40 articles for H Nakai
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
Data
Article Title
Organization
New potent antagonists of leukotrienes C4 and D4. 1. Synthesis and structure-activity relationships.
Ono Pharmaceutical
Discovery of novel 2',4'-dimethyl-[4,5'-bithiazol]-2-yl amino derivatives as orally bioavailable TRPV4 antagonists for the treatment of pain: Part 2.
Shionogi
Synthesis and evaluation of¿-lactam analogs of PGE2 as EP4 and EP2/EP4 agonists.
Minase Research Institute
Discovery of orally available spirodiketopiperazine-based CCR5 antagonists.
Minase Research Institute
Discovery of long-acting N-(cyanomethyl)-N-alkyl-L-prolinamide inhibitors of dipeptidyl peptidase IV.
Minase Research Institute
Design and synthesis of DPP-IV inhibitors lacking the electrophilic nitrile group.
Ono Pharmaceutical
Discovery of new chemical leads for prostaglandin D2 receptor antagonists.
Minase Research Institute
Development of orally active nonpeptidic inhibitors of human neutrophil elastase.
Cortech
Discovery of novel prostaglandin analogs as potent and selective EP2/EP4 dual agonists.
Minase Research Institute
Pyrrolo[1,2-b]pyridazines, pyrrolo[2,1-f]triazin-4(3H)-ones, and related compounds as novel corticotropin-releasing factor 1 (CRF¿?) receptor antagonists.
Minase Research Institute
Discovery of a novel EP2/EP4 dual agonist with high subtype-selectivity.
Minase Research Institute
Synthesis and evaluation of novel modified¿-lactam prostanoids as EP4 subtype-selective agonists.
Minase Research Institute
Discovery of new orally active prostaglandin D2 receptor antagonists.
Ono Pharmaceutical
Pyrazolo[1,5-a]pyrimidines, triazolo[1,5-a]pyrimidines and their tricyclic derivatives as corticotropin-releasing factor 1 (CRF¿?) receptor antagonists.
Minase Research Institute
Design and synthesis of new prostaglandin D2 receptor antagonists.
Minase Research Institute
6,7-Dihydro-5H-cyclopenta[d]pyrazolo[1,5-a]pyrimidines and their derivatives as novel corticotropin-releasing factor 1 receptor antagonists.
Minase Research Institute
Discovery of selective indole-based prostaglandin D2 receptor antagonist.
Minase Research Institute
Discovery of 4-[4-({(3R)-1-butyl-3-[(R)-cyclohexyl(hydroxy)methyl]-2,5-dioxo-1,4,9-triazaspiro[5.5]undec-9-yl}methyl)phenoxy]benzoic acid hydrochloride: a highly potent orally available CCR5 selective antagonist.
Ono Pharmaceutical
Spirodiketopiperazine-based CCR5 antagonist: discovery of an antiretroviral drug candidate.
Ono Pharmaceutical
3-(2-Aminocarbonylphenyl)propanoic acid analogs as potent and selective EP3 receptor antagonists. Part 3: Synthesis, metabolic stability, and biological evaluation of optically active analogs.
Minase Research Institute
Discovery of novel N-acylsulfonamide analogs as potent and selective EP3 receptor antagonists.
Minase Research Institute
3-(2-Aminocarbonylphenyl)propanoic acid analogs as potent and selective EP3 receptor antagonists. Part 1: discovery and exploration of the carboxyamide side chain.
Minase Research Institute
3-(2-Aminocarbonylphenyl)propanoic acid analogs as potent and selective EP3 receptor antagonists. part 2: optimization of the side chains to improve in vitro and in vivo potencies.
Minase Research Institute
Spirodiketopiperazine-based CCR5 antagonists: Improvement of their pharmacokinetic profiles.
Minase Research Institute
Design and synthesis of new potent dipeptidyl peptidase IV inhibitors with enhanced ex vivo duration.
Minase Research Institute
Design and synthesis of long-acting inhibitors of dipeptidyl peptidase IV.
Minase Research Institute
Discovery of orally active prostaglandin D2 receptor antagonists.
Minase Research Institute
Clarification of mechanism of human sputum elastase inhibition by a new inhibitor, ONO-5046, using electrospray ionization mass spectrometry.
Minase Research Institute
Design and synthesis of orally bioavailable inhibitors of inducible nitric oxide synthase. Part 1: synthesis and biological evaluation of dihydropyridin-2-imines.
Fukui Research Institute
Design and synthesis of a highly selective EP4-receptor agonist. Part 2: 5-thia and 9beta-haloPG derivatives with improved stability.
Minase Research Institute
Design and synthesis of a highly selective EP4-receptor agonist. Part 1: 3,7-dithiaPG derivatives with high selectivity.
Minase Research Institute
Design and synthesis of a highly selective EP2-receptor agonist.
Minase Research Institute
Design and synthesis of new orally active nonpeptidic inhibitors of human neutrophil elastase.
Colorado State University
Pharmacological evaluation of novel (6-aminopyridin-3-yl)(4-(pyridin-2-yl)piperazin-1-yl) methanone derivatives as TRPV4 antagonists for the treatment of pain.
Shionogi
