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62 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Influence of polar side chains modifications on the dual enkephalinase inhibitory activity and conformation of human opiorphin, a pain perception related peptide.EBI
Institute of Advanced Chemistry of Catalonia (Iqac-Csic)
Modulation of disulfide dual ENKephalinase inhibitors (DENKIs) activity by a transient N-protection for pain alleviation by oral route.EBI
Pharmaleads
New orally active dual enkephalinase inhibitors (DENKIs) for central and peripheral pain treatment.EBI
Pharmaleads
Discovery of the first potent and selective Mycobacterium tuberculosis Zmp1 inhibitor.EBI
University of Siena
Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid- hydrolysis.EBI
University of Lille
Thiol-based angiotensin-converting enzyme 2 inhibitors: P1 modifications for the exploration of the S1 subsite.EBI
Glaxosmithkline
 
Dual metalloprotease inhibitors. III. utilization of bicyclic and monocyclic diazepinone based mercaptoacetylsEBI
TBA
 
Dual metalloprotease inhibitors. II. Effect of substitution and stereochemistry on benzazepinone based mercaptoacetylsEBI
TBA
 
Dual metalloprotease inhibitors. I. constrained peptidomimetics of mercaptoacyl dipeptidesEBI
TBA
Macrocycles are great cycles: applications, opportunities, and challenges of synthetic macrocycles in drug discovery.EBI
Universite£
Novelß-amino acid derivatives as inhibitors of cathepsin A.EBI
Sanofi-Aventis Deutschland
Remarkable potential of thea-aminophosphonate/phosphinate structural motif in medicinal chemistry.EBI
Wroclaw University of Technology
Proposed Bioactive Conformations of Opiorphin, an Endogenous Dual APN/NEP Inhibitor.EBI
TBA
Structure-activity relationship study of opiorphin, a human dual ectopeptidase inhibitor with antinociceptive properties.EBI
Institute of Advanced Chemistry of Catalonia (Iqac-Csic)
Targeting ACE and ECE with dual acting inhibitors.EBI
Universit£
Designed multiple ligands. An emerging drug discovery paradigm.EBI
Organon Laboratories
Endothelin-converting enzyme-1 inhibition and growth of human glioblastoma cells.EBI
University Institute of Pathology
Computer-aided selection of potential antihypertensive compounds with dual mechanism of action.EBI
Institute of Biomedical Chemistry of Russian Academy of Medical Sciences
Long lasting antinociceptive properties of enkephalin degrading enzyme (NEP and APN) inhibitor prodrugs.EBI
University of Paris
Design and synthesis of potent, selective inhibitors of endothelin-converting enzyme.EBI
Novartis Pharmaceuticals
Potent and systemically active aminopeptidase N inhibitors designed from active-site investigation.EBI
University of Paris
 
Potent non-peptidic dual inhibitors of endothelin-converting enzyme and neutral endopeptidase 24.11EBI
TBA
 
Synthesis and evaluation of 2-(biphenylmethyl)glutaric acid amide derivatives as neutral endopeptidase inhibitors.EBI
TBA
 
Solid phase synthesis of phosphinic acid endothelin converting enzyme inhibitorsEBI
TBA
 
Dual inhibition of neutral endopeptidase and angiotensin-converting enzyme by N-phosphonomethyl and N-carboxyalkyl dipeptidesEBI
TBA
Structure-based design of dipeptide derivatives for the human neutral endopeptidase.EBI
Kao
Synthesis and evaluation of heteroarylalanine diacids as potent and selective neutral endopeptidase inhibitors.EBI
Pfizer
Phosphinic tripeptides as dual angiotensin-converting enzyme C-domain and endothelin-converting enzyme-1 inhibitors.EBI
Cea
 
Dual inhibition of angiotensin-converting enzyme and neutral endopeptidase by tricyclic benzazepinone thiolsEBI
TBA
 
Studies on the structural feature of S'1 subsite of neprilysin (EC.3.4.24.11): Stereochemical requirement for the enzyme-inhibitor docking processEBI
TBA
 
Non-peptidic inhibitors of neutral endopeptidase 24.11 2. Design and pharmacology of orally active phosphonate prodrugsEBI
TBA
 
Synthesis of 6-amino-5-oxo-7-phenyl-1,4-oxazepines as conformationally constrained gauche (−) dipeptide mimeticsEBI
TBA
Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge.EBI
University of Athens
Homology modeling and site-directed mutagenesis to identify selective inhibitors of endothelin-converting enzyme-2.EBI
Mount Sinai School of Medicine
Thiol-based angiotensin-converting enzyme 2 inhibitors: P1' modifications for the exploration of the S1' subsite.EBI
Glaxosmithkline
Novel selective inhibitors of neutral endopeptidase for the treatment of female sexual arousal disorder.EBI
Pfizer
Novel selective inhibitors of neutral endopeptidase for the treatment of female sexual arousal disorder. Synthesis and activity of functionalized glutaramides.EBI
Pfizer
Probing the Requirements for Dual Angiotensin-Converting Enzyme C-Domain Selective/Neprilysin Inhibition.EBI
University of Cape Town
Amide Bond Bioisosteres: Strategies, Synthesis, and Successes.EBI
University of Nebraska Medical Center
Asymmetric synthesis of BB-3497--a potent peptide deformylase inhibitor.EBI
British Biotech Pharmaceuticals
2-(2-Oxo-1,4-dihydro-2H-quinazolin-3-yl)- and 2-(2,2-dioxo-1,4-dihydro-2H-2lambda6-benzo[1,2,6]thiadiazin-3-yl)-N-hydroxy-acetamides as potent and selective peptide deformylase inhibitors.EBI
F. Hoffmann-La Roche
Molecular Basis for Omapatrilat and Sampatrilat Binding to Neprilysin-Implications for Dual Inhibitor Design with Angiotensin-Converting Enzyme.EBI
University of Bath
Structure-Guided Design of Substituted Biphenyl Butanoic Acid Derivatives as Neprilysin Inhibitors.EBI
Novartis Institutes For Biomedical Research
Meta-substituted benzofused macrocyclic lactams as zinc metalloprotease inhibitors.EBI
Ciba-Geigy
Ortho-substituted benzofused macrocyclic lactams as zinc metalloprotease inhibitors.EBI
Novartis Pharmaceuticals
Discovery of TD-0212, an Orally Active Dual Pharmacology ATEBI
Theravance Biopharma Us
A mechanism-based inactivation study of neutral endopeptidase 24.11.EBI
Salk Biotechnology/Industrial Associates
New dual inhibitors of neutral endopeptidase and angiotensin-converting enzyme: rational design, bioavailability, and pharmacological responses in experimental hypertension.EBI
University of Paris
Substituted?-mercaptoketones, new types of specific neprilysin inhibitors.EBI
Pharmaleads
Approaches towards the development of chimeric DPP4/ACE inhibitors for treating metabolic syndrome.EBI
Ranbaxy Laboratories
In vitro inhibition effect and structure-activity relationships of some saccharin derivatives on erythrocyte carbonic anhydrase I and II.BDB
Sakarya University
Inhibitors of human mitotic kinesin Eg5: characterization of the 4-phenyl-tetrahydroisoquinoline lead series.BDB
Bristol-Myers Squibb
The First Biologically Active Synthetic Analogues of FK228, the Depsipeptide Histone Deacetylase Inhibitor.BDB
University of Southampton
Discovery of nonsteroidal androgens.BDB
University of Tennessee At Memphis