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Crystal structures, binding interactions, and ADME evaluation of brain penetrant N-substituted indazole-5-carboxamides as subnanomolar, selective monoamine oxidase B and dual MAO-A/B inhibitors.

Ntz Lab

Neuroprotective effects of benzyloxy substituted small molecule monoamine oxidase B inhibitors in Parkinson's disease.

China Pharmaceutical University

2-Benzylidene-1-indanone derivatives as inhibitors of monoamine oxidase.

North-West University

3-(Piperidin-4-ylmethoxy)pyridine Containing Compounds Are Potent Inhibitors of Lysine Specific Demethylase 1.

Baylor College of Medicine

Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases.

University of Bari Aldo Moro

Novel arylalkenylpropargylamines as neuroprotective, potent, and selective monoamine oxidase B inhibitors for the treatment of Parkinson's disease.

A* Star

N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor.

Laboratorio De Quimica Medica (Iqog, Csic)

Reversible and irreversible small molecule inhibitors of monoamine oxidase B (MAO-B) investigated by biophysical techniques.

Dart Neuroscience

Indazole- and indole-5-carboxamides: selective and reversible monoamine oxidase B inhibitors with subnanomolar potency.

University of Bonn

In silico design of novel 2H-chromen-2-one derivatives as potent and selective MAO-B inhibitors.

University of Bari Aldo Moro

Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease.

Okayama University

Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6'-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N-methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors.

University of Bari Aldo Moro

Structural insights into monoamine oxidase inhibitory potency and selectivity of 7-substituted coumarins from ligand- and target-based approaches.

University of Bari Aldo Moro

Coumarins derivatives as dual inhibitors of acetylcholinesterase and monoamine oxidase.

University of Lausanne

Impact of species-dependent differences on screening, design, and development of MAO B inhibitors.

University of Geneva

Inhibition of monoamine oxidases by functionalized coumarin derivatives: biological activities, QSARs, and 3D-QSARs.

University of Lausanne

Synthesis and evaluation of a set of para-substituted 4-phenylpiperidines and 4-phenylpiperazines as monoamine oxidase (MAO) inhibitors.

Neurosearch Sweden

Molecular Insights into Human Monoamine Oxidase B Inhibition by the Glitazone Anti-Diabetes Drugs.

TBA

Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine.

Laboratorio De Radicales Libres Y Qu�Mica Computacional (Iqog, Csic)

Synthesis and inhibitory effect of piperine derivates on monoamine oxidase.

General Hospital of Pla

Interactions of monoamine oxidases with the antiepileptic drug zonisamide: specificity of inhibition and structure of the human monoamine oxidase B complex.

University of Pavia

2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors.

University of Chile

Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors.

University of Chile

A new therapeutic approach in Alzheimer disease: some novel pyrazole derivatives as dual MAO-B inhibitors and antiinflammatory analgesics.

Hacettepe University

Alkylamino derivatives of 4-aminomethylpyridine as inhibitors of copper-containing amine oxidases.

University of Genoa

Selective inhibitors of monoamine oxidase. 4. SAR of tricyclic N-methylcarboxamides and congeners binding at the tricyclics' hydrophilic binding site.

Wellcome Research Laboratories

5-[4-(benzyloxy)phenyl]-1,3,4-oxadiazol-2(3H)-one derivatives and related analogues: new reversible, highly potent, and selective monamine oxidase type B inhibitors.

Paris Diderot University

Aliphatic propargylamines: potent, selective, irreversible monoamine oxidase B inhibitors.

University of Saskatchewan

Stereoisomers of allenic amines as inactivators of monoamine oxidase type B. Stereochemical probes of the active site.

Syntex Research

(+/-)-4-Aryl-4,5-dihydro-3H-1,3-benzodiazepines. 1. Synthesis and evaluation of (+/-)-4,5-dihydro-2,3-dimethyl-4-phenyl-3H-1,3-benzodiazepine and analogues as potential antidepressant agents.

TBA

 

Alkylbenzyl ethers of hydroquinones as monoamine oxidase B inhibitors

TBA

 

Synthesis of coumarins as subtype-selective inhibitors of monoamine oxidase

TBA

Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.

Universitat Aut£Noma De Barcelona

Development of selective and reversible pyrazoline based MAO-B inhibitors: virtual screening, synthesis and biological evaluation.

Birla Institute of Technology

Design of novel nicotinamides as potent and selective monoamine oxidase a inhibitors.

Nanjing University

Proposed structural basis of interaction of piperine and related compounds with monoamine oxidases.

University of Cambridge

Towards development of selective and reversible pyrazoline based MAO-inhibitors: Synthesis, biological evaluation and docking studies.

Institute of Technology

Synthesis and molecular modeling of some novel hexahydroindazole derivatives as potent monoamine oxidase inhibitors.

Hacettepe University

Discovery of a novel class of potent coumarin monoamine oxidase B inhibitors: development and biopharmacological profiling of 7-[(3-chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one methanesulfonate (NW-1772) as a highly potent, selective, reversible, and orally active monoamine oxidase B

Universita Degli Studi Di Bari

New pyrazoline bearing 4(3H)-quinazolinone inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity.

Hacettepe University

Ultrasound promoted synthesis of 2-imidazolines in water: a greener approach toward monoamine oxidase inhibitors.

Universidade Federal De Santa Maria

Structural and mechanistic studies of mofegiline inhibition of recombinant human monoamine oxidase B.

Emory University

Pyrazoline-based mycobactin analogues as MAO-inhibitors.

Institute of Technology

Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoamine oxidase.

University of Bari

Human and rat monoamine oxidase-A are differentially inhibited by (S)-4-alkylthioamphetamine derivatives: insights from molecular modeling studies.

University of Santiago De Chile

Privileged scaffolds as MAO inhibitors: Retrospect and prospects.

Babu Banarasi Das Northern India Institute of Technology

Pyrazolone structural motif in medicinal chemistry: Retrospect and prospect.

Northwest University

A comprehensive review of monoamine oxidase inhibitors as Anti-Alzheimer's disease agents: A review.

Jamia Millia Islamia

3-[5-(4,5-dihydro-1H-imidazol-2-yl)-furan-2-yl]phenylamine (Amifuraline), a promising reversible and selective peripheral MAO-A inhibitor.

Università

Synthesis, structural reassignment, and biological activity of type B MAO inhibitors based on the 5H-indeno[1,2-c]pyridazin-5-one core.

FacultéS Universitaires N.D. De La Paix

The Repertoire of Small-Molecule PET Probes for Neuroinflammation Imaging: Challenges and Opportunities beyond TSPO.

Massachusetts General Hospital

Discovery of 3, 6-disubstituted isobenzofuran-1(3H)-ones as novel inhibitors of monoamine oxidases.

Chinese Academy of Medical Sciences & Peking Union Medical College

The evaluation of N-propargylamine-2-aminotetralin as an inhibitor of monoamine oxidase.

North-West University

Synthesis of 3-benzyl-2-substituted quinoxalines as novel monoamine oxidase A inhibitors.

University of Alexandria

Novel pyridazino[4,3-b]indoles with dual inhibitory activity against Mycobacterium tuberculosis and monoamine oxidase.

Russian Academy of Sciences

Synthetic approaches to unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles and their MAO-B inhibitory activity. A review.

Medical University-Sofia

The synthesis and biological evaluation of a novel series of antimicrobials of the oxazolidinone class.

Abbott Laboratories

Synthesis of N-propargylphenelzine and analogues as neuroprotective agents.

Cv Technologies

Acetylene Group, Friend or Foe in Medicinal Chemistry.

St. John'S University

Propargylamine-derived multi-target directed ligands for Alzheimer's disease therapy.

Universidade De Lisboa

Synthesis and biological evaluation of 4-arylcoumarins as potential anti-Alzheimer's disease agents.

University of Jinan-Shandong Academy of Medical Sciences

Bioactive Dimeric Acylphloroglucinols from the Mexican Fern Elaphoglossum paleaceum.

Universidad Aut£Noma Del Estado De Morelos

New 6-Aminoquinoxaline Derivatives with Neuroprotective Effect on Dopaminergic Neurons in Cellular and Animal Parkinson Disease Models.

Paris-Sud University

8-Substituted 1,3-dimethyltetrahydropyrazino[2,1-f]purinediones: Water-soluble adenosine receptor antagonists and monoamine oxidase B inhibitors.

University of Bonn

Molecular determinants of MAO selectivity in a series of indolylmethylamine derivatives: biological activities, 3D-QSAR/CoMFA analysis, and computational simulation of ligand recognition.

Universitat AutòNoma De Barcelona

Rasagiline derivatives combined with histamine H

Heinrich Heine University D£Sseldorf

(Pyrrolo-pyridin-5-yl)benzamides: BBB permeable monoamine oxidase B inhibitors with neuroprotective effect on cortical neurons.

Ntz Lab

Carboxamides vs. methanimines: Crystal structures, binding interactions, photophysical studies, and biological evaluation of (indazole-5-yl)methanimines as monoamine oxidase B and acetylcholinesterase inhibitors.

Ntz Lab

Multi-target design strategies for the improved treatment of Alzheimer's disease.

China Pharmaceutical University

Inhibition of monoamine oxidase-B by condensed pyridazines and pyrimidines: effects of lipophilicity and structure-activity relationships.

Université

Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018).

Csir-Central Drug Research Institute

Selective inhibitors of monoamine oxidase (MAO). 5. 1-Substituted phenoxathiin inhibitors containing no nitrogen that inhibit MAO A by binding it to a hydrophobic site.

The Wellcome Research Laboratories

Rational Design of Multitarget-Directed Ligands: Strategies and Emerging Paradigms.

China Pharmaceutical University

Selective inhibitors of monoamine oxidase. 3. Structure-activity relationship of tricyclics bearing imidazoline, oxadiazole, or tetrazole groups.

Wellcome Research Laboratories

Fine molecular tuning at position 4 of 2H-chromen-2-one derivatives in the search of potent and selective monoamine oxidase B inhibitors.

University of Bari Aldo Moro

Inhibition of monoamine oxidase by 3,4-dihydro-2(1H)-quinolinone derivatives.

North-West University

Selective inhibitors of monoamine oxidase. 2. Arylamide SAR.

Burroughs Wellcome

Selected furanochalcones as inhibitors of monoamine oxidase.

North-West University

Inhibition of monoamine oxidase by phthalide analogues.

North-West University

Dual targeting of adenosine A(2A) receptors and monoamine oxidase B by 4H-3,1-benzothiazin-4-ones.

University of Bonn

Inhibition of monoamine oxidase-B by 5H-indeno[1,2-c]pyridazines: biological activities, quantitative structure-activity relationships (QSARs) and 3D-QSARs.

Université

Selective and potent monoamine oxidase type B inhibitors: 2-substituted 5-aryltetrazole derivatives.

Université

Donepezil-based multi-functional cholinesterase inhibitors for treatment of Alzheimer's disease.

China Pharmaceutical University

Design, synthesis and biological evaluation of lazabemide derivatives as inhibitors of monoamine oxidase.

Hainan Normal University

Synthesis of some novel potent and selective catechol O-methyltransferase inhibitors.

Orion

Synthesis, monoamine oxidase inhibition activity and molecular docking studies of novel 4-hydroxy-N'-[benzylidene or 1-phenylethylidene]-2-H/methyl/benzyl-1,2-benzothiazine-3-carbohydrazide 1,1-dioxides.

Government College University

Evaluation of multifunctional synthetic tetralone derivatives for treatment of Alzheimer's disease.

Wuhan University of Technology

Substituted 2-[2-(phenyl) ethylamino] alkaneamide derivatives and their use as sodium and/or calcium channel modulators

Newron Pharmaceuticals

Derivatives of propargylamine having neuroprotective capacity for the treatment of Alzheimer's and Parkinson's diseases

Consejo Superior De Investigaciones Cientificas

Synthesis, Biological Evaluation, and Molecular Simulation of Chalcones and Aurones as Selective MAO-B Inhibitors.

Pontificia Universidad Catolica De Chile

Comparison of the structural properties of the active site cavities of human and rat monoamine oxidase A and B in their soluble and membrane-bound forms.

Emory University

N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. in vitro characterization and pharmacokinetic properties.

Pudue Pharma Discovery Research

Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors.

Eli Lilly

Antiparkinsonian agent piribedil displays antagonist properties at native, rat, and cloned, human alpha(2)-adrenoceptors: cellular and functional characterization.

Institut De Recherches Servier

S18616, a highly potent, spiroimidazoline agonist at alpha(2)-adrenoceptors: I. Receptor profile, antinociceptive and hypothermic actions in comparison with dexmedetomidine and clonidine.

Centre De Recherches De Croissy

ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholinopyridin-3-yl)pyrido[2, 3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties: I. In vitro characterization and acute antinociceptive effects in the mouse.

Abbott Laboratories

Thiazole derivatives as inhibitors of purified bovine liver mitochondrial monoamine oxidase-B: structure-activity relationships and theoretical study.

University of Catania

Site-activated chelators targeting acetylcholinesterase and monoamine oxidase for Alzheimer's therapy.

The Weizmann Institute of Science

Synthesis and monoamine oxidase inhibitory activity of new pyridazine-, pyrimidine- and 1,2,4-triazine-containing tricyclic derivatives.

University of Bari

Demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase B by specific reversible inhibitors.

Emory University

Novel dual inhibitors of AChE and MAO derived from hydroxy aminoindan and phenethylamine as potential treatment for Alzheimer's disease.

Teva Pharmaceutical Industries