BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.2M data for 1.4M Compounds and 11.4K Targets. Of those, 1.6M data for 756K Compounds and 4.8K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

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19 articles for FP Bymaster

The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
1-(1,2,5-Thiadiazol-4-yl)-4-azatricyclo[2.2.1.0(2,6)]heptanes as new potent muscarinic M1 agonists: structure-activity relationship for 3-aryl-2-propyn-1-yloxy and 3-aryl-2-propyn-1-ylthio derivatives.EBI
Novo Nordisk
Functionally selective M1 muscarinic agonists. 3. Side chains and azacycles contributing to functional muscarinic selectivity among pyrazinylazacycles.EBI
Eli Lilly
Identification of side chains on 1,2,5-thiadiazole-azacycles optimal for muscarinic m1 receptor activation.EBI
Novo Nordisk
 
Synthesis and structure activity relationships of alkyl substituted analogues of the functional M1 selective muscarinic receptor agonist xanomelineEBI
TBA
Duloxetine (Cymbalta), a dual inhibitor of serotonin and norepinephrine reuptake.EBI
Eli Lilly
1,2,5-Thiadiazole analogues of aceclidine as potent m1 muscarinic agonists.EBI
Eli Lilly
Conformationally constrained analogues of the muscarinic agonist 3-(4-(methylthio)-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydro-1-methylpyr idine. Synthesis, receptor affinity, and antinociceptive activity.EBI
Novo Nordisk
Muscarinic analgesics with potent and selective effects on the gastrointestinal tract: potential application for the treatment of irritable bowel syndrome.EBI
Lilly Research Laboratories
Novel functional M1 selective muscarinic agonists. Synthesis and structure-activity relationships of 3-(1,2,5-thiadiazolyl)-1,2,5,6-tetrahydro-1-methylpyridines .EBI
Novo Nordisk Cns Division
Novel functional M1 selective muscarinic agonists. 2. Synthesis and structure-activity relationships of 3-pyrazinyl-1,2,5,6-tetrahydro-1-methylpyridines. Construction of a molecular model for the M1 pharmacophore.EBI
Eli Lilly
Heterocyclic inhibitors of monocarboxylate transporterBDB
The Scripps Research Institute
Aminoindane-, aminotetrahydronaphthalene- and aminobenzocyclobutane-derived PRMT5-inhibitorsBDB
Ctxt
Sphinogosine-1-phosphate receptor modulators for treatment of cardiopulmonary disordersBDB
The Scripps Research Institute
Urea and amide derivatives of aminoalkylpiperazines and use thereofBDB
Southern Research Institute
Compositions and methods of modulating 15-PGDH activityBDB
University of Kentucky Research Foundation
CXCR7 antagonistsBDB
Chemocentryx
DcpS as a therapeutic target for spinal muscular atrophy.BDB
Decode Chemistry
Structure-based design of an organoruthenium phosphatidyl-inositol-3-kinase inhibitor reveals a switch governing lipid kinase potency and selectivity.BDB
University of Pennsylvania
Structure of the BH3 domains from the p53-inducible BH3-only proteins Noxa and Puma in complex with Mcl-1.BDB
University of Otago