BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.2M data for 1.4M Compounds and 11.4K Targets. Of those, 1.6M data for 745K Compounds and 4.7K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

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10 articles for SG Hymowitz

The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Minor Structural Change to Tertiary Sulfonamide RORc Ligands Led to Opposite Mechanisms of Action.EBI
Genentech
Potent and selective Bruton's tyrosine kinase inhibitors: discovery of GDC-0834.EBI
Genentech
Reduction in lipophilicity improved the solubility, plasma-protein binding, and permeability of tertiary sulfonamide RORc inverse agonists.EBI
Genentech
Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity.EBI
Abbvie
Structure-based design of substituted hexafluoroisopropanol-arylsulfonamides as modulators of RORc.EBI
Genentech
Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152).EBI
Genentech
Filling a nick in NIK: Extending the half-life of a NIK inhibitor through structure-based drug design.EBI
Genentech
Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-κB Inducing Kinase.EBI
Genentech
Heterocyclic compounds and their use as dopamine D1 ligandsBDB
Pfizer
Tricyclic compounds as anticancer agentsBDB
Bristol-Myers Squibb