111 articles for thisTarget
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Virtual screening and experimental validation identify novel modulators of nuclear receptor RXRa from Drugbank database.
Xiamen University
Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARa Selective Agonist.
Bristol-Myers Squibb Co.
Binding characterization, synthesis and biological evaluation of RXRa antagonists targeting the coactivator binding site.
Xiamen University
Identification of potent and selective retinoic acid receptor gamma (RAR¿) antagonists for the treatment of osteoarthritis pain using structure based drug design.
Eli Lilly and Company
Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR)ß Agonist.
Vitae Pharmaceuticals Inc
Chiral Dihydrobenzofuran Acids Show Potent Retinoid X Receptor-Nuclear Receptor Related 1 Protein Dimer Activation.
University of Gothenburg
SAR Exploration Guided by LE and Fsp(3): Discovery of a Selective and Orally Efficacious ROR¿ Inhibitor.
Central Pharmaceutical Research Institute
Conformationally Defined Rexinoids and Their Efficacy in the Prevention of Mammary Cancers.
University of Alabama at Birmingham
Positron emission tomography to elucidate pharmacokinetic differences of regioisomeric retinoid x receptor agonists.
Okayama University Graduate School of Medicine
Rexinoids isolated from Sophora tonkinensis with a gene expression profile distinct from the synthetic rexinoid bexarotene.
Aichi Gakuin University
Small molecule inhibitors targeting activator protein 1 (AP-1).
University of Texas Medical Branch
Identification of the first inverse agonist of retinoid-related orphan receptor (ROR) with dual selectivity for RORß and ROR¿t.
Phenex Pharmaceuticals AG
Methyl substitution of a rexinoid agonist improves potency and reveals site of lipid toxicity.
University of Alabama at Birmingham
Synthesis and SAR study of modulators inhibiting tRXRa-dependent AKT activation.
Xiamen University
Mechanism of retinoid X receptor partial agonistic action of 1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1H-benzotriazole-5-carboxylic acid and structural development to increase potency.
Okayama University Graduate School of Medicine
Design, synthesis, and biological evaluation of indenoisoquinoline rexinoids with chemopreventive potential.
Purdue University
Identification, synthesis, and biological evaluation of the metabolites of 3-amino-6-(3'-aminopropyl)-5H-indeno[1,2-c]isoquinoline-5,11-(6H)dione (AM6-36), a promising rexinoid lead compound for the development of cancer chemotherapeutic and chemopreventive agents.
The University of Illinois at Chicago
RXR Partial Agonist CBt-PMN Exerts Therapeutic Effects on Type 2 Diabetes without the Side Effects of RXR Full Agonists.
TBA
Identification of diaryl ether-based ligands for estrogen-related receptora as potential antidiabetic agents.
Johnson & Johnson Pharmaceutical Research and Development LLC
Modification at the Lipophilic Domain of RXR Agonists Differentially Influences Activation of RXR Heterodimers.
TBA
Fluorescent retinoid X receptor ligands for fluorescence polarization assay.
Okayama University
Modification at the acidic domain of RXR agonists has little effect on permissive RXR-heterodimer activation.
Okayama University
Identification of a naturally occurring rexinoid, honokiol, that activates the retinoid X receptor.
Aichi Gakuin University
Synthesis and pharmacological validation of a novel series of non-steroidal FXR agonists.
Phenex Pharmaceuticals AG
Modeling, synthesis and biological evaluation of potential retinoid X receptor (RXR) selective agonists: novel analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene).
Arizona State University
Synthesis and structure-activity relationships of potent conformationally restricted retinoid X receptor ligands
TBA
Synthesis of highly potent RXR-specific retinoids: The use of a cyclopropyl group as a double bond isostere
TBA
Synthesis and pharmacological activity of conformationally restricted, acetylenic retinoid analogs
TBA
Differential RXR & RAR activity of stilbene retinoid analogs bearing thiazole and imidazole carboxylic acids
TBA
Replacing alkyl sulfonamide with aromatic sulfonamide in sulfonamide-type RXR agonists favors switch towards antagonist activity.
Okayama University Graduate School of Medicine
Synthesis and structure-activity relationship of RXR antagonists based on the diazepinylbenzoic acid structure.
Tsukuba Research Institute
Synthesis and structure-activity relationship of novel RXR antagonists: orally active anti-diabetic and anti-obesity agents.
Tsukuba Research Institute
Dihydro-[1H]-quinolin-2-ones as retinoid X receptor (RXR) agonists for potential treatment of dyslipidemia.
Johnson and Johnson Pharmaceutical Research and Development
RXR-LXR heterodimer modulators for the potential treatment of dyslipidemia.
Johnson and Johnson Pharmaceutical Research and Development
Aza-retinoids as novel retinoid X receptor-specific agonists.
Ligand Pharmaceuticals Inc
Ligand recognition by RAR and RXR receptors: binding and selectivity.
Universidad de Santiago de Compostela
Increased Molecular Flexibility Widens the Gap between
Okayama University Graduate School of Medicine
Oxaprozin Analogues as Selective RXR Agonists with Superior Properties and Pharmacokinetics.
Goethe-University Frankfurt
Design, synthesis and structure-activity relationship of novel RXR-selective modulators.
Ligand Pharmaceuticals Inc
Design and synthesis of novel RXR-selective modulators with improved pharmacological profile.
Ligand Pharmaceuticals Inc
Convenient Retinoid X Receptor Binding Assay Based on Fluorescence Change of the Antagonist NEt-C343.
Okayama University Graduate School of Medicine
Discovery of a "Gatekeeper" Antagonist that Blocks Entry Pathway to Retinoid X Receptors (RXRs) without Allosteric Ligand Inhibition in Permissive RXR Heterodimers.
Okayama University Graduate School of Medicine
Novel (2E,4E,6Z)-7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes.
Ligand Pharmaceuticals Inc
The Discovery, Preclinical, and Early Clinical Development of Potent and Selective GPR40 Agonists for the Treatment of Type 2 Diabetes Mellitus (LY2881835, LY2922083, and LY2922470).
Lilly Research Laboratories
Retinoic acid receptor ligands based on the 6-cyclopropyl-2,4-hexadienoic acid.
Ligand Pharmaceuticals Inc
Creation of Fluorescent RXR Antagonists Based on CBTF-EE and Application to a Fluorescence Polarization Binding Assay.
Okayama University Graduate School of Medicine
Synthesis and characterization of a new RXR agonist based on the 6-tert-butyl-1,1-dimethylindanyl structure.
Universidade de Vigo
An improved synthesis of the C-linked glucuronide of N-(4-hydroxyphenyl)retinamide.
The Ohio State University
Novel 5-substituted 2,4-thiazolidinedione and 2,4-oxazolidinedione derivatives as insulin sensitizers with antidiabetic activities.
Takeda Chemical Industries, Ltd
Discovery of 3?,7?,11?-Trihydroxy-6?-ethyl-5?-cholan-24-oic Acid (TC-100), a Novel Bile Acid as Potent and Highly Selective FXR Agonist for Enterohepatic Disorders.
TES Pharma S.r.l.
l-Thyroxin and the Nonclassical Thyroid Hormone TETRAC Are Potent Activators of PPAR?.
Goethe-University Frankfurt
Enantioselective syntheses of potent retinoid X receptor ligands: differential biological activities of individual antipodes.
Allergan Inc
Discovery of Second Generation ROR? Inhibitors Composed of an Azole Scaffold.
Kyoto Prefectural University of Medicine
3H-Imidazo[4,5-b]pyridine-6-carboxylic acid derivatives as rexinoids with reduced teratogenicity.
Okayama University Graduate School of Medicine
Modeling, Synthesis, and Biological Evaluation of Potential Retinoid X Receptor (RXR)-Selective Agonists: Analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and 6-(Ethyl(5,5,8,8-tetrahydronaphthalen-2-yl)amino)nicotinic Acid (NEt-TMN).
Arizona State University
Design, synthesis and biological evaluation of tetrazole-containing RXR? ligands as anticancer agents.
Xiamen University
Competitive Binding Assay with an Umbelliferone-Based Fluorescent Rexinoid for Retinoid X Receptor Ligand Screening.
Okayama University Graduate School of Medicine
Tuning Nuclear Receptor Selectivity of Wy14,643 towards Selective Retinoid X Receptor Modulation.
Goethe University Frankfurt
Structure-activity relationship studies of novel heteroretinoids: induction of apoptosis in the HL-60 cell line by a novel isoxazole-containing heteroretinoid.
Università di Ferrara
Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis.
Genomics Institute of the Novartis Research Foundation (GNF)
Stereoselective synthesis and receptor activity of conformationally defined retinoid X receptor selective ligands.
Allergan Inc
Synthesis of retinoid X receptor-specific ligands that are potent inducers of adipogenesis in 3T3-L1 cells.
Ligand Pharmaceuticals Inc
Synthesis and characterization of heteroarotinoids demonstrate structure specificity relationships.
University of Oklahoma Health Sciences Center
Computer-Assisted Discovery and Structural Optimization of a Novel Retinoid X Receptor Agonist Chemotype.
Goethe-University Frankfurt
Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers.
University of Tokyo
Discovery of potent and selective PPAR?/? dual antagonists and initial biological studies.
Inception Sciences
Cytotoxic Components from Hypericum elodeoides Targeting RXR? and Inducing HeLa Cell Apoptosis through Caspase-8 Activation and PARP Cleavage.
Xiamen University
Conformationally defined 6-s-trans-retinoic acid analogs. 3. Structure-activity relationships for nuclear receptor binding, transcriptional activity, and cancer chemopreventive activity.
University of Alabama at Birmingham
Synthesis and structure-activity relationships of retinoid X receptor selective diaryl sulfide analogs of retinoic acid.
Allergan Inc
A Novel Biphenyl-based Chemotype of Retinoid X Receptor Ligands Enables Subtype and Heterodimer Preferences.
Goethe-University Frankfurt
Identification of the first retinoid X, receptor homodimer antagonist.
Ligand Pharmaceuticals Inc
Discovery of novel retinoic acid receptor agonists having potent antiproliferative activity in cervical cancer cells.
Ligand Pharmaceuticals Inc
Structure-activity relationships for lipoprotein lipase agonists that lower plasma triglycerides in vivo.
Ume£ University
Identification of a New RXR? Antagonist Targeting the Coregulator-Binding Site.
Xiamen University
Conformational effects on retinoid receptor selectivity. 1. Effect of 9-double bond geometry on retinoid X receptor activity.
SRI International
Synthesis of high specific activity [3H]-9-cis-retinoic acid and its application for identifying retinoids with unusual binding properties.
Ligand Pharmaceuticals Inc
Synthesis and structure-activity relationships of novel retinoid X receptor-selective retinoids.
Ligand Pharmaceuticals Inc
Discovery of a small molecular compound simultaneously targeting RXR and HADC: design, synthesis, molecular docking and bioassay.
Shenyang Pharmaceutical University
Structure-activity relationship study on benzoic acid part of diphenylamine-based retinoids.
Tohoku Pharmaceutical University
Conformational effects on retinoid receptor selectivity. 2. Effects of retinoid bridging group on retinoid X receptor activity and selectivity.
SRI International
Design and synthesis of potent retinoid X receptor selective ligands that induce apoptosis in leukemia cells.
Ligand Pharmaceuticals Inc
Synthesis and structure-activity relationships of stilbene retinoid analogs substituted with heteroaromatic carboxylic acids.
Allergan Inc
Conformationally defined 6-s-trans-retinoic acid analogs. 2. Selective agonists for nuclear receptor binding and transcriptional activity.
University of Alabama at Birmingham
Synthesis and characterization of a highly potent and effective antagonist of retinoic acid receptors.
Allergan Inc
Sulfonyl-containing phenyl-pyrrolyl pentane analogues: Novel non-secosteroidal vitamin D receptor modulators with favorable physicochemical properties, pharmacokinetic properties and anti-tumor activity.
China Pharmaceutical University
Design and synthesis of a potent, highly selective, orally bioavailable, retinoic acid receptor alpha agonist.
King's College
Computer-Assisted Discovery of Retinoid X Receptor Modulating Natural Products and Isofunctional Mimetics.
Swiss Federal Institute of Technology (ETH)
Indazole-based ligands for estrogen-related receptor ? as potential anti-diabetic agents.
Janssen Research and Development LLC
Natural-Products-Inspired Use of the gem-Dimethyl Group in Medicinal Chemistry.
St. John's University
The comparative pharmacology and up-regulation of rat neuronal nicotinic receptor subtype binding sites stably expressed in transfected mammalian cells.
Georgetown University
Engineering novel specificities for ligand-activated transcription in the nuclear hormone receptor RXR.
University of Texas Southwestern Medical Center
8-(4-Methoxyphenyl)pyrazolo[1,5-a]-1,3,5-triazines: selective and centrally active corticotropin-releasing factor receptor-1 (CRF1) antagonists.
Bristol-Myers Squibb Co.