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56 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review

Article Title
Synthesis of Novel c(AmpRGD)-Sunitinib Dual Conjugates as Molecular Tools Targeting theaEBI
Universit£ degli Studi di Parma
University of California San Francisco
Cyclic RGD peptidomimetics containing 4- and 5-amino-cyclopropane pipecolic acid (CPA) templates as dualaV▀3 anda5▀1 integrin ligands.EBI
University of Florence
Rational improvement of the affinity and selectivity of integrin binding of grafted lasso peptides.EBI
Philipps-Universit£t Marburg
Targeting integrinsav▀3 anda5▀1 with new▀-lactam derivatives.EBI
University of Bologna
Pharmacophoric modifications lead to superpotentav▀3 integrin ligands with suppresseda5▀1 activity.EBI
Technische Universit£t M£nchen
Small Macrocycles As Highly Active Integrin?2?1 Antagonists.EBI
Sanofi R & D
Synthesis and in vitro evaluation of a novel radioligand forav▀3 integrin receptor imaging: [18F]FPPA-c(RGDfK).EBI
University Hospital of Geneva
Modulation ofav▀3- anda5▀1-integrin-mediated adhesion by dehydro-▀-amino acids containing peptidomimetics.EBI
University of Bologna
Arylsulfonamide pyrimidines as VLA-4 antagonists.EBI
Elan Pharmaceuticals, Inc.
Biselectivity of isoDGR peptides for fibronectin binding integrin subtypesa5ß1 andavß6: conformational control through flanking amino acids.EBI
Technische Universit£t M£nchen
SAR of N-phenyl piperidine based oral integrin alpha5beta1 antagonists.EBI
Jerini AG
Discovery of orally available integrin alpha5beta1 antagonists.EBI
Jerini AG
Non-peptide fibrinogen receptor antagonists. 7. Design and synthesis of a potent, orally active fibrinogen receptor antagonist.EBI
Merck Research Laboratories
Structure-activity relationship of a series of non peptidic RGD integrin antagonists targetinga5ß1: part 1.EBI
Structure-activity relationship of a series of non peptidic RGD integrin antagonists targetinga5ß1: part 2.EBI
Antiangiogenic effect of dual/selective alpha(5)beta(1)/alpha(v)beta(3) integrin antagonists designed on partially modified retro-inverso cyclotetrapeptide mimetics.EBI
Universita degli Studi di Bologna
Selective cell adhesion inhibitors: Barbituric acid based alpha4beta7--MAdCAM inhibitors.EBI
Millennium Pharmaceuticals
Discovery of subnanomolar arginine-glycine-aspartate-based alphaVbeta3/alphaVbeta5 integrin binders embedding 4-aminoproline residues.EBI
Universit£ di Parma
Design, synthesis, and biochemical evaluation of novel alpha V beta 3 integrin ligands.EBI
3-Dimensional Pharmaceuticals Inc
Selective alpha4beta7 integrin antagonists and their potential as antiinflammatory agents.EBI
Genentech Inc
Non-peptide glycoprotein IIb/IIIa inhibitors. 17. Design and synthesis of orally active, long-acting non-peptide fibrinogen receptor antagonists.EBI
Merck Research Laboratories
Ultrasmall particle of iron oxide--RGD peptidomimetic conjugate: synthesis and characterisation.EBI
Universit£ Catholique de Louvain
Multiple N-methylation by a designed approach enhances receptor selectivity.EBI
Technische Universität München
Synthesis and biological evaluation of non-peptide alpha(v)beta(3)/alpha(5)beta(1) integrin dual antagonists containing 5,6-dihydropyridin-2-one scaffolds.EBI
Università di Bologna
Design and synthesis of a new class of selective integrin alpha5beta1 antagonists.EBI
Jerini AG
Ligand binding analysis for human alpha5beta1 integrin: strategies for designing new alpha5beta1 integrin antagonists.EBI
Università di Napoli Federico II
Design, synthesis, and biological evaluation of novel potent and selective alphavbeta3/alphavbeta5 integrin dual inhibitors with improved bioavailability. Selection of the molecular core.EBI
Johnson and Johnson Pharmaceutical Research & Development
Rational design and synthesis of novel heparan sulfate mimetic compounds as antiadhesive agents.EBI
RIKEN Discovery Research Institute
Solid-phase synthesis of a small library of 3-phenylthio-3-nicotinyl propionic acid derivatives acting as antagonists of the integrin alphaVbeta3.EBI
Synthesis and biological evaluation of nonpeptide integrin antagonists containing spirocyclic scaffolds.EBI
Pharmaceutical Research Institute
Improvement of biological activity and proteolytic stability of peptides by coupling with a cyclic peptide.EBI
Kyowa Hakko Kogyo Co., Ltd
Tuning the Biological Activity of RGD Peptides with Halotryptophans?.EBI
Bielefeld University
Nonpeptide RGD antagonists: a novel class of mimetics, the 5,8-disubstituted 1-azabicyclo[5.2.0]nonan-2-one lactam.EBI
University of Montpellier
Thiophene-based vitronectin receptor antagonists.EBI
Shire BioChem Inc
Dual antagonists of ?5?1/?v?1 integrin for airway hyperresponsiveness.EBI
University of California San Francisco
New ?-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins.EBI
University of Bologna
Design and synthesis of potent and selective inhibitors of integrin VLA-4.EBI
Novartis Institute for BioMedical Research
Novel cilengitide-based cyclic RGD peptides as ?v?EBI
Division of Organic Chemistry CSIR-National Chemical Laboratory (NCL)
2-Acylimino-3H-thiazoline derivatives: a novel template for platelet GPIIb/IIIa receptor antagonists.EBI
Taisho Pharmaceutical Co., Ltd
Discovery and evaluation of potent, tyrosine-based alpha4beta1 integrin antagonists.EBI
Celltech Chiroscience
Selective Targeting of Integrin ?v?8 by a Highly Active Cyclic Peptide.EBI
Technische Universit£t M£nchen
Selective, tight-binding inhibitors of integrin alpha4beta1 that inhibit allergic airway responses.EBI
Biogen Inc
Cyclization of RGD Peptides by Suzuki-Miyaura Cross-Coupling.EBI
Bielefeld University
Could Dissecting the Molecular Framework of ?-Lactam Integrin Ligands Enhance Selectivity?EBI
University of Bologna
Discovery of potent isoxazoline glycoprotein IIb/IIIa receptor antagonists.EBI
DuPont Pharmaceuticals Company
Dehydro-?-proline Containing ?4?1 Integrin Antagonists: Stereochemical Recognition in Ligand-Receptor Interplay.EBI
University of Bologna
Strategies to inhibit tumor associated integrin receptors: rationale for dual and multi-antagonists.EBI
University of Bradford
Non-peptide fibrinogen receptor antagonists. 2. Optimization of a tyrosine template as a mimic for Arg-Gly-Asp.EBI
Merck Research Laboratories
Design and synthesis of novel cyclic RGD-containing peptides as highly potent and selective integrin alpha IIb beta 3 antagonists.EBI
Telios Pharmaceuticals, Inc.
Discovery of ( S)-3-(3-(3,5-Dimethyl-1 H-pyrazol-1-yl)phenyl)-4-(( R)-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)butanoic Acid, a Nonpeptidic ?EBI
University of Strathclyde
Simultaneous Targeting of RGD-Integrins and Dual Murine Double Minute Proteins in Glioblastoma Multiforme.EBI
Universit£ degli Studi di Napoli "Federico II"
Emergence of Small-Molecule Non-RGD-Mimetic Inhibitors for RGD Integrins.EBI
University of Strathclyde
Non-peptide fibrinogen receptor antagonists. 1. Discovery and design of exosite inhibitors.EBI
Merck Research Laboratories