46 articles for A Simeonov
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
Cmpds
Data
Article Title
Organization
27
A potent and selective inhibitor targeting human and murine 12/15-LOX.
University of California
42
Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies.
Harvard Medical School
74
Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase.
National Institutes of Health
44
Identification of ML251, a Potent Inhibitor of T. brucei and T. cruzi Phosphofructokinase.
National Center For Advancing Translational Sciences
57
Structure-activity relationship studies and biological characterization of human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors.
National Center For Advancing Translational Sciences
37
Synthesis and SAR studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives as potent inhibitors of Bloom helicase.
National Center For Advancing Translational Sciences
14
Discovery of a novel noniminosugar acida glucosidase chaperone series.
National Center For Advancing Translational Sciences
32
Synthesis, biological evaluation, and structure-activity relationships of a novel class of apurinic/apyrimidinic endonuclease 1 inhibitors.
National Center For Advancing Translational Sciences
19
Comprehensive mechanistic analysis of hits from high-throughput and docking screens against beta-lactamase.
University of California San Francisco
39
Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.
National Human Genome Research Institute
54
Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1.
National Human Genome Research Institute
37
Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines.
University of North Carolina at Chapel Hill
14
Complementarity between a docking and a high-throughput screen in discovering new cruzain inhibitors.
University of California San Francisco
35
Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.
National Human Genome Research Institute
41
Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease.
National Human Genome Research Institute
32
Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schistosomiasis.
National Human Genome Research Institute
14
Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a.
University of North Carolina
10
A high-throughput screen for aggregation-based inhibition in a large compound library.
University of California San Francisco
1
Discovery and Optimization of Pyrrolopyrimidine Derivatives as Selective Disruptors of the Perinucleolar Compartment, a Marker of Tumor Progression toward Metastasis.
University of Kansas
13
Venglustat Inhibits Protein N-Terminal Methyltransferase 1 in a Substrate-Competitive Manner.
Purdue University
5
Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2.
University of California Santa Cruz
95
Discovery and Optimization of 2
National Center For Advancing Translational Sciences
3
Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite
University of Cape Town
89
Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties.
National Institutes of Health
25
Discovery and Structure-Activity Relationship Study of (
Dana-Farber Cancer Institute
39
Design, Synthesis, and Biological Evaluation of Quinazolin-4-one-Based Hydroxamic Acids as Dual PI3K/HDAC Inhibitors.
National Center For Advancing Translational Sciences
20
Structure-Activity Relationship Study of Covalent Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors.
Dana-Farber Cancer Institute
70
Synthesis and structure-activity relationship studies of N-benzyl-2-phenylpyrimidin-4-amine derivatives as potent USP1/UAF1 deubiquitinase inhibitors with anticancer activity against nonsmall cell lung cancer.
National Center For Advancing Translational Sciences
5
Non-iminosugar glucocerebrosidase small molecule chaperones.
National Human Genome Research Institute
45
Characterization of chemical libraries for luciferase inhibitory activity.
National Human Genome Research Institute
7
Structure-Based Engineering of Irreversible Inhibitors against Histone Lysine Demethylase KDM5A.
The University of Texas M.D. Anderson Cancer Center
107
Discovery of Orally Bioavailable, Quinoline-Based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity.
National Center For Advancing Translational Sciences
70
Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors.
National Center For Advancing Translational Sciences
67
Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH).
National Center For Advancing Translational Sciences
12
Insights into the Action of Inhibitor Enantiomers against Histone Lysine Demethylase 5A.
The University of Texas M.D. Anderson Cancer Center
261
Methods for treating ulcerative colitis using 3-((1R,3s,5S)-3-((7-((5-methyl-1H-pyrazol-3-yl)amino)-1,6-naphthyridin-5-yl)amino)-8-azabicyclo[3.2.1]octan-8-yl)propanenitrile
Theravance Biopharma R&D Ip
10
Fluoro-substituted 3,5-dicyano-4-(1H-indazol-5-yl)-2,6-dimethyl-1,4-dihydropyridine derivatives and methods of use thereof
Bayer Pharma Aktiengesellschaft
4
Identification of inhibitors that target dual-specificity phosphatase 5 provide new insights into the binding requirements for the two phosphate pockets.
Texas Wesleyan University
7
Novel synthesis of dihydropyrimidines for a-glucosidase inhibition to treat type 2 diabetes: in vitro biological evaluation and in silico docking.
Comsats Institute of Information Technology
3
Identification of the molecular mechanisms by which the diterpenoid salvinorin A binds to kappa-opioid receptors.
Case Western Reserve University
3
Demonstration of a specific site of covalent labeling of the human motilin receptor using a biologically active photolabile motilin analog.
Mayo Clinic