34 articles for T Harrison
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
Data
Article Title
Organization
Flat SAR of P3-methylsulphonamide based small molecule legumain inhibitors.
Queen'S University Belfast
P3 SAR exploration of biphenyl carbamate based Legumain inhibitors.
Queen'S University Belfast
An orally active, water-soluble neurokinin-1 receptor antagonist suitable for both intravenous and oral clinical administration.
Merck
High affinity, selective neurokinin 2 and neurokinin 3 receptor antagonists from a common structural template.
Merck Sharp Laboratory
Piperidine-ether based hNK1 antagonists 1: Determination of the relative and absolute stereochemical requirements
TBA
3-Substituted gem-cyclohexane sulfone based gamma-secretase inhibitors for Alzheimer's disease: conformational analysis and biological activity.
Merck Sharp and Dohme Research Laboratories
3,4-Fused cyclohexyl sulfones as gamma-secretase inhibitors.
Neuroscience Research Centre
7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine: a functionally selective gamma-aminobutyric acid(A) (GABA(A)) alpha2/alpha3-subtype selective agonist that exhibits potent anxiolytic activity but is not sedating in animal models.
Merck Sharp and Dohme Research Laboratories
Cyclic sulfamide gamma-secretase inhibitors.
Merck Sharp and Dohme Research Laboratories
Aryl sulfones: a new class of gamma-secretase inhibitors.
Merck Sharp & Dohme Research Laboratories
A novel series of potent gamma-secretase inhibitors based on a benzobicyclo[4.2.1]nonane core.
Merck Sharp & Dohme Research Laboratories
High affinity, bioavailable 3-amino-1,4-benzodiazepine-based gamma-secretase inhibitors.
Merck Sharp & Dohme Research Laboratories
Synthesis and gamma-secretase activity of APP substrate-based hydroxyethylene dipeptide isosteres.
Merck Sharp & Dohme Research Laboratories
Spirocyclic NK(1) antagonists II: [4.5]-spiroethers.
Merck Sharp & Dohme Research Laboratories
Spirocyclic NK(1) antagonists I: [4.5] and [5.5]-spiroketals.
Merck Sharp and Dohme Research Laboratories
High affinity phenylglycinol-based NK1 receptor antagonists.
Merck Sharp and Dohme Research Laboratories
4,4-Disubstituted piperidine high-affinity NK1 antagonists: structure-activity relationships and in vivo activity.
Merck Sharp and Dohme Research Laboratories
Identification and SAR exploration of a novel series of Legumain inhibitors.
Queen'S University Belfast
Development of a potent and selective cell penetrant Legumain inhibitor.
Queen'S University Belfast
Novel orally bioavailable gamma-secretase inhibitors with excellent in vivo activity.
Merck Sharp & Dohme Research Laboratories
Sulfonamide derivatives of bridgehead substituted bicyclo[4.2.1]nonanes as gamma-secretase inhibitors.
Merck Sharp and Dohme Research Laboratories
Identification and Structure-Guided Development of Pyrimidinone Based USP7 Inhibitors.
Almac Discovery
BISPECIFIC ANTAGONISTS OF RETINOL-BINDING PROTEIN 4 THAT STABILIZE TRANSTHYRETIN TETRAMERS, THEIR PREPARATION, AND USE IN THE TREATMENT OF COMMON AGE-RELATED COMORBIDITIES
Columbia University
1-pyridazin-/triazin-3-yl-piper(-azine)/idine/pyrolidine derivatives and compositions thereof for inhibiting the activity of SHP2
Novartis