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15 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Irreversible inhibitors of cysteine proteases.EBI
Dart Neuroscience
Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation.EBI
University of Florida
Identification of promiscuous small molecule activators in high-throughput enzyme activation screens.EBI
University of Illinois
Exploiting differences in caspase-2 and -3 S2 subsites for selectivity: structure-based design, solid-phase synthesis and in vitro activity of novel substrate-based caspase-2 inhibitors.EBI
Chdi Management
Synthesis of novel caspase inhibitors for characterization of the active caspase proteome in vitro and in vivo.EBI
University of Edinburgh
Discovery of S-217622, a Noncovalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19.EBI
Shionogi
Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors.EBI
Merck Frosst Centre For Therapeutic Research
Discovery of a Series of Pyrimidine Carboxamides as Inhibitors of Vanin-1.EBI
Pfizer
Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19.EBI
Pfizer
Discovery of Fluoromethylketone-Based Peptidomimetics as Covalent ATG4B (Autophagin-1) Inhibitors.EBI
Roche Pharma Research and Early Development
Synthesis and antitumor activities of 1,2,3-triazines and their benzo- and heterofused derivatives.EBI
University of Palermo
Selective caspase inhibitors and uses thereofBDB
Novagenesis Foundation
Potent and selective nonpeptide inhibitors of caspases 3 and 7.BDB
Glaxosmithkline
Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors.BDB
Shanghai Institutes For Biological Sciences
Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design.BDB
Sunesis Pharmaceuticals