine derivatives.EBI
Cracow University of Technology
Benzazaborinines as Novel Bioisosteric Replacements of Naphthalene: Propranolol as an Example.EBI
Janssen Pharmaceutica N.V.
Synthesis and pharmacological evaluation of optically pure, novel carbonyl guanidine derivatives as dual 5-HT2B and 5-HT7 receptor antagonists.EBI
Astellas Pharma Inc
New 1-arylindoles based serotonin 5-HT7 antagonists. Synthesis and binding evaluation studies.EBI
Universit£ de Lyon
Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT? receptor.EBI
Universit£ degli Studi di Bari A. Moro
Synthesis and evaluation of 1-[2-(4-[(11)C]methoxyphenyl)phenyl]piperazine for imaging of the serotonin 5-HT7 receptor in the rat brain.EBI
National Institute of Radiological Sciences
Synthesis and evaluation of pharmacological properties of some new xanthone derivatives with piperazine moiety.EBI
Jagiellonian University Medical College
Synthesis and pharmacological properties of novel hydrophilic 5-HT4 receptor antagonists.EBI
Drug Discovery Laboratory AS
3,4-Dihydro-2H-benzoxazinones as dual-acting 5-HT1A receptor antagonists and serotonin reuptake inhibitors.EBI
GlaxoSmithKline
Principal component analysis differentiates the receptor binding profiles of three antipsychotic drug candidates from current antipsychotic drugs.EBI
Solvay Pharma
Aminoalkyl phenyl sulfones--a novel series of 5-HT7 receptor ligands.EBI
Merck Sharp and Dohme Research Laboratories
Discovery of the first potent, selective 5-hydroxytryptamine1D receptor antagonist.EBI
GlaxoSmithKline
Discovery of a potent and selective 5-ht5A receptor antagonist by high-throughput chemistry.EBI
GlaxoSmithKline
Optimization of the pharmacophore model for 5-HT7R antagonism. Design and synthesis of new naphtholactam and naphthosultam derivatives.EBI
Universidad Complutense
A novel ergot alkaloid as a 5-HT(1A) inhibitor produced by Dicyma sp.EBI
GlaxoSmithKline R&D
2a-[4-(Tetrahydropyridoindol-2-yl)butyl]tetrahydrobenzindole derivatives: new selective antagonists of the 5-hydroxytryptamine7 receptor.EBI
Meiji Seika Kaisha Ltd.
Tetrahydrobenzindoles: selective antagonists of the 5-HT7 receptor.EBI
Meiji Seika Kaisha Ltd.
Analogs of penfluridol as chemotherapeutic agents with reduced central nervous system activity.EBI
Texas Tech University Health Sciences Center
Synthesis and antidepressant-like activity of novel aralkyl piperazine derivatives targeting SSRI/5-HTEBI
Shanghai Institute of Pharmaceutical Industry
Novel multi-target azinesulfonamides of cyclic amine derivatives as potential antipsychotics with pro-social and pro-cognitive effects.EBI
Jagiellonian University Medical College
Amino Acid Hot Spots of Halogen Bonding: A Combined Theoretical and Experimental Case Study of the 5-HTEBI
Polish Academy of Sciences
Discovery of ?-Arrestin Biased Ligands of 5-HTEBI
Korea Institute of Science and Technology
Structure-Activity Relationships and Therapeutic Potentials of 5-HTEBI
Universit£ di Catania
Spiro[pyrrolidine-3,3'-oxindoles] as 5-HTEBI
Hungarian Academy of Sciences
Synthesis and activity of di- or trisubstituted N-(phenoxyalkyl)- or N-{2-[2-(phenoxy)ethoxy]ethyl}piperazine derivatives on the central nervous system.EBI
Jagiellonian University Medical College
Modulating the Serotonin Receptor Spectrum of Pulicatin Natural Products.EBI
University of the Philippines
MF-8, a novel promising arylpiperazine-hydantoin based 5-HTEBI
Jagiellonian University Medical College
Synthesis and antidepressant activity of a series of arylalkanol and aralkyl piperazine derivatives targeting SSRI/5-HTEBI
Shanghai Institute of Pharmaceutical Industry
Novel 5-HTEBI
Jagiellonian University Medical College
Structural insights into serotonin receptor ligands polypharmacology.EBI
Polish Academy of Sciences
Computer-aided insights into receptor-ligand interaction for novel 5-arylhydantoin derivatives as serotonin 5-HTEBI
Jagiellonian University Medical College
Novel non-sulfonamide 5-HTEBI
Palack£ University
Novel naphthyloxy derivatives - Potent histamine HEBI
Jagiellonian University Medical College
Identification and biological evaluation of thiazole-based inverse agonists of ROR?t.EBI
Phenex Pharmaceuticals AG
Hydrophilic, Potent, and Selective 7-Substituted 2-Aminoquinolines as Improved Human Neuronal Nitric Oxide Synthase Inhibitors.EBI
Northwestern University
Novel 3-(1,2,3,6-Tetrahydropyridin-4-yl)-1H-indole-Based Multifunctional Ligands with Antipsychotic-Like, Mood-Modulating, and Procognitive Activity.EBI
Jagiellonian University Medical College
Return of DEBI
University of Nebraska Medical Center
The impact of the halogen bonding on DEBI
Jagiellonian University Medical College
The recent outbreaks of human coronaviruses: A medicinal chemistry perspective.BDB
University of Bonn
Synthesis, Biological Evaluation, and Molecular Docking of 8-imino-2-oxo-2H,8H-pyrano[2,3-f]chromene Analogs: New Dual AChE Inhibitors as Potential Drugs for the Treatment of Alzheimer's Disease.BDB
Yogi Vemana University
Inhibition of Zinc-Dependent Histone Deacetylases with a Chemically Triggered Electrophile.BDB
Broad Institute
Design, Synthesis, Biological Evaluation, and Docking Study of Acetylcholinesterase Inhibitors: New Acridone-1,2,4-oxadiazole-1,2,3-triazole Hybrids.BDB
Tehran University of Medical Sciences
Discovery of new 4-alkoxyquinazoline-based derivatives as potent VEGFR2 inhibitors.BDB
Nanjing University
Structure and Inhibition of Microbiome -Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity.BDB
University of North Carolina at Chapel Hill
Design and synthesis of newer potential 4-(N-acetylamino)phenol derived piperazine derivatives as potential cognition enhancers.BDB
Panjab University
Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroreceptor.BDB
Northwestern University
Interactions of (+)- and (-)-8- and 7-hydroxy-2-(di-n-propylamino)tetralin at human (h)D3, hD2 and h serotonin1A receptors and their modulation of the activity of serotoninergic and dopaminergic neurones in rats.BDB
Institut de Recherches Servier
In vitro and in vivo pharmacological characterization of N6-cyclopentyl-9-methyladenine (N-0840): a selective, orally active A1 adenosine receptor antagonist.BDB
Whitby Research, Inc.
Putative selective 5-HT-2 antagonists block serotonin 5-HT-1c receptors in the choroid plexus.BDB
Vanderbilt University
Chemical probes of UDP-galactopyranose mutase.BDB
University of Wisconsin-Madison
Calorimetric investigation of ethidium and netropsin binding to chicken erythrocyte chromatin.BDB
Universite de Liege