BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.2M data for 1.4M Compounds and 11.4K Targets. Of those, 1.6M data for 756K Compounds and 4.8K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

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19 articles for A Gobbi

The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Identification of N-sulfonyl-tetrahydroquinolines as RORc inverse agonists.EBI
Genentech
Discovery of imidazo[1,5-a]pyridines and -pyrimidines as potent and selective RORc inverse agonists.EBI
Genentech
Minor Structural Change to Tertiary Sulfonamide RORc Ligands Led to Opposite Mechanisms of Action.EBI
Genentech
Reduction in lipophilicity improved the solubility, plasma-protein binding, and permeability of tertiary sulfonamide RORc inverse agonists.EBI
Genentech
A reversed sulfonamide series of selective RORc inverse agonists.EBI
Argenta Discovery
Identification of tertiary sulfonamides as RORc inverse agonists.EBI
Genentech
Structure-based design of substituted hexafluoroisopropanol-arylsulfonamides as modulators of RORc.EBI
Genentech
Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a 5-Fluoro-4-(3EBI
Genentech
Discovery of oxa-sultams as RORc inverse agonists showing reduced lipophilicity, improved selectivity and favorable ADME properties.EBI
Genentech
Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors.EBI
Genentech
Discovery of Potent Benzolactam IRAK4 Inhibitors with Robust in Vivo Activity.EBI
Genentech
Therapeutic compounds and methods of use thereofBDB
Genentech
Compound useful for the treatment of degenerative and inflammatory diseasesBDB
Galapagos
Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activityBDB
Astex Therapeutics
Heteroarylbenzimidazole compoundsBDB
Bayer Pharma Aktiengesellschaft
Substituted 7-azabicycles and their use as orexin receptor modulatorsBDB
Janssen Pharmaceutica
Substituted pyrrolopyrimidines as HDM2 inhibitorsBDB
Merck Sharp & Dohme
The antiparasitic clioquinol induces apoptosis in leukemia and myeloma cells by inhibiting histone deacetylase activity.BDB
Soochow University
Compounds and methods useful for directing stem cell differentiationBDB
Vanderbilt University