BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.2M data for 1.4M Compounds and 11.4K Targets. Of those, 1.5M data for 737K Compounds and 4.7K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

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15 articles for PR Maloney

The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Discovery of ML314, a Brain Penetrant Non-Peptidicβ-Arrestin Biased Agonist of the Neurotensin NTR1 Receptor.EBI
Sanford-Burnham Medical Research Institute
Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptor.EBI
Sanford-Burnham Medical Research Institute
6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity.EBI
TBA
Identification of a chemical tool for the orphan nuclear receptor FXR.EBI
Glaxo Wellcome Research & Development
Structure-activity relationships for inhibition of type 1 and 2 human 5 alpha-reductase and human adrenal 3 beta-hydroxy-delta 5-steroid dehydrogenase/3-keto-delta 5-steroid isomerase by 6-azaandrost-4-en-3-ones: optimization of the C17 substituent.EBI
Glaxo Inc. Research Institute
6-Azasteroids: structure-activity relationships for inhibition of type 1 and 2 human 5 alpha-reductase and human adrenal 3 beta-hydroxy-delta 5-steroid dehydrogenase/3-keto-delta 5-steroid isomerase.EBI
Glaxo Inc. Research Institute
Optimization of a urea-containing series of nicotinamide phosphoribosyltransferase (NAMPT) activators.EBI
Sanford Burnham Prebys Medical Discovery Institute
Novel selective small molecule agonists for peroxisome proliferator-activated receptor delta (PPARdelta)--synthesis and biological activity.EBI
Glaxosmithkline
Discovery of small molecule antagonists of chemokine receptor CXCR6 that arrest tumor growth in SK-HEP-1 mouse xenografts as a model of hepatocellular carcinoma.EBI
Sanford Burnham Prebys Medical Discovery Institute
3-Benzisothiazolylpiperazine derivatives as potential atypical antipsychotic agents.EBI
Pfizer
6-Azasteroids: potent dual inhibitors of human type 1 and 2 steroid 5 alpha-reductase.EBI
Glaxo Inc. Research Institute
An orally available, brain-penetrant CAMKK2 inhibitor reduces food intake in rodent model.EBI
Glaxosmithkline
Carboxylic acid compoundsBDB
Sumitomo Dainippon Pharma
Methods for treating depressive symptomsBDB
Alkermes Pharma Ireland
Aminopyrimidine derivatives as LRRK2 modulatorsBDB
Genentech