36 articles for SV Frye
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
Data
Article Title
Organization
Design and Synthesis of Novel Macrocyclic Mer Tyrosine Kinase Inhibitors.
University of North Carolina at Chapel Hill
Structure-Activity Relationships and Kinetic Studies of Peptidic Antagonists of CBX Chromodomains.
University of North Carolina at Chapel Hill
UNC2025, a potent and orally bioavailable MER/FLT3 dual inhibitor.
University of North Carolina at Chapel Hill
Discovery of a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8.
University of North Carolina at Chapel Hill
Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis.
Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh
Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors.
University of North Carolina at Chapel Hill
Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP.
University of North Carolina at Chapel Hill
Small-molecule ligands of methyl-lysine binding proteins: optimization of selectivity for L3MBTL3.
University of North Carolina at Chapel Hill
Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors.
University of North Carolina at Chapel Hill
Structure-functional selectivity relationship studies ofß-arrestin-biased dopamine D2 receptor agonists.
University of North Carolina at Chapel Hill
Orally active adenosine A(1) receptor agonists with antinociceptive effects in mice.
University of North Carolina at Chapel Hill
Discovery of Novel Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia.
TBA
Identification of non-peptide malignant brain tumor (MBT) repeat antagonists by virtual screening of commercially available compounds.
University of North Carolina at Chapel Hill
Structure-activity relationships for inhibition of type 1 and 2 human 5 alpha-reductase and human adrenal 3 beta-hydroxy-delta 5-steroid dehydrogenase/3-keto-delta 5-steroid isomerase by 6-azaandrost-4-en-3-ones: optimization of the C17 substituent.
Glaxo Inc. Research Institute
6-Azasteroids: structure-activity relationships for inhibition of type 1 and 2 human 5 alpha-reductase and human adrenal 3 beta-hydroxy-delta 5-steroid dehydrogenase/3-keto-delta 5-steroid isomerase.
Glaxo Inc. Research Institute
Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines.
University of North Carolina at Chapel Hill
Small-molecule ligands of methyl-lysine binding proteins.
University of North Carolina at Chapel Hill
Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines.
University of North Carolina at Chapel Hill
Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a.
University of North Carolina
Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain.
University of North Carolina Eshelman School of Pharmacy
An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1.
UNC Eshelman School of Pharmacy
Fused Tetrahydroquinolines Are Interfering with Your Assay.
University of North Carolina at Chapel Hill
Discovery of a 53BP1 Small Molecule Antagonist Using a Focused DNA-Encoded Library Screen.
University of North Carolina at Chapel Hill
UNC5293, a potent, orally available and highly MERTK-selective inhibitor.
University of North Carolina at Chapel Hill
Design, synthesis, and protein methyltransferase activity of a unique set of constrained amine containing compounds.
The Center For Combinatorial Chemistry and Drug Discovery of Jilin University
Inhibition of Inositol Polyphosphate Kinases by Quercetin and Related Flavonoids: A Structure-Activity Analysis.
National Institute of Environmental Health Sciences
The structure-activity relationships of L3MBTL3 inhibitors: flexibility of the dimer interface.
University of North Carolina
6-Azasteroids: potent dual inhibitors of human type 1 and 2 steroid 5 alpha-reductase.
Glaxo Inc. Research Institute
Highly Selective MERTK Inhibitors Achieved by a Single Methyl Group.
Unc Eshelman School of Pharmacy
Characterization of LY344864 as a pharmacological tool to study 5-HT1F receptors: binding affinities, brain penetration and activity in the neurogenic dural inflammation model of migraine.
Eli Lilly
In vitro and in vivo pharmacological characterization of N6-cyclopentyl-9-methyladenine (N-0840): a selective, orally active A1 adenosine receptor antagonist.
Whitby Research