47 articles for CJ Schofield
The following articles (labelled with PubMed ID or TBD) are for your review
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Article Title
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8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors.
The Institute of Cancer Research
Ejection of structural zinc leads to inhibition of¿-butyrobetaine hydroxylase.
University of Oxford
On the histone lysine methyltransferase activity of fungal metabolite chaetocin.
Imperial College
Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity.
Kyoto Prefectural University of Medicine
Structural basis for inhibition of the fat mass and obesity associated protein (FTO).
University of Oxford
Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors.
University of Oxford
Progress in the development and application of small molecule inhibitors of bromodomain-acetyl-lysine interactions.
University of Oxford
Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases.
University of Oxford
Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic acid demethylase.
University of Oxford
Structural and mechanistic basis of penicillin-binding protein inhibition by lactivicins.
Joseph Fourier University
The inhibition of metallo-beta-lactamase by thioxo-cephalosporin derivatives.
University of Huddersfield
Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor.
University of Oxford
Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches.
University of Oxford
Using NMR solvent water relaxation to investigate metalloenzyme-ligand binding interactions.
University of Oxford
Synthesis and evaluation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors.
University of Oxford
A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response.
GlaxoSmithKline R&D
Selective targeting of human TET1 by cyclic peptide inhibitors: Insights from biochemical profiling.
University of Oxford
5-Substituted Pyridine-2,4-dicarboxylate Derivatives Have Potential for Selective Inhibition of Human Jumonji-C Domain-Containing Protein 5.
University of Oxford
Differentiating Inhibition Selectivity and Binding Affinity of Isocitrate Dehydrogenase 1 Variant Inhibitors.
University of Oxford
Focused Screening Identifies Different Sensitivities of Human TET Oxygenases to the Oncometabolite 2-Hydroxyglutarate.
University of Oxford
Alkyne Derivatives of SARS-CoV-2 Main Protease Inhibitors Including Nirmatrelvir Inhibit by Reacting Covalently with the Nucleophilic Cysteine.
University of Oxford
Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors.
University of Oxford
Inhibition of the Oxygen-Sensing Asparaginyl Hydroxylase Factor Inhibiting Hypoxia-Inducible Factor: A Potential Hypoxia Response Modulating Strategy.
China Pharmaceutical University
Penicillin Derivatives Inhibit the SARS-CoV-2 Main Protease by Reaction with Its Nucleophilic Cysteine.
University of Oxford
Discovery of neuroprotective agents that inhibit human prolyl hydroxylase PHD2.
University of New South Wales (Unsw)
Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases.
Oxford University
Synthesis and evaluation of delta-lactams (piperazones) as elastase inhibitors.
The Oxford Centre For Molecular Sciences and The Dyson Perrins Laboratory
Small-molecule active pharmaceutical ingredients of approved cancer therapeutics inhibit human aspartate/asparagine-β-hydroxylase.
University of Oxford
Mass spectrometry reveals elastase inhibitors from the reactive centre loop of alpha1-antitrypsin.
The Oxford Centre For Molecular Sciences
Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases.
University of Oxford
Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor.
University of Oxford
Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities.
Sapienza University of Rome
Competitive inhibitors of the CphA metallo-beta-lactamase from Aeromonas hydrophila.
University of Liege
Investigations on small molecule inhibitors targeting the histone H3K4 tri-methyllysine binding PHD-finger of JmjC histone demethylases.
University of Oxford
Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-β-lactamases.
University of Oxford
In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-β-lactamase Inhibitors.
University of Leeds
Adenosine receptor activity of methyl/ethyl 3-(substituted benzoyl)-6,8-dimethylindolizine-2-substituted-1-carboxylates
King Faisal University
Methods for treating Crohn's disease using 3-((1R,3s,5S)-3-((7-((5-methyl-1H-pyrazol-3-yl)amino)-1,6-naphthyridin-5-yl)amino)-8-azabicyclo[3.2.1]octan-8-yl)propanenitrile
Theravance Biopharma R&D Ip
Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
Merck Sharp & Dohme