BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.2M data for 1.4M Compounds and 11.4K Targets. Of those, 1.5M data for 737K Compounds and 4.7K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

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37 articles for JW Daly

The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
8-Aryl-and 8-cycloalkyl-1,3-dipropylxanthines: further potent and selective antagonists for A1-adenosine receptors.EBI
National Institute of Diabetes, Digestive and Kidney Diseases
Synthesis and adrenergic activity of ring-fluorinated phenylephrines.EBI
TBA
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.EBI
TBA
Halogenated and isosteric cytisine derivatives with increased affinity and functional activity at nicotinic acetylcholine receptors.EBI
National Institute of Diabetes and Digestive and Kidney Diseases
Synthesis of 2',5'-dideoxy-2-fluoroadenosine and 2',5'-dideoxy-2,5'-difluoroadenosine: potent P-site inhibitors of adenylyl cyclase.EBI
National Institute of Diabetes and Digestive and Kidney Diseases
Imidazo[2,1-i]purin-5-ones and related tricyclic water-soluble purine derivatives: potent A(2A)- and A(3)-adenosine receptor antagonists.EBI
University of Bonn
6beta-Acetoxynortropane: a potent muscarinic agonist with apparent selectivity toward M2-receptors.EBI
National Institute of Diabetes and Digestive and Kidney Diseases
Syntheses of 2,5- and 2,6-difluoronorepinephrine, 2,5-difluoroepinephrine, and 2,6-difluorophenylephrine: effect of disubstitution with fluorine on adrenergic activity.EBI
National Institute of Diabetes and Digestive and Kidney Diseases
N6,9-disubstituted adenines: potent, selective antagonists at the A1 adenosine receptor.EBI
University of South Florida
Activity of N6-substituted 2-chloroadenosines at A1 and A2 adenosine receptors.EBI
University of South Florida
Sulfur-containing 1,3-dialkylxanthine derivatives as selective antagonists at A1-adenosine receptors.EBI
Niddk
Syntheses and adrenergic activities of ring-fluorinated epinephrines.EBI
National Institute of Diabetes
Binary drugs: conjugates of purines and a peptide that bind to both adenosine and substance P receptors.EBI
TBA
N6-substituted N-alkyladenosine-5'-uronamides: bifunctional ligands having recognition groups for A1 and A2 adenosine receptors.EBI
TBA
Functionalized congeners of adenosine: preparation of analogues with high affinity for A1-adenosine receptors.EBI
TBA
1,3-Dialkyl-8-(p-sulfophenyl)xanthines: potent water-soluble antagonists for A1- and A2-adenosine receptors.EBI
TBA
Adenosine receptors: targets for future drugs.EBI
TBA
Synthesis of poison-frog alkaloids 233A, 235U, and 251AA and their inhibitory effects on neuronal nicotinic acetylcholine receptors.EBI
University of Toyama
1,8-disubstituted xanthine derivatives: synthesis of potent A2B-selective adenosine receptor antagonists.EBI
University of Bonn
6beta-Acyloxy(nor)tropanes: affinities for antagonist/agonist binding sites on transfected and native muscarinic receptors.EBI
National Institute of Diabetes and Digestive and Kidney Diseases
Syntheses of (R)- and (S)-2- and 6-fluoronorepinephrine and (R)- and (S)-2- and 6-fluoroepinephrine: effect of stereochemistry on fluorine-induced adrenergic selectivities.EBI
National Institute of Diabetes and Digestive and Kidney Diseases
Tetrahydrobenzothiophenone derivatives as a novel class of adenosine receptor antagonists.EBI
National Institute of Diabetes
Effect of trifluoromethyl and other substituents on activity of xanthines at adenosine receptors.EBI
National Institutes of Health
Synthesis and biological properties of 2-, 5-, and 6-fluoronorepinephrines.EBI
TBA
Synthesis of paraxanthine analogs (1,7-disubstituted xanthines) and other xanthines unsubstituted at the 3-position: structure-activity relationships at adenosine receptors.EBI
Pharmazeutische Chemie
Mesoionic xanthine analogues: antagonists of adenosine receptors.EBI
TBA
Xanthine functionalized congeners as potent ligands at A2-adenosine receptors.EBI
TBA
Analogues of caffeine and theophylline: effect of structural alterations on affinity at adenosine receptors.EBI
TBA
Benzo[1,2-c:5,4-c']dipyrazoles: non-xanthine adenosine antagonists.EBI
Merrell Dow Research Institute
Analogues of 1,3-dipropyl-8-phenylxanthine: enhancement of selectivity at A1-adenosine receptors by aryl substituents.EBI
TBA
Anticonvulsant activity of piperidinol and (dialkylamino)alkanol esters.EBI
TBA
Functionalized congeners of 1,3-dialkylxanthines: preparation of analogues with high affinity for adenosine receptors.EBI
TBA
Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions.EBI
National Institutes of Health
7-Deaza-2-phenyladenines: structure-activity relationships of potent A1 selective adenosine receptor antagonists.EBI
National Institute of Diabetes
Imidazodiazepinediones: a new class of adenosine receptor antagonists.EBI
National Institute of Diabetes
Effect of fluorine substitution on the adrenergic properties of 3-(tert-butylamino)-1-(3,4-dihydroxyphenoxy)-2-propanol.EBI
National Institute of Diabetes
Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases.BDB
Irbm/Merck Research Laboratories