46 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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Tight binding enantiomers of pre-clinical drug candidates.
Victoria University of Wellington
Stereoelectronic factors in the binding of substrate analogues and inhibitors to purine nucleoside phosphorylase isolated from human erythrocytes.
TBA
N-phosphonocarbonylpyrrolidine derivatives of guanine: a new class of bi-substrate inhibitors of human purine nucleoside phosphorylase.
Academy of Sciences of The Czech Republic
Synthesis of analogs of forodesine HCl, a human purine nucleoside phosphorylase inhibitor-Part II.
Biocryst Pharmaceuticals
Third-generation immucillins: syntheses and bioactivities of acyclic immucillin inhibitors of human purine nucleoside phosphorylase.
Industrial Research
Immucillins in custom catalytic-site cavities.
Albert Einstein College of Medicine of Yeshiva University
Simplified analogues of immucillin-G retain potent human purine nucleoside phosphorylase inhibitory activity.
University of Siena
Targeting the polyamine pathway with transition-state analogue inhibitors of 5'-methylthioadenosine phosphorylase.
Industrial Research
Synthesis of second-generation transition state analogues of human purine nucleoside phosphorylase.
Industrial Research
Exploring structure-activity relationships of transition state analogues of human purine nucleoside phosphorylase.
Industrial Research
Nucleosides. 5. Synthesis of guanine and formycin B derivatives as potential inhibitors of purine nucleoside phosphorylase.
National Defense Medical Center
Structure-based design of inhibitors of purine nucleoside phosphorylase. 3. 9-Arylmethyl derivatives of 9-deazaguanine substituted on the methylene group.
Biocryst Pharmaceuticals
Inhibitors of human purine nucleoside phosphorylase. Synthesis of pyrrolo[3,2-d]pyrimidines, a new class of purine nucleoside phosphorylase inhibitors as potentially T-cell selective immunosuppressive agents. Description of 2,6-diamino-3,5-dihydro-7-(3-thienylmethyl)-4H-pyrrolo[3,2-d] pyrimidin-4-o
Warner-Lambert
Inhibitors of human purine nucleoside phosphorylase. Synthesis and biological activities of 8-amino-3-benzylhypoxanthine and related analogues.
Warner-Lambert
Synthesis and evaluation of 5-amino-1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamidine and certain related nucleosides as inhibitors of purine nucleoside phosphorylase.
Nucleic Acid Research Institute
Inhibitors of human purine nucleoside phosphorylase. Synthesis, purine nucleoside phosphorylase inhibition, and T-cell cytotoxicity of 2,5-diaminothiazolo[5,4-d]pyrimidin-7(6H)-one and 2,5-diaminothiazolo[4,5-d]pyrimidin-7(6H)-one. Two thio isosteres of 8-aminoguanine.
TBA
Synthesis of 8-amino-3-deazaguanine via imidazole precursors. Antitumor activity and inhibition of purine nucleoside phosphorylase.
TBA
Benzimidazole-4,7-diones as inhibitors of protozoal (Toxoplasma gondii) purine nucleoside phosphorylase.
University of Lyon 1
Phosphonate derivatives of N9-benzylguanine: a new class of potent purine nucleoside phosphorylase inhibitors
TBA
Exploring new inhibitors of Plasmodium falciparum purine nucleoside phosphorylase.
Instituto De ParasitologíA Y Biomedicina LóPez-Neyra
Enzymatic transition states and dynamic motion in barrier crossing.
Albert Einstein College of Medicine
Structural-based design and synthesis of novel 9-deazaguanine derivatives having a phosphate mimic as multi-substrate analogue inhibitors for mammalian PNPs.
Tokyo University of Pharmacy and Life Sciences
Structural basis for selective inhibition of purine nucleoside phosphorylase from Schistosoma mansoni: kinetic and structural studies.
Universidade Federal Da Bahia
Synthesis of analogs of forodesine HCl, a human purine nucleoside phosphorylase inhibitor-Part I.
Biocryst Pharmaceuticals
NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family.
Johann Wolfgang Goethe University
Synthesis and application of small molecules approved for the treatment of lymphoma.
The First Affiliated Hospital of Zhengzhou University
Perspectives and challenges in developing small molecules targeting purine nucleoside phosphorylase.
Sichuan University
Synthesis and biological evaluation of 9-deazaguanine derivatives connected by a linker to difluoromethylene phosphonic acid as multi-substrate analogue inhibitors of PNP.
Tokyo University of Pharmacy and Life Sciences
Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors.
The Czech Academy of Sciences
Computational, in vitro and radiation-based in vivo studies on acetamide quinazolinone derivatives as new proposed purine nucleoside phosphorylase inhibitors for breast cancer.
National Center for Radiation Research and Technology
Pyrazolotriazines: Biological activities, synthetic strategies and recent developments.
Mazandaran University of Medical Sciences
Chemotherapeutics for
Shandong First Medical University and Shandong Academy of Medical Sciences
8-Aza-immucillins as transition-state analogue inhibitors of purine nucleoside phosphorylase and nucleoside hydrolases.
Industrial Research
Pharmacological urate-lowering approaches in chronic kidney disease.
West China Hospital of Sichuan University
Synthesis and biological evaluation of 1,1-difluoro-2-(tetrahydro-3-furanyl)ethylphosphonic acids possessing a N9-purinylmethyl functional group at the ring. a new class of inhibitors for purine nucleoside phosphorylases.
Tokyo University of Pharmacy & Life Science
Plasmodium Purine Metabolism and Its Inhibition by Nucleoside and Nucleotide Analogues.
University of Montpellier
Guanine, pyrazolo[3,4-d]pyrimidine, and triazolo[4,5-d]pyrimidine (8-azaguanine) phosphonate acyclic derivatives as inhibitors of purine nucleoside phosphorylase.
Burroughs Wellcome
Structure-based design of inhibitors of purine nucleoside phosphorylase. 1. 9-(arylmethyl) derivatives of 9-deazaguanine.
Biocryst Pharmaceuticals
9-[(Phosphonoalkyl)benzyl]guanines. Multisubstrate analogue inhibitors of human erythrocyte purine nucleoside phosphorylase.
Burroughs Wellcome
Structure-based design of inhibitors of purine nucleoside phosphorylase. 4. A study of phosphate mimics.
Ciba-Geigy
[[(Guaninylalkyl)phosphinico]methyl]phosphonic acids. Multisubstrate analogue inhibitors of human erythrocyte purine nucleoside phosphorylase.
Burroughs Wellcome
Acyclic amine inhibitors of nucleoside phosphorylases and hydrolases
Industrial Research
Rational design of quinazoline-based irreversible inhibitors of human erythrocyte purine nucleoside phosphorylase.
Arizona State University
Altered enthalpy-entropy compensation in picomolar transition state analogues of human purine nucleoside phosphorylase.
Albert Einstein College of Medicine